Clinical trials: Seizures Disorders
Epilepsy, Epilepsies, Partial
An Open-Label Extension Study of the Effectiveness and Safety of the Investigational Compound RWJ-333369 in Patients With Epilepsy
The purpose of this study is to evaluate the effectiveness and safety of the novel compound RWJ-333369 in reducing the frequency of seizures in patients with epilepsy.
- Trial name
- NCT00210522
- Testing
- RWJ 333369
- Volunteers
- 421 people
- Sponsor
- SK Life Science, Inc.
Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE)
Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)
This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging…
- Conditions
- Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest, Hypoxic Ischemic Encephalopathy of Newborn
- Trial name
- GEN-HOPE (NCT07264166)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Healing Hope International
Epilepsy, Drug Resistant
Clinical Trial : TROCC (Quick Oral Treatment of Cluster Epileptic Seizures)
This is a double blind, placebo controlled, add-on clinical trial, of levetiracetam efficacy and safety, in epilepsy cluster seizure. Efficacy is evaluated in the range of 2 to 24 hours after taking the tablet.
- Trial name
- NCT00376766
- Testing
- levetiracetam
- Where
- 10 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Grenoble
Psychogenic Nonepileptic Seizures (PNES)
Cognitive Rehabilitation for Veterans With PNES
Psychogenic nonepileptic seizures (PNES) reflect a subtype of functional neurological disorder (FND) that is common and extremely disabling in Veterans.
- Trial name
- CRVWP (NCT07316543)
- Testing
- Cognitive Rehabilitation And Functional Treatment (CRAFT)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- VA Office of Research and Development
Epilepsy, Cognitive Dysfunction, Cognitive Disorder
HOBSCOTCH-YOUTH and Young Adults
The goal of this clinical trial is to learn more about the home-based epilepsy self-management program, HOBSCOTCH, for improving cognitive function (thinking and memory) and quality of life specifically in young adults, ages 18 …
- Conditions
- Epilepsy, Cognitive Dysfunction, Cognitive Disorder, Memory and Thinking Problems
- Trial name
- NCT07735715
- Testing
- HOBSCOTCH/HOBSCOTCH-YOUTH
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Refractive Errors
Apioc Toric/Spherical Single Vision Contact Lens
The Lentechs Apioc-S and Apioc-A contact lenses are made in an FDA-approved contact lens material indicated for single-vision and astigmatism.
- Trial name
- NCT03970512
- Testing
- Apioc-A and Apioc-S Contact Lenses
- Where
- 2 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Lentechs, LLC
First Suspected Epileptic Seizure
Improving Diagnostics and Care After First Seizure
A first epileptic seizure is a distressing experience, often leading to a complicated and discouraging journey before an epilepsy diagnosis is confirmed. Early diagnostics can help alleviate this uncertainty.
- Trial name
- EPI-NY (NCT06814665)
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Haukeland University Hospital
Epilepsy
Risk Factors and Etiologies of Epilepsy in Urban and Rural Rwanda
Epilepsy is one of the most common chronic brain disorders. Up to 85% of persons living with epilepsy (PwE) live in the developing world. In sub-Saharan Africa (SSA), Rwanda has one of the highest prevalence rates (±5%).
- Trial name
- REpiCa (NCT05698537)
- Testing
- EEG, Neuroimaging, Blood sample
- Where
- Rwanda
- Volunteers
- 1,745 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Nervous System Diseases
Open-label Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Children With Status Epilepticus (Convulsive) in a Healthcare Setting in Japan
The purpose of this study is to assess the efficacy, safety and pharmacokinetics of MHOS/SHP615 administered buccally in children with status epilepticus (convulsive) in a healthcare setting.
- Trial name
- NCT03336645
- Testing
- SHP615
- Where
- 23 sites in Japan
- Volunteers
- 25 people
- Sponsor
- Shire
Epilepsy
Prospective Study of Comparison Between the Modified Atkins Diet and Classic Ketogenic Diet for Intractable Childhood Epilepsy
The Ketogenic diet is a now proven, evidence based treatment of refractory epilepsy. the classic ketogenic diet (KD) is based on a ratio of fat to carbohydrate and protein, usually 3:1 or 4:1.
- Trial name
- NCT02100501
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Yonsei University
Epilepsy (Treatment Refractory)
Clinical Trial of the Effects of DHA in the Treatment of Seizure Disorders
For many years, there has been interest in the question of whether a special diet of some sort could be used to help control epileptic seizures.
- Trial name
- NCT01769092
- Testing
- Fish Oil, Safflower Oil
- Where
- 2 sites in Canada
- Volunteers
- 6 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Depression, Unipolar Depression
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for depression.
- Conditions
- Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CREST-MST (NCT03191058)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 239 people
- Sponsor
- University of Texas Southwestern Medical Center
ECT, Anesthesia
Sevoflurane in Electroconvulsive Therapy
The purpose of the study was to investigate the effects of different doses of sevoflurane used in electroconvulsive therapy (ECT) on duration of seizure, hemodynamic response and recovery profiles
- Trial name
- NCT01905904
- Testing
- sevorane
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Inonu University
Lennox-Gastaut Syndrome (LGS)
Study of Perampanel as Adjunctive Treatment for Inadequately Controlled Seizures Associated With Lennox-Gastaut Syndrome
This study is being conducted to demonstrate that perampanel given as adjunctive anti-epileptic treatment is superior to placebo in reducing the number of drop seizures in participants with inadequately controlled seizures…
- Trial name
- NCT02834793
- Testing
- Perampanel
- Where
- 65 sites in United States, Australia and 5 more
- Volunteers
- 101 people
- Sponsor
- Eisai Inc.
Depression
Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression
This is a randomized controlled study assessing the effect of pre-emptive hyperventilation on ECT seizure duration, cerebral desaturation and remission of depressive symptoms in patients with Major Depressive Disorder.
- Trial name
- NCT02924090
- Testing
- Etomidate, Ketamine, Hyperventilation
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
Epilepsy
A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures
This study is being done to help scientists learn about the use of a device called an atomic magnetometer. The device uses sensors called optically-pumped magnetometers (OPM) which function at room temperature.
- Trial name
- NCT04515316
- Testing
- OPM sensors, SQUID sensors
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Refractory Status Epilepticus
Application of tDCS Stimulation in Controlling Refractory Status Epilepticus
The purpose of the study is to assess the efficacy and safety of targeting tDCS stimulation for treatment of Refractory status epilepticus
- Trial name
- tDCS (NCT06344338)
- Testing
- tDCS stimulation
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy
Efficacy of YKP3089 in Patients With Photosensitive Epilepsy
The aim of this study is to evaluate the ability of a single oral dose of YKP3089 to abolish or clearly reduce the IPS-induced photo-paroxysmal EEG response in photosensitive epilepsy patients, and to measure the onset and…
- Trial name
- NCT00616148
- Testing
- YKP3089
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- SK Life Science, Inc.
Epilepsy, Brain Diseases
Human Epilepsy Project 2: Resistant Focal Seizures Study
The HEP2 study is designed to better understand the challenges of living with focal seizures that do not respond to medication, by following 205 people with medication-resistant focal epilepsy over two years to measure changes in…
- Conditions
- Epilepsy, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases
- Trial name
- HEP2 (NCT03531008)
- Where
- 10 sites in United States
- Volunteers
- 157 people
- Sponsor
- Epilepsy Foundation of America
Epilepsy, Temporal Lobe
Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation
The overall goal of this study is to open up the promising treatment of repetitive transcranial magnetic stimulation (rTMS), which has been shown to be effective against seizures in patients with surface neocortical foci, to a…
- Trial name
- NCT02339376
- Testing
- Low-frequency repetitive transcranial magnetic stimulation, High-frequency repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Beth Israel Deaconess Medical Center