Clinical trials: Sedation;
Conscious Sedation
Monitored Anesthesia Care: Dexmedetomidine-Ketamine Versus Dexmedetomidine- Propofol For Chronic Subdural Hematoma
Inadequate sedation and analgesia indicated by intraoperative movements are markers of inadequate MAC during burr-hole surgery for chronic subdural hematoma evacuation especially when general anesthesia poses high risk for the…
- Trial name
- NCT04621526
- Testing
- dexmedetomidine- ketamine, dexmedetomidine- propofol
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Rectal Prolapse
Endoluminal and Needlescopic Assisted Repair of Rectal Prolapse
The purpose of this study is to evaluate the safety and feasibility of endoluminal rectal prolapse repair under sedation and local anesthesia using CO2 colonoscopy to fix the rectum with sutures to the abdominal wall under…
- Trial name
- NCT01980043
- Testing
- endoluminal rectal prolapse repair under sedation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Weill Medical College of Cornell University
Sedative Adverse Reaction, Analgesic Adverse Reaction
The Use of Midazolam and Remifentanil During Dialysis Access Procedures
BACKGROUND: Sedation and analgesia are related to unexpected adverse events in chronic renal failure patients undergoing arteriovenous fistula placement procedures under monitored anesthesia care (MAC).
- Conditions
- Sedative Adverse Reaction, Analgesic Adverse Reaction, Midazolam Adverse Reaction, Adverse Reaction to Drug
- Trial name
- NCT04226443
- Testing
- Midazolam intravenous injection, Remifentanil intravenous bolus dose
- Volunteers
- 99 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Performance of Non-anesthesiologists Residents for the Management of Sedation's Complications
High Fidelity Simulation and Sedation Training of Non-anesthesiologists Residents
Objective Sedation is a depression of consciousness varies between anxiolysis and general anesthesia. It is used to facilitate diagnostic tests and minor surgeries.
- Trial name
- DedSim (NCT02722226)
- Testing
- Simulation, Airway management, Crisis resource management
- Volunteers
- 32 people
- Sponsor
- Issam Tanoubi
Long-term Sedation for Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Remimazolam vs Propofol for Long-Term Sedation in Mechanically Ventilated ICU Patients
This multicenter, randomized, controlled, non-inferiority trial is designed to determine whether remimazolam is non-inferior to propofol for prolonged sedation in adult ICU patients requiring mechanical ventilation for ≥48 hours.
- Trial name
- RePro-ICU (NCT07880548)
- Testing
- Remimazolam group, Propofol group
- Where
- 21 sites in China
- Volunteers
- 274 people
- Sponsor
- Sun Yat-sen University
Lung Cancers, Peripheral Pulmonary Nodules
General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound
The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs.
- Trial name
- RESSOURCE (NCT06950515)
- Testing
- Peripheral EBUS under Concious sedation, Peripheral EBUS under General Anesthesia
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Sedation Complication, Frailty
Advers Events in Patients Undergoing Gastrointestinal Procedural Sedation
Investigators will include in our study patients aged 60 and over who have been evaluated in the pre-anesthesia clinic for procedures such as endoscopy, colonoscopy, ERCP, PEG, EUS, and ESD, and who have received sedation by an…
- Trial name
- NCT06044298
- Testing
- procedural sedation
- Where
- Turkey (Türkiye)
- Volunteers
- 1,500 people
- Sponsor
- Uludag University
Ventilation
Bispectral Index (BIS) on Ventilated Patients in the Prehospital Setting
To evaluate the effectiveness of use of the bispectral index for monitoring of depth of sedation in ventilated patients during their prehospital management by a physician- staffed EMS.
- Trial name
- OHBIS (NCT00919971)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Beaujon Hospital
Auditory Brainstem Response
Intranasal Dexmedetomidine for Sedated Hearing Testing
Auditory brainstem response testing is necessary in children who are not able to be tested by classical audiogram, because of their age or an associated retarded psycho-motor development or behavioral and cognitive troubles.
- Trial name
- NCT03530371
- Testing
- Dexmedetomidine Hydrochloride
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Lenval
Acute Lung Injury, Acute Respiratory Distress Syndrome
Airway Pressure Release Ventilation in Acute Lung Injury
The purpose of this study is to compare airway pressure release ventilation (APRV) to conventional mechanical ventilation (MV) in patients with acute lung injury (ALI) to determine if APRV can reduce agitation, delirium, and…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Mechanical Ventilation
- Trial name
- NCT00750204
- Testing
- APRV, Conventional MV
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Surgery, Hypoventilation
A Comparison of the Detection of Hypoventilation During Deep Sedation Utilizing Nasal End Title CO@ Versus Transcutaneous CO2 Measurement Techniques
The estimation of the partial pressure of carbon dioxide (PCO2) in the arterial blood is used to judge the adequacy of ventilation during spontaneous and controlled ventilation.
- Trial name
- NCT00954733
- Testing
- Arterial blood draw
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Inflammatory Disorder of Immune System, Sepsis
Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status
ICU patients always experience all kinds of pain, discomfort and sleep disturbance,especially the sepsis patients. Appropriate sedation and analgesia is must,the newest sepsis guideline strongly recommend that mechanically…
- Trial name
- NCT02135055
- Testing
- blood sample collection, Midazolam, Morphine
- Volunteers
- 80 people
- Sponsor
- Xiangya Hospital of Central South University
Sedative Adverse Reaction
The Effect of Real-time Binaural Sound on Sedation Using Dexmedetomidine
The aim of the study is to evaluate whether real-time binaural sound affects the dose of dexmedetomidine in patients undergoing sedation with dexmedetomidine after spinal anesthesia.
- Trial name
- NCT04866433
- Testing
- Real-time binaural sound, Music, Control
- Where
- South Korea
- Volunteers
- 189 people
- Sponsor
- Seoul National University Hospital
Hypoxia, Gastric Cancer
Efficacy and Safety of Remimazolam Tosylate for Sedation in Gastroscopy
Propofol is the most commonly used intravenous anesthetic for painless gastroscopy, but propofol significantly inhibits the respiratory and circulatory systems.
- Conditions
- Hypoxia, Gastric Cancer, Sedation Complication, Propofol Adverse Reaction
- Trial name
- NCT04727034
- Testing
- Remimazolam tosylate, Propofol
- Where
- 5 sites in China
- Volunteers
- 1,800 people
- Sponsor
- RenJi Hospital
Severe Traumatic Brain Injury, Intracranial Hypertension
Ketamine for Sedation in Severe Traumatic Brain Injury
This protocol is for an open-label randomized trial evaluating the safety of using ketamine in combination with propofol for sedation versus the standard of care analgosedation in patients admitted to the intensive care unit with…
- Conditions
- Severe Traumatic Brain Injury, Intracranial Hypertension, Intracranial Hemorrhage, Hypertensive
- Trial name
- Ketamine (NCT06429657)
- Testing
- Ketamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Pain, Anesthesia
Pupillary Dilation After Incremental Tetanic Stimulations Under Ketamine Sedation
The aim of the study was to describe the relationship between the intensity of a standardized tetanic stimulation and the associated reflex pupillary dilation in patients under ketamine sedation.
- Trial name
- NCT02648412
- Testing
- ketamine, Tetanic stimulations of incremental intensities
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Pr Isabelle CONSTANT
Driving Performance, Cognitive Impairment
The Effects of Cannabidiol on the Driving Ability of Healthy Adults
A randomized, parallel-group, double-blind, exploratory two-arm trial to assess the effects of CBD on driving ability along with changes in psychological status (i.e. mood, drowsiness, sedation) and cognitive function.
- Conditions
- Driving Performance, Cognitive Impairment, Sedation Complication, Mood
- Trial name
- NCT04590495
- Testing
- 300 mg Cannabidiol (CBD) oil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Mechanical Ventilation, Dexmedetomidine
Dexmedetomidine vs Midazolam on Resting Energy Expenditure in Critically Ill Patients
The aim of this study is to compare the effect of dexmedetomidine on resting energy expenditure in relation to the midazolam in critically ill patients using indirect calorimetry
- Conditions
- Mechanical Ventilation, Dexmedetomidine, Midazolam, Sedation
- Trial name
- NCT03030911
- Testing
- Dexmedetomidine, Midazolam, Fentanyl
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Analgesia, Postoperative Pain
The Availability and Safety Study of Remimazolam Besylate for Injection on Sedation of ERAS Patients
This trial intends to evaluate Remimazolam Besylate's availability and safety compared with propofol.
- Trial name
- NCT04947345
- Testing
- Remimazolam Besylate, Propofol
- Volunteers
- 84 people
- Sponsor
- Peking Union Medical College Hospital
Delirium
Enhancing European Management of Analgesia, Sedation and Delirium
This prospective, multicenter study aims to evaluate the effect of routine training of intensive care unit (ICU) staff on the implementation rate of screening tools for pain, agitation and delirium (PAD) ) in three one day…
- Trial name
- NCT03553719
- Where
- Germany
- Volunteers
- 430 people
- Sponsor
- Charite University, Berlin, Germany