Clinical trials: Sedatives
Delirium, Sleep Disorders, Circadian Rhythm
Study of Sleep and Delirium in the Intensive Care Unit (ICU)
The investigators will perform a prospective, cohort study of 100 older intensive care unit (ICU) patients, to investigate the association between sleep disruption and ICU delirium.
- Trial name
- SID (NCT01280097)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of California, San Francisco
Endoscopic Ultrasound (EUS), Endoscopic Retrograde Cholangiopancreatography (ERCP)
Adjunct Sedatives in Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) Procedures
The purpose of this study is to compare meperidine/midazolam with diphenhydramine, meperidine/midazolam with promethazine, and meperidine/midazolam with placebo as sedation methods.
- Trial name
- NCT00937924
- Testing
- Meperidine, Midazolam, Diphenhydramine, Promethazine
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Extracorporeal Membrane Oxygenation, Pharmacokinetics
Pharmacokinetics in Extracorporeal Membrane Oxygenation
The main purpose of the present study is to investigate the risk factors that affect drug pharmacokinetic (PK) during extracorporeal membrane oxygenation (ECMO).
- Trial name
- NCT03766282
- Testing
- ECMO
- Where
- China
- Volunteers
- 50 people
- Sponsor
- China-Japan Friendship Hospital
Sedation
Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects
The study will evaluate the pharmaco-economic consequences of the use of a remifentanil based regimen compared with a conventional sedative based regimen in terms of duration of mechanical ventilation, length of stay in ICU…
- Trial name
- NCT00158873
- Testing
- midazolam, lorazepam, fentanyl
- Where
- 15 sites in Netherlands
- Volunteers
- 224 people
- Sponsor
- GlaxoSmithKline
PreTerm Neonate, Sedation for Invasive Mechanical Ventilation
Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants
Very preterm neonates (born before 32 weeks' gestation) often require invasive mechanical ventilation (IMV) to manage respiratory insufficiency.
- Conditions
- PreTerm Neonate, Sedation for Invasive Mechanical Ventilation, Very Preterm Neonates With Sedation for Invasive Mechanical Ventilation
- Trial name
- DEXPRE (NCT06878703)
- Testing
- Midazolam, Dexmedetomidine
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intensive Care Unit Patient, Mechanical Ventilation
Evaluation of Decision Capacity of ICU Patients Under Sedatives. A Prospective Observational Multicenter Study.
This prospective observational multicenter study is intended to investigate the impact of sedatives on the decision capacity of intensive care units patients.
- Conditions
- Intensive Care Unit Patient, Mechanical Ventilation, Sedatives, Decision-making Capacity
- Trial name
- DexCap (NCT04193540)
- Testing
- ACE questionnaire
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anxiety
Pre-procedural Anxiety and Sedation.
Colonoscopy is an outpatient procedure performed frequently as a screening test for diagnosis and treatment of a wide range of gastrointestinal problems.
- Trial name
- NCT01958151
- Testing
- State-Trait Anxiety Inventory Scores
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Basak Ceyda MECO
Patients Undergoing Diagnostic EGD
Meperidine for Patients Expected to Have Poor Tolerance During Diagnostic Esophagogastroduodenoscopy.
Our pilot results showed that meperidine reduce patient discomfort during EGD (esophagogastroduodenoscopy). But many patients can tolerate EGD well without any sedative agents.
- Trial name
- NCT01948921
- Testing
- Meperidine
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Dalin Tzu Chi General Hospital
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Knee Injuries
Effect of Loading of Midazolam or Dexmedetomidine on Hemodynamics
Loading dose of dexmedetomidine is related hemodynamic instability such as bradycardia and hypertension.
- Trial name
- NCT02634021
- Testing
- dexmedetomidine group, midazolam group
- Where
- South Korea
- Sponsor
- Konkuk University Medical Center
General Anesthesia
Unhealthy Alcohol Drinking and Anesthetic Requirement in Women
Unhealthy alcohol drinking is negatively influencing health of people and costing a large number of annual finance via "secondhand" effects.
- Trial name
- UNADAREW (NCT00741507)
- Testing
- Alcohol drinking
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Sedation
Intranasal Midazolam in Children as a Pre-Operative Sedative - Part 2
Midazolam is often given before surgery to sedate a patient before anesthesia is given. Children are often given a small dose either by mouth or squirted into the nose.
- Trial name
- NCT02356705
- Testing
- Midazolam, xylocaine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Jennifer Victory, RN, CCRC
Sedative Overdose
Local Anesthesia Impact on Dental Sedation
The goal of this observational study is to investigate the impact of local anesthesia in health children who were sedated for dental procedures.
- Trial name
- NCT06218173
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara University
Intensive Care Patients, Relatives
Family Involvement in ICU
The aim of this prospective cohort study was to investigate the effect of the time spent with relatives of patients treated in a tertiary intensive care unit on patient outcomes.
- Conditions
- Intensive Care Patients, Relatives, Delirium in the Intensive Care Unit, Sedatives
- Trial name
- NCT06770751
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Istanbul University - Cerrahpasa
Unconsciousness, Apnea, Postanesthetic
Race-Specific Propofol Titration to Effect for Procedural Sedation
Prospectively evaluate newly established guidelines and make clinicians aware of inter-racial difference in propofol sensitivity.
- Conditions
- Unconsciousness, Apnea, Postanesthetic, Sedative Overdose, Hypoxemia
- Trial name
- NCT03290859
- Testing
- Titrate propofol monotherapy infusion to effect
- Where
- United States
- Volunteers
- 2,780 people
- Sponsor
- University of Florida
Flexible Bronchoscopy
Effect of the Topical Application of Anaesthetics With EnkFiberoptic Atomizer During the Bronchoscopy
The aim of this prospective study is to examine the benefits and risks of administration of local anaesthetics with a special atomizing set (Enk Fiberoptic Atomizer, Cook Medical) during flexible bronchoscopy.
- Trial name
- EnkAtomizerII (NCT02262442)
- Testing
- Enk Fiberoptic Atomizer, bronchoscope
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- RWTH Aachen University
Cholelithiasis, Postoperative Nausea and Vomiting
A Randomized Controlled Trial Comparing the Effects of Different Anesthetic Sedatives on PONV in Laparoscopic Cholecystectomy
This study is designed to compare three sedative medications used during general anesthesia for gallbladder removal surgery (laparoscopic cholecystectomy) and their effects on nausea and vomiting after surgery.
- Trial name
- NCT07758803
- Testing
- Propofol, Ciprofol, Remimazolam
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Xi'an Aerospace General Hospital
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Arteriovenous Fistula
Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery
The investigators designed a prospective randomized study to compare the conventionally used sedative drug propofol with a latest alternative dexmedetomidine (DEX), in patients with end-stage renal disease undergoing…
- Trial name
- NCT02447796
- Testing
- Propofol, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Baskent University
Bipolar Disorder
Study Measuring Differences in Cognition Due to Sedative Effects of Risperidone and Quetiapine in Stable Bipolar I Outpatients
The purpose of this study is to determine whether the sedating (causing sleepiness) effects of risperidone or quetiapine alter cognitive (person's ability to think, perceive, recognize, remember, judge, and reason) functioning in…
- Trial name
- NCT00097032
- Testing
- risperidone; quetiapine
- Volunteers
- 30 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.