Clinical trials: Seizures, Epileptic
Convulsion, Non-Epileptic
Retraining and Control Therapy (ReACT)- Adults
The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of…
- Trial name
- ReACT (NCT06570954)
- Testing
- ReACT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Epilepsy, Partial
Open Label Safety and Efficacy Study of Levetiracetam in Korean Patients With Epilepsy
A Korean open-label, community-based trial assessing the efficacy and safety of levetiracetam as adjunctive therapy in partial epilepsy. Similarity with a similar study conducted in Caucasian epileptic subjects will be assessed.
- Trial name
- NCT00160628
- Testing
- Levetiracetam
- Volunteers
- 100 people
- Sponsor
- UCB Pharma
Partial Seizures, Epilepsies, Partial
Once-A-Day Pregabalin For Partial Seizures
Approximately 30% percent of subjects with partial seizures are refractory to treatment with single or combination antiepileptic drugs.
- Trial name
- NCT01262677
- Testing
- pregabalin
- Where
- 82 sites in United States, Argentina and 16 more
- Volunteers
- 325 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Epilepsy, Seizures
Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-epileptic Drugs (AEDs) in Patients With Epilepsy.
The purpose of this research study is to compare the long term effectiveness, safety and tolerability of carisbamate compared to two other frequently prescribed anti-epileptic drugs (AEDs) in patients with epilepsy.
- Trial name
- NCT00563459
- Testing
- carisbamate, topiramate, levetiracetam
- Volunteers
- 89 people
- Sponsor
- SK Life Science, Inc.
Seizures, Epilepsy
Exercise Education for Adults With Seizure Disorders
Study Population -People with seizures benefit from regular exercise. Exercise may help decrease the number of seizures they have. It also improves overall health and quality of life.
- Trial name
- NCT01856335
- Testing
- Patient Education, exercise: increase physical activity/goal setting
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy With Partial Onset Seizures With or Without Secondary Generalization
Lacosamid-i.v.-Register
Lacosamide is a new antiepileptic drug (AED) marketed as Vimpat with three different formulations, tablets, oral syrup and a solution for intravenous infusion.
- Trial name
- LCM (NCT01620840)
- Testing
- Lacosamide 10mg/ml
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- University Hospital Schleswig-Holstein
Epilepsy, Monotherapy
Evaluating Long Term Safety of Lacosamide (LCM) to Carbamazepine Controlled-release (CBZ-CR); Initial Monotherapy in Epilepsy Subjects 16 Years and Older
Compare safety of Lacosamide (LCM) to Carbamazepine Controlled-Release (CBZ-CR) as monotherapy in newly or recently newly diagnosed subjects with primary safety variables including spontaneous reports of Adverse Events (AEs)…
- Trial name
- NCT01465997
- Testing
- Lacosamide, Carbamazepine-Controlled Release (CBZ-CR)
- Where
- 150 sites in United States, Australia and 27 more
- Volunteers
- 551 people
- Sponsor
- UCB BIOSCIENCES GmbH
Epilepsy
Multicentre Study on Rapid Versus Slow Withdrawal of Antiepileptic Monotherapy
The main objective of the present study will be to establish whether a slow (within 160 days) or a rapid (within 60 days) withdrawal schedule of antiepileptic monotherapy influence relapse rate in adult patients with epilepsy…
- Trial name
- RASLOW (NCT05236166)
- Testing
- Rapid withdrawal of antiepileptic, Slow withdrawal of antiepileptic
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- University Magna Graecia
Dissociative Seizures
Cognitive Behavioural Therapy in Dissociative Seizures
The purpose of this study is to determine whether adults with disoociative (psychogenic non-epileptic) seizures receiving cognitive behavioural therapy (CBT) show a greater reduction in seizures and health service use and greater…
- Trial name
- NCT00688727
- Testing
- CBT, Standard Care
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- South London and Maudsley NHS Foundation Trust
Autoimmune Encephalitis, Epilepsy
Acute Sympotomatic Seizure Secondary to Autoimmune Encephalitis and Autoimmune-associated Epilepsy
Previously, scholars called the seizures secondary to autoimmune encephalitis（AE） "autoimmune related epilepsy", but the seizures secondary to AE are usually controlled after the improvement of encephalitis, which does not meet…
- Conditions
- Autoimmune Encephalitis, Epilepsy, Seizures
- Trial name
- NCT05422664
- Testing
- Lacosamide
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Liu Yonghong
Epilepsy
Epilepsy Motion Sensing
Evaluate patient motion during seizures.
- Trial name
- NCT01850498
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- MedtronicNeuro
Epilepsies, Partial
A Long Term Follow up Administration Study of L059 (Levetiracetam) in Epilepsy Patients With Partial Onset Seizures
This study is planned to evaluate the safety and efficacy of L059 (levetiracetam) in long-term administration in patients who completed N01020 [NCT00160165] or N01221 [NCT00280696].
- Trial name
- NCT00367432
- Testing
- Levetiracetam
- Where
- 53 sites in Japan
- Volunteers
- 398 people
- Sponsor
- UCB Japan Co. Ltd.
Epilepsy, Depressive Symptoms
Adapting Project UPLIFT for Blacks in Georgia
Evaluate the efficacy of Project UPLIFT for reducing symptoms of depression and anxiety among African Americans at immediate posttest and after 3 months.
- Conditions
- Epilepsy, Depressive Symptoms, Anxiety Disorders and Symptoms
- Trial name
- NCT02909387
- Testing
- Project UPLIFT
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Morehouse School of Medicine
Partial Epilepsies
Trial to Assess Lacosamide as the First add-on Anti-epileptic Drug Treatment in Patients With Partial-onset Seizures
To evaluate the efficacy and safety of oral Lacosamide as first add on treatment in subjects with uncontrolled partial-onset seizures after prior treatment with a monotherapy Antiepileptic Drug (AED) regimen compared to subjects…
- Trial name
- NCT00955357
- Testing
- Lacosamide
- Where
- 109 sites in United States, Austria and 13 more
- Volunteers
- 461 people
- Sponsor
- UCB Pharma
Hypercholesterolemia, Carotid Intimal Medial Thickness 1
Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy
This research is being done to evaluate the short term and long term effects of ketogenic diets on measures of cardiovascular health.
- Conditions
- Hypercholesterolemia, Carotid Intimal Medial Thickness 1, Seizure, Epilepsy
- Trial name
- NCT02694094
- Testing
- Modified Atkins or Ketogenic Diet
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Epilepsy, Treatment Adherence
Evaluation Of A Mobile Messaging Service In Improving Adherence Of Anti-Seizure Medications
This will be a behavioural intervention with no investigational medicinal product. The intervention will be a mobile messaging service that sends short messaging service (SMS) as texts or graphics to people with epilepsy to…
- Trial name
- NCT05321641
- Testing
- Mobile phone message reminders.
- Where
- Kenya
- Volunteers
- 1,200 people
- Sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
Epilepsy
Eslicarbazepine Acetate (BIA 2-093) as Monotherapy in Patients With Newly Diagnosed Partial-onset Seizures
This is a Phase III, multinational, open-label, non-controlled study with subjects under treatment in the double-blind BIA-2093-311 study (NCT01162460).
- Trial name
- NCT02484001
- Testing
- ESL 800 mg, ESL 1200 mg, ESL 1600 mg
- Volunteers
- 206 people
- Sponsor
- Bial - Portela C S.A.
Seizure, Epilepsy
Efficacy of Low Glycemic Index Diet Versus Classic Ketogenic Diet in Pediatric Epilepsy Treatment
Epilepsy is a common disease among children. Today, treating epilepsy remains a major challenge, with many children affected by this condition. According to reports, 30% of children with epilepsy do not respond well to treatment.
- Conditions
- Seizure, Epilepsy, Drug Resistant Epilepsy
- Trial name
- NCT06703983
- Testing
- Low Glycemic index therapy, Classic Ketogenic Diet
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Mashhad University of Medical Sciences
Epilepsy
Trial to Demonstrate the Efficacy and Safety of Conversion to Lacosamide Monotherapy for Partial-onset Seizures
The objective of this historical-controlled trial is to demonstrate the efficacy and safety of conversion to Lacosamide monotherapy in subjects with Partial-onset Seizures who are withdrawn from 1 to 2 marketed antiepileptic…
- Trial name
- ALEX-MT (NCT00520741)
- Testing
- Lacosamide
- Where
- 158 sites in United States, Australia and 11 more
- Volunteers
- 426 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Dravet Syndrome
A Clinical Study to Evaluate the Safety and Efficacy of ETX101, an AAV9-Delivered Gene Therapy in Children With SCN1A-positive Dravet Syndrome (Australia Only)
WAYFINDER is a Phase 1/2 study in Australia to evaluate the safety and efficacy of ETX101 in participants with SCN1A-positive Dravet syndrome aged 6 to <84 months. The study follows an open-label, dose-escalation design.
- Trial name
- NCT06112275
- Testing
- ETX101
- Where
- Australia
- Volunteers
- 4 people
- Sponsor
- Encoded Therapeutics