Clinical trials: Sedation and Analgesia
Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary)
Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy
This study will evaluate whether quantitative pupillometry measurements can be used to identify children at risk for postoperative opioid-induced respiratory depression (OIRD) following tonsillectomy.
- Conditions
- Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary), Respiratory Complications Due to Anesthesia
- Trial name
- NCT07573150
- Testing
- Infrared Pupillometry
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- NeurOptics Inc
Uterine Fibroids, Polyps
Comparative Sedation Study of the MyoSure Hysteroscopic Tissue Removal System
The purpose of this study is to develop a recommended local anesthetic protocol and post-treatment pain management regimen, in order to assure patient comfort during office-based treatment with the MyoSure Hysteroscopic Tissue…
- Trial name
- NCT00979342
- Testing
- Hysteroscopic Morcellator
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Hologic, Inc.
Respiratory Depression, Sedation
Incidence of Opioid-Induced Respiratory Depression in Medical and Trauma Patients
The primary objective of this prospective, blinded observational study is to correlate assessment of sedation and respiratory status with capnography and pulse oximetry monitoring in hospitalized adult medical and trauma patients…
- Trial name
- NCT03647696
- Sponsor
- Poudre Valley Health System
Colonoscopy, Sedation and Analgesia
Dose-sparing Balanced Propofol Sedation in Colonoscopy
This randomized controlled trial compared two balanced propofol analgosedation strategies in adults undergoing elective colonoscopy.
- Trial name
- NCT07885059
- Testing
- Standard-dose balanced propofol analgosedation, Dose-sparing balanced propofol analgosedation
- Where
- 2 sites in Croatia
- Volunteers
- 76 people
- Sponsor
- University of Split, School of Medicine
Intensive Care Medicine, Respiratory Distress Syndrome (RDS)
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care Medicine, Respiratory Distress Syndrome (RDS), Sedation and Analgesia, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- ECMO-SED (NCT07032987)
- Testing
- Not an intervention study
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Transcranial Direct Current Stimulation (tDCS)
Evaluation of the Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) for Sedated Patients in Intensive Care Unit.
Pain management for sedated ICU patients is complex, partly because of the difficulty of assessing pain in non-communicative patients, and partly because of the side effects associated with excessive use of morphine.
- Trial name
- REASTIM (NCT06179199)
- Testing
- SOOMA™ tDCS™
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Procedural Sedation
Intranasal Ketamine and Midazolam Mixture for Procedural Sedation in Children With Mental Disabilities:
Ketamine and Midazolam are well known sedative drugs that can be given through different routes such as intravenous, intramuscular, oral, rectal and intranasal route.
- Trial name
- NCT03860831
- Testing
- Ketamine + midazolam
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Pediatric Burns
Magnesium Sulfate in Pediatric Burn Dressing Changes
Prospective feasibility trial utilizing adjuvant magnesium sulfate for analgesia/sedation during pediatric sedated burn dressing changes, which is ultimately hypothesized to decrease ketamine and/or sedative requirements.
- Trial name
- NCT07126795
- Testing
- magnesium sulfate, Normal Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hennepin Healthcare Research Institute
Pain Management, Endoscopy, Gastrointestinal
Construction and Effectiveness Evaluation of Painless Digestive Endoscopy Mode Led by Anesthesia Nurses Under the Guidance of Anesthesiologists
The purpose is to verify the effectiveness and safety of the painless digestive endoscopy mode led by anesthesia nurses under the guidance of anesthesiologists.
- Trial name
- NCT06712264
- Where
- China
- Volunteers
- 18,000 people
- Sponsor
- The Affiliated Hospital of Qingdao University
End of Life
Survey on Palliative Care and Law Perception
The primary objective of the current survey study is to obtain detailed information about European intensive care unit (ICU) clinicians' awareness of palliative care and relevant, local end-of-life (EoL) legislation.
- Trial name
- PCLAW (NCT06245525)
- Testing
- This is not an interventional study
- Where
- Greece
- Volunteers
- 523 people
- Sponsor
- University of Athens
Behavior Management
Effect of Audio-analgesia Using Binaural Beats and Instrumental Music on the Behaviour of Minimally Sedated Pediatric Patients
The aim of this study is to evaluate the effect of audio analgesia (using binaural beats and instrumental music) in conjunction with a minimal dose of intranasal aerosolized midazolam on acquiring satisfactory patient cooperation.
- Trial name
- NCT07770321
- Testing
- Audio analgesia, 0.3 mg/kg midazolam, 0.5 mg/kg midazolam
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Rania Ahmedien
Optic Nerve Sheath Diameter
The Application of Ultrasonic Measurement of Optic Nerve Sheath Diameter in Liposuction Surgery
The main purpose of this study is to investigate the effect of changes in Optic Nerve Sheath Diameter (ONSD) measured at different operating position during Liposuction Surgery.
- Trial name
- NCT06685952
- Where
- China
- Volunteers
- 55 people
- Sponsor
- The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Analgesia, Ketamine Toxicity
Efficacy and Safety of Continuous Infusion of Ketamine in Pediatric Intensive Care Unit (KISS Study)
This study, prospectively evaluate the efficacy and safety of ketamine administered in continuous infusion lasted more than 12 hours in children admitted to Pediatric Intensive Care Unit of Padova.
- Conditions
- Analgesia, Ketamine Toxicity, Bronchospasm, Sedation Complication
- Trial name
- KISS (NCT04427605)
- Where
- Italy
- Volunteers
- 57 people
- Sponsor
- Azienda Ospedaliera di Padova
Procedural Sedation and Analgesia
Combined Ketamine/Propofol for Emergency Department Procedural Sedation
Introduction Numerous drugs and combinations of drugs are used for procedural sedation and analgesia (PSA) in Emergency Departments, including propofol, ketamine, benzodiazepines, narcotics, barbiturates, and others, but propofol…
- Trial name
- NCT01126957
- Testing
- Ketamine, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Colonoscopy
Comparison Between Two Different Dosages of Remifentanil During Colonoscopy
The purpose of this randomized double-blind trial is to define the correct dosage of Remifentanil during operative and diagnostic endoscopic procedures.
- Trial name
- NCT01229527
- Testing
- Remifentanil, Meperidine
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Ospedale San Raffaele