Clinical trials: Sedation and Analgesia
Emergency Department Procedural Sedation, Fracture Reduction
Ketofol vs Propofol for Emergency Department Procedural Sedation and Analgesia
When patients come to the Emergency Department with injuries and infections they often need to have painful procedures performed that are essential to allowing them to recover.
- Conditions
- Emergency Department Procedural Sedation, Fracture Reduction, Abscess Incision and Drainage, Electrical Cardioversion
- Trial name
- NCT01211158
- Testing
- Ketofol, Propofol alone
- Where
- Canada
- Volunteers
- 284 people
- Sponsor
- Lions Gate Hospital
Analgesia, Sedation
Intranasal Dexmedetomidine for Procedural Pain Management in Elderly Adults in Palliative Care
Dexmedetomidine is allowed in Switzerland for intravenous (IV) medication in the intensive care unit in the adult patient. Its active molecule, Dexmedetomidine (Dex), is a selective and powerful α2-Adrenoreceptors (AR) agonist…
- Conditions
- Analgesia, Sedation, Anxiolysis
- Trial name
- INDEX (NCT03151863)
- Testing
- Opioids, Dexmedetomidine
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- Walid HABRE
Procedural Sedation and Analgesia During Bone Marrow Aspiration and Biopsy
Dexmedetomidine Versus Midazolam Added to Ketamine in Pediatric Patients Undergoing Bone Marrow Aspiration and Biopsy
Group I :The patients will receive midazolam intravenously (i.v.) in a dose of 0.05 mg/kg diluted by 50ml saline over 10 minutes using syringe pump plus 1 mg/kg ketamine (iv).
- Trial name
- NCT03647579
- Testing
- midazolam intravenous infusion of 0.05 mg/kg plus 1 mg/kg ketamine, Dexmedetomidine intravenous infusion of 2mic/kg plus 1 mg/kg ketamine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Conscious Sedation Failure During Procedure, Analgesia
Lidocaine as Local Anesthetics in Children Under Ketamine Sedation
Ketamine seems an obvious choice in the setting of an emergency department in laceration repair. Lidocaine is the local anesthetics widespread used. Ketamine leads to dissociative amnesia.
- Conditions
- Conscious Sedation Failure During Procedure, Analgesia, Anesthesia
- Trial name
- NCT02205502
- Testing
- Lidocaine, Normal saline
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Pain
Use of Sedation and Local Anesthesia in Meatotomy: A Prospective Comparison Study
The aim of the study is to prospectively investigate the feasibility, pain control, and outcome of meatotomy performed under sedation and local anaesthesia compared with general anaesthesia with and without patient block
- Trial name
- NCT00480519
- Testing
- Meatotomy
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Rabin Medical Center
Mechanical Ventilation
Rapip Study: Clinical Trial on Remifentanyl for Analgesia and Sedation of Ventilated Neonates and Infants
It shall be investigated whether ventilated neonates and infants with a remifentanyl based analgesia and sedation can be extubated faster after discontinuation of the opioid infusion compared to neonates and infants with a…
- Trial name
- NCT00419601
- Testing
- Remifentanyl, Fentanyl
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University of Cologne
Central Nervous System Diseases
Dexmedetomidine in Patients After Intracranial Surgery
Dexmedetomidine is a highly selective a2-adrenoreceptor agonist that produces dose-dependent sedation and analgesia without respiratory depression.
- Trial name
- NCT01445639
- Testing
- Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Capital Medical University
Analgesia, Critical Illness
Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study
The aim of this prospective, randomized, active control, double blinded study is to assess the effect and safety of continuous infusion nefopam in mechanically ventilated ICU patients compared to standard of care.
- Conditions
- Analgesia, Critical Illness, Mechanical Ventilation, Sedation
- Trial name
- NCT05071352
- Testing
- Nefopam, Standard of care in the ICU for assessment and management of pain, sedation, and delirium.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Sedation and Analgesia
Dexmedetomidine Versus Ketamine Versus Midazolam in Endoscopic Procedures
This study aims to assess the safety and efficacy of dexmedetomidine versus ketamine versus midazolam combined with propofol in cancer patients undergoing gastrointestinal endoscopic procedures.
- Trial name
- NCT04597268
- Testing
- Dexmedetomidine, Ketamine, Midazolam
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute, Egypt
Analgesia
Pharmacoeconomic Consequences Of Analgesia in the Intensive Care Unit (ICU)
This study will be a multicentre randomized, open-label, phase IIIb study. This study will evaluate two different techniques of sedation: an analgesia based regimen with remifentanil versus a conventional sedation based regimen…
- Trial name
- NCT00436345
- Testing
- Remifentanil, Propofol
- Where
- 6 sites in Italy
- Volunteers
- 39 people
- Sponsor
- GlaxoSmithKline
Septic Shock, Mechanical Ventilation Complication
Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients
Sedation and analgesia in patients with sepsis and hemodynamic instability may be challenging in the ICU. Opioids and propofol can further exacerbate tissue infusion in septic shock by reducing cardiac contractility, increasing…
- Trial name
- NCT05839366
- Testing
- Esketamine, Saline, Remifentanil + propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Ventilator Lung; Newborn
NIPE as an Indicator of Pain in Sedated/Ventilated Patient Under 3 Years-old Hospitalized in Intensive Care Unit
The main objective is to assess correlation between Newborn Infant Parasympathetic Index values and external evaluation by Comfort Behaviour Scale during painful medical cares in sedated intubated children admitted in pediatric…
- Trial name
- NIPE (NCT04195672)
- Testing
- NIPE (MDoloris®) and CBS values
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille
Clinical Trial
Optimal Dosage of Melatonin for Preoperative Sedation in FESS
To determine the optimal dosage of Melatonin for preoperative sedation in patients undergoing FESS.
- Trial name
- FESS (NCT07550751)
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Pain, Sedation
Assessment of Analgesia, Sedation, Physical Restraints and Delirium in Spanish Intensive Care Units
This study assess which Spanish intensive care units evaluate and record, in a standardized way, levels of pain, sedation / agitation, use of physical restraints and prevalence of delirium.
- Conditions
- Pain, Sedation, Agitation, Delirium
- Trial name
- ASCyD (NCT03773874)
- Testing
- Assessment
- Where
- Spain
- Volunteers
- 1,574 people
- Sponsor
- Hospital Universitario Getafe
Mechanical Ventilation, Sedation and Analgesia
Fentanyl Versus Hydromorphone in Patients on Mechanical Ventilation
Patients with respiratory failure who require mechanical ventilation are not only at risk of death, but also of complications of prolonged ICU stay.
- Conditions
- Mechanical Ventilation, Sedation and Analgesia, Critical Care, Intensive Care
- Trial name
- FenHydro (NCT07224620)
- Testing
- fentanyl, Hydromorphone
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Beth Israel Deaconess Medical Center
Withdrawal Syndrome
Efficacy and Safety of Dexmedetomidine During Weaning From Analgesia and Sedation in PICU (TIP-15-01)
This interventional study evaluates the efficacy of dexmedetomidine during weaning from analgesic and sedative drugs in reducing the occurrence of the withdrawal syndrome in PICU.
- Trial name
- TIP-15-01 (NCT03645603)
- Testing
- Dexmedetomidine
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Effect of Drug
Analgesia From Conscious Sedation Versus Paracervical Block for Manual Vacuum Aspiration
Miscarriage is one of the major causes of early pregnancy losses. Incomplete miscarriage is a major cause of maternal morbidity and mortality.
- Trial name
- NCT06539143
- Testing
- Lidocaine
- Where
- Nigeria
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Analgesia, Sedation
Surgical Stress Index as a Tool for Monitoring Analgesia and/or Sedation in Critically Ill Patients
The hypothesis of the study is: Does the Surgical Stress Index (SSI) correlate with the Behavioral Pain Scale (BPS), the Ramsay Sedation Scale (RSS)and/or the Behavioral Pain Scale(BPV) and can therefore be used to monitor the…
- Conditions
- Analgesia, Sedation, Mechanical Ventilation, Pain
- Trial name
- NCT00789412
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Schleswig-Holstein
Transcranial Direct Current Stimulation (tDCS)
Evaluation of the Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) for Sedated Patients in Intensive Care Unit.
Pain management for sedated ICU patients is complex, partly because of the difficulty of assessing pain in non-communicative patients, and partly because of the side effects associated with excessive use of morphine.
- Trial name
- REASTIM (NCT06179199)
- Testing
- SOOMA™ tDCS™
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Pain
Analgesia During Pediatric Digestive Endoscopy: a Comparison of Two Protocols for Procedural Sedation
The purpose of this study is to determine whether ketamine, midazolam, and meperidine are more effective than midazolam and meperidine alone for procedural sedation and analgesia in pediatric digestive endoscopy.
- Trial name
- NCT01168492
- Testing
- ketamine
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Université de Montréal