Clinical trials: Seizures Disorders
Epilepsy
Pre-oxygenation and Measures of Gas Exchanges During Seizures in the Epilepsy Monitoring Unit
The primary goal of the study is to assess the effect of pre-oxygenation on oxygen and carbon dioxide levels during seizures in patients admitted at the Epilepsy Monitoring Unit (EMU).
- Trial name
- NCT02241798
- Testing
- oxygen
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- NYU Langone Health
Neonatal Seizure
AI-assisted cEEG Diagnosis of Neonatal Seizures in Neonatal Intensive Care Unit
A diagnostic accuracy study on Artificial intelligence assisted continue EEG diagnostic tool is to carried out comparing with manually EEG interpretation as the golden standard for neonatal seizure.
- Trial name
- NCT04991779
- Testing
- AI-assisted cEEG detection tool
- Where
- 3 sites in China
- Sponsor
- Children's Hospital of Fudan University
Seizures
An Open-label Extension Trial of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures
The purpose of this study is to assess the long-term safety and tolerability of CVL-865 as adjunctive therapy in participants with focal onset seizures.
- Trial name
- NCT04686786
- Testing
- CVL-865
- Where
- 56 sites in United States, Australia and 5 more
- Volunteers
- 105 people
- Sponsor
- AbbVie
Seizures
Intramuscular Midazolam Versus Intravenous Diazepam for Acute Seizure in Children
IM-midazolam in acute seizures, whenever IV cannulation is not possible. It is easy to administer and can be used in prehospital settings as IV cannulation requires experience, especially in pediatric age group.
- Trial name
- NCT06271096
- Testing
- Intra muscular Midazolam, Intravascular Diazepam
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Arooj Khan
Epilepsy Intractable
Ciprofloxacin in Drug-resistant Epilepsy
This study aims to investigate the effect of a short-term prescription of ciprofloxacin on intestinal microbial pattern and seizure frequency of patients with drug-resistant epilepsy.
- Trial name
- CIDRE (NCT04763070)
- Testing
- Ciprofloxacin Oral Product
- Where
- Iran
- Volunteers
- 23 people
- Sponsor
- Mazandaran University of Medical Sciences
Dravet Syndrome
Verapamil as Therapy for Children and Young Adults With Dravet Syndrome
This study will assess how well the drug verapamil can improve control of seizures and dysautonomia symptoms in children and young adults diagnosed with Dravet syndrome.
- Trial name
- NCT01607073
- Testing
- Verapamil
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Gillette Children's Specialty Healthcare
Epilepsy (Treatment Refractory), Epilepsy Comorbidities
Low-Intensity Focused Ultrasound Neuromodulation for Epilepsy
This study is an invite only study looking at the effects of Low-Intensity Focused Ultrasound (LIFU) on epilepsy patients with implanted electrodes under the care of Dr. Shah.
- Trial name
- NCT07353918
- Testing
- Low-intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Carilion Clinic
Epilepsy
A Long-term, Safety, Tolerability, and Efficacy Study of Retigabine Immediate-release (IR) in Asian Adults With Partial Onset Seizures
This is a multicentre, long-term, open-label extension (OLE) study to assess the long-term safety, tolerability and efficacy of retigabine immediate-release (IR) as adjunctive therapy in adult Asian subjects with drug-resistant…
- Trial name
- NCT01777139
- Testing
- Retigabine IR
- Where
- 12 sites in Malaysia, South Korea and 1 more
- Volunteers
- 30 people
- Sponsor
- GlaxoSmithKline
Epilepsy With Partial On-set Seizures
A Study of a Drug to be Used in Addition With Another Drug to Treat Adults With Uncontrolled Partial-onset Seizures
A study of a drug to be used in addition with another drug to treat adults with Uncontrolled Partial-onset Seizures
- Trial name
- NCT03116828
- Testing
- Eslicarbazepine acetate
- Where
- 55 sites in United States, Canada
- Volunteers
- 102 people
- Sponsor
- Sumitomo Pharma America, Inc.
Ischemic Stroke, Hemorrhagic Shock
Predictors Of Stroke Outcome In Chidren
Stroke can be defined as an abrupt loss of brain function that is caused by decreased cerebral blood flow. Stroke can occur at all stages of life, but presentation is variable depending on age, involved artery, and underlying…
- Trial name
- NCT04331457
- Testing
- Brain magnetic resonance imaging (MRI) , computed tomography (CT)
- Volunteers
- 30 people
- Sponsor
- Assiut University
Epileptic Seizure, Epilepsy Intractable
REC2Stim as a Treatment for Refractory Epilepsy in the Primary Sensorimotor Cortex.
People with central lobe epilepsy (CLE), with seizures arising from the primary sensorimotor cortex, typically show a high rate of convulsive seizures that do not respond to anti-epileptic drugs, but have a large impact on…
- Conditions
- Epileptic Seizure, Epilepsy Intractable, Motor Seizure
- Trial name
- REC2Stim (NCT04158531)
- Testing
- ECoG sensing and stimulation
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Partial Epilepsies
Trial to Assess Lacosamide as the First add-on Anti-epileptic Drug Treatment in Patients With Partial-onset Seizures
To evaluate the efficacy and safety of oral Lacosamide as first add on treatment in subjects with uncontrolled partial-onset seizures after prior treatment with a monotherapy Antiepileptic Drug (AED) regimen compared to subjects…
- Trial name
- NCT00955357
- Testing
- Lacosamide
- Where
- 109 sites in United States, Austria and 13 more
- Volunteers
- 461 people
- Sponsor
- UCB Pharma
Epilepsy; Seizure, Child Development
Genotype, Phenotype, and Disease Progression of Developmental Epileptic Encephalopathy With Onset Before 2 Years of Age
According to estimates by the World Health Organization in 2019, more than 50 million people around the world have epilepsy. Nearly 80% of patients with epilepsy live in developing countries.
- Conditions
- Epilepsy; Seizure, Child Development, Gene Abnormality, Early Onset Disorder
- Trial name
- NCT06278428
- Where
- 2 sites in Vietnam
- Volunteers
- 50 people
- Sponsor
- Number 2 Children's Hospital, Ho Chi Minh City
Myopia
Fitting Evaluation of Hydrogel and Silicone Hydrogel Sphere Design Contact Lenses
The aim of this non-dispensing fitting study is to evaluate the short term lens fit, vision performance of three monthly replacement sphere lenses.
- Trial name
- NCT03098745
- Testing
- Omafilcon A, Somofilcon A, Omafilcon A - Proclear (PC)
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Psychomotor Status, Muscle Strain, Lower Leg
The Effect of Dance Training on Psychomotor, Biomechanical and Biochemical Parameters in Adults
Clinical Trial, repeated-measures design, pilot study. 81 young adults, male (30) and female (51) underwent research protocol. The aim of the research will be to assess the impact of long-term dance training on psychomotor…
- Conditions
- Psychomotor Status, Muscle Strain, Lower Leg, Muscle Strain Back, Balanced
- Trial name
- Dance (NCT06600594)
- Testing
- Beginners dance training, Experience dance training
- Where
- Poland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Elderly, Epilepsy
Tolerability and Efficacy of Depakote-extended Release in the Elderly
There is a bimodal distribution to the new onset seizures with one peak occurring in the very young and the second peak occurring in persons over age 65 years.
- Conditions
- Elderly, Epilepsy, Seizures
- Trial name
- NCT00318929
- Testing
- Divalproex Sodium Extended-Release Tablets
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Virginia Commonwealth University
Diarrhea Infectious, Seizures
Pilot Trial of a Clinical Decision-Support App for Managing Emergencies Among Clinicians in a Rural Ugandan Hospital
This study is testing a new mobile application called the OASES App, developed by the University of Milano-Bicocca. The App is designed to help frontline clinicians (nurses, clinical officers, and nursing assistants) provide…
- Conditions
- Diarrhea Infectious, Seizures, Emergency Care, Clinical Decision Support Systems
- Trial name
- OASES (NCT07257705)
- Testing
- OASES App
- Where
- Uganda
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Drug Resistant Epilepsy, Drop Seizures
Novel Helmet Design in Patients With Seizures
This is a two-part study that aims to determine the reliability and safety of the use of the Hövding inflatable helmet in seizures, as evidenced by the deployment of the helmet during seizures, and qualitative patient reporting.
- Conditions
- Drug Resistant Epilepsy, Drop Seizures, Generalized Tonic Clonic Seizure, Complex Partial Seizure
- Trial name
- NCT03443388
- Testing
- Hövding inflatable helmet
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Michael A. Gelfand, MD, PhD
Epilepsy, Tonic-Clonic
EpiWatch: Evaluation of a Non-EEG Physiological Signal Based Seizure Monitoring System
To demonstrate the safety and effectiveness of the EpiWatch device in identifying tonic-clonic (TC) seizures, notifying a third-party of TC seizure occurrence, and collecting non-EEG physiological data for subsequent review…
- Trial name
- NCT05059002
- Testing
- Physiological signal monitoring and seizure detection
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- EpiWatch, Inc.
Pre-eclampsia
New Magnesium Sulphate Protocol for Pre-eclampsia
there is a standard magnesium sulphate protocol and newer protocols for pre-eclampsia, we need to make a trial to find the best protocol
- Trial name
- NCT01846156
- Testing
- MgSO4
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Cairo University
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