Clinical trials: Seizure, Epileptic
Focal Onset Seizures
Study of EQU-001 for Uncontrolled Focal Onset Seizures
This study is a Phase 2 multinational, double-blind, placebo-controlled, randomized (1:1:1), efficacy and safety study of adjunctive EQU-001 for the treatment of focal onset seizures in subjects aged 18 to 65 years, who have been…
- Trial name
- NCT05473442
- Testing
- EQU-001
- Where
- 13 sites in United States, Israel
- Volunteers
- 27 people
- Sponsor
- Equilibre Biopharmaceuticals B.V.
Epilepsy in Children, Sleep Disorder
Advanced EEG Technology in Childhood Epilepsy
A lot of effort has already been put into the development of smaller, wearable and more user-friendly devices to monitor seizures in patients with epilepsy.
- Trial name
- PnP (NCT04584385)
- Testing
- EEG
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Seizures, Epilepsy
Exercise Education for Adults With Seizure Disorders
Study Population -People with seizures benefit from regular exercise. Exercise may help decrease the number of seizures they have. It also improves overall health and quality of life.
- Trial name
- NCT01856335
- Testing
- Patient Education, exercise: increase physical activity/goal setting
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Partial Seizures
Safety and Efficacy of Oxcarbazepine Monotherapy in Adults With Partial Seizures
This study is aimed to evaluate the efficacy, safety and tolerability of oxcarbazepine monotherapy in adults with partial seizures.
- Trial name
- NCT00275925
- Testing
- Oxcarbazepine
- Where
- 7 sites in Russia
- Volunteers
- 80 people
- Sponsor
- Novartis
Epilepsy, Asystole
Cardiac Arrhythmias in Epilepsy: the CARELINK-study
Patients with difficult-to-treat epilepsy ("refractory epilepsy") are at high risk of sudden death: sudden unexpected death in epilepsy (SUDEP). Cardiac arrhythmias are one of the possible causes of SUDEP.
- Conditions
- Epilepsy, Asystole, Cardiac Arrhythmias
- Trial name
- CARELINK (NCT01946776)
- Testing
- implantable heart rate monitor
- Where
- 4 sites in Netherlands
- Volunteers
- 49 people
- Sponsor
- Stichting Epilepsie Instellingen Nederland
Epilepsy
Computational Decision Support in Epilepsy Using Retrospective EEG
The primary aim is to validate a set of computational biomarkers as potential decision support in epilepsy on a large cohort of study participants that were diagnosed with epilepsy and controls that ended up with another…
- Trial name
- NCT05384782
- Where
- United Kingdom
- Volunteers
- 825 people
- Sponsor
- Cornwall Partnership NHS Foundation Trust
Lennox Gastaut Syndrome (LGS)
EEG Dynamics in Lennox-Gastaut Syndrome Patients Undergoing Fenfluramine Treatment
This study plans to learn if certain markers found during electroencephalogram (EEG) analysis could predict fenfluramine responsiveness to give clinicians greater insight into the effectiveness of fenfluramine in people with…
- Trial name
- NCT07555171
- Testing
- fenfluramine HCl
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Seizures, Epileptic
An Observational Study of the Safety of Topiramate in Adults and Children With Epilepsy
The purpose of this observational study is to evaluate the safety of topiramate in adults and children with epilepsy (or seizures) who have not received or have not responded to treatment with previous antiepileptic medication.
- Trial name
- NCT00297323
- Testing
- Topiramate
- Volunteers
- 80 people
- Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
Epilepsy, Temporal Lobe
Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation
The overall goal of this study is to open up the promising treatment of repetitive transcranial magnetic stimulation (rTMS), which has been shown to be effective against seizures in patients with surface neocortical foci, to a…
- Trial name
- NCT02339376
- Testing
- Low-frequency repetitive transcranial magnetic stimulation, High-frequency repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Beth Israel Deaconess Medical Center
Epilepsy
Controlled Randomized Vagus Nerve Stimulation (VNS) Therapy Versus Resection (CoRaVNStiR)
Background: There are a variety of treatment options for medically refractory medial temporal lobe epilepsy. Evidence from randomized trials indicates vagus nerve stimulation therapy can be used as a proven therapy for medically…
- Trial name
- CoRaVNStiR (NCT02089243)
- Testing
- Vagus nerve stimulation therapy, Resective surgery
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
Epilepsies, Myoclonic
A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome
The primary purpose of the study is to demonstrate that lorcaserin has superior efficacy compared to placebo on percent change in frequency of convulsive seizures per 28 days in participants with Dravet syndrome.
- Trial name
- MOMENTUM 1 (NCT04572243)
- Testing
- Lorcaserin
- Where
- 30 sites in United States, Canada
- Volunteers
- 22 people
- Sponsor
- Eisai Inc.
Generalized Epileptic
Study on Serum Zinc and Selenium Levels in Epileptic Patients
This study was carried out with the purpose of evaluating zinc and selenium levels in serum of epileptic patients and compare with normal individuals.
- Trial name
- NCT01764516
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Arak University of Medical Sciences
Status Epilepticus, Refractory Status Epilepticus
Feasibility Study: tDCS for Treatment of Refractory Status Epilepticus
Status epilepticus, or recurrent seizures without return to baseline, is a neurologic emergency. Refractory status epilepticus occurs when seizures are resistant to multiple first line anti-seizure medications.
- Trial name
- NCT05934903
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Yale University
Electroencephalographic Neonatal Seizures, Epilepsy
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Lacosamide in Neonates With Repeated Electroencephalographic Neonatal Seizures
The purpose of the study is to evaluate the efficacy of lacosamide (LCM) versus an Active Comparator chosen based on standard of care (StOC) in severe and nonsevere seizure burden (defined as total minutes of…
- Trial name
- LENS (NCT04519645)
- Testing
- Lacosamide intravenous, Lacosamide oral, Active Comparator
- Where
- 18 sites in United States, Australia and 1 more
- Volunteers
- 29 people
- Sponsor
- UCB Biopharma SRL
Epilepsies, Epilepsies, Focal
Home Ultra-long Term EEG Monitoring for Rare Epilepsies and Developmental and Epileptic Encephalopathies
With this study the Investigator expects to develop a precise patient-centered model of care by means of home ultra-long-term EEG monitoring with a minimally invasive wearable EEG device (sqEEG).
- Conditions
- Epilepsies, Epilepsies, Focal, Epileptic Encephalopathy
- Trial name
- EMIRE (NCT06855901)
- Testing
- Ultra-longterm EEG monitoring at home by means of a scubscalp electrode implant.
- Where
- 4 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Epilepsy
PHArmacotherapy Assessed Using Neuroprobing With TransOsseal Magnetic Stimulation
The goal of this observational study is to investigate how prescribed anti-seizure medications (ASMs) affect cortical excitability in adults with epilepsy. The main questions it aims to answer are: 1.
- Trial name
- PHANTOMS (NCT06892457)
- Testing
- TMS-EEG
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Epilepsy, Brain Tumor
Mapping of Human Cognition
The purpose of this study is to compare organization of normal brain function as detected using Functional magnetic resonance imaging (fMRI) in normal subjects as opposed to patients with epilepsy or brain tumors, to ascribe…
- Trial name
- NCT05989893
- Testing
- Language-based tasks
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The University of Texas Health Science Center, Houston
Epilepsies Refractory
Trial of Multi-Strain Probiotic Supplementation (Hexbio®) in Malaysian Patients With Drug-Resistant Epilepsy (ProbE)
Probiotics are good, live bacteria and/or yeast, that live in our guts and causes no harm. They help in digestion and overall well-being of our gut system.
- Trial name
- ProbE (NCT07100743)
- Testing
- Probiotic Agent
- Where
- Malaysia
- Volunteers
- 78 people
- Sponsor
- National University of Malaysia
Epilepsy, Rolandic
Safety and Efficacy of Topamax Versus Carbamazepine in Benign Rolandic Epilepsy
The purpose of this study is to determine the efficacy and safety of Topiramate in comparison to Carbamazepine in Benign rolandic epilepsy.
- Trial name
- NCT00216567
- Testing
- topamax
- Volunteers
- 114 people
- Sponsor
- Janssen Korea, Ltd., Korea
Dravet Syndrome
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
ENDEAVOR is a Phase 1/2, 2-part, multicenter study to evaluate the safety and efficacy of ETX101 in participants with SCN1A-positive Dravet syndrome aged ≥6 to <36 months (Part 1A), aged ≥48 months to <18 years (Part 1B), and…
- Trial name
- ENDEAVOR (NCT05419492)
- Testing
- ETX101
- Where
- 14 sites in United States, Australia and 1 more
- Volunteers
- 113 people
- Sponsor
- Encoded Therapeutics
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