Clinical trials: Self Injury
Suicide Prevention
Feasibility Trial of a Single Session of Crisis Response Planning for Youth at High Risk for Suicide
The current study is a clinical trial, meaning a research study in which human subjects are prospectively assigned to one or more interventions to evaluate the effects of those interventions on health-related behavioral outcomes.
- Trial name
- NCT06164106
- Testing
- Virtual Crisis Response Planning, In-Person Crisis Response Planning, Crisis Risk Counseling
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Ohio State University
Autism Spectrum Disorder
A Feasibility Study of N-acetylcysteine for Self-injurious Behavior in Children With Autism Spectrum Disorder
The purpose of this study is to demonstrate the feasibility of a 9-week, randomized trial of N-acetylcysteine (NAC) compared to placebo in 14 children (age 5 to 12 years) with Autism Spectrum Disorder (ASD) and a moderate level…
- Trial name
- NAC (NCT03008889)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Emory University
Anxiety, Depression
Improving Obesity Self-Care Among Mentally Ill Veterans
The purpose of this study is to find out which of two programs, MH MOVE! or the enhanced usual care MOVE! program is most effective in improving participation in and completion of MOVE! among Veterans with depression, anxiety…
- Conditions
- Anxiety, Depression, PTSD, Obesity
- Trial name
- MH MOVE! (NCT02642536)
- Testing
- MH MOVE, Enhanced Usual Care
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Burns
Evaluation of Antimicrobial Soft Silicone, Silver Containing, Foam Dressing, Mepilex Border Ag, in Second Degree Burns
The investigation is designed as an open, non-controlled, post-marketing investigation. Subjects with at least one second degree burn less than 9.5x15 cm in size at 1-3 sites will be included.
- Trial name
- NCT01418482
- Testing
- Mepilex Border Ag
- Where
- 2 sites in Sweden
- Volunteers
- 15 people
- Sponsor
- Molnlycke Health Care AB
Self-Injurious Behavior, Deliberate Self-Harm
A Study Examining Adolescents With Non-Suicidal Self-Injury
This study will examine longitudinal brain development in young adolescent girls with a history of Non-Suicidal Self-Injury (NSSI).
- Trial name
- RDoC (NCT02947308)
- Where
- 3 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Substance Misuse, Suicide
A Digital Game Targeting Suicide Prevention in Adolescents Who Report Substance Misuse
The primary aim of this study is to design and develop a digital game that models the process of a safety planning intervention.
- Trial name
- NCT05517382
- Testing
- supportED, Control
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Yale University
Suicidal Ideation
Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality
This within-person, crossover, 2-condition, placebo-controlled study compares the impact of two perimenstrual conditions on severity of suicidal symptoms in females with past-month suicidality but minimal risk of imminent suicide…
- Trial name
- NCT03720847
- Testing
- Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone, Inactive Clear Patch
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Bipolar Disorder, Major Depressive Episode
Ketamine for Suicidality in Bipolar Depression
This study is designed to compare the effectiveness of two medications, Ketamine and Midazolam, for rapidly relieving suicidal thoughts in people suffering from bipolar depression.
- Conditions
- Bipolar Disorder, Major Depressive Episode, Suicidal Ideation
- Trial name
- NCT01944293
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- New York State Psychiatric Institute
Borderline Personality Disorder
Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder
This study will determine whether dialectical behavior therapy and fluoxetine are more effective combined or alone in treating people with borderline personality disorder.
- Trial name
- NCT00533117
- Testing
- Fluoxetine, Dialectical Behavior Therapy, Supportive psychotherapy
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- New York State Psychiatric Institute
Anxiety, Depression
Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study
Psychological treatments are effective, but take a long time and can be burdensome. Therefore, avenues to optimize behavioral treatments are needed.
- Conditions
- Anxiety, Depression, Personality Disorders, Trauma and Stress-related Disorders
- Trial name
- NCT02573246
- Testing
- Cognitive Restructuring, rTMS
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Duke University
Acute Respiratory Failure, Mechanical Ventilation Complication
Assessing Ventilator Safety in Patients on Pressure-Support Ventilation
ASOP is a prospective cohort study comparing three methods for assessing risk of self-induced lung injury in patients with acute respiratory failure being managed with pressure-support ventilation.
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- ASOP (NCT05125952)
- Testing
- Viasys Avea Ventilator, Philips Respironics NM3 device, Servo U ventilator
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Spinal Cord Injury
Self-Catheterization Mirror System for Female Patients
The purpose of this study is to test a modified mirror system for female patients to use during self-catheterization.
- Trial name
- NCT05406258
- Testing
- Modified Self-Catheterization Mirror, Standard Self-Catheterization Mirror
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Shirley Ryan AbilityLab
Depression
iTBS for Adolescent Depression: An Open Label Study Evaluating Safety and Efficacy of Treatment
This is an open label, pilot, feasibility study evaluating effects of Intermittent Theta Burst Transcranial Magnetic Stimulation (iTBS) on 5 eligible adolescents for the treatment of depression.
- Trial name
- NCT04485455
- Testing
- iTBS Device/Motor Threshold Coil, iTBS Device/Treatment Coil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Suicide, Suicide, Attempted
Drivers of Suicide Mobile App Study
The central purpose of this project is to evaluate and facilitate access to evidence-based best practices for individuals struggling with suicidal ideation and co-occurring behavioral problems, including alcohol misuse, and…
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation, Alcohol Use Disorder
- Trial name
- NCT05427734
- Testing
- WisePath for Adults, Active-Control app + electronic wellness resources brochure
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Evidence-Based Practice Institute, Seattle, WA
Borderline Personality Disorder
Ketamine in Borderline Personality Disorder
The purpose of this study is to test the potential of the rapid-acting anti-depressant ketamine to decrease suicidality in Borderline Personality Disorder (BPD).
- Trial name
- NCT03395314
- Testing
- Ketamine, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Yale University
Suicide
eLearning for Suicide Prevention
Project WISE (Workplace Integrated Support \& Education) includes developmental and pilot research to create an e-learning training in suicide safety planning enhanced with novel skill-building technologies that can be integrated…
- Trial name
- NCT05178121
- Testing
- eLearning Training in Suicide Safety Planning
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Washington
Rumination, Depression
Adolescent Mindfulness Mobile App Study (RCT)
Rumination involves focusing on negative emotions repeatedly and is a risk factor for developing depression, anxiety, and self-injury. These negative outcomes increase in adolescence.
- Conditions
- Rumination, Depression, Anxiety, Self-Injurious Behavior
- Trial name
- AMMASRCT (NCT03900416)
- Testing
- Mindfulness App
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Lawrence University
Trichotillomania, Obsessive Compulsive Disorder
Marinol in Trichotillomania or Obsessive Compulsive Disorder
The goal of the proposed study is to evaluate the efficacy and safety of dronabinol in individuals with obsessive-compulsive disorder (OCD) or the obsessive-compulsive spectrum disorders, trichotillomania (TTM) or pathological…
- Trial name
- NCT01093976
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Chicago
Insomnia, Suicidal Ideation
RCT of Brief CBT-I in Primary Care Veterans With Suicidal Thoughts
There is a strong association between insomnia and suicidal thoughts and behaviors. Insomnia also frequently co-occurs with other common conditions associated with suicide such as depression and posttraumatic stress disorder.
- Trial name
- NCT03603717
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene
- Where
- 3 sites in United States
- Volunteers
- 283 people
- Sponsor
- VA Office of Research and Development
Self-Harm, Depression
Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents
To measure NAC-induced changes to concentrations of glutathione (GSH) in the anterior cingulate cortex (ACC) as measured by magnetic resonance spectroscopy (MRS) in 36 adolescents and young adults with NSSI (12 in each group…
- Conditions
- Self-Harm, Depression, Suicide
- Trial name
- NCT04005053
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota