Clinical trials: Seizures Disorders
Epilepsy
Impact of SPEAC® System Data on Therapeutic Decisions Related to Convulsive Seizure Patients With a New Diagnosis
This is an open label, randomized, prospective study of the impact on healthcare utilization of a surface Electromyography (sEMG) based seizure monitoring and alerting system for Veterans with a history of motor seizures…
- Trial name
- NCT03742661
- Testing
- SPEAC System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brain Sentinel
Epilepsy, Seizures
Genetic Markers of Cardiovascular Disease in Epilepsy
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age.
- Conditions
- Epilepsy, Seizures, Syncope, Channelopathy
- Trial name
- NCT02824822
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mayo Clinic
Primary Generalized Epilepsy
Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in PGTC Seizures
This trial is intended to study the safety and effectiveness of an new anti-epileptic drug (AED) on Primary Generalized Tonic-Clonic (PGTC) Seizures.
- Trial name
- NCT03678753
- Testing
- Cenobamate
- Where
- 116 sites in United States, Australia and 10 more
- Volunteers
- 169 people
- Sponsor
- SK Life Science, Inc.
Ametropia, Myopia
Apioc Contact Lens Feasibility
This clinical trial will document the feasibility of the Apioc lens design by assessing which lens shape parameters yield successful on-eye-fit and movement of the Apioc contact lens design and evaluate the subjectively-reported…
- Conditions
- Ametropia, Myopia, Hyperopia, Astigmatism
- Trial name
- NCT03688672
- Testing
- Apioc Contact Lens Design
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lentechs, LLC
Succinic Semialdehyde Dehydrogenase Deficiency, SSADH Deficiency
PET Imaging of GABA Receptors in Succinic Semialdehyde Dehydrogenase Deficiency
This study will use brain imaging to map brain cell receptors for a chemical called GABA, a chemical that inhibits the activities of nerve cells.
- Trial name
- NCT00246870
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Epilepsy Intractable
Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet
The purpose of this pilot study is to measure adherence and quality of life in adults with intractable epilepsy following the Modified Atkins Diet (MAD) with Betaquik, a ready-to-use medium chain triglyceride (MCT) emulsion, as…
- Conditions
- Epilepsy, Epilepsy Intractable, Seizures, Seizure Disorder
- Trial name
- NCT03790436
- Testing
- Betaquik
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Epilepsy, Partial
To Evaluate the Effect of Perampanel on Objective and Subjective Sleep in Subjects With Insomnia and Partial Onset Seizures
This will be a multi-center, randomized, double-blind, placebo-controlled, crossover study to evaluate the effects of 2007/Fycompa (perampanel) on sleep, in subjects with well controlled partial onset seizures (on an…
- Trial name
- NCT02220972
- Testing
- Perampanel
- Sponsor
- Eisai Inc.
Hearing Loss, Hearing Abnormality
Optimisation of Hearing Aid Fitting
This study aims to explore if objective brain responses to speech stimuli (words and running speech) can be used to evaluate hearing aid fitting in adults.
- Trial name
- NCT03279367
- Testing
- Objective speech response detection
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Southampton
Epilepsy, Seizures
Study of Verapamil in Refractory Epilepsy
Epilepsy is one of the most common chronic neurological diseases, affecting 300,000 Canadians. One in 3 epilepsy patients have refractory seizures meaning that all antiseizure drugs fail to control their seizures.
- Trial name
- NCT01126307
- Testing
- Verapamil
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University Health Network, Toronto
Status Epilepticus, Seizure
EEG in In-hospital Patients With Seizure or Altered Mental State
In Kuopio University Department of Clinical Neurophysiology there have been designed a fast EEG electrode, that is suitable for acute emergency use.
- Conditions
- Status Epilepticus, Seizure, Altered Mental Status
- Trial name
- NCT02383745
- Testing
- Acute EEG with fast EEG electrode
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Kuopio University Hospital
Status Epilepticus, Refractory Status Epilepticus
Refractory Status Epilepticus Treatment: Quality and Efficacy of Coma Induction
This study is to investigate the effects of different treatment characteristics regarding the use of intravenous anesthetic drugs (IVADs) as a rescue treatment for refractory Status epilepticus (RSE) on course and outcome.
- Trial name
- RESET (NCT04333082)
- Testing
- Data collection
- Where
- Switzerland
- Volunteers
- 147 people
- Sponsor
- University Hospital, Basel, Switzerland
Seizures
Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children
Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management.
- Trial name
- NCT03419260
- Testing
- Clinically indicated EEG monitoring.
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Children's Hospital of Philadelphia
Epilepsy
Neuroliten MVP System Clinical Observation Study
This is an observational study for data collection from subjects diagnosed with Epilepsy/intractable seizures. The Neuroliten MVP System will not be used for patient management or treatment decisions.
- Trial name
- NCT05520476
- Testing
- Neuroliten MVP system
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Enliten AI
Epilepsy, Seizures
A Study on Safety and Efficacy of Two Doses of Topiramate as Monotherapy in the Treatment of Newly Diagnosed or Recurrent Epilepsy
The purpose of this study is to compare the safety and effectiveness of two doses of topiramate as monotherapy in the treatment of pediatric and adult patients with newly diagnosed or recurrent epilepsy.
- Conditions
- Epilepsy, Seizures, Epilepsies, Partial, Epilepsy, Generalized
- Trial name
- NCT00231556
- Testing
- topiramate
- Volunteers
- 750 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Epilepsy, Generalized, Helicobacter Pylori Infection
Helicobacter Pylori Eradication Therapy for Epileptic Children
Helicobacter pylori (H. pylori) infection is associated with several health problems. The role of H. pylori infection in epilepsy has been investigated in a few studies.
- Trial name
- NCT05297695
- Testing
- Triple therapy for H. pylori infection
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Sohag University
Seizures, Epilepsy
Thalamic Stimulation for Epilepsy Study
In this study, the investigator aims to perform cortical stereo electroencephalogram (sEEG) recordings during simultaneous anterior nucleus of the thalamus (ANT) recording and stimulation to better understand the following: 1)…
- Conditions
- Seizures, Epilepsy, Seizure Disorder
- Trial name
- NCT04102254
- Testing
- ANT recording and stimulation
- Where
- United States
- Sponsor
- Duke University
Seizures
Bioequivalency Study of Levetiracetam 1g Under Fasted Conditions
The objective of this study was to prove the bioequivalence of Levetiracetam 1000 mg Tablets under fasted conditions
- Trial name
- NCT00826722
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Citrate Transporter Deficiency, Epilepsy
SLC13A5 Deficiency Natural History Study - Remote Only
SLC13A5 deficiency (Citrate Transporter Disorder, EIEE 25) is a rare genetic disorder with neurodevelopmental delays and seizure onset in the first few days of life.
- Conditions
- Citrate Transporter Deficiency, Epilepsy, Rare Diseases, Movement Disorders
- Trial name
- NCT04681781
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- TESS Research Foundation
Partial Seizure Disorder
A Study of the Safety and Efficacy of Depakote Sprinkle Capsules in the Treatment of Partial Seizures in Children
The purpose of this study is to compare the safety and efficacy of two concentration ranges of valproate using Depakote Sprinkle Capsules as adjunctive therapy in the treatment of partial seizures, with or without secondary…
- Trial name
- NCT00067431
- Testing
- Divalproex Sodium (Depakote® Sprinkle Capsules)
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Abbott
Alzheimer Disease, Epilepsy
An Investigation of Levetiracetam in Alzheimer's Disease
The study proposed aims to evaluate the effect of Levetiracetam in patients with Alzheimer's disease (AD) in a Phase 2 Clinical Trial.
- Trial name
- ILiAD (NCT03489044)
- Testing
- Levetiracetam
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Oxford
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