Clinical trials: Seizures Disorders
Epilepsy, HHV6B Infection
Relationship of HHV-6B Virus to Seizures and Brain Injury
This study will look for evidence that a virus called HHV-6B may be related to seizures and to a form of brain injury called mesial temporal sclerosis that is associated with seizures.
- Trial name
- NCT00597285
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Status Epilepticus, Seizure
Ketogenic Diet for Refractory Status Epilepticus
This research is being done to observe the safety, tolerability, side effects, and effectiveness of the ketogenic diet in people with continuous seizures (status epilepticus) being treated in a neurointensive care unit.
- Conditions
- Status Epilepticus, Seizure, Epilepsy, Refractory Status Epilepticus
- Trial name
- NCT01796574
- Testing
- Ketogenic diet
- Where
- 9 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Partial Onset Seizures, Epilepsy
A Study to Assess Safety and Efficacy of Perampanel in Indian Participants as an Adjunctive Treatment in Partial Onset Seizures With or Without Secondary Generalized Seizures in Participants With Epilepsy Aged 12 Years or Older
The purpose of this study is to assess the safety of perampanel in the treatment of partial onset seizures in participants of age 12 years and older with epilepsy.
- Trial name
- NCT03836924
- Testing
- Perampanel
- Where
- 12 sites in India
- Volunteers
- 200 people
- Sponsor
- Eisai Pharmaceuticals India Pvt. Ltd
Epilepsy
Feasibility Study on LITT for Medical Refractory Epilepsy
Multicenter, open-label, prospective designed study to characterize the performance of brain laser interstitial thermal therapy (LITT) ablation using the Monteris NeuroBlate System for the treatment of drug-refractory medial…
- Trial name
- NCT02820740
- Testing
- NeuroBlate System
- Where
- 5 sites in United States
- Volunteers
- 4 people
- Sponsor
- Monteris Medical
Seizures
Dose-Optimization, Adjunctive Treatment Study of Ezogabine/Retigabine Immediate Release in Partial-onset Seizures
This is a Phase IV adjunctive treatment dose-optimization study evaluating the efficacy, safety, and health outcomes of ezogabine/retigabine immediate release (IR) (GW582892) compared with placebo in adult subjects with…
- Trial name
- NCT01721317
- Testing
- Ezogabine/Retigabine IR
- Where
- 11 sites in United States, Greece
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Epilepsy, Aging Disorder
ZEBinix® Retention Rate in Epilepsy in Elderly Patients
The incidence of provoked and unprovoked seizures is known to increase with advancing age. Eslicarbazepine acetate (ESL) is one of the third generation of antiepileptic drugs (AEDs) that have been developed in the last ten years…
- Conditions
- Epilepsy, Aging Disorder, Aging, Epilepsy; Seizure
- Trial name
- ZEBRE (NCT04221282)
- Testing
- Zebinix
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Seizure, Epileptic
Antiepileptic Drugs in Elderly Patients
The purpose is to study the population pharmacokinetics, effectiveness and safety of antiepileptic drug (phenytoin, carbamazepine, lamotrigine, levetiracetam, parempanel, etc) in elderly patients and recommend optimized dosage…
- Trial name
- NCT05459597
- Testing
- antiepileptic drugs
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Wei Zhao
Epilepsy, Epilepsy in Children
Standardization of Anti-Seizure Medications Withdrawals After Seizure Remission in Young Patients With Epilepsy
The proper period of anti-seizure medication (ASM) treamtment is important for decreasing side effect of ASM and recurrence of seizure.
- Trial name
- ADORE (NCT05740423)
- Where
- South Korea
- Volunteers
- 1,200 people
- Sponsor
- Asan Medical Center
Epilepsy
A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures
The purpose of the study is to evaluate the long-term safety and tolerability of brivaracetam.
- Trial name
- NCT04715646
- Testing
- Brivaracetam
- Where
- 36 sites in United States, Belgium and 9 more
- Volunteers
- 70 people
- Sponsor
- UCB Biopharma SRL
Epilepsy
An Open Label Study to Evaluate the Effects of Ezogabine/Retigabine Added to Existing Anti-epileptic Drug(s) on Urinary Voiding Function in Subjects With Partial Onset Seizures
This is a multicentre, open label study to examine the effect of ezogabine/retigabine on the voiding function of adult subjects with drug-resistant partial onset seizures (POS).
- Trial name
- NCT01607346
- Testing
- ezogabine/retigabine
- Where
- 7 sites in United States, France and 1 more
- Volunteers
- 10 people
- Sponsor
- GlaxoSmithKline
Succinic Semialdehyde Dehydrogenase Deficiency, SSADH Deficiency
PET Imaging of GABA Receptors in Succinic Semialdehyde Dehydrogenase Deficiency
This study will use brain imaging to map brain cell receptors for a chemical called GABA, a chemical that inhibits the activities of nerve cells.
- Trial name
- NCT00246870
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Traumatic, Brain Injuries, Traumatic
HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) -Post-Traumatic Epilepsy (PTE)
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-PTE, to improve the quality of life and cognitive function in Service Members, Veterans and civilians with post traumatic epilepsy…
- Trial name
- HOBSCOTCHPTE (NCT05235061)
- Testing
- Home Based Self-management and Cognitive Training Changes lives in post traumatic epilepsy (HOBSCOTCH-PTE), HOBSCOTCH-PTE for Caregivers
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Partial Seizures
A Study to Assess the Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Extension Study)
The purpose of this study is to assess the long-term safety and efficacy of zonisamide used as an adjunctive treatment in pediatric subjects treated with 1 or 2 other anti-epileptic drugs (AEDs).
- Trial name
- NCT01136954
- Testing
- Zonisamide
- Where
- Italy
- Volunteers
- 144 people
- Sponsor
- Eisai Limited
Refractory Epilepsy
A Controlled Clinical Trial of Cathodal Transcranial Direct Current Stimulation in Patients With Refractory Epilepsy
There is a continuous necessity for the search of new alternatives for safe, affordable and effective noninvasive therapies for patients that are not eligible for focal resective or palliative surgery.
- Trial name
- NCT01763294
- Testing
- Nicolet Endeavor CR: 30min, Nicolet Endeavor CR: 60min, Nicolet Endeavor CR: 30min for 3 days
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Psychomotor Status, Schizophrenia
The Motor Neurological Soft Signs (MNSS) in Persons With Schizophrenia
The aim is to contribute to the knowledge of the relationship between Motor Neurological Soft Signs (MNSS) and schizophrenia, as well as to point out the implications and recommendations for clinical and rehabilitative practices…
- Conditions
- Psychomotor Status, Schizophrenia, Motor Skills Disorders
- Trial name
- MNSS (NCT04495998)
- Testing
- Brief Motor Scale_portuguese version (BMS_pt)
- Where
- Portugal
- Volunteers
- 103 people
- Sponsor
- Faculdade de Motricidade Humana
Epilepsy, Psychogenic Non-epileptic Seizures
Study on the Rapid Diagnostic Value of Sudden Clap Provocation Test in Psychogenic Nonepileptic Seizures
To explore the clinical value of the sudden clap provocation test in the differential diagnosis between epileptic seizures and psychogenic non-epileptic seizures, so as to provide a new strategy for rapid, low-cost differential…
- Trial name
- PNES ACPT (NCT07742709)
- Testing
- Abrupt Clap Provocation Test
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Seizures
Pharmacokinetics and Tolerability of Rufinamide in Healthy Chinese Subjects
The purpose of this study was to determine the pharmacokinetic (PK) and safety profile of single and multiple doses of rufinamide.
- Trial name
- NCT02332174
- Testing
- rufinamide
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sensorineural Hearing Loss, Bilateral
Comparison in New Cochlear Implanted Subjects of a Tonotopy-based Fitting With or Without Fine Structure Coding
Brief Summary: Main objective: Comparison of a tonotopy based fitting strategy (TFS) with fine structure coding to a tonotopy based fitting strategy without fine structure coding (TnoFS) for speech perception in noise.
- Trial name
- NCT05754918
- Testing
- TnoFs then TFS (Cochlear implant), TFS then TnoFS (Cochlear implant)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Epilepsy, Brain Diseases
Human Epilepsy Project 2: Resistant Focal Seizures Study
The HEP2 study is designed to better understand the challenges of living with focal seizures that do not respond to medication, by following 205 people with medication-resistant focal epilepsy over two years to measure changes in…
- Conditions
- Epilepsy, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases
- Trial name
- HEP2 (NCT03531008)
- Where
- 10 sites in United States
- Volunteers
- 157 people
- Sponsor
- Epilepsy Foundation of America
Seizure Disorder, Hypogonadism
Treatment of Sexual Dysfunction in Hypogonadal Men With Epilepsy With Testosterone and Either Anastrozole or Placebo
The purpose of this study is to determine if treatment using a medication (anastrozole/Arimidex), which lowers estrogen levels in the blood is better than placebo, a tablet that does not contain any active medication, when…
- Conditions
- Seizure Disorder, Hypogonadism, Erectile Dysfunction
- Trial name
- NCT00179517
- Testing
- Anastrozole 1mg
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
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