Clinical trials: Sedation
Sedation Complication, Endoscopic Submucosal Dissection
Efficacy and Safety of Etomidate Sedation in Gastric Endoscopic Submucosal Dissection
During endoscopy, the patient is sedated to relieve pain and improve the ease of the procedure. Sedation endoscopy using propofol is effective, but has the disadvantage that cardiopulmonary side effects are frequently observed.
- Conditions
- Sedation Complication, Endoscopic Submucosal Dissection, Esophagogastroduodenoscopy
- Trial name
- NCT05407870
- Testing
- Etomidate Injection, Propofol Injection
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Korea University Anam Hospital
Sedation in the Upper Gastrointestinal Endoscopy
A Study of Remimazolam Tosilate for Sedation in the Upper Gastrointestinal Endoscopy
The purpose of this study is to evaluate the efficacy and safety of Remimazolam Tosilate for Injection for sedation in Upper Gastrointestinal Endoscopy
- Trial name
- NCT06169995
- Testing
- Remimazolam Tosilate
- Where
- 2 sites in China
- Volunteers
- 31 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Procedural Anxiety, Procedural Pain
Remimazolam Sedation for Nerve Blocks
Observational study recording sedation and safety of patients undergoing remimazolam sedation for peripheral nerve blocks. Objectives: To explore the safety and efficacy of remimazolam for neuraxial procedures and peripheral…
- Trial name
- REMI-SEN (NCT05415202)
- Testing
- Remimazolam 20 MG [Byfavo]
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Utah
Geriatrics, Outpatients
Dexmedetomidine vs. Remifentanil Undergoing Cataract Surgery in Geriatrics
Dexmedetomidine is an α2-adrenergic receptor agonist used for its sympatholytic effect, providing sedation, analgesia, and cardiovascular stabilization in the perioperative period.
- Conditions
- Geriatrics, Outpatients, Personal Satisfaction
- Trial name
- NCT04935541
- Testing
- Dexmedetomidine infusion, Remifentanil infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Selcuk University
Anesthesia, Deep Sedation
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Anesthesia
Hypothesis: There is a statistically measurable correlation between qNOX and rough clinical signs of insufficient anti-nociception such as movements during Laryngeal Mask Airway (LMA) insertion, skin Incision, LMA removal.
- Trial name
- NCT02928172
- Testing
- qCON-qNOX, BIS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Palliative Sedation
Measuring Comfort During Palliative Sedation
Background. In case of untreatable suffering at the end of life, palliative sedation may be chosen to assure comfort by reducing the patient's level of consciousness.
- Trial name
- COMPAS (NCT03273244)
- Testing
- NeuroSense monitoring and ANI monitoring
- Where
- 2 sites in Belgium
- Volunteers
- 12 people
- Sponsor
- Vrije Universiteit Brussel
Dental Anxiety
Sevoflurane Associated With Oral Midazolam and Ketamine for Dental Sedation
There is still extensive debate on the best method of controlling the behavior of preschool children during dental treatment. Protective stabilization, moderate sedation and general anesthesia are advanced behavior control…
- Trial name
- NCT02284204
- Testing
- Midazolam, Ketamine and Sevoflurane, Midazolam and Ketamine
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Universidade Federal de Goias
Emergence Agitation
A Comparison of Emergence Agitation by Sevoflurane for Intraoperative Sedation Associated With Caudal Block
This study was performed to compare the incidence of EA between two dose of sevoflurane for sedation with caudal block in children, and intended to find the optimal dose for prevention of sevoflurane induced emergence agitation
- Trial name
- NCT03134547
- Testing
- low dose sevoflurane group, high dose sevoflurane group
- Volunteers
- 40 people
- Sponsor
- Yeungnam University College of Medicine
Anesthesia; Reaction
Dexmedetomidine-Propofol and Ketamine-Propofol During Upper Gastrointestinal System Sedation
Sedation with dexmedetomidine-propofol or ketamine-propofol was planned in patients with upper gastrointestinal endoscopy.
- Trial name
- NCT04399226
- Testing
- Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Anesthesia, Regional Anesthesia Morbidity
Feasibility of Serratus Plane Block Associated With Sedation in Axillary Dissection
INTRODUCTION: The axillary lymphadenectomy procedure is known to be associated with late postoperative complications, such as chronic pain and changes in shoulder mobility.
- Conditions
- Anesthesia, Regional Anesthesia Morbidity, Axillary Metastases, Nerve Block
- Trial name
- NCT03740815
- Testing
- Serratus plane block, Axillary dissection, Intravenous sedation
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
ARDS, Human
Depth of Sedation and Its Impact on Cerebrovascular Reactivity in Acute Respiratory Distress Syndrome: a Pilot Analysis
Investigation of the feasibility of monitoring processed transcutaneous electroencephalography (EEG), a method of interpreting brain activity, and near-infrared spectroscopy (NIRS), a method of determining levels of tissue…
- Trial name
- NCT05847634
- Testing
- Masimo O3 NIRS cerebral oximetry and SedLine processed EEG
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Hypoxia, Hysteroscopy
The Effects of Remimazolam on the Incidence of Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients
Hypoxia is a common adverse event during sedated hysteroscopy for assisted reproduction, and it is more likely to occur in overweight or obese patients.
- Conditions
- Hypoxia, Hysteroscopy, Overweight or Obesity
- Trial name
- EROP (NCT06004843)
- Testing
- remimazolam, Propofol
- Where
- China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
TAVI(Transcatheter Aortic Valve Implantation)
Respiratory and Haemodynamic Effects of Conscious Sedation With Dexmedetomidine for a TAVI Procedure
Transcatheter aortic valve implantation (TAVI) is now the standard procedure for elderly patients with severe aortic stenosis. This patient group is characterised by increased frailty, multiple comorbidities and limited…
- Trial name
- NCT07532733
- Testing
- Sedation with dexmedetomidine, sedation propofol and remifentanil
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Erasme University Hospital
Cataract, Preoperative Sedation
Intranasal Dexmedetomidine for Adult Patients Undergoing Phacoemulsification Cataract Surgery
The investigators designed this study to examine whether the intranasal dexmedetomidine, as a preoperative drug, could improve the satisfaction of adult patients undergoing phacoemulsification cataract surgery.
- Trial name
- NCT05698758
- Testing
- Dextrometropine and 0.9% sodium chloride solution
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Guangzhou First People's Hospital
Procedural Anxiety, Procedural Pain
Oral Surgery Virtual Reality Glasses Study
The goal of this randomized trial is to investigate if using virtual reality (VR) glasses for patients who require non-emergent oral surgery procedures under intravenous (IV) sedation improves their overall experience compared to…
- Trial name
- NCT06723158
- Testing
- Virtual reality (VR) glasses with relaxation module
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Boston University
Laceration of Skin
IN Ketamine vs IN Midazolam and Fentanyl for Laceration Repair
Often, repair of the cuts (laceration repair) proves to be traumatic for the children and the parents. Nasal spray (Intranasal/IN) approaches for procedural pain reduction, such as during dental work, have been demonstrated to…
- Trial name
- NCT03528512
- Testing
- Ketamine, Midazolam and fentanyl
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Corewell Health East
Constipation, Opioid-Induced
Fiber-Enriched Enteral Nutrition and Opioid-Induced Constipation in the ICU
Opioid use for sedation and analgesia is widespread among mechanically ventilated ICU patients, often leading to gastrointestinal dysfunction and opioid-induced constipation (OIC).
- Trial name
- NCT07201428
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Traumatic Brain Injury
A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury
To explore the cerebral protective effect of midazolam in patients with traumatic brain injury, we will collect blood samples from patients treated with or without midazolam when the patient is admitted to ICU, 24 h, 48 h and 72…
- Trial name
- NCT02071407
- Testing
- Midazolam
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Subei People's Hospital of Jiangsu Province
Sedation, Pediatric
Sedation Safety Assessment Using IPI Monitoring in Pediatric Hematologic Procedures
Pediatric hematologic procedures such as lumbar puncture and bone marrow aspiration often require deep sedation due to pain and the need for immobility.
- Conditions
- Sedation, Pediatric, Integrated Pulmonary Index, BIS
- Trial name
- NCT07733544
- Testing
- Deep Sedation with IPI and BIS Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
Outpatient Colonoscopy for Colorectal Cancer Screening or for Symptoms Suggestive of Colonic Diseases
Effect of Anesthesia on Force Application During Colonoscopy
The aim of the study is to determine if more force is used during colonoscopy when patients receive monitored anesthesia with propofol versus conscious sedation.
- Trial name
- CFM (NCT02101099)
- Testing
- Colonoscopy Force Monitor
- Where
- 3 sites in United States
- Volunteers
- 102 people
- Sponsor
- Artann Laboratories