Clinical trials: Sedatives
Endotracheal Intubation, Continuous IV Sedation
Cerebral Perfusion Pressure Using Precedex and Other Sedatives
The purpose of this study is to examine the effects of using dexmedetomidine (Precedex) in addition to the current standard-of-care for sedation.
- Conditions
- Endotracheal Intubation, Continuous IV Sedation, ICP Monitoring
- Trial name
- C3PO (NCT01169467)
- Testing
- Standard-of-Care plus Dexmedetomidine, Standard-of-Care
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Duke University
Colonoscopy, Adjunct Anesthesia Medication
Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids
To access the efficacy of adding diphenhydramine as adjunct to improve sedation and to reduce the amount of standard sedatives used during colonoscopy in patients on chronic opioids.
- Trial name
- NCT01967433
- Testing
- Diphenhydramine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Oklahoma
Critical Illness
Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol.
The purpose of this study is to determine whether the use of both a nurse-driven sedation protocol and daily sedative interruption, compared with a sedation protocol alone, result in better outcomes for mechanically ventilated…
- Trial name
- SLEAP (NCT00675363)
- Testing
- Protocolized Sedation, Protocolized sedation, with daily interruption
- Where
- 16 sites in United States, Canada
- Volunteers
- 410 people
- Sponsor
- Mount Sinai Hospital, Canada
Delirium
Effect of Auditory Stimulation by Family Voices in Preventing Delirium: A Randomized Controlled Trial
Delirium is an acute cerebral dysfunction syndrome characterized by acute fluctuating changes in consciousness, cognitive dysfunction, and disorientation.
- Trial name
- NCT05732584
- Testing
- structured family voice stimulation, unstructured family voice stimulation
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypoxia, Obesity
High-flow Nasal Oxygen Therapy in Obese Patients Undergoing Sedativegastrointestinal Endoscopy
Obese patients often have fat accumulation in the head and neck, increased soft tissue in the oropharynx, decreased lung compliance, decreased lung volume and residual volume, and some obese patients also suffer from obstructive…
- Conditions
- Hypoxia, Obesity, Gastrostomy
- Trial name
- NCT06585306
- Testing
- jaw lift, increasing oxygen flow, mask ventilation, intubation
- Where
- China
- Volunteers
- 864 people
- Sponsor
- XiaoLiang Wang
Sedative Drug Consumption, Mechanically Ventilated ICU Patients
Efficacy of Music on Reduction of Sedative Drugs in Mechanically Ventilated Intensive Care Unit Patients
Major objective: a three-days interventional cross-over trial [one day music on, one day wash-out, one day music off][two periods of listening/day], to evaluate: 1. Impact on sedative drug consumption. 2.
- Trial name
- MUSIC (NCT00880035)
- Testing
- MP3 music program listening
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Université de Sherbrooke
Chronic Insomnia
Insomnia Behavioral Intervention Study
This randomized pilot study (n=20) explores the effects of a behavioral intervention, that includes sleep hygiene improvements, in long-term users of sleeping pills, aiming to alleviate or stabilize symptoms of insomnia, monitor…
- Trial name
- IBI (NCT05301543)
- Testing
- Experimental: Behavioral approach 1, Comparator: Behavioral approach 2
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Delirium, Sleep Disorders, Circadian Rhythm
Study of Sleep and Delirium in the Intensive Care Unit (ICU)
The investigators will perform a prospective, cohort study of 100 older intensive care unit (ICU) patients, to investigate the association between sleep disruption and ICU delirium.
- Trial name
- SID (NCT01280097)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of California, San Francisco
Sedative Overdose
Local Anesthesia Impact on Dental Sedation
The goal of this observational study is to investigate the impact of local anesthesia in health children who were sedated for dental procedures.
- Trial name
- NCT06218173
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara University
General Anesthesia
Unhealthy Alcohol Drinking and Anesthetic Requirement in Women
Unhealthy alcohol drinking is negatively influencing health of people and costing a large number of annual finance via "secondhand" effects.
- Trial name
- UNADAREW (NCT00741507)
- Testing
- Alcohol drinking
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Arthritis, Degenerative
Intraoperative Sedatives and Postoperative Pain
In this study, based on the hypothesis that dexmedetomidine administered intraoperatively for sedation can reduce postoperative pain than that of propofol, the investigators examined the ability of dexmedetomidine to reduce…
- Trial name
- NCT02784626
- Testing
- Dexmedetomidine, Propofol
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Seoul National University Bundang Hospital
Chronic Subdural Hematoma, Anesthesia
Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH
A prospective, multicenter, randomized controlled trial is designed to evaluate the safety of nerve block anesthesia combined with sedative anesthesia versus general anesthesia during burr hole craniostomy with drainage for…
- Trial name
- NCT05888389
- Testing
- Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia, General Anesthesia
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Beijing Tiantan Hospital
Cholelithiasis, Postoperative Nausea and Vomiting
A Randomized Controlled Trial Comparing the Effects of Different Anesthetic Sedatives on PONV in Laparoscopic Cholecystectomy
This study is designed to compare three sedative medications used during general anesthesia for gallbladder removal surgery (laparoscopic cholecystectomy) and their effects on nausea and vomiting after surgery.
- Trial name
- NCT07758803
- Testing
- Propofol, Ciprofol, Remimazolam
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Xi'an Aerospace General Hospital