Clinical trials: Secondary Headache Disorders
Migraine in Children, Posttraumatic Headache
A Pilot Study of Intranasal Lidocaine in Acute Management of Pediatric Migraine
Headaches in children are very common and are a source of significant distress for the patient and their family. Migraines are the most common headache disorder in children and are associated with episodic pain and other symptoms…
- Trial name
- NCT03806595
- Testing
- Lidocaine 2% Injectable Solution, Normal Saline Flush, 0.9% Injectable Solution
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Post-Dural Puncture Headache
Is Aminophylline More Effective Than Neostigmine/Atropine Mixture in the Treatment of Post-dural Puncture Headache
Objectives: To compare the safety and efficacy of IV aminophylline versus IV neostigmine/atropine mixture in the treatment of post-dural puncture headache (PDPH).
- Trial name
- RCT (NCT03997006)
- Testing
- IV Aminophylline, IV Neostigmine Methylsulfate + Atropine Sulphate
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Migraine, Tension Headache
Muscle Function and Tenderness Differences in Headache Patients
This cross-sectional study aims to compare muscle function of the neck, and shoulder and muscle tenderness in three groups of headache patients: migraine, tension-type headache, and posttraumatic headache.
- Conditions
- Migraine, Tension Headache, Posttraumatic Headache
- Trial name
- NCT06859463
- Testing
- Muscle function
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Danish Headache Center
Posttraumatic Headache, Mild Traumatic Brain Injury
Treatment of Acute PTH With a CGRP Receptor mAb in Military Service Members and Civilians With mTBI
This study aims to assess the effect and safety of erenumab compared to placebo for the treatment of acute posttraumatic headache (PTH) in military service members and civilians with mild traumatic brain injury (mTBI).
- Trial name
- NCT05049057
- Testing
- Erenumab 140 Mg/mL Subcutaneous Solution
- Where
- 4 sites in United States
- Volunteers
- 404 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Headache Disorders, Secondary
Thoracic Spine Thrust Manipulation for Cervicogenic Headaches: A Randomized Clinical Trial
Headaches have been listed as 1 of the 10 most disabling conditions worldwide. (Stovner et al., 2007) and cervicogenic headaches (CeHs) comprise 15% of the individuals with these complaints.
- Trial name
- NCT02708953
- Testing
- Thoracic manipulation (Manipulation Group), Thoracic Manipulation (Control wait-list)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Colorado, Denver
Post-Dural Puncture Headache
Sphenopalatine Block or Epidural Bloodpatch for Post Dural Puncture Headache: Randomized Controlled Trial
Introduction: Recently sphenopalatine block emerged as an alternative to epidural blood patch for post dural puncture headache but the investigators do not know if it has significant efficacy when compared to epidural blood…
- Trial name
- NCT02984618
- Testing
- Sphenopalatine ganglion block, Epidural blood patch
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Brasilia University Hospital
Mild Traumatic Brain Injury, Concussion, Post Concussive Syndrome, Chronic
Effect of Mental Imagery in Patients With Persistent Post-concussion Symptoms
Background: Mild Traumatic Brain Injury (mTBI) often results in persistent emotional, cognitive, and somatic symptoms-such as headaches and dizziness.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Post Concussive Syndrome, Chronic, Post Traumatic Headache
- Trial name
- NCT07166536
- Testing
- Provocation Test for Symptoms Using Mental Imagery
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Reuth Rehabilitation Hospital
Cervicogenic Headache
Effects of Strain Counterstrain Versus Post Isometric Relaxation on Pain, Headache Frequency, and Quality of Life in Females With Cervicogenic Headache.
Cervicogenic headache is a secondary headache disorder associated with dysfunction of the cervical spine and surrounding muscles.
- Trial name
- SCS-PIR (NCT07897695)
- Testing
- Post Isometric Relaxation, Strain Counterstrain
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Qurat Ul Ain Ashfaq
Post-Dural Puncture Headache
Sphenopalatine Ganglion Block for Management of Post- Dural Puncture Headache in Obstetric Patients
The purpose of this trial is to study the efficacy and efficiency of sphenopalatine ganglion block for management of post dural puncture headache in obstetric patients
- Trial name
- NCT04793490
- Testing
- Sphenopalatine ganglion block, paracetamol
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Post-Dural Puncture Headache
Effect of Nebulized Dexmedetomidine on Post-dural Puncture Headache
Dural puncture during neuroaxial procedures is the most frequent major complication that causes the development of post-dural puncture headache (PDPH) in 16%-86% of cases.
- Trial name
- NCT06470854
- Testing
- Nebulized Dexmedetomidine, Bilateral greater occipital nerve block
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Analgesia
Management of Post Dural Pucture Headache After Lower Limb Surgeries: Oral Prednisolone vs Oral Pregabalin
The aim of this study is to compare between oral prednisolone and oral pregabalin in management of PDPH to detect effectiveness of the treatment in reducing severity of PDPH, total rescue analgesic consumption and adverse effects…
- Trial name
- NCT04662125
- Testing
- caffeine, paracetamol tablet, Oral prednisolone, oral pregabalin
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Postdural Puncture Headache
Role of Prophylaxis by Oral Fluid Supplementation in Prevention of Postdural Puncture Headache
Postdural puncture headache (PDPH) is defined, according to the International Headache Society, as any headache develops within 5 days after a lumbar puncture.
- Trial name
- PROPHYDRA (NCT02859233)
- Testing
- Lack of hyperhydration
- Where
- 4 sites in France
- Volunteers
- 554 people
- Sponsor
- Nantes University Hospital
Cervicogenic Headache
Proprioceptive Training Reduces Headache Burden and Center of Pressure Path Length in Patients With Cervicogenic Headache
Cervicogenic headache (CGH) is a secondary headache originating from dysfunction in the cervical spine and is associated with impaired sensorimotor control and postural instability.
- Trial name
- PTRHBCOP-CGH (NCT07271004)
- Testing
- Proprioception, Conventional physical therapy
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Hungarian University of Sports Science
Headache, Cervicogenic Headache
Dry Needling for Cervicogenic Headache
This is a single-blinded randomized clinical trial. The primary aim of this study is to compare the effectiveness of dry needling of myofascial trigger points in the muscles of the head and cervical spine in addition to an upper…
- Trial name
- NCT04305223
- Testing
- Dry Needling, Upper extremity stretching program
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Emory University
Post-Traumatic Headache
Behavior Therapy vs Education for Persistent Headache After Mild TBI
This study will test a new treatment, called Headache reprocessing, for persistent post-traumatic headache. The new treatment will be compared to a headache education intervention.
- Trial name
- NCT07229391
- Testing
- Headache reprocessing, Headache education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Chronic Headache, Analgesic Rebound Headache
Propofol Injection for Daily Headache
Hypothesis A single subanesthetic dose of propofol will result in improved pain and quality of life for the next 30 days in persons with chronic daily headache (CDH) Specific objectives To measure the effect of a single infusion…
- Conditions
- Chronic Headache, Analgesic Rebound Headache, Chronic Daily Headache, Headache, Intractable
- Trial name
- NCT00228267
- Testing
- Propofol
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Alberta
Cervicogenic Headache
Impact of Adding Instrument-assisted Soft Tissue Mobilization to Mulligan Therapy in Patients With Cervicogenic Headache
this study will be conducted to investigate the impact of adding Instrument assisted soft tissue mobilization technique to mulligan therapy in patients with cervicogenic headache
- Trial name
- CGH (NCT07373912)
- Testing
- instrumeted assissted soft tissue mobilization and mulligan therapy, mulligan therapy, postural correction exercises
- Volunteers
- 60 people
- Sponsor
- Cairo University
Post-Dural Puncture Headache
Different Approaches for the Management of Post-dural Puncture Headache
Detecting the efficacy and safety of trans-nasal sphenopalatine ganglion block using either lidocaine 2% or bupivacaine 0.5 % as a treatment line for post-dural puncture headache
- Trial name
- NCT05253014
- Testing
- sphenopalatine ganglion block, paracetamol
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Bahaa Mohammed Refaie
Cervicogenic Headache, Proprioceptive Disorders
Manual Therapy vs. Multicomponent Exercise in Cervicogenic Headache
The purpose of this study is to compare the effects of manual therapy and a multicomponent exercise program on suboccipital muscle thickness, joint position sense, pain, central sensitization, balance, and kinesiophobia in…
- Conditions
- Cervicogenic Headache, Proprioceptive Disorders, Neck Pain Musculoskeletal
- Trial name
- NCT07776093
- Testing
- Manual Therapy Protocol, Multicomponent Exercise Program
- Volunteers
- 32 people
- Sponsor
- Pamukkale University
Post-Traumatic Headaches
A Prospective Controlled Treatment Trial for Post-Traumatic Headaches
Post-traumatic headaches (PTH) are the most common complaint after traumatic brain injury, possibly generated by a number of stressors to the trigeminovascular and cervical plexus networks, including inflammation of the high…
- Trial name
- NCT03007420
- Testing
- Occipital Nerve Block (ONB) using lidocaine and dexamethosone, Cervical Medial Branch Block (CMBB) using lidocaine and dexamethosone
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital