Clinical trials: Seizures, Epileptic
Epilepsy; Seizure
Thalamus Seizure Detection With a Deep Brain Stimulator System
The purpose of this study is to determine the feasibility of chronic ambulatory thalamus seizure detection. The sensitivity, specificity, and false alarm rate of thalamus seizure detection will be calculated using recordings from…
- Trial name
- NCT06700356
- Testing
- Phase 1-Validation of thalamus seizure detection with concurrent video EEG monitoring, Phase 2-DBS Stimulation with Medtronic Percept DBS device-Out Patient
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Epilepsy, Seizures, Focal
Thermocoagulation in Drug Resistant Focal Epilepsy
Therapeutic thermocoagulation will be carried out in patients with drug-resistant focal epilepsy in cases where an epileptogenic zone is found and proven according to stereo-electroencephalography (SEEG) data.
- Conditions
- Epilepsy, Seizures, Focal, Epilepsy Intractable, Epilepsies, Partial
- Trial name
- NCT05248269
- Testing
- Radiofrequency thermocoagulation
- Where
- Russia
- Volunteers
- 75 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Epilepsy
Eslicarbazepine Acetate (BIA 2-093) as Monotherapy in Patients With Newly Diagnosed Partial-onset Seizures
This is a Phase III, multinational, open-label, non-controlled study with subjects under treatment in the double-blind BIA-2093-311 study (NCT01162460).
- Trial name
- NCT02484001
- Testing
- ESL 800 mg, ESL 1200 mg, ESL 1600 mg
- Volunteers
- 206 people
- Sponsor
- Bial - Portela C S.A.
Epilepsy
Evaluation and Treatment of Patients With Epilepsy
This protocol has three purposes: 1) to screen patients with seizures for participation in research studies of NINDS s Clinical Epilepsy Section (CES), 2) to follow the natural course of seizure disorders, and 3) to train CES…
- Trial name
- NCT00013845
- Where
- United States
- Volunteers
- 1,278 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
CDKL5 Deficiency Disorder
Efficacy and Safety Evaluation of Hyperthermic Baths in the Treatment of Seizures in CDKL5 Deficiency Disorder
The primary objective of this research is to study the efficacy and safety of hyperthermic baths as adjunctive therapy for reducing the frequency of seizures in CDKL5 deficiency.
- Trial name
- NCT06447675
- Testing
- Hyperthermic Baths
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Xuanwu Hospital, Beijing
Lennox-Gastaut Syndrome
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut Syndrome
OBJECTIVES: I. Evaluate the safety and efficacy of oral topiramate in patients with Lennox-Gastaut syndrome.
- Trial name
- NCT00004776
- Testing
- topiramate
- Volunteers
- 10 people
- Sponsor
- National Center for Research Resources (NCRR)
Rolandic Epilepsy, Rolandic Epilepsy, Benign
Sleep Spindles and Memory in Rolandic Epilepsy
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI)…
- Conditions
- Rolandic Epilepsy, Rolandic Epilepsy, Benign, Centrotemporal Epilepsy, Centrotemporal; EEG Spikes, Epilepsy of Childhood
- Trial name
- NCT04569708
- Testing
- Closed loop auditory stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Epilepsies, Myoclonic
A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome
The primary purpose of the study is to demonstrate that lorcaserin has superior efficacy compared to placebo on percent change in frequency of convulsive seizures per 28 days in participants with Dravet syndrome.
- Trial name
- MOMENTUM 1 (NCT04572243)
- Testing
- Lorcaserin
- Where
- 30 sites in United States, Canada
- Volunteers
- 22 people
- Sponsor
- Eisai Inc.
Epilepsy
Use of the Atkins Diet for Children With Intractable Epilepsy: A Comparison of Daily Carbohydrate Limits
This study is designed to further investigate the use of a modified Atkins diet for children with intractable, daily seizures. It is a follow-up to a study recently completed by our institution.
- Trial name
- NCT00181090
- Testing
- Modified Atkins diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Epilepsy
ESIS in Pediatric DRE
The main reason for this research study is to gain information about how the brain makes seizures by causing seizures using very small amounts of current, or electrical stimulation.
- Trial name
- NCT05469373
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Sarah Katie Ihnen
Epilepsy
Assess Safety and Efficacy of Lacosamide in Patients With Partial Seizures
The main purpose of this trial is to determine safety and efficacy of Lacosamide under long term therapy.
- Trial name
- NCT00515619
- Testing
- Lacosamide
- Where
- 54 sites in Australia, Croatia and 11 more
- Volunteers
- 376 people
- Sponsor
- UCB Pharma
Epilepsy, Depressive Symptoms
Preventing Depression in People With Epilepsy: an Extension of Project UPLIFT
Project UPLIFT, a home-based treatment for depression in people with epilepsy, was designed to be delivered to groups by telephone or Web.
- Conditions
- Epilepsy, Depressive Symptoms, Depression, Seizure Disorder
- Trial name
- NCT01941706
- Testing
- Project UPLIFT
- Where
- 4 sites in United States
- Volunteers
- 130 people
- Sponsor
- Emory University
Seizure, Epilepsy
Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria
Pediatric cerebral malaria (CM) affects more than 3 million children each year killing ~20% and leaving one third of survivors with long term neurologic and psychiatric sequelae.
- Conditions
- Seizure, Epilepsy, Cerebral Malaria
- Trial name
- LVT1 (NCT01660672)
- Testing
- LEVETIRACETAM
- Where
- Malawi
- Volunteers
- 7 people
- Sponsor
- University of Rochester
Seizures, Brain Diseases
A Multicentre Clinical Investigation of a Decision Support Algorithm for Neonatal Seizure Detection
The ANSeR Clinical Investigation is a multi-centre, randomised, controlled, clinical investigation of a standalone decision support Algorithm for Neonatal Seizure Recognition, the ANSER Software system.
- Conditions
- Seizures, Brain Diseases, Central Nervous System Diseases, Epilepsy
- Trial name
- ANSeR (NCT02431780)
- Testing
- ANSeR Software System
- Where
- 8 sites in Ireland, Netherlands and 2 more
- Volunteers
- 264 people
- Sponsor
- University College Cork
Epilepsy; Seizure
Clinical Validation of a Video-based Epilepsy Examination Service
The main purpose of this study is to validate the ability of the Nelli system (video-based epilepsy examination system) to detect epileptic motor seizure behaviors in patients at rest.
- Trial name
- Nelli (NCT04171934)
- Where
- Denmark
- Volunteers
- 182 people
- Sponsor
- Tampere University
Highly Drug-resistant Focal Epilepsy
A Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal Epilepsy
This study is to assess the efficacy, safety, and tolerability of the investigational drug UCB0942in adult subjects with drug-resistant focal epilepsy across multiple centers in Europe.
- Trial name
- NCT02495844
- Testing
- UCB0942
- Where
- 18 sites in Belgium, Bulgaria and 4 more
- Volunteers
- 55 people
- Sponsor
- UCB Biopharma S.P.R.L.
Epilepsy
Seizure Advisory System Feasibility Study
The purpose of this prospective, single-arm, unblinded, multicenter clinical study is to evaluate the safety and effectiveness of the NeuroVista Seizure Advisory System (SAS) in patients with medically refractory epilepsy.
- Trial name
- NCT01043406
- Testing
- Seizure Advisory System
- Where
- 3 sites in Australia
- Volunteers
- 15 people
- Sponsor
- NeuroVista Corporation
Epilepsy
Study in Pediatric Subjects With Epilepsy
This is an open-label study to evaluate the pharmacokinetics, safety and tolerability of ezogabine/retigabine in subjects aged 12 years to less than 18 years with uncontrolled partial onset seizures or Lennos-Gastaut syndrome.
- Trial name
- NCT01494584
- Testing
- ezogabine/retigabine
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- GlaxoSmithKline
Primary Brain Tumor, Epilepsy
Trial of Levetiracetam in Patients With Primary Brain Tumors and Symptomatic Seizures Who Undergo Surgery
The purpose of this study is to determine the feasibility, efficacy and safety of intravenous and oral antiepileptic treatment with levetiracetam in patients with primary brain tumors and symptomatic epilepsy in the period of…
- Trial name
- NCT00571155
- Testing
- levetiracetam
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Tuebingen
Epilepsy
The Impact of Mindfulness Meditation in Veterans With Epilepsy
Epilepsy is one of the fourth most common neurological disorder and affects people of all ages and about 25 % of those patients have medically intractable epilepsy.
- Trial name
- NCT03589755
- Testing
- Mindfulness meditation
- Where
- United States
- Sponsor
- Miami VA Healthcare System