Clinical trials: Seizures, Epileptic
Focal Epilepsy
Long-term Safety and Tolerability of BHV-7000
A study to determine if BHV- 7000 is safe and tolerable in adults with refractory focal onset epilepsy
- Trial name
- NCT06443463
- Testing
- BHV-7000
- Where
- 283 sites in United States, Argentina and 25 more
- Volunteers
- 660 people
- Sponsor
- Biohaven Therapeutics Ltd.
Cognition, Medically Intractable Epilepsy
Electrochemical and Electrophysiological Study
This study will utilize computerized algorithms in combination with real-time intracranial neurophysiological and neurochemical recordings and microstimulation to measure cognitive and affective behavior in humans.
- Trial name
- NCT05273970
- Testing
- Behavioral testing under intracranial monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arizona
Epilepsy, Seizures, Focal
Thermocoagulation in Drug Resistant Focal Epilepsy
Therapeutic thermocoagulation will be carried out in patients with drug-resistant focal epilepsy in cases where an epileptogenic zone is found and proven according to stereo-electroencephalography (SEEG) data.
- Conditions
- Epilepsy, Seizures, Focal, Epilepsy Intractable, Epilepsies, Partial
- Trial name
- NCT05248269
- Testing
- Radiofrequency thermocoagulation
- Where
- Russia
- Volunteers
- 75 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Seizures
Magnetoencephalography in Absence Seizures
Background: An absence seizure is a type of seizure that usually begins in childhood and goes away by early adulthood. Scientists do not yet know where absence seizures begin in the brain.
- Trial name
- NCT00884351
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Landau-Kleffner Syndrome, Status Epilepticus, Electrographic
Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome
The purpose of this study is to compare the effectiveness of the medications acetazolamide and diazepam in the treatment of continuous spike wave in sleep (CSWS) and Landau-Kleffner syndrome (LKS).
- Trial name
- NCT02904265
- Testing
- Diazepam, Acetazolamide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Partial Seizures With or Without Secondary Generalization, Epilepsy
A Study to Evaluate the Efficacy and Safety of Brivaracetam in Study Participants (>=16 to 80 Years of Age) With Epilepsy
The purpose of the study is to evaluate the efficacy of brivaracetam (BRV) compared to placebo (PBO) as adjunctive treatment in subjects (>=16 to 80 years of age) with partial seizures with or without secondary generalization…
- Trial name
- NCT03083665
- Testing
- Brivaracetam
- Where
- 94 sites in China, Japan and 5 more
- Volunteers
- 449 people
- Sponsor
- UCB Biopharma SRL
Lennox-Gastaut Syndrome
A Placebo-Controlled, Double-Blind Comparative Study of E2080 in Lennox-Gastaut Syndrome Patients (Study E2080-J081-304)
To confirm that the combination therapy of rufinamide has superior efficacy compared to placebo in patients with Lennox-Gastaut syndrome.
- Trial name
- NCT01146951
- Testing
- Rufinamide (E2080)
- Where
- 23 sites in Japan
- Volunteers
- 66 people
- Sponsor
- Eisai Limited
KCNQ2-related Epilepsy
Clinical Phenotype and Omics Study of KCNQ2-related Epilepsy
The aims of study on KCNQ2-related epilepsy: (1) establish phenotype database and sample database of KCNQ2-related epilepsy; (2) to establish genotype-phenotype association of KCNQ2-related epilepsy; (3) to study the brain…
- Trial name
- NCT05157737
- Testing
- Electrophysiological detection of KCNQ2 mutation, Multi-modal brain image and EEG, Omics testing
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fudan University
Epilepsy
Pediatric Epilepsy Trial in Subjects 1-24 Months
This study is being conducted to evaluate the effectiveness and safety of LAMICTAL added to the current therapy of pediatric patients age 1-24 months old with partial seizures.
- Trial name
- NCT00043875
- Testing
- lamotrigine
- Where
- 65 sites in United States, Australia and 12 more
- Volunteers
- 177 people
- Sponsor
- GlaxoSmithKline
Epilepsy
Seizure Rescue Medication (RM) as Part of a Comprehensive Epilepsy Self-management Package of Care
This study will be done in two phases. Using stakeholder input (community advisory board (CAB)), the study team will adapt the SMART program to incorporate education and self-management support for use of Rescue Medication (RM)…
- Trial name
- NCT06346262
- Testing
- SMART RM, Valtoco Nasal Product
- Where
- 2 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Epileptic Seizure
Epileptic Seizures in Intensive Care Units
This retrospective observational cohort study is to assess and analyze clinical, electroencephalographic, laboratory, comorbidity, and treatment characteristics of Intensive care unit (ICU)-patients with epileptic seizures and to…
- Trial name
- NCT03860467
- Testing
- collection of patient data
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Epilepsy
Heart Rate Changes During Normal Activity, Exercise, and Seizures in Subjects With Epilepsy
Characterization of the cardiac response (ECG) preceding an epileptic seizure.
- Trial name
- NCT01214707
- Testing
- Exercise
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Cyberonics, Inc.
Seizure Disorder, Partial
To Evaluate the Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.
To evaluate the long-term safety and tolerability of pregabalin in patients with partial seizures.
- Trial name
- NCT00141336
- Testing
- Pregabalin
- Where
- 103 sites in United States, Canada
- Volunteers
- 750 people
- Sponsor
- Pfizer
Epilepsy, Epilepsy, Complex Partial
Effect of Vigabatrin on Brain Blood Flow and Glucose Metabolism
This study is designed to test the effects of vigabatrin (gamma-vinyl-GABA) an experimental drug used for the treatment of epilepsy.
- Trial name
- NCT00001489
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Cardiac Disease
Epileptic Potentials During Cardiac Surgery and Association With Postoperative Neurological Outcome
Primarily, the investigators want to test the hypothesis that it is possible to detect epileptiform EEG during cardiac surgery under general anesthesia.
- Conditions
- Epilepsy, Cardiac Disease, Peroperative Complications, Anesthesia; Adverse Effect
- Trial name
- EPOCAS (NCT02976584)
- Where
- Switzerland
- Volunteers
- 1,067 people
- Sponsor
- Heiko Kaiser
Neonatal Seizure, Epilepsy
Evaluating the Role of Inflammation in Neonatal Epileptogenesis
The purpose of this study evaluate the relationship between inflammation and epilepsy in neonates with seizures after birth.
- Conditions
- Neonatal Seizure, Epilepsy, Seizures, Inflammatory Response
- Trial name
- NSR-RISE (NCT04259125)
- Testing
- Blood draw, Survey
- Where
- 4 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Francisco
Epilepsia Partialis Continua, Status Epilepticus
Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Epilepsy
The purpose of this study is to assess the effects of repetitive transcranial magnetic stimulation (rTMS) as a treatment for Epilepsia Partialis Continua (EPC) or refractory Status Epilepticus (SE), when standard clinical…
- Trial name
- NCT02560597
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Ghent
Epilepsy, Partial
A Placebo-controlled Study of Levetiracetam In Children (1mo to 4yrs of Age) With Partial Onset Seizures.
To evaluate the safety and efficacy of levetiracetam used as adjunctive treatment in pediatric subjects age 1 month to less than 4 years with partial onset seizures.
- Trial name
- NCT00175890
- Testing
- Levetiracetam
- Where
- 86 sites in United States, Argentina and 13 more
- Volunteers
- 116 people
- Sponsor
- UCB Pharma
Epilepsy, Seizure
Predictors of Drug Resistant Epilepsy Among Pediatric Patients
1. This study aims to determine the main predictors of drug resistance in pediatric epilepsy by examining clinical data, EEG abnormalities, and neuroimaging results, in order to support early identification of resistant cases and…
- Conditions
- Epilepsy, Seizure, Resistance
- Trial name
- NCT07241754
- Volunteers
- 200 people
- Sponsor
- Assiut University
Epilepsy, Seizures
Registry of Subjects With Drug Resistant Epilepsy and Treated With the VNS Therapy System.
Multicenter global post-market registry of subjects diagnosed with drug resistant epilepsy and treated with the VNS Therapy System.
- Conditions
- Epilepsy, Seizures, Drug Resistant Epilepsy
- Trial name
- CORE-VNS (NCT03529045)
- Testing
- Vagus Nerve Stimulation (VNS) Therapy
- Where
- 62 sites in United States, Australia and 14 more
- Volunteers
- 827 people
- Sponsor
- LivaNova