Clinical trials: Seizures Disorders
Epilepsies, Partial
Open-label Extension to Protocol 1042-0600
To allow open-label extension to patients who have completed Protocol 1042-0600.
- Trial name
- NCT00512317
- Testing
- ganaxolone
- Where
- 25 sites in United States
- Volunteers
- 123 people
- Sponsor
- Marinus Pharmaceuticals
Partial Seizures
Evaluating the Efficacy and Safety of Zonisamide in the Treatment of Partial Seizures
The objectives of this trial are to evaluate the safety and efficacy of Zonisamide as adjunctive therapy in medically refractory patients receiving other antiepileptic drugs (AEDs).
- Trial name
- NCT00327717
- Testing
- Zonisamide
- Where
- 8 sites in China
- Volunteers
- 240 people
- Sponsor
- Eisai Inc.
Epilepsies, Partial
Vimpat® Added as Adjunctive Therapy to One Baseline Antiepileptic Drug
The purpose of this study is to systematically and prospectively collect data from patients with partial-onset seizures in routine clinical practice setting receiving adjunctive Vimpat®.
- Trial name
- VITOBA (NCT01098162)
- Where
- 113 sites in Germany
- Volunteers
- 576 people
- Sponsor
- UCB Pharma GmbH
Focal Epilepsy, Generalized Epilepsy
Post-market Study of AMPA Receptor Antagonists for Epilepsy Patients in Hong Kong
Background: Epilepsy is a chronic neurological disease which affects approximately 70,000 patients in Hong Kong and 50 billion people worldwide. Among these patients one-third remained unresponsive to antiepileptic agents.
- Conditions
- Focal Epilepsy, Generalized Epilepsy, Partial Seizures, Simple
- Trial name
- NCT03457961
- Testing
- Perampanel
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Hearing Loss, Sensorineural
Self Fitting Hearing Aid Clinical Investigation
Pre-market Clinical Investigation whose primary purpose is to evaluate efficacy and effectiveness of self-fitting hearing aids
- Trial name
- NCT05612763
- Testing
- Self fitting hearing device
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Starkey Laboratories, Inc
Depression
Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression
This is a randomized controlled study assessing the effect of pre-emptive hyperventilation on ECT seizure duration, cerebral desaturation and remission of depressive symptoms in patients with Major Depressive Disorder.
- Trial name
- NCT02924090
- Testing
- Etomidate, Ketamine, Hyperventilation
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
Epilepsy
Progesterone vs Placebo Therapy for Women With Epilepsy
The purpose of this investigation was to determine if cyclic adjunctive progesterone supplement is superior to placebo in the treatment of intractable seizures in women with and without catamenial epilepsy.
- Trial name
- NCT00029536
- Testing
- Progesterone Lozenges
- Where
- 15 sites in United States, Canada
- Volunteers
- 294 people
- Sponsor
- Beth Israel Deaconess Medical Center
Seizures
Retigabine Efficacy and Safety Trial for Partial Onset Refractory Seizures in Epilepsy
This Phase 3 study is being conducted to evaluate the efficacy and safety of retigabine dosed at 900 mg/day and 600 mg/day, in three equally divided doses, compared with placebo in patients with epilepsy who are receiving up to…
- Trial name
- RESTORE2 (NCT00235755)
- Testing
- Retigabine
- Where
- 70 sites in United States, Australia and 11 more
- Volunteers
- 539 people
- Sponsor
- GlaxoSmithKline
Vascular Diseases
Early Postoperative Fitting of the Air- Limb Prosthesis for Transtibial Amputees
The aim of the study is to check whether an early adjustment of the Air-Limb prosthesis to Transtibial amputees due to vascular diseases, will shorten the healing time of the stump and the process of rehabilitation.
- Trial name
- NCT00616668
- Testing
- Air- Limb
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Epilepsy
Trial Evaluating the Efficacy and Safety of Perampanel Added to Monotherapy in Participants With Partial Onset Seizures With or Without Secondary Generalization
This is a multi-center, open-label, single-arm, phase 4 study to evaluate the efficacy of perampanel added to monotherapy for partial onset seizures with or without secondarily generalized seizures (total seizures).
- Trial name
- NCT02726074
- Testing
- Perampanel
- Where
- 6 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- Eisai Korea Inc.
Epilepsia Partialis Continua, Kojewnikov's Epilepsy
Clobazam Use in Epilepsia Partialis Continua - Pilot Study
The purpose of this study is to evaluate whether clobazam, brand name Onf®, is more effective as an adjunctive or monotherapy in terminating Epilepsia Partialis Continua (EPC) than either lorazepam and/or clonazepam.
- Conditions
- Epilepsia Partialis Continua, Kojewnikov's Epilepsy, Epilepsy
- Trial name
- NCT02134366
- Testing
- Clobazam, Clonazepam, Lorazepam
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- The Cooper Health System
Epilepsy, Seizures
Correlation of Serum Level of Perampanel (PER) Level to Cerebrospinal Fluid (CSF) Levels of PER
Perampanel is a drug used to treat patients with epilepsy/seizures. This study is designed to determine how much perampanel actually crosses the blood brain barrier into the cerebral spinal fluid when the drug is taken.
- Trial name
- NCT04118829
- Testing
- Perampanel
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Carilion Clinic
Type 1 Diabetes Mellitus
BMI and Its Relationship to Hypoglycemic Seizures in Children With Insulin-requiring Diabetes
The landmark study Diabetes Control and Complication Trial (DCCT) clearly showed that intensive insulin management delays the onset and progression of longterm complications in adolescents with type 1 diabetes mellitus (T1DM).
- Trial name
- NCT00717483
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- Baylor College of Medicine
Epilepsy
Open Label Trial to Study the Long-term Safety and Efficacy of Seletracetam for the Treatment of Epilepsy
This is a safety and efficacy study of add-on therapy with seletracetam in epilepsy patients who have participated in a previous seletracetam study
- Trial name
- NCT00175851
- Testing
- Seletracetam (ucb 44212)
- Sponsor
- UCB Pharma
Seizures, Epilepsy
Development of an Epileptic Seizure Detection Algorithm by Continuous Analysis of the Electrocardiogram
The aim of our project is to develop an epileptic seizure detection algorithm based on the the continuous analysis of the Electrocardiogram
- Conditions
- Seizures, Epilepsy, Electrocardiography
- Trial name
- EPICARD (NCT03369522)
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Epilepsy; Seizure, Blood Pressure
Observational Study on Dynamic Changes of Blood Pressure During Post-epileptic Seizure Stage (OCBPS)
This article details a multicenter study on changes of blood pressure and heart rate during post-epileptic seizure stage.
- Trial name
- NCT06790810
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Xuanwu Hospital, Beijing
Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS)
A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex
The goal of this clinical trial is to learn the best way to switch children with Lennox-Gastaut Syndrome (LGS) or Dravet Syndrome (DS) taking 'artisanal' (non pharmaceutical-grade) cannabidiol (CBD) to Epidiolex for treatment of…
- Trial name
- CANN-SWITCH (NCT06924827)
- Testing
- Epidiolex 100 mg/mL Oral Solution
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Elizabeth Donner
Conversion Disorder
Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders
Functional Neurological Disorder (FND/ Conversion Disorder) is a highly prevalent and disabling neuropsychiatric condition. Motor FND symptoms include Nonepileptic Seizures, Functional Movement Disorders and Functional Weakness.
- Trial name
- NCT03398070
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Osteonecrosis, Osteoarthritis
A Short Metaphyseal Fitting Total Hip Arthroplasty in Young and Elderly Patients
The investigators determined whether 1. new short, metaphyseal-fitting cementless anatomical femoral stem provides major functional improvements 2. radiographically secure implant fixation is achieved with this new stem 3.
- Trial name
- NCT01345097
- Testing
- Total Hip Arthroplasty
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Ewha Womans University
Epilepsy
Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
Background: The blood-brain barrier separates the brain from the rest of the body. Epilepsy is a neurological disease that causes seizures. It can affect this barrier.
- Trial name
- NCT02531880
- Testing
- Mangafodipir, Gadolinium
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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