Clinical trials: Sedation or Anesthesia
Emergence Agitation, Remimazolam Besylate
Effect of Rematazolam Besylate, Propofol, and Sevoflurane Perioperative Sedation on Incidence of Emergence Agitation and Hemodynamics in Patients Undergoing Laparoscopic Abdominal Surgery
Emergence agitation (EA) is a transient, self-limited, non-fluctuating state of psychomotor excitement, which closely revolves around the emergence of general anesthesia.
- Conditions
- Emergence Agitation, Remimazolam Besylate, Perioperative Sedation, Laparoscopic Abdominal Surgery
- Trial name
- NCT05624424
- Testing
- Rematazolam Besylate, Propofol, Sevoflurane
- Where
- 6 sites in China
- Volunteers
- 1,317 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Anesthesia, Sedation
Gastro-laryngeal Tube During Transesophageal Echocardiography
To analyze the effects of the use of Gastro-laryngeal Tube on intraoperative and postoperative hemodynamics, procedure comfort, and cardiologist and patient satisfactions during transesophageal echocardiography.
- Conditions
- Anesthesia, Sedation, Analgesia, Airway Complication of Anesthesia
- Trial name
- GLT (NCT05272306)
- Testing
- Number of attempts for successful transesophageal echocardiography, A questionnaire for cardiologist satisfaction, A questionnaire for patient satisfaction
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Bezmialem Vakif University
Anesthesia, Sedation
A Study Evaluating the Mass Balance of Micro-dose[14C]HSK3486 Emulsion Injection in Healthy Adults
This study is designed to evaluate the mass balance in healthy Chinese male subjects after receiving a single dose of intravenous [14C]HSK3486, so as to assess the overall pharmacokinetics and safety of HSK3486 in humans and…
- Trial name
- NCT03751969
- Testing
- HSK3486
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Dacryocystorhinostomy, Sedation
Controlled Sedoanalgesia in External DCR Surgery
In our study, we aim to compare general anesthesia and controlled sedoanalgesia methods in dacryocystorhinostomy (DCR) surgery in terms of hemodynamic data, bleeding amount, postoperative complications (bleeding, pain, etc.) and…
- Conditions
- Dacryocystorhinostomy, Sedation, General Anesthesia
- Trial name
- NCT05397301
- Testing
- Controlled sedoanalgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
Anesthesia, Anesthesia Complication
Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk
Light to moderate sedation is recommended during surgery with spinal anesthesia . This study is exploring which sedation drug is better, midazolam or dexmedetomidine for transurethral resection of bladder and prostate in patients…
- Conditions
- Anesthesia, Anesthesia Complication, Osa Syndrome, Transurethral Resection of Prostate
- Trial name
- NCT04817033
- Testing
- Spinal anesthesia with intraoperative dexmedetomidine sedation, Spinal anesthesia with intraoperative midazolam sedation, Dexmedetomidine
- Where
- Croatia
- Volunteers
- 115 people
- Sponsor
- University Hospital of Split
Stress, Anesthesia
LEGO MRI: Decreasing the Need for Sedation, and Improving Patient Anxiety.
The objective of the LEGO®Bricks MRI project is to study a new play-based tool for use in children preparing to undergo MRI and evaluate its ability to reduce the need for anesthesia.
- Conditions
- Stress, Anesthesia, Children, Only, Anxiety
- Trial name
- LEGO MRI (NCT04172909)
- Testing
- LEGO Bricks MRI, Mock MRI tube
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Anesthesia, Sedation
Automated Postoperative Sedation After Cardiac Surgery
This study compares automated administration of propofol and remifentanil guided by the Bispectral index (BIS) versus manual administration for sedation after cardiac surgery.
- Conditions
- Anesthesia, Sedation, Surgery, Cardiac
- Trial name
- SEPOCA (NCT03517735)
- Testing
- EasyTiva (algorithm is the property of Medsteer SAS), Propofol, Remifentanil
- Where
- France
- Volunteers
- 7 people
- Sponsor
- CMC Ambroise Paré
Anesthesia, Deep Sedation
Intranasal Dexmedetomidine Sedation at Dose of 2 mcg/kg Versus 4 mcg/kg in Children Undergoing MRI
This study aimed to compare the effectiveness of intranasal Dexmedetomidine sedation at Dose of 2 mcg/kg and 4 mcg/kg in Children Undergoing MRI at Cipto Mangunkusumo Hospital
- Conditions
- Anesthesia, Deep Sedation, Magnetic Resonance Imaging, Pediatric ALL
- Trial name
- NCT05091151
- Testing
- Intranasal dexmedetomidine at dose of 2 mcg/kg and 4 mcg/kg
- Where
- Indonesia
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Local Anesthesia Assisted Sedation
A Trial of Efficacy and Safety of Remimazolam Tosilate for Injection in Local Anesthesia Assisted Sedation
To evaluate the efficacy and safety of Remimazolam Tosilate for injection in local anesthesia assisted sedation, and to explore the dose range of remazolam toluenesulfonate for injection in local anesthesia assisted sedation.
- Trial name
- NCT05015361
- Testing
- Remimazolam Tosilate, Propofol Injection.
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Anesthesia, Sedation
A Study Evaluating Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of HSK3486 Single Bolus Dose Followed With a 30 Minute Constant Infusion in Healthy Male Subjects
This study was a single center, open-label, single dose escalation study in healthy male subjects to investigate a bolus dose followed by a 30 minute constant infusion of HSK3486 over two cohorts.
- Trial name
- NCT04029766
- Testing
- HSK3486
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Anesthesia, Sedation
A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Voriconazole Tablets
This is a single-center, open-label, randomized, two-stage, two-way crossover study evaluating the effect of voriconazole on the PK, PD, and safety of HSK3486 in healthy subjects.
- Trial name
- NCT04145583
- Testing
- HSK3486, voriconazole +HSK3486
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Sedation or Anesthesia
A Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion in Subjects Undergoing Fiberoptic Bronchoscopy
This is a Multi-Center, Randomized, Double-Blind, Propofol-Controlled Phase III Clinical Trial. Around 260 eligible subjects are planned to be enrolled and randomized in a 1:1 ratio to either the HSK3486 arm or propofol arm.
- Trial name
- NCT04111159
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 267 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Multiparametric Magnetic Resonance Imaging, Propofol Adverse Reaction
Safety Evaluation of Propofol Sedation for Magnetic Resonance Imaging in Pediatric Patients
Propofol is often used for sedation in children undergoing magnetic resonance imaging. The investigators will perform a chart review of 4 month of activity (about 100 cases) and review the incidence and severity of adverse events…
- Conditions
- Multiparametric Magnetic Resonance Imaging, Propofol Adverse Reaction, Sedation Complication, Anesthesia; Adverse Effect
- Trial name
- NCT04455776
- Testing
- Propofol
- Where
- Belgium
- Volunteers
- 99 people
- Sponsor
- Brugmann University Hospital
Pediatric Sedation, Radiotherapy
Sevoflurane Insufflation vs Intravenous Sedation for Radiotherapy in Pediatric Patients
aim of this cross-over study is to compare sedation with insufflated sevoflurane and intravenous sedation for pediatric radiotherapy patients
- Conditions
- Pediatric Sedation, Radiotherapy, Inhalation Anesthesia
- Trial name
- NCT04483258
- Testing
- Sedation with sevoflurane insufflation, intravenous sedation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara City Hospital Bilkent
Anesthesia, Sedation
A Study Evaluating Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Single IV Dose of HSK3486 Injectable Emulsion in Healthy Subjects.
his single-center, open-label, uncontrolled, and dose-escalation study evaluated the safety, tolerability, and pharmacokinetics/pharmacodynamics of single IV dose of HSK3486 injectable emulsion in healthy subjects.
- Trial name
- NCT03773835
- Testing
- HSK3486
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Anesthesia, Sedation
A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486
This is a Phase I, single-center, open-label, randomized,two-way crossover, propofol-controlled, two-stage study evaluating the safety and pharmacokinetics/pharmacodynamics of IV maintenance dose after an initial dose and IV…
- Trial name
- NCT03745625
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Anesthesia, Sedation
A Study Evaluating the Mass Balance of [14C]HSK3486 Emulsion Injection in Healthy Adults.
This study is designed to evaluate the mass balance and biotransformation pathways of HSK3486 in healthy Chinese male subjects administered with a single intravenous dose of [14C]HSK3486, so as to characterize the drug's general…
- Trial name
- NCT03751956
- Testing
- HSK3486
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Anesthesia, Sedation
A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Rifampin Capsules
This is a Phase I, single-center, open-label, randomized,two-way crossover, propofol-controlled, two-stage study evaluating the safety and pharmacokinetics/pharmacodynamics of IV maintenance dose and IV single loade dose plus…
- Trial name
- NCT03758469
- Testing
- HSK3486, rifampin , HSK3486
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Anesthesia, Sedation
Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Female Subjects.
This study was a single-center positive-controlled, randomized, dose-escalation study of HSK3486 in healthy female subjects administered as a single IV bolus dose.Subjects were confined to the study unit from the evening of Day…
- Trial name
- NCT04037657
- Testing
- HSK3486, Propofol
- Volunteers
- 25 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Anesthesia, Sedation
A Study Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Subjects.
This is the first clinical trial of HSK3486 and will be conducted in healthy volunteers to determine the safety, tolerability (including pain on injection), and PK(only to be assessed for subjects who are randomized to HSK3486 in…
- Trial name
- NCT04033939
- Testing
- HSK3486, Propofol
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd