Clinical trials: Secondary Stroke
Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)
A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers
Study BT200-01 is a first in human (FIH) study in male and female normal human volunteers (NHVs) that uses an Integrated Protocol Design.
- Conditions
- Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis), Intracranial Arteriosclerosis
- Trial name
- NCT04103034
- Testing
- BT200, Desmopressin
- Where
- Austria
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Band Therapeutics
Aneurysmal Subarachnoid Hemorrhage
Hypercapnia to Prevent Secondary Ischemia in SAH
Delayed cerebral vasospasm and secondary ischemic infarction are feared complications after aneurysmal subarachnoid hemorrhage (aSAH). To date, there is no effective therapy to prevent these ischemic complications.
- Trial name
- SAHCO2 (NCT01799525)
- Testing
- Hypercapnia by reduction of respiratory volume
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Wuerzburg University Hospital
Stroke, Acute
Improving Follow up Care for People After Minor Stroke
The goal of this feasibility study is to ascertain if this follow-up programme of care can feasibly be implemented within a healthcare system with people after minor stroke.
- Trial name
- NCT05897905
- Testing
- Personalised, holistic follow-up appointments underpinned by self determination theory
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College Healthcare NHS Trust
Ischemic Stroke, Medication Persistence
Affect of Multiple Health Education on Medication Persistence and Clinical Prognosis of Ischemic Stroke Patients
The study aimed to demonstrate the relationship between secondary prevention medication persistence and clinical prognosis of ischemic stroke patients at 3,6,12 months
- Trial name
- NCT02140619
- Testing
- multiple health education interventions
- Where
- China
- Volunteers
- 3,111 people
- Sponsor
- yongjun wang
Cerebrovascular Accident, Transient Ischemic Attack
E-Selectin Nasal Spray to Prevent Stroke Recurrence
This study will test the safety and effectiveness of a protein called E-selectin, given as a nasal spray, in preventing the formation of blood clots that can cause stroke.
- Trial name
- NCT00012454
- Testing
- E-Selectin nasal spray
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebral Infarction
Cilostazol Stroke Prevention Study : A Placebo-controlled Double-blind Trial for Secondary Prevention of Cerebral Infarction.
The multi-center, double-blind, placebo-controlled, randomized, group-comparison study was designated to assess the long-term safety and efficacy of the antiplatelet drug cilostazol in preventing the recurrence of cerebral…
- Trial name
- CSPS (NCT00766545)
- Testing
- cilostazol
- Where
- Japan
- Volunteers
- 1,095 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Atherosclerosis, Ischemia
Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737)
The study is designed to determine whether vorapaxar, when added to the existing standard of care (SOC) for preventing heart attack and stroke (eg, aspirin, clopidogrel) in participants with a known history of atherosclerosis…
- Conditions
- Atherosclerosis, Ischemia, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00526474
- Testing
- Vorapaxar
- Volunteers
- 26,449 people
- Sponsor
- Merck Sharp & Dohme LLC
Ischemic Stroke, CYP2C19 Polymorphism
Implementation of Onsite Rapid CYP2C19 Assay for Genotype Guided Dual Antiplatelet Therapy After Acute Ischemic Stroke
The goal of this observational study is to use a genetic test to help doctors prescribe the most effective medications after a patient has a stroke. One type of stroke is caused by a blood clot in brain vessels.
- Trial name
- ORCA-AIS (NCT06292117)
- Testing
- CYP2C19 Genotype
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Virginia
Acute Stroke
Investigation of the Reliability and Validity of the Movement Imagination Questionnaire - Revised Second in Acute Stroke Patients
Our study was planned to investigate the reliability validity of the Movement Imagery Questionnaire- RS in acute stroke patients.
- Trial name
- NCT04283760
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Stroke, Moyamoya Disease
Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project)
The goal of this clinical trial is to obtain initial feedback on the implementation of the STRATIF-AI platform and digital twin in the secondary prevention phase in patients with stroke, Moyamoya disease and Cerebral amyloid…
- Conditions
- Stroke, Moyamoya Disease, Cerebral Amyloid Angiopathy
- Trial name
- SMART (NCT06714097)
- Testing
- AI, healthy dialogue
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Stroke
The Secondary Prevention Trial for Ischemic Stroke With DengzhanShengmai Capsule
In order to observe the secondary preventive effect of the Dengzhanshengmai capsule on ischemic stroke, the investigators hold the large randomized control trial (RCT).
- Trial name
- SPIRITDZSM1 (NCT00548223)
- Testing
- Dengzhan Shengmai capsule
- Where
- 84 sites in China
- Volunteers
- 3,143 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Stroke
Brazilian Adaptation of an Intervention Developed in Ireland to Promote Healthy Lifestyle Behaviors Post-stroke: a Feasibility Study
Introduction: Low- and middle-income countries, such as Brazil, are most impacted by the high burden of recurrent stroke. These countries also lack structured interventions to promote the adoption of healthy lifestyle behaviors…
- Trial name
- NCT07119047
- Testing
- A Brazilian adaptation of the Irish intervention "iHELP Stroke"
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Federal University of Minas Gerais
Cerebrovascular Accident, Hypertension
Secondary Prevention of Small Subcortical Strokes Trial
The goal of this study is to learn if combination antiplatelet therapy (aspirin and clopidogrel) is more effective than aspirin alone for the prevention of recurrent stroke and cognitive decline, and if intensive blood pressure…
- Trial name
- SPS3 (NCT00059306)
- Testing
- aspirin, clopidogrel, Target of Blood Pressure
- Where
- 63 sites in United States, Canada and 5 more
- Volunteers
- 3,020 people
- Sponsor
- University of British Columbia
Ischemic Stroke, Transient Ischemic Attack
Trial of a Secondary Stroke Prevention Program
The purpose of this study is to determine whether an outpatient program can reduce the risk of recurrent stroke.
- Trial name
- NCT01071408
- Testing
- Stroke prevention care program
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Sepulveda Research Corporation
Stroke, Embolism
Non-interventional Local Study on Prescription Behavior of Anticoagulation Therapy in Secondary Stroke Prevention in Atrial Fibrillation Patients
This is local prospective multicenter observational non-interventional local study. Primary study objective is investigate and describe prescription pattern of neurologists in secondary stroke or non-CNS (non-Central Nervous…
- Trial name
- NEURO-XAR (NCT01925755)
- Testing
- Rivaroxaban ( Xarelto, BAY59-7939)
- Where
- Russia
- Volunteers
- 209 people
- Sponsor
- Bayer
Stroke, Ischemic
MidregiOnal Proatrial Natriuretic Peptide to Guide SEcondary Stroke Prevention
The present trial is addressing the question if a biologically distinct subgroup of ischemic stroke patients without known atrial fibrillation at admission, selected by a cut-off level of MRproANP concentration, which represents…
- Trial name
- MOSES (NCT03961334)
- Testing
- Dabigatran, Apixaban, Edoxaban
- Where
- 14 sites in Greece, Norway and 3 more
- Volunteers
- 620 people
- Sponsor
- University of Zurich
Stroke
Long-term Follow-up After Stroke (The LAST-long Trial)
Despite the improved treatment of acute stroke over the past decades, those suffering from stroke still are at an increased risk of functional and cognitive decline in the long term.
- Trial name
- LAST-long (NCT03859063)
- Testing
- Intervention, Control
- Where
- 4 sites in Norway
- Volunteers
- 301 people
- Sponsor
- Norwegian University of Science and Technology
Stroke, Hypertension
Feasibility of Home Telehealth Monitoring for Improvement in Management of Hypertension for Secondary Stroke Prevention
This research is being done to determine how home blood pressure monitoring, using a commercially available blood pressure monitor with the capability of transmitting readings to stroke doctors can help manage blood pressure in…
- Trial name
- NCT03517709
- Testing
- Primary Care Physician Management of blood pressure, Withings Smart Blood Pressure Monitor
- Where
- United States
- Sponsor
- Johns Hopkins University
Hemiplegia, Hemiparesis
Evaluation of the Safety and Performance of the AWAKE Device in Patients With Hemiplegia or Hemiparesis Secondary to Stroke (ACV).
Stroke is a leading cause of disability in adults, with gait impairment being a key functional limitation. Although lower limb exoskeletons are used in rehabilitation, the available evidence focuses on bilateral devices used in…
- Trial name
- VAWAKE (NCT07867847)
- Testing
- Bionic System (AWAKE)
- Volunteers
- 20 people
- Sponsor
- Bionic Mobility Solutions, S.L.
Socioeconomic Status, Secondary Prevention
Socioeconomic Status, Secondary Prevention Activities and Recurrence After a Myocardial Infarction
This is a nationwide cohort study on real-world patients (n≈30,000) surviving a first myocardial infarction (MI) 2006-2013 and alive to attend a routine 1-year follow-up.
- Conditions
- Socioeconomic Status, Secondary Prevention, Myocardial Infarction, Cardiovascular Disease
- Trial name
- NCT04199663
- Volunteers
- 30,191 people
- Sponsor
- Karolinska Institutet