Clinical trials: Secondary Hypertension
Obstructive Sleep Apnea, Secondary Hypertension
Obstructive Sleep Apnea and Endothelial Function in Patients With Resistant Hypertension
The purpose of this study is to determine the prevalence of obstructive sleep apnea and associate it with the endothelial function behavior in patients with resistant hypertension.
- Trial name
- NCT01854190
- Testing
- WatchPAT
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Rio de Janeiro State University
Hypertension, Diabetes
A Study for Prevention of Kidney Disease in Diabetic Patients (BENEDICT)
The BENEDICT study is conducted to examine the effects of an ACE inhibitor, calcium channel blockade, a combination of these, and placebo, in the prevention of micro- and macro-albuminuria in Type 2 diabetic patients.
- Trial name
- BENEDICT (NCT00235014)
- Testing
- trandolapril, trandolapril/verapamil, verapamil
- Volunteers
- 1,204 people
- Sponsor
- Abbott
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension
Effects of Ventavis in Patients With Pulmonary Hypertension (PH) Secondary to Chronic Obstructive Pulmonary Disease (COPD)
This is a phase 2, Multi-center, double-blind, randomized, placebo-controlled study to evaluate the effects of inhaled Iloprost in patients with pulmonary hypertension secondary to COPD.
- Trial name
- NCT01437878
- Testing
- Iloprost
- Where
- 11 sites in United States, France and 1 more
- Volunteers
- 2 people
- Sponsor
- Actelion
Splenomegaly; Congestive, Chronic, Panhematopenia; Splenic
Ultrasound Guided Microwave Ablation of Splenomegaly in Children
Children with liver cirrhosis frequently develops portal hypertension. One of the serious complications to portal hypertension is splenomegaly, which may result in pancytopenia, especially thrombocytopenia that may cause bleeding…
- Conditions
- Splenomegaly; Congestive, Chronic, Panhematopenia; Splenic, Portal Hypertension
- Trial name
- NCT05050994
- Testing
- Microwave ablation
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
Renal Artery Stenosis Atherosclerotic, Secondary Hypertension Renal Arterial
Fractional Flow Reserve to Determine Atherosclerosis Renovascular Hypertension Stenting
Although randomized trials have demonstrated there is no benefit of renal-artery stenting in addition to medical therapy for patients with atherosclerosis renal artery stenosis, many patients indeed gained benefit in daily…
- Trial name
- FAIR-Pilot (NCT05732077)
- Testing
- Dopamine, Fractional Flow Reserve, Renal, Renal artery stenting
- Where
- 13 sites in China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Glaucoma, Glaucoma Eye
MicroPulse TLT - UK Study
This Prospective Interventional Study will assess the efficacy of MPTLT in the UK.
- Conditions
- Glaucoma, Glaucoma Eye, Glaucoma, Open-Angle, Glaucoma Secondary
- Trial name
- MPTLTUKS (NCT05593354)
- Testing
- Micropulse Transscleral laser therapy
- Volunteers
- 250 people
- Sponsor
- Imperial College Healthcare NHS Trust
Hypertension in Pregnancy, Hypertension
Inorganic Nitrate Supplementation in Chronic Hypertensive Pregnancies
High blood pressure during pregnancy poses significant risks to both the mother and baby. A combination of factors, including advancing maternal age, rising obesity rates, and metabolic health issues, have amplified the…
- Conditions
- Hypertension in Pregnancy, Hypertension, Pregnancy
- Trial name
- NIT_CH (NCT06105775)
- Testing
- Inorganic Nitrate Capsule
- Where
- Brazil
- Volunteers
- 144 people
- Sponsor
- University of Sao Paulo
Portal Hypertension
Endoscopic Variceal Ligation (EVL)+ Drugs Versus Endoscopic Variceal Ligation (EVL) Alone For Secondary Prophylaxis
Background: Both endoscopic variceal ligation (EVL) and propranolol are valuable methods for secondary prophylaxis of variceal bleeding. Addition of ISMN to propranolol improves the efficacy of drug therapy.
- Trial name
- Secondary (NCT00766805)
- Testing
- EVL + Propranolol + Isosorbide 5 mononitrate, EVL alone
- Where
- India
- Volunteers
- 177 people
- Sponsor
- Govind Ballabh Pant Hospital
Pre-Eclampsia, Cathepsin B Level
The Role of Pentraxin 3 and Cathepsin B Levels in Preeclamptic Pregnancy
In this study, the investigator aim was to compare Cathepsin B and Pentraxin 3 levels measured from maternal serum of pregnant women diagnosed with preeclampsia in the second trimester, the effects of these levels on maternal/…
- Conditions
- Pre-Eclampsia, Cathepsin B Level, Pentraxin 3 Level
- Trial name
- NCT05924061
- Testing
- Cathepsin B and pentraxin 3 levels in preeclampsia with pregnant women
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Preeclampsia Severe, Pre-Eclampsia
Metformin and Esomeprazole in Preterm Pre-eclampsia
The purpose of this study is to better understand diagnosis and treatment of preterm preeclampsia. Currently, there are limited laboratory tests that can be used to diagnosis preeclampsia.
- Conditions
- Preeclampsia Severe, Pre-Eclampsia, Preeclampsia, Preeclampsia Second Trimester
- Trial name
- NCT06359015
- Testing
- Metformin, Esomeprazole
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Christiana Care Health Services
Hypertension, Pulmonary
Catheter Denervation of Pulmonary Arteries in Treatment of IPAH & SPAH
The aim of research proposal is to assess and compare the safety and efficacy of radiofrequency denervation of pulmonary arteries on decrease in pulmonary vascular resistance and mean pulmonary artery pressure (MPAP) in 20…
- Trial name
- CADOPA (NCT02403908)
- Testing
- nMARQ Circular and Crescent catheters
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb
Glaucoma, Angle-Closure
Outcome of GATT Combined With Goniosynechiolysis in Glaucoma Patients With Secondary Synechial Angle Closure.
To evaluate the intraocular pressure reduction effect of combined gonioscopy-assisted transluminal trabeculotomy (GATT) with goniosynechialysis in eyes with secondary synechial angle closure glaucoma.
- Trial name
- NCT06445634
- Testing
- Gonioscopy-Assisted Transluminal Trabeculotomy Combined with Goniosynechiolysis
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Kasr El Aini Hospital
To Investigate the Relationship Between the Adherence of HHEP After ISTIA and Stroke Recurrence or Cardiovascular Events.
A Nested Case-control Study on the Secondary Prevention of Ischemic Stroke and TIA by Hypertension Health Education Protocol (HHEP): The Post-Stroke Preventive Trial
Patients with a diagnosis of ischemic stroke or TIA (ISTIA), who are treated at hospital are asked to participate in our pre specified hypertension health education protocol (HHEP) after discharge from our hospital.HHEP was used…
- Trial name
- NCT01812421
- Testing
- Hypertension Health Education Protocol (HHEP)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Intracerebral Hemorrhage
Retrospective Cohort Study of Intracerebral Hemorrhage
The investigators design a retrospective, observational cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective, treatments and prognosis of Chinese hospitalized…
- Trial name
- REST (NCT04803292)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cerebrovascular Accident, Hypertension
Secondary Prevention of Small Subcortical Strokes Trial
The goal of this study is to learn if combination antiplatelet therapy (aspirin and clopidogrel) is more effective than aspirin alone for the prevention of recurrent stroke and cognitive decline, and if intensive blood pressure…
- Trial name
- SPS3 (NCT00059306)
- Testing
- aspirin, clopidogrel, Target of Blood Pressure
- Where
- 63 sites in United States, Canada and 5 more
- Volunteers
- 3,020 people
- Sponsor
- University of British Columbia
Metastatic Colorectal Cancer (Mcrc), Intrahepatic Cholangiocarcinoma (Icc)
PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma
Background: One way to treat liver cancer is to deliver chemotherapy drugs only to the liver (and not to the whole body). Researchers want to see if adding the drug PDS01ADC can improve the treatment.
- Conditions
- Metastatic Colorectal Cancer (Mcrc), Intrahepatic Cholangiocarcinoma (Icc), Intrahepatic Bile Duct Cancer, Colorectal Neoplasms
- Trial name
- NCT05286814
- Testing
- Dexamethasone, PDS01ADC, Intera 3000 Hepatic Artery Infusion Pump (HAIP)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Preeclampsia, Pregnancy Biomarker
MATERNAL SERUM CADHERİN-6 AS A PREDİCTOR OF PREECLAMPSİA
Preeclampsia is a pregnancy-specific hypertensive disorder that remains one of the leading causes of maternal and perinatal morbidity and mortality worldwide.
- Conditions
- Preeclampsia, Pregnancy Biomarker, Cadherin-6
- Trial name
- NCT07467226
- Testing
- Maternal serum cadherin-6 measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Samsun University
Intra-Abdominal Hypertension
The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients
Intra-abdominal hypertension (IAH) is a frequent cause of organ dysfunction in critically ill patients. Secondary IAH is mainly caused by excessive fluid resuscitation.The World Society for the Abdominal Compartment Syndrome…
- Trial name
- NCT01072071
- Testing
- furosemide
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Ziekenhuis Netwerk Antwerpen (ZNA)
Liver Cirrhosis, Portal Hypertension
Underdilated VCX-TIPS Versus EVL Plus NSBB for Secondary Prophylaxis of Variceal Bleeding in Cirrhosis
Variceal bleeding is a major complication of portal hypertension in patients with cirrhosis and is associated with substantial risks of rebleeding and death.
- Conditions
- Liver Cirrhosis, Portal Hypertension, Gastroesophageal Varices Bleeding, Esophageal Varices
- Trial name
- U-TIPS (NCT07587671)
- Testing
- Underdilated VCX-TIPS, Endoscopic Variceal Ligation, Nonselective Beta-Blockers
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- West China Hospital
Liver Cirrhosis, Esophageal and Gastric Varices
The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding
To compare the efficacy and safety of Carvedilol and Propranolol in patients with cirrhosis-related esophagogastric varices after multiple endoscopic treatments for secondary prophylaxis.
- Conditions
- Liver Cirrhosis, Esophageal and Gastric Varices, Hemorrhage
- Trial name
- NCT02385422
- Testing
- Carvedilol, Propranolol
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shanghai Zhongshan Hospital