Clinical trials: Seizure Disorder, Post Traumatic
Post-Traumatic Seizure Disorder, Head Injuries
Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures
OBJECTIVES: I. Determine whether treating head injured patients with valproate sodium will reduce the risk of developing seizures as a result of the head injury. II.
- Trial name
- NCT00004817
- Testing
- phenytoin, valproate sodium
- Volunteers
- 385 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Traumatic Brain Injury, Epilepsy
Preventing Epilepsy After Traumatic Brain Injury With Topiramate
Our hypothesis is that topiramate will reduce acute seizures after traumatic brain injury and will help prevent the development of epilepsy after traumatic brain injury.
- Trial name
- PEPTO (NCT00598923)
- Testing
- topiramate, phenytoin
- Volunteers
- 6 people
- Sponsor
- University of Pennsylvania
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe
Biperiden Trial for Epilepsy Prevention
One of the most important neurological consequences following Traumatic Brain Injury (TBI) is the development of post traumatic epilepsy (PTE).
- Conditions
- Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe, Post Traumatic Epilepsy
- Trial name
- BIPERIDEN (NCT04945213)
- Testing
- Biperiden
- Where
- 10 sites in Brazil
- Volunteers
- 312 people
- Sponsor
- Hospital Sirio-Libanes
Epilepsy, Post-Traumatic
Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy
This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging.
- Trial name
- NCT03999164
- Testing
- [18F]DPA-714 Positron Emission Tomography Scan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
Traumatic Brain Injury, Cortical Excitability
Cortical Excitability in Post-traumatic Epilepsy
To test whether measures of cortical excitability derived from motor cortex transcranial magnetic stimulation (TMS) in patients with traumatic brain injury reflect heightened excitability relative to healthy controls and whether…
- Conditions
- Traumatic Brain Injury, Cortical Excitability, Epilepsy
- Trial name
- NCT05517954
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mid-Atlantic Epilepsy and Sleep Center, LLC
Epilepsy
Symptoms of Post-traumatic Stress in Adult Drug-resistant Epilepsies
Epilepsy is a neurological disease that can cause many comorbid psychiatric disorders, among them: generalized anxiety disorder and depression.
- Trial name
- SPIRALE (NCT04749901)
- Testing
- Psycho-emotional and semiological measures
- Where
- France
- Volunteers
- 129 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Psychogenic Nonepileptic Seizures (PNESs), Post Traumatic Stress Disorder PTSD
Treatment for Psychogenic Nonepileptic Seizures and Post-traumatic Stress Disorder Using Prolonged Exposure Therapy (PE) or Psychoeducation for PNES
An outpatient randomized controlled clinical trial conducted at the Northeast Regional Epilepsy Group's PNES Program, involving mental health clinicians certified in PE and trained in administering PsychoEd.
- Trial name
- PNES (NCT07344766)
- Testing
- imaginal and in vivo exposure, psychoeducation for psychogenic nonepileptic seizures
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Northeast Regional Epilepsy Group
Convulsion, Non-Epileptic, Conversion Disorder
Treatment Trial for Psychogenic Nonepileptic Seizures
The investigators propose that patients who receive targeted pharmacotherapy (sertraline) or focused psychotherapy (cognitive behavioral therapy-informed psychotherapy (CBT-ip) for NES) or combined treatment (CBT-ip + sertraline)…
- Conditions
- Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic
- Trial name
- NEST-T_1 (NCT00835627)
- Testing
- sertraline, CBT-ip, Combined (sertraline + CBT-ip)
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Rhode Island Hospital
Epilepsy, Traumatic, Brain Injuries, Traumatic
HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) -Post-Traumatic Epilepsy (PTE)
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-PTE, to improve the quality of life and cognitive function in Service Members, Veterans and civilians with post traumatic epilepsy…
- Trial name
- HOBSCOTCHPTE (NCT05235061)
- Testing
- Home Based Self-management and Cognitive Training Changes lives in post traumatic epilepsy (HOBSCOTCH-PTE), HOBSCOTCH-PTE for Caregivers
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Hearing Impairment, Hearing Aid Fitting
Blast Exposed Veterans With Auditory Complaints
The purpose of this study is to study blast-exposed Veterans who report hearing handicap but show normal or near normal results on standard audiometric testing.
- Trial name
- NCT02122458
- Testing
- mild-gain hearing aids with high-frequency emphasis over 6-months
- Where
- 3 sites in United States
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Epilepsy, Post-Traumatic
Prevention of Post-traumatic Seizures With Levetiracetam
Post-traumatic seizures can appear frequently after a severe traumatic brain injury. Two types of seizures are usually identified: early seizures during the week following the trauma and late epilepsy afterward.
- Trial name
- TRACK (NCT00566046)
- Testing
- Levetiracetam
- Where
- 15 sites in France
- Volunteers
- 23 people
- Sponsor
- Rennes University Hospital
Convulsion, Non-Epileptic, Conversion Disorder
Treatments for Psychogenic Nonepileptic Seizures (NES)
The investigators propose that treatment of the comorbid disorders (depression, anxiety, and impulsivity) with sertraline in patients with lone psychogenic nonepileptic seizures (NES), will result in a decreased number of NES.
- Conditions
- Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic
- Trial name
- NES (NCT00159965)
- Testing
- sertraline
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Rhode Island Hospital
Epilepsy
Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers
Recently, a possible subtype of temporal lobe epilepsy (TLE) has been proposed: this subtype presents ipsilateral amygdala enlargement (AE) without any other lesion.
- Trial name
- STELLA (NCT03464370)
- Testing
- Measure of emotional stressors
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse