Clinical trials: Seizures Disorders
Epilepsies, Partial
Safety, Tolerability, and Pharmacokinetic Study of Pregabalin in Pediatric Patients With Partial Onset Seizures
The purpose of the study is to evaluate the safety, tolerability, and pharmacokinetics of multiple doses of pregabalin in pediatric patients with partial onset seizures that are incompletely controlled on their current…
- Trial name
- NCT00437281
- Testing
- Pregabalin
- Where
- 18 sites in United States, Mexico and 1 more
- Volunteers
- 65 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Epilepsy, Status Epilepticus
De-identified UNMH EEG Corpus Database Creation With Fully De-identified Clinical Information
This proposal outlines the steps required for the creation of a pilot database of EEG recordings and de-identified medical records from patients internally referred within the UNMH Comprehensive Epilepsy Center.
- Conditions
- Epilepsy, Status Epilepticus, Seizures
- Trial name
- NCT05140265
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- University of New Mexico
Cardiac Arrest
Seizure Detection Using SEDline During Therapeutic Hypothermia in Cardiac Arrest Victims
Current guidelines recommend the use of sedatives and neuromuscular blocking agents to avoid shivering during therapeutic hypothermia in cardiac arrest victims.
- Trial name
- NCT01946802
- Testing
- Frontal 4 channel EEG
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Gil Joon Suh
Keratoconus, Astigmatism High
Enhancing Scleral Lens Fit With Advanced Imaging
The goal of this experimental clinical trial is to enhance the predictability and precision of scleral lens fitting in patients with complex corneal conditions such as keratoconus, post-surgical irregularities, and severe dry eye…
- Trial name
- SPLEPICA (NCT06751615)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fernando Fernandez Velazquez
Psychogenic Nonepileptic Seizures (PNESs)
Quality of Life and Psychogenic Nonepileptic Seizures.
The goal of this study is to identify the prognostic factors of quality of life in patients with psychogenic non-epileptic seizures
- Trial name
- PronoCNEP (NCT02821208)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux
Generalized Convulsive Status Epilepticus
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus
Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population.
- Trial name
- NCT03025906
- Testing
- Phenobarbital, Valproate
- Where
- 6 sites in China
- Volunteers
- 120 people
- Sponsor
- Xuanwu Hospital, Beijing
Post Stroke Epilepsy, Stroke
Predisposing Factors for Post-stroke Epilepsy
The goal of this observational study is to learn about epilepsy after a stroke (post-stroke epilepsy). The main questions it aims to answer are: What make some patients develop epilepsy after a stroke? Does sleep have an impact…
- Conditions
- Post Stroke Epilepsy, Stroke, Epilepsy, Seizures
- Trial name
- PRESTEP (NCT05864547)
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Generalized Epilepsy, Infantile Spasms
Metabolic Abnormalities in Children With Epilepsy
This study is designed to use positron emission tomography to measure brain energy use. Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain.
- Conditions
- Generalized Epilepsy, Infantile Spasms, Metabolic Disease, Partial Epilepsy
- Trial name
- NCT00001325
- Testing
- 18 FDG
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Ischemic, Stroke Hemorrhagic
Transnasal Induction of Normothermia for Neurogenic Fever
The objective of this study is to evaluate the efficacy of the COOLSTAT® Transnasal Thermal Regulating Device in reducing temperature in a population of febrile subjects who meet the inclusion/exclusion criteria.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Seizures, Metabolic Encephalopathy
- Trial name
- NCT06038513
- Testing
- Transnasal Thermal Regulating Device
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- CoolTech LLC
Epilepsy
A Study to Assess utiLity of BIoEP as an Early Prognostic Indicator for Predicting Anti-Seizure Medication (ASM) Efficacy
This multisite prospective clinical study is to investigate the relationship between seizure type and frequency with the BioEP result during ASM titration in newly diagnosed patients with epilepsy, and to assess the utility of…
- Trial name
- ECLIPSE (NCT06354868)
- Volunteers
- 158 people
- Sponsor
- Neuronostics Ltd
Seizures, Lennox Gastaut Syndrome
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
The primary objective is to evaluate the efficacy of carisbamate (YKP509) as adjunctive treatment in reducing the number of drop seizures (tonic, atonic, and tonic-clonic) compared with placebo in pediatric and adult subjects…
- Trial name
- NCT05219617
- Testing
- Carisbamate
- Where
- 71 sites in United States, Argentina and 14 more
- Volunteers
- 252 people
- Sponsor
- SK Life Science, Inc.
Alzheimer's Disease
A Retrospective Database Study for the Development and Validation of Algorithms for Intracerebral Hemorrhage and Seizures in Alzheimer's Disease
The primary objective of this study is to develop and validate claims-based algorithms to identify intracerebral hemorrhage >1 cm in diameter, ensuring differentiation from amyloid-related imaging abnormality-microhemorrhage and…
- Trial name
- NCT07723950
- Testing
- No intervention
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Eisai Inc.
Epilepsy
Safety of Autologous MSC Infusion to Treat Epilepsy
The goal of this study was to evaluate the safety and efficacy of autologous MSC application for the therapy of drug-resistant symptomatic epilepsy.
- Trial name
- AMSCDRSE (NCT02497443)
- Testing
- Autologous mesenchymal stem cells
- Volunteers
- 60 people
- Sponsor
- Ministry of Public Health, Republic of Belarus
Trauma Injury, Brain Injuries
The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia
Oropharynx is the main source of pathogen microorganisms for the ventilator - associated pneumoniae. As known bacteriophages can eliminate different pathogen microorganisms or reduce a degree of a pathogen's colonization.
- Conditions
- Trauma Injury, Brain Injuries, Abdominal Sepsis, Pancreatitis
- Trial name
- SGDC-VAP (NCT04325685)
- Testing
- Control, Antiseptic Solution, Bacteriophage
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Northern State Medical University
Epilepsies, Partial
Effectiveness Study Comparing Treatment With Drug(s) or Adjunctive VNS Therapy for Pharmacoresistant Partial Seizures
To compare outcomes over 12 months of treatment with antiepileptic drugs (AEDs) alone or vagus nerve stimulation (VNS) therapy plus AEDs in patients who have partial seizures refractory to at least two, but not more than five…
- Trial name
- NCT00215215
- Testing
- Vagus Nerve Stimulation Therapy
- Where
- 23 sites in United States
- Volunteers
- 360 people
- Sponsor
- Cyberonics, Inc.
Epilepsy, Partial Onset Seizures
An Open Label Study of Levetiracetam Monotherapy in Patients With Newly Diagnosed Focal Epilepsy
The purpose of this study is to evaluate the efficacy of Levetiracetam (LEV) used as monotherapy, with efficacy measured as 6-month seizure freedom at the last evaluated dose in the LEV 1000 mg/day to 2000 mg/day group, in newly…
- Trial name
- NCT01506882
- Testing
- Levetiracetam (LEV)
- Where
- 27 sites in Japan
- Volunteers
- 71 people
- Sponsor
- UCB Japan Co. Ltd.
Vascular Diseases
Early Postoperative Fitting of the Air- Limb Prosthesis for Transtibial Amputees
The aim of the study is to check whether an early adjustment of the Air-Limb prosthesis to Transtibial amputees due to vascular diseases, will shorten the healing time of the stump and the process of rehabilitation.
- Trial name
- NCT00616668
- Testing
- Air- Limb
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Schizophrenia
Magnetic Seizure Therapy Versus Electroconvulsive Therapy for Schizophrenia
This trial attempts to evaluate the treatment efficacy of magnetic seizure therapy (MST) and its safety among schizophrenia patients.
- Trial name
- NCT03007628
- Testing
- Magpro X100, ThymatronSystem Ⅳ Electroconvulsive System, Treatment as usual (TAU)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Mental Health Center
Dependency on Medications Prescribed for Patient, Types of Seizures and Epileptic Syndromes
A Simulation-based Intervention for Caregivers of Children With Seizures
Caregivers of children with seizures receiving simulation based seizure management teaching in addition to the traditional seizure teaching will report more confidence with seizure management and demonstrate a higher level of…
- Trial name
- NCT01831063
- Testing
- Simulation
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Focal Epilepsy, Electrodes, Implanted
Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients
The main goal of this project is to study the mechanisms of epileptic activities using intracranial macro and micro electrodes in epileptic patients undergoing pre-surgical investigation.
- Conditions
- Focal Epilepsy, Electrodes, Implanted, Cognitive Function, Neurophysiology
- Trial name
- EpiMicro (NCT04653012)
- Testing
- Intracranial macro-microelectrode recording
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France