Clinical trials: Seizure, Epileptic
Epilepsy, Seizures
Correlation of Serum Level of Perampanel (PER) Level to Cerebrospinal Fluid (CSF) Levels of PER
Perampanel is a drug used to treat patients with epilepsy/seizures. This study is designed to determine how much perampanel actually crosses the blood brain barrier into the cerebral spinal fluid when the drug is taken.
- Trial name
- NCT04118829
- Testing
- Perampanel
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Carilion Clinic
Epilepsy
Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients With Acupuncture Treatment
The purpose of this study is to determine effects of Acupuncture on a Patient's mood and cognition,evaluate changes in clinically-reported seizure frequency and severity and analyze effects of Acupuncture on electrographic…
- Trial name
- NCT04677751
- Testing
- Acupuncture intervention
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Epilepsy, Treatment Adherence
Evaluation Of A Mobile Messaging Service In Improving Adherence Of Anti-Seizure Medications
This will be a behavioural intervention with no investigational medicinal product. The intervention will be a mobile messaging service that sends short messaging service (SMS) as texts or graphics to people with epilepsy to…
- Trial name
- NCT05321641
- Testing
- Mobile phone message reminders.
- Where
- Kenya
- Volunteers
- 1,200 people
- Sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
Seizures
Intranasal Midazolam Versus Rectal Diazepam for Treatment of Seizures
The investigators will conduct a randomized controlled trial comparing the use of nasal midazolam, using a Mucosal Atomization Devise, to rectal diazepam for the treatment of acute seizure activity in children under the age of 18…
- Trial name
- NCT00326612
- Testing
- Midazolam, Diazepam
- Where
- United States
- Volunteers
- 358 people
- Sponsor
- University of Utah
Epilepsy
Identification of Volatile Organic Compounds (VOCs) as Biopredictors of Epileptic Seizures
The unpredictable nature of epileptic seizures places people with epilepsy under permanent psychological stress, which contributes significantly to a restriction in their quality of life.
- Trial name
- ICONE (NCT05865561)
- Testing
- VOC sampling
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Post Cerebral Hemorrhage
Seizures Post Intracerebral Hemorrhage
This study examines early antiepileptic treatment with valproic acid for acute cerebral hemorrhage against a placebo group immediately post event to evaluate the outcome of these patients regarding seizures and neurological…
- Trial name
- NCT01115959
- Testing
- valproic acid
- Volunteers
- 72 people
- Sponsor
- Wolfson Medical Center
Intractable Epilepsy, Convulsive Seizures
Pilot Trial to Evaluate The Effect of Oral Methylprednisolone on Seizure Frequency in Children With Epilepsy
Although corticosteroids have been shown to be beneficial anecdotally for refractory epilepsy, the effects of corticosteroids on pediatric epilepsy have primarily been studied retrospectively amongst a heterogeneous patient…
- Trial name
- NCT04219995
- Testing
- methylprednisolone sodium succinate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
KCNT1-Related Epilepsy
A Natural History Study of Participants With Potassium Sodium-Activated Channel Subfamily T Member 1 (KCNT1)-Related Epilepsy
The primary objective of the study is to characterize seizures in participants with KCNT1-related epilepsy. The secondary objectives are to characterize head growth, symptom severity, neurocognitive and social functions, adaptive…
- Trial name
- K1Te (NCT04924153)
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Biogen
Epilepsy, Localization-related Epilepsy
Epilepsy Phenome/Genome Project
The purpose of this study is to collect detailed information about the characteristics and genetics of a large number of individuals with epilepsy.
- Conditions
- Epilepsy, Localization-related Epilepsy, Infantile Spasms, Lennox-Gastaut Syndrome
- Trial name
- EPGP (NCT00552045)
- Where
- 25 sites in United States, Argentina and 1 more
- Volunteers
- 4,150 people
- Sponsor
- University of California, San Francisco
Epilepsy, Seizures
University of Alabama at Birmingham (UAB) Pediatric CBD Program
The purpose of this study is to evaluate the safety and tolerability of Epidiolex at various doses between 5 mg/kg/day and 50 mg/kg/day as an additional (add-on) drug for treating debilitating, drug-resistant epilepsy.
- Trial name
- NCT02695537
- Testing
- Epidiolex
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Alabama at Birmingham
Epilepsy, Seizure
Predictors of Drug Resistant Epilepsy Among Pediatric Patients
1. This study aims to determine the main predictors of drug resistance in pediatric epilepsy by examining clinical data, EEG abnormalities, and neuroimaging results, in order to support early identification of resistant cases and…
- Conditions
- Epilepsy, Seizure, Resistance
- Trial name
- NCT07241754
- Volunteers
- 200 people
- Sponsor
- Assiut University
Partial Epilepsy
Cenobamate Expanded Access Program (EAP)
This Cenobamate Expanded Access Program (EAP) is designed to continue providing treatment with Cenobamate (YKP3089) to patients with partial-onset epilepsy that were enrolled in the SK Life Science clinical trial YKP3089C013…
- Trial name
- NCT04513860
- Testing
- YKP3089
- Sponsor
- SK Life Science, Inc.
Drug Resistant Epilepsy, Seizure
NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy
To evaluate the safety and efficacy of using NaviFUS™ system in patients with drug resistant epilepsy
- Conditions
- Drug Resistant Epilepsy, Seizure, Seizure Disorder, Epilepsy
- Trial name
- NCT04999046
- Testing
- NaviFUS System
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- NaviFUS Corporation
Epilepsy
A Study With an Open-label Extension Phase to Evaluate the Effect of Perampanel (E2007) on Cognition, Growth, Safety, Tolerability, and Pharmacokinetics in Adolescents
This study is designed to investigate the short- and long-term effects of perampanel on cognition, growth, and development in adolescents.
- Trial name
- NCT01161524
- Testing
- Perampanel
- Where
- 37 sites in United States, Australia and 9 more
- Volunteers
- 133 people
- Sponsor
- Eisai Inc.
Status Epilepticus
Randomized Therapy In Status Epilepticus
This study evaluated the effectiveness and safety of an investigational product (IP), intravenous (IV) ganaxolone, to treat participants with status epilepticus (SE).
- Trial name
- RAISE (NCT04391569)
- Testing
- Ganaxolone
- Where
- 74 sites in United States, Australia and 1 more
- Volunteers
- 100 people
- Sponsor
- Marinus Pharmaceuticals
Drug-resistant Epilepsy, Focal-Onset Seizures
Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy
The purpose of the study is to characterize the dose-response relationship with respect to efficacy of Padsevonil administered concomitantly with up to 3 anti-epileptic drugs (AEDs) for treatment of observable focal-onset…
- Trial name
- ARISE (NCT03373383)
- Testing
- Padsevonil
- Where
- 148 sites in United States, Australia and 17 more
- Volunteers
- 411 people
- Sponsor
- UCB Biopharma S.P.R.L.
Epilepsy Surgery, Drug Resistant Epilepsy
Cortical Resections in Drug Resistant Epilepsy
The aim of the study is to evaluate safety and efficacy of epilepsy surgery in the form of cortical resections in patients with refractory epilepsy and to review outcomes of resection procedures in focal epilepsy.
- Trial name
- NCT04553354
- Testing
- cortical resections
- Volunteers
- 35 people
- Sponsor
- Assiut University
Temporal Lobe Epilepsy
Advanced Magnetic Resonance Imaging in Temporal Lobe Epilepsy
We aim to o evaluate the role of conventional and advanced MRI sequences in diagnosis of idiopathic temporal lobe epilepsy including identification and lateralization of epileptogenic focus.
- Trial name
- NCT03643471
- Testing
- MRI
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Postoperative Intracranial Hematoma, Postoperative Intracranial Haemorrhage
A New Approach in Intensive Care Unit Consciousness Assessment: FIVE Score
1. The primary aim of this study is to investigate the correlation between the length of ICU stay and a newly developed FIVE score in neuro-intensive care patients. 2.
- Conditions
- Postoperative Intracranial Hematoma, Postoperative Intracranial Haemorrhage, Supratentorial Cancer, Infratentorial Neoplasms
- Trial name
- NCT06036732
- Where
- Turkey (Türkiye)
- Volunteers
- 223 people
- Sponsor
- Istanbul University - Cerrahpasa
Lennox Gastaut Syndrome
Carisbamate in Adult & Pediatric Subjects With Lennox-Gastaut Syndrome
This is an open-label, multi-center study of carisbamate in adult and pediatric subjects with LGS, with single- and multiple-dose PK assessments from Days 1 through 73.
- Trial name
- NCT03731715
- Testing
- Carisbamate
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- SK Life Science, Inc.
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