Clinical trials: Seizures Disorders
Seizures, Epilepsy
Efficacy of BGG492 in Individuals With Refractory Partial Seizures Undergoing Inpatient Evaluation for Epilepsy Surgery
This study will asses the safety and efficacy of BGG492 in reducing the seizure rate in therapy-refractory partial seizures.
- Trial name
- NCT00887861
- Testing
- Investigational new drug, company code: BGG492
- Where
- 6 sites in Germany
- Volunteers
- 37 people
- Sponsor
- Novartis
Proton Pump Inhibitor Adverse Reaction, Hypomagnesemia
Hypomagnesemia Associated With Proton-Pump Inhibitor Use
Use of proton pump inhibitors has been associated with hypomagnesemia. However, various case-control or prospective studies have found conflicting results with regards to proton pump inhibitors use and development of…
- Conditions
- Proton Pump Inhibitor Adverse Reaction, Hypomagnesemia, Arrhythmias, Cardiac, Seizures
- Trial name
- PPI_HypoMg (NCT04426994)
- Testing
- proton pump inhibitor use
- Where
- Singapore
- Volunteers
- 211,672 people
- Sponsor
- Changi General Hospital
Epilepsy
Management Strategies For Electrical Status Epilepticus During Sleep
Electrical status epilepticus during slow wave sleep is a condition in which the epileptic patient starts to develop neurocognitive deterioration, any type of seizures and continuous electrical activity in the EEG during non…
- Trial name
- NCT03251820
- Testing
- corticosteroid
- Volunteers
- 50 people
- Sponsor
- Randa Abdelbadie Abdelaleem
Myopia
Lens Fitting Evaluation of CooperVision MyDay™ Compared With 1-DAY ACUVUE® TruEye® and DAILIES TOTAL1®
Lens Fitting Evaluation of CooperVision MyDay™ Compared with 1-DAY ACUVUE® TruEye® and DAILIES TOTAL1®
- Trial name
- NCT02341859
- Testing
- stenfilcon A, delefilcon A, narafilcon A
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- CooperVision, Inc.
Epilepsy, Complex Partial
A Treatment Use Protocol for Subjects Continuing on From the Open-label Extension 0601
This study is designed to provide ganaxolone to those patients deriving significant benefit from current treatment in protocol 1042-0601.
- Trial name
- 0602 (NCT01002820)
- Testing
- ganaxolone
- Where
- 7 sites in United States
- Volunteers
- 11 people
- Sponsor
- Marinus Pharmaceuticals
Generalized Epilepsy
Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy
Epilepsy is one of the most common and frequently encountered neurological conditions that impose a huge burden on the healthcare systems.
- Trial name
- NCT03590197
- Testing
- Melatonin 3 mg
- Where
- India
- Volunteers
- 104 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Coma, Electrographic Status Epilepticus
Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
The goal of this comparative effectiveness trial is to study electrographic status epilepticus (ESE) treatment in comatose patients after cardiac arrest.
- Trial name
- TELSTAR-2 (NCT06549426)
- Testing
- anti-seizure medication + sedative agent(s)
- Where
- 21 sites in Belgium, Netherlands
- Volunteers
- 150 people
- Sponsor
- University of Twente
Seizures, Epilepsy
Bioequivalency Study of 600 mg Oxcarbazepine Tablets Under Fasting Conditions
The objective of this study was to assess the bioequivalence of a potential generic 600 mg oxcarbazepine tablet formulation compared with Novartis Pharmaceutical's 600 mg oxcarbazepine tablet, Trileptal, following a single 600 mg…
- Trial name
- NCT00616681
- Testing
- Oxcarbazepine
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Seizures
Bioequivalency Study of Levetiracetam 750 mg Tablets Under Fed Conditions
The objective of this study was to prove the bioequivalence of Levetiracetam 750 mg Tablets under fed conditions
- Trial name
- NCT00826787
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Epilepsy
Long Term Follow-up Study With Keppra XR (Levetiracetam XR) for Partial Seizures
To provide continued treatment of Keppra XR (Levetiracetam XR) and to assess the long term safety of Keppra XR in subjects with partial onset seizures.
- Trial name
- NCT00419393
- Testing
- Keppra XR (Levetiracetam XR)
- Where
- 35 sites in United States, Mexico and 2 more
- Volunteers
- 190 people
- Sponsor
- UCB Pharma
Partial Seizures
A Study of Perampanel as Add-on Therapy in Adult and Adolescent Participants With Focal Seizures
The primary objective of the present study will be to assess the effectiveness of add-on perampanel in participants with focal seizures in a real-life clinical setting.
- Trial name
- NCT04257604
- Testing
- Perampanel
- Volunteers
- 243 people
- Sponsor
- Eisai Limited
Baker Gordon Syndrome, Rare Neurodevelopmental Conditions
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)
Rare genetic neurodevelopmental disorders, such as Syt-1 or Baker Gordon Syndrome (BAGOS) arise from mutations in genes essential for brain development and function, often disrupting neurotransmission and neuronal connectivity.
- Conditions
- Baker Gordon Syndrome, Rare Neurodevelopmental Conditions, Rare Neurogenetic Conditions, Syt-1 Disorder
- Trial name
- NCT07329257
- Testing
- No Intervention: Observational Cohort
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Childhood Absence Epilepsy, Absence Seizures
Assessing Comorbidities in Epilepsy Using Eye Movement Recordings
This study wants to make it easier to find kids with a type of epilepsy called childhood absence epilepsy (CAE) who might have problems with ongoing seizures and thinking.
- Conditions
- Childhood Absence Epilepsy, Absence Seizures, Epilepsy Comorbidities
- Trial name
- ACER (NCT06310772)
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eysz, Inc.
Seizures
A Study of the Pharmacokinetics, Safety and Tolerability of Topiramate in Infants (Age 1-24 Months) With Refractory Partial-onset Seizures
The purpose of this study is to evaluate the pharmacokinetics safety and tolerability of topiramate in infants aged 1-24 months with refractory partial-onset seizures.
- Trial name
- NCT00233012
- Testing
- Topiramate
- Volunteers
- 16 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
GRIN-related Disorders
Honeycomb: Evaluation of Radiprodil in Children with GRIN-related Disorder
Study RAD-GRIN-101 is a phase 1B trial to assess safety, tolerability, PK, and potential efficacy of radiprodil for the treatment of GRIN-related disorder in children with a Gain-of-Function (GoF) genetic variant.
- Trial name
- NCT05818943
- Testing
- Radiprodil
- Where
- 15 sites in United States, Australia and 6 more
- Volunteers
- 24 people
- Sponsor
- GRIN Therapeutics, Inc.
Autoimmune Encephalitis, Epilepsy
Acute Sympotomatic Seizure Secondary to Autoimmune Encephalitis and Autoimmune-associated Epilepsy
Previously, scholars called the seizures secondary to autoimmune encephalitis（AE） "autoimmune related epilepsy", but the seizures secondary to AE are usually controlled after the improvement of encephalitis, which does not meet…
- Conditions
- Autoimmune Encephalitis, Epilepsy, Seizures
- Trial name
- NCT05422664
- Testing
- Lacosamide
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Liu Yonghong
Pre-eclampsia
Randomized Study of Nimodipine Versus Magnesium Sulfate in the Prevention of Eclamptic Seizures in Patients With Severe Preeclampsia
OBJECTIVES: I. Determine the effectiveness of nimodipine versus magnesium sulfate in the prevention of eclamptic seizures in patients with severe preeclampsia.
- Trial name
- NCT00004399
- Testing
- magnesium sulfate, nimodipine
- Volunteers
- 2,000 people
- Sponsor
- FDA Office of Orphan Products Development
Status Epilepticus
LORA-PITA IV General Investigation
Secondary Data Collection:To confirm the effectiveness and safety profiles under the actual medical practice of LORA-PITA in Japan.
- Trial name
- NCT03905798
- Testing
- Lorazepam
- Where
- Japan
- Volunteers
- 206 people
- Sponsor
- Pfizer
Seizures, Seizure Disorder
Modulating Movement Intention Via Cortical Stimulation
The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies.
- Conditions
- Seizures, Seizure Disorder, Psychogenic Movement Disorder
- Trial name
- NCT03233399
- Testing
- rTMS of left or right angular gyrus (AG) or frontal cortex (FC), Anodal tDCS of left or right AG or FC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Seizures, Epilepsy
Investigating Epilepsy: Screening and Evaluation
Background: Epilepsy affects about 1 percent of the U.S. population. Most people with epilepsy respond well to medicine, but some do not.
- Conditions
- Seizures, Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT03478852
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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