Clinical trials: Self-harm
Nonsuicidal Self Injury, Suicidal Ideation
Digital Mental Health Intervention for Nonsuicidal Self-Injury in Young Adults
This is a feasibility trial of a digital mental health intervention aimed at young adults (ages 18-25) with nonsuicidal self-injury and who are not currently engaged in mental health treatment.
- Conditions
- Nonsuicidal Self Injury, Suicidal Ideation, Depression, Anxiety
- Trial name
- NCT05325944
- Testing
- Self-guided digital intervention for NSSI, Digital intervention for NSSI with coaching, Active control
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Northwestern University
Suicide, Psychosis
Cognitive Behavioral Suicide Prevention for Psychosis: Aim 2
Investigators will evaluate the feasibility and preliminary effectiveness of modified Cognitive Behavioral Suicide Prevention for psychosis (CBSPp) in comparison to services-as-usual (SAU) in a randomized controlled trial.
- Trial name
- NCT05345184
- Testing
- Cognitive Behavioral Suicide Prevention for psychosis (CBSPp), Services as Usual (SAU)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Michigan
Mental Health
An Evaluation of Innerview™, a Web-based Tool to Support the Integration of Mental Health in the Primary Care Setting
Innerview can address some of the challenges of integrating mental health and primary care by accurately and reliably collecting mental health evidence and activities directly from patients, and then organizing and automating…
- Trial name
- NCT02025647
- Where
- 5 sites in United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Pearson/Clinical Assessment
Healthy
Electrophysiological Biomarkers of AV-101
Suicide is 2-7x higher in Veterans than non-veterans, and may be related to brain kynurenine pathway (KP) dysregulation and NMDA receptor (NMDAR) hyperactivation.
- Trial name
- NCT03583554
- Testing
- AV-101 720 mg, AV-101 1440 mg
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Marijn Lijffijt, PhD
Suicide
Adaptive Implementation Intervention for VA Suicide Risk Identification Strategy
The overall objective of this national quality improvement project is to develop an adaptive implementation strategy to improve the implementation of suicide risk screening and evaluation in Veterans Health Administration…
- Trial name
- NCT04243330
- Testing
- Audit and Feedback, External Facilitation
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder)
Epidiolex in Obsessive Compulsive Disorder and Related Disorders
The primary objective of the proposed study is to evaluate the safety and efficacy of Epidiolex (cannabidiol) in adults with obsessive compulsive and related disorders (OCRDs).
- Conditions
- Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder), Tourette Syndrome, Hoarding Disorder
- Trial name
- NCT04978428
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Chicago
Suicidal Ideation, Treatment Engagement
Motivational Interviewing to Prevent Suicide in High Risk Veterans
The purpose of study is to test the efficacy of an adaptation of Motivational Interviewing to Address Suicidal Ideation (MI-SI) on the severity of suicidal ideation in psychiatrically hospitalized Veterans at high risk for…
- Trial name
- NCT01544127
- Testing
- MI-SI+TAU, MI-SI-R+TAU, TAU Alone
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- VA Office of Research and Development
Substance Use Disorders, Depression
Study of a Transdiagnostic, Emotion-focused Group Intervention for Young Adults With Substance Use Disorders
The overall aim of this pilot study is to conduct a preliminary trial to evaluate the acceptability and feasibility of adding a transdiagnostic, emotion-focused group intervention (the Unified Protocol, UP) to treatment as usual…
- Conditions
- Substance Use Disorders, Depression, Anxiety, Emotional Disorder
- Trial name
- ARMS UP (NCT03315208)
- Testing
- Unified Protocol (UP), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Major Depressive Disorder
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
The purpose of this study is to advance a non-pharmacologic suicide preventive intervention with wide dissemination potential as an innovative high-yield solution to reduce suicide rates.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Mood Disorders, Suicide
- Trial name
- NCT05317481
- Testing
- BE-SMART-DR, psychoeducational control comparator condition (CC)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Suicide, Self Harm
An Adaptive Intervention for Adolescents at Risk for Suicide: A Pilot SMART
To inform the development of a technology-augmented adaptive intervention for adolescents at risk for suicide, the goal of this study is to conduct a Sequential, Multiple Assignment, Randomized Trial (SMART) pilot of a…
- Trial name
- NCT03838198
- Testing
- MI-Enhanced Safety Plan at Hospitalization (1st Component), MI-Enhanced Text Boosters (2nd Component), MI-Enhanced Booster Call (3rd Component)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Michigan
Suicide, Nurse's Role
Nurse Suicide: Physiologic Sleep Health Promotion Trial
The purpose of this study is to identify factors (sleep, psychiatric characteristics, stressful life events, and work environment characteristics) that potentiate or mitigate adverse effects of real-world stressors that…
- Conditions
- Suicide, Nurse's Role, Work Environment Adverse Effects, Sleep
- Trial name
- NCT06079853
- Testing
- PureSomni Sleep Health Product Kit
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Columbia University
Posttraumatic Stress Disorder, Depression
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Pilot
The goal of this pilot study is to develop and implement a larger scale, multi-site stepped collaborative care trial that targets injured patients with presentations of posttraumatic stress disorder (PTSD) and related…
- Conditions
- Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation
- Trial name
- TSOS6 (NCT02335125)
- Testing
- Motivational Interviewing, Cognitive Behavioral Therapy Elements, Psychotropic Drugs
- Volunteers
- 40 people
- Sponsor
- University of Washington
Suicidal Ideation
Observational Study to Compare Outcomes of Different Psychiatric Treatment of Suicidal Adolescents
To address the unmet need of optimizing the treatment and management for adolescent suicidality, the investigators propose to evaluate the effectiveness and safety of telehealth services compared to inpatient and OCIC for…
- Trial name
- Pre-START (NCT04625686)
- Testing
- Mental Health Treatment
- Where
- 4 sites in United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Suicide
REACH VET Implementation Program Evaluation
The VA's Office of Mental Health and Suicide Prevention implemented an new program to increase suicide prevention outreach for Veterans at highest risk for suicide.
- Trial name
- REACH VET (NCT03280225)
- Testing
- External facilitation
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Autism Spectrum Disorder, Depression
Group Depression Treatment for Autistic Youth
Higher rates of depression are reported by autistic adolescents as compared to their non-autistic peers, which is problematic given adverse outcomes (e.g., negative self-esteem, lower academic performance) that are associated…
- Conditions
- Autism Spectrum Disorder, Depression, Suicidal Ideation, Self Esteem
- Trial name
- NCT05430022
- Testing
- Autism-adapted Group Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University Medical Center
Suicidal Ideation, Thoughts of Self Harm
Virtual Hope Box - Effectiveness of a Smartphone App for Coping With Suicidal Ideation
A hope box or self soothing kit is a therapeutic tool employed by clinicians with patients expressing suicidal ideation, significant distress, or otherwise at risk of suicidal or non-suicidal self harm.
- Conditions
- Suicidal Ideation, Thoughts of Self Harm, Coping
- Trial name
- VHB-RCT (NCT01982773)
- Testing
- Virtual Hope Box Smartphone App, Enhanced Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 118 people
- Sponsor
- National Center for Telehealth and Technology
Lesch-Nyhan Disease, Self-injurious Behavior
Ecopipam Treatment of Self-Injurious Behavior in Subjects With Lesch-Nyhan Disease
The purpose of this research study is to gather scientific information about the effectiveness and safety of the study drug, Ecopipam (PSYRX 101), for the treatment of self-injurious behaviors when compared with the effectiveness…
- Trial name
- NCT01751802
- Testing
- Ecopipam
- Where
- 2 sites in United States, Spain
- Volunteers
- 9 people
- Sponsor
- Emalex Biosciences Inc.
Suicidal Ideation
Home-based tDCS for Prevention of Suicidal Ideation
Risk for suicide is elevated in the period after discharge from hospital among adults with major affective disorder. The primary objective of this study is to investigate the feasibility of delivering tDCS sessions for high-risk…
- Trial name
- NCT05280756
- Testing
- Home-based transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Rochester
Aggression, Self-Injurious Behavior
Treatment of Severe Destructive Behavior: FCT Versus Wait-List Control
Children with an intellectual disability often display severe destructive behavior (e.g., aggression, self-injury) that pose risks to themselves or others and represent barriers to community integration.
- Trial name
- NCT02483572
- Testing
- Functional Communication Training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Nebraska
Suicide
Ottawa Suicide Prevention in Men Pilot Study
To refine a novel intervention using a combination of a smart phone application with best practice psychotherapy for men who have presented to hospital with intentional self-harm.
- Trial name
- OSSUPilot (NCT02718248)
- Testing
- CHESS Mobile Health smart phone application, Problem solving therapy
- Where
- 2 sites in Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Ottawa