Clinical trials: Seizures, Epileptic
Partial Epilepsy
A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures
This is a multicenter, double-blind, randomized, placebo-controlled dose response study, with an 8-week prospective baseline and an 18 week double-blind treatment period (including a 6-week titration phase and 12 week maintenance…
- Trial name
- NCT01866111
- Testing
- YKP3089
- Where
- 67 sites in United States, Australia and 13 more
- Volunteers
- 437 people
- Sponsor
- SK Life Science, Inc.
Epilepsy, Seizures
Monitoring Patients With Uncontrolled Epilepsy
This study is designed to evaluate patients with uncontrolled seizures. Seizures can be associated with and monitored by abnormal electrical activity in the brain.
- Trial name
- NCT00001149
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy
Pediatric Epilepsy Study
This study will evaluate the safety and effectiveness of oxcarbazepine (Trileptal) as monotherapy in the treatment of partial seizures in pediatric patients 1 month to 3 years of age.
- Trial name
- NCT00050947
- Testing
- oxcarbazepine
- Where
- 30 sites in United States, Brazil and 2 more
- Volunteers
- 94 people
- Sponsor
- Novartis Pharmaceuticals
Childhood Absence Epilepsy, Petit Mal Epilepsy
Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study
The purpose of this study is to determine the best initial treatment for childhood absence epilepsy.
- Conditions
- Childhood Absence Epilepsy, Petit Mal Epilepsy, Epilepsy, Seizures
- Trial name
- NCT00088452
- Testing
- Ethosuximide, Lamotrigine, Valproic acid
- Where
- 31 sites in United States
- Volunteers
- 453 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Epilepsy
Study to Evaluate the Safety and Effectiveness of USL255 in Patients With Refractory Partial-onset Seizures
The purpose of this study is to examine the safety and effectiveness of USL255 as adjunctive therapy in patients with refractory partial onset-seizures.
- Trial name
- NCT01142193
- Testing
- USL255
- Where
- 69 sites in United States, Argentina and 14 more
- Volunteers
- 249 people
- Sponsor
- Upsher-Smith Laboratories
Rolandic Epilepsy, Benign Childhood Epilepsy With Centrotemporal Spikes
The Effect of Music Periodicity on Interictal Epileptiform Discharges
The purpose of this study is to determine if having children listen to the music of Wolfgang Amadeus Mozart (Sonata for Two Pianos in D Major, K.
- Conditions
- Rolandic Epilepsy, Benign Childhood Epilepsy With Centrotemporal Spikes, Epilepsy, Seizures
- Trial name
- NCT01515436
- Testing
- Mozart alternating with Beethoven, Beethoven alternating with Mozart
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
PCDH19-Related Epilepsy
Study of Adjunctive Ganaxolone Treatment in Female Children With Protocadherin 19 (PCDH19)-Related Epilepsy (Violet Study)
A clinical study to evaluate the efficacy, safety, and tolerability of adjunctive ganaxolone therapy compared to placebo for the treatment of seizures in female children and young adults with genetically confirmed PCDH19 gene…
- Trial name
- NCT03865732
- Testing
- Ganaxolone
- Where
- 12 sites in United States, Hungary and 3 more
- Volunteers
- 29 people
- Sponsor
- Marinus Pharmaceuticals
Focal Seizure, Epilepsy
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures
This is a clinical research study for an investigational drug called RAP-219 in adult participants with focal seizures. This study is being conducted to determine if RAP-219 is safe and effective in reducing focal seizure…
- Conditions
- Focal Seizure, Epilepsy, Focal Epilepsy
- Trial name
- FOCUS 2 (NCT07594119)
- Testing
- RAP-219
- Where
- 13 sites in United States
- Volunteers
- 312 people
- Sponsor
- Rapport Therapeutics Inc.
Convulsion, Non-Epileptic
Retraining and Control Therapy (ReACT) R33 Phase
The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of…
- Trial name
- ReACT (NCT06007053)
- Testing
- ReACT, Supportive Therapy
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Epilepsy
Long-Term Safety Study of Retigabine Immediate Release (IR) as Adjunctive Therapy in the Treatment of Adults With Partial-Onset Seizures (POS)
The purpose of this Phase III study is to assess the long-term safety, tolerability and efficacy of flexibly dosed retigabine Immediate Release (IR) as adjunctive therapy in adult subjects with partial-onset seizures.
- Trial name
- IR (NCT01336621)
- Testing
- Retigabine IR
- Where
- 31 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 98 people
- Sponsor
- GlaxoSmithKline
Epilepsy in Children
Promoting Implementation of Seizure Detection Devices in Epilepsy Care
This is a multicenter home-based medical device intervention study, with prospective validation of the wearable seizure detection device (Nightwatch) and retrospective validation of remote sensors (video and audio detection) in…
- Trial name
- PROMISE (NCT03909984)
- Testing
- Nightwatch
- Where
- 3 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Stichting Epilepsie Instellingen Nederland
Somatoform Disorders, Irritable Bowel Syndrome
Neurovegetative Decoupling in Somatoform Disorders : Biofeedback Interest
Evaluation of the physiological and clinical effects of the biofeedback training with patients suffering from somatoform disorders, depending on their neurovegetative profile related to a visceral-brain decoupling.
- Conditions
- Somatoform Disorders, Irritable Bowel Syndrome, Psychogenic Non-Epileptic Seizure
- Trial name
- BIOFEESOMATO (NCT04807933)
- Testing
- Heart rate variability Biofeedback [HRV-BFB]
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Grenoble
Epilepsy
A Prospective Diagnostic Belief Updating Study to verIfy the Utility of BioEP in First Seizure Clinics.
The goal of this belief updating study is to assess the utility of BioEP as a complementary support tool in aiding clinical decision making in adults in first seizure clinics.
- Trial name
- PRISTINE (NCT05764252)
- Testing
- BioEP
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- Neuronostics Ltd
Epilepsy
Epidemiology of Suspected Epileptic Seizures
The occurrence of isolated or recurring epileptic seizures accounts for an important use of the healthcare system. Typically, epileptic patient will consult ten times a year a physician (specialist or familial doctor) and will…
- Trial name
- EPI-lepsie (NCT04147663)
- Testing
- describe the management of the adult population suffering from suspected seizure by the emergency structures
- Where
- France
- Volunteers
- 2,300 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Epilepsy
Hybrid Micro-macro Electrodes in Patients With Epilepsy
The aim of the MicroEPI study is to know whether it is possible to use safely a medical device (a micro-electrode) that allows recording the activity of neurons in the human brain.
- Trial name
- MicroEPI (NCT05335187)
- Testing
- micro-macro electrode implantation
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- Pierre Mégevand
Sleep Deprivation, Epilepsies, Partial
A Study of Lyrica as Treatment for Sleep Problems in Patients With Sleep Problems and Seizures
The purpose of this study is to determine the effects of pregabalin on sleep problems in patients with seizures.
- Trial name
- NCT00643136
- Testing
- Pregabalin
- Where
- 2 sites in Netherlands
- Volunteers
- 17 people
- Sponsor
- Pfizer
Epilepsy
Open Label, Zonegran (Zonisamide) In Partial Onset Seizures
To determine the efficacy and safety of adjunctive open label Zonegran treatment in patients with refractory partial seizures.
- Trial name
- NCT00215592
- Testing
- Zonegran
- Where
- 33 sites in Austria, Denmark and 5 more
- Volunteers
- 1,000 people
- Sponsor
- Eisai Limited
Glioma, Glioma of Brain
Seizure Prophylaxis in Patients With Glioma or Brain Metastasis
This protocol is designed to assess the need for seizure prophylaxis in the perioperative period for patients undergoing neurosurgical procedure (gross-total resection, sub-total resection or biopsy) for suspected diagnosis of…
- Conditions
- Glioma, Glioma of Brain, Brain Tumor
- Trial name
- NCT03436433
- Testing
- Lacosamide, Levetiracetam
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Partial-Onset or Primary Generalized Tonic-Clonic Seizures
Perampanel as Adjunctive Therapy in Pediatrics With Partial Onset Seizures or Primary Generalized Tonic Clonic Seizures
This is an open-label, multicenter study with an Extension Phase to evaluate the safety and tolerability of perampanel oral suspension when administered as an adjunctive therapy in children (ages 4 to less than [<] 12 years) with…
- Trial name
- NCT02849626
- Testing
- Perampanel
- Where
- 91 sites in United States, Belgium and 10 more
- Volunteers
- 180 people
- Sponsor
- Eisai Inc.
Epilepsy, Partial Seizures
Open-label, Randomized, Active-controlled Study of LEV Used as Monotherapy in Patients With Partial-Onset Seizures
To demonstrate the non-inferiority of Levetiracetam (1000 mg/day) versus Carbamazepine Immediate-Release (400 mg/day) used as monotherapy for at least 6 months in a Chinese population with newly or recently diagnosed Epilepsy who…
- Trial name
- NCT01954121
- Testing
- Levetiracetam, Carbamazepine
- Where
- 28 sites in China
- Volunteers
- 436 people
- Sponsor
- UCB Pharma SA