Clinical trials: Sedatives
Abuse Potential
An Abuse Potential Study of Orally Administered HORIZANT in Healthy, Non-dependent, Recreational Drug Users
The purpose of this study is to assess the abuse potential of gabapentin enacarbil in healthy adult, non-dependent, recreational drug users.
- Trial name
- NCT06097676
- Testing
- Alprazolam 2 mg, Gabapentin Enacarbil Immediate Release (GE-IR) 200 mg, Gabapentin Enacarbil Immediate Release (GE-IR) 450 mg
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Arbor Pharmaceuticals, Inc.
Hypercapnia, Ventilatory Depression
Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation
Opioids can decrease breathing and co-administration of benzodiazepines with opioids can further decrease breathing. It is unknown whether certain other drugs also decrease breathing when co-administered with opioids.
- Trial name
- NCT04310579
- Testing
- Oxycodone and Midazolam, Oxycodone, Paroxetine, and Quetiapine
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Tobacco Use Disorder
The Effects of Sedatives on Tobacco Use Disorder
This proposal will obtain preliminary data on the effect of a single sub-anesthetic dose of a sedative on cigarette craving and smoking behavior as well as measuring tolerability and acceptability.
- Trial name
- SED-TUD (NCT03813121)
- Testing
- midazolam intravenous infusion, ketamine intravenous infusion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Glioma
Sedatives' Effects on Neurological Function in Patients With Eloquent Area Glioma
Sedation in the operating room, the Post Anesthesia Care Unit and the Intensive Care Unit is common and often necessary for patients with intracranial brain tumor.
- Trial name
- NCT02439164
- Testing
- Midazolam
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative
Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain
The objective of the study is to evaluate the efficacy and safety of a single oral dose of naproxen sodium 440 mg in combination with DPH (diphenhydramine) 25 mg in subjects with postsurgical dental pain and phase advanced sleep.
- Trial name
- Morpheus/DPH (NCT01495858)
- Testing
- Naproxen Sodium 440 mg / DPH 25 mg (BAY98-7111), Naproxen Sodium 440 mg (BAYH6689), DPH 50 mg
- Where
- 2 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Bayer
Propofol, Anesthesia
Investigating Near-Threshold Perception During Anesthetic Sedation
The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia. Propofol is FDA approved for use in patients undergoing an anesthetic for medical treatment but is not approved for…
- Conditions
- Propofol, Anesthesia, fMRI
- Trial name
- NCT06403852
- Testing
- Functional Magnetic Resonance Imaging (fMRI) with propofol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Abuse Potential
Evaluating the Abuse Potential of NEURONTIN® When Taken Orally in Healthy Non-drug Dependent Participants With Sedative Drug Abuse Experience
This will be a randomized, double-blind, double-dummy, placebo- and active controlled, 5 treatment, 10 sequence, 5 period crossover single dose, Williams square design study in healthy adult, non drug dependent male and female…
- Trial name
- NCT04570436
- Testing
- gabapentin 600 mg, gabapentin 1200 mg, gabapentin 1800 mg
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Viatris Specialty LLC
Psychomotor Impairment
Sedative-Anxiolytic Effects on Simulated Driving Performance
This study evaluates the effect of anxiety drugs taken at night on the ability to drive a car the next day. Participants will receive alprazolam, placebo, or zolpidem at night before bed or in the morning before using a driving…
- Trial name
- NCT03297944
- Testing
- Alprazolam 2mg (2ALP/PLC), Alprazolam 1mg (1ALP/PLC), Alprazolam 0.5mg (0.5ALP/PLC)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marion Coe
Breast Augmentation
Asian Outcomes of Primary Breast Augmentation
In 162 Asian patients, primary breast augmentations were performed by a single surgeon during 5 years. The purpose of this study evaluates Asian outcomes in primary breast augmentation using single antibiotic breast irrigation by…
- Trial name
- BA (NCT02235285)
- Testing
- primary breast augmentation
- Where
- South Korea
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Winners Clinic
Endoscopic Ultrasound (EUS), Endoscopic Retrograde Cholangiopancreatography (ERCP)
Adjunct Sedatives in Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) Procedures
The purpose of this study is to compare meperidine/midazolam with diphenhydramine, meperidine/midazolam with promethazine, and meperidine/midazolam with placebo as sedation methods.
- Trial name
- NCT00937924
- Testing
- Meperidine, Midazolam, Diphenhydramine, Promethazine
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Abuse Liability of Staccato Alprazolam
Staccato Alprazolam Abuse Liability
Compare the abuse liabilities of Staccato Alprazolam, oral immediate-release alprazolam, and Staccato Placebo.
- Trial name
- NCT00603980
- Testing
- Inhaled alprazolam 0.5 mg, Inhaled alprazolam 1 mg, Inhaled alprazolam 2 mg
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Nova Pneuma Inc.
Driving Impaired
Driving Simulation to Assess Non-Sedative Effects of Tolperisone
This is a randomized blinded study to assess the sedative effect of 150 mg TID tolperisone and 10 mg TID cyclobenzaprine compared to placebo on simulated driving performance and cognitive functioning in healthy adult volunteers.
- Trial name
- NCT03353922
- Testing
- Cyclobenzaprine 10 Mg Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Neurana Pharmaceuticals, Inc.