Clinical trials: Seizures, Motor
Electroconvulsive Therapy
Comparision of Motor Seizure Duration of Ketofol and Propofol for Electroconvulsive Therapy
Propofol is routinely used in our hospital for ECT. It causes hypotension and has anticonvulsant actions. Use of ketofol ( 1:1 combination of ketamine and propofol) during ECT can have longer seizure duration and better…
- Trial name
- NCT05408000
- Testing
- ketofol vs propofol
- Where
- Nepal
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Motor Seizures
Study of Algorithm for Epilepsy Alert Device
An accelerometer with transmitting ability is worn on the wrist. Data of movements during seizures will be analyzed to upgrade algorithm that will identify seizures.
- Trial name
- NCT00497835
- Volunteers
- 15 people
- Sponsor
- Biolert
Mitochondrial Diseases, Drug Resistant Epilepsy
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy
This is a parallel-arm, double-blind, placebo-controlled study with a screening phase that includes a 28-day run-in phase to establish baseline seizure frequency, followed by a 24-week, randomized, placebo-controlled phase.
- Conditions
- Mitochondrial Diseases, Drug Resistant Epilepsy, Leigh Disease, Leigh Syndrome
- Trial name
- MIT-E (NCT04378075)
- Testing
- Vatiquinone
- Where
- 27 sites in United States, Canada and 7 more
- Volunteers
- 68 people
- Sponsor
- PTC Therapeutics
Epilepsy, Autism Spectrum Disorder
Biomarkers for Epilepsy Development and the Effect of Physical Exercise in Children With Autism
This study aims to identify novel biomarkers for epilepsy development in children with autism and to evaluate the effects of physical exercise on these biomarkers and clinical outcomes.
- Trial name
- ASD/EP (NCT07373431)
- Testing
- Physical activity program
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Skane
Epilepsy, Epilepsia
Physical Exercise in Subjects With Juvenile Myoclonic Epilepsy
Epilepsy is a chronic neurologic disorder characterized by seizures. Beside seizures people suffering from epilepsy experience several challenges related to education, work and everyday life such as learning-, problem-solving…
- Conditions
- Epilepsy, Epilepsia, Epileptic Seizures, Seizure Disorder
- Trial name
- EFA (NCT01450423)
- Testing
- Physical activity
- Where
- 2 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Lars Bo Andersen
Epilepsy, Essential Tremor
Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation
This is a research study to determine how COBENFY KarXT (FDA approved), a drug which has been approved for treatment of certain disorders, affects brain activity and cognitive tasks which may be regulated by the cholinergic…
- Conditions
- Epilepsy, Essential Tremor, Seizures, Memory Consolidation
- Trial name
- NCT07721272
- Testing
- Cobenfy KarXT pill (50/20 mg)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Altered Mental Status
Putting Electroencephalography (EEG) in the Emergency Department
The proposed study aims to test the impact of microEEG on clinical management (diagnosis and treatment) of emergency department patients with Altered Mental Status (AMS).
- Trial name
- NCT01671475
- Testing
- microEEG (Bio-Signal microEEG)
- Where
- 2 sites in United States
- Volunteers
- 149 people
- Sponsor
- Bio-Signal Group Corp.
Epilepsy
Epilepsy Motion Sensing
Evaluate patient motion during seizures.
- Trial name
- NCT01850498
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- MedtronicNeuro
Drug-Resistant Epilepsy, ARX-Related Epilepsy
Occupational Therapy Approach in ARX-Related Epilepsy
This study evaluated the effects of medical ketogenic diet therapy combined with occupational therapy in children with ARX-related epilepsy. Twenty children were included.
- Trial name
- NCT07745608
- Testing
- Occupational Therapy, Medikal Ketogenic Diet Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Uskudar University
Seizures
Phase I Trail for Intramuscular Administration of Midazolam Using An Autoinjector
Purpose of the study is to determine midazolam's safety and dose-linearity when delivered intramuscularly via an autoinjector. The proposed initial treatment dosage for seizures induced by exposure to nerve agents.
- Trial name
- AAS (NCT00534378)
- Testing
- Midazolam
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- U.S. Army Office of the Surgeon General
Non-convulsive Seizures
Seizures After Cardiac Surgery -- A Study With Continuous EEG Monitoring
The aim of this study is to determine the frequency of nonconvulsive seizures after cardiac surgery using an electroencephalogram or EEG, which records brainwaves through the scalp.
- Trial name
- NCT01291992
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Epilepsy, Epilepsy; Seizure
Yoga and Aerobic Exercise in Epilepsy
In recent years, there is growing interest in illustrating the health benefits of exercise among epilepsy. Although exercise is recommended for patients with epilepsy, there is uncertainty concerning the effects of yoga and…
- Conditions
- Epilepsy, Epilepsy; Seizure, Epilepsy Idiopathic
- Trial name
- NCT05066880
- Testing
- Exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dokuz Eylul University
Status Epilepticus, Epilepsy
Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus
The main purpose of this study is to know on one hand if lorazepam is more (effective) than clonazepam and on the other hand if lorazepam is also effective as the association clonazepam + fosphenytoin in out-of-hospital treatment…
- Trial name
- LORACLOFT (NCT01870024)
- Testing
- Clonazepam, Fosphenytoin, Lorazepam
- Where
- France
- Volunteers
- 434 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy
Impact of SPEAC® System Data on Therapeutic Decisions Related to Convulsive Seizure Patients With a Recent Non-diagnostic EMU Visit
This is an open label, randomized, prospective study of the impact on healthcare utilization of a surface Electromyography (sEMG) based seizure monitoring and alerting system for Veterans with seizures with upper extremity motor…
- Trial name
- NCT03741205
- Testing
- SPEAC System
- Volunteers
- 40 people
- Sponsor
- Brain Sentinel
Altered Mental Status, Generalized Nonconvulsive Seizure Disorder
Putting Electroencephalography (EEG) in the Emergency Department
The aim of the proposed research is to compare the diagnostic accuracy of a portable wireless electroencephalography (EEG) device (Biosignal Micro-EEG) to standard EEG in identifying abnormal EEG patterns (mainly non-convulsive…
- Conditions
- Altered Mental Status, Generalized Nonconvulsive Seizure Disorder, Status-epilepticus
- Trial name
- NCT01355211
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Bio-Signal Group Corp.
Epilepsy
Impact of SPEAC® System Data on Therapeutic Decisions Related to Convulsive Seizure Patients With a New Diagnosis
This is an open label, randomized, prospective study of the impact on healthcare utilization of a surface Electromyography (sEMG) based seizure monitoring and alerting system for Veterans with a history of motor seizures…
- Trial name
- NCT03742661
- Testing
- SPEAC System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brain Sentinel
Non-convulsive Seizures
Detecting Non-convulsive Seizures in the Paediatric Intensive Care Unit
The objective of this study is to determine if paediatric intensive care nurses and physicians can identify non-convulsive seizures in critically ill children using quantitative electroencephalography (EEG), in real time at the…
- Trial name
- NCT03856775
- Testing
- Quantitative EEG and Seizure detector
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McMaster University
Epilepsies, Partial
Post-Authorization Safety Study to Assess the Safety of Vimpat as add-on Therapy in Patients With Partial-onset Seizures
SP942 is a non-interventional post-authorization safety study (PASS) to evaluate the long-term safety and tolerability of Vimpat® (Lacosamide, LCM) as add-on treatment in patients with Epilepsy 16 years and older with…
- Trial name
- PASS (NCT00771927)
- Testing
- Lacosamide
- Where
- 62 sites in France, Germany and 3 more
- Volunteers
- 1,005 people
- Sponsor
- UCB Pharma
Seizures, Tonic-Clonic
Detection of Motor Seizures Using WBAN
This study aims to collect the motor movement data using sensors to detect Generalized Tonic Clonic Seizures . Wearable sensors similar to smart watches will be used to detect seizures.
- Trial name
- DMS-WBAN (NCT03283748)
- Testing
- Wearable sensors
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Mohawk College