Clinical trials: Self-harm Behavior
Suicidal Ideation, Suicide, Attempted
Skills to Enhance Positive Affect in Suicidal Adolescents
The prevalence of suicidal behaviors in adolescents remains unacceptably high and is a significant public health concern. The investigators propose a new treatment approach in which skills to increase positive emotions are taught…
- Trial name
- STEP (NCT02130583)
- Testing
- Positive Affect Skills Training, Treatment as Usual
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Brown University
Substance Use Disorders, Depression
Study of a Transdiagnostic, Emotion-focused Group Intervention for Young Adults With Substance Use Disorders
The overall aim of this pilot study is to conduct a preliminary trial to evaluate the acceptability and feasibility of adding a transdiagnostic, emotion-focused group intervention (the Unified Protocol, UP) to treatment as usual…
- Conditions
- Substance Use Disorders, Depression, Anxiety, Emotional Disorder
- Trial name
- ARMS UP (NCT03315208)
- Testing
- Unified Protocol (UP), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Suicide, Attempted
Ketamine + Cognitive Training for Suicidality in the Medical Setting: Pilot
This project seeks to identify the acute and longer-term impact of a single dose of intravenous ketamine among suicidal patients referred for psychiatric consultation/liaison in the medical inpatient setting.
- Trial name
- NCT04154150
- Testing
- Intravenous ketamine, Cognitive training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Rebecca Price
Depression, Suicidal Ideation
Engaging Black Youth in Depression and Suicide Prevention Treatment Within Urban Schools
Completing evidence-based treatments for depression has been shown to be particularly problematic for Black adolescents. If Black adolescents' depression treatment needs are to be met, the engagement challenges and the factors…
- Trial name
- NCT03940508
- Testing
- Making Connections Intervention, IPT-A
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- New York University
Suicidal Ideation
Repetitive Transcranial Magnetic Stimulation as Treatment for Acute Suicidality in Adult Patients
Suicide was responsible for almost 40,000 deaths in 2011 in America. It is still singularly difficult to predict who is going to commit suicide and how to establish adequate interventions.
- Trial name
- rTMS (NCT02693743)
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Suicide Prevention
Feasibility Trial of a Single Session of Crisis Response Planning for Youth at High Risk for Suicide
The current study is a clinical trial, meaning a research study in which human subjects are prospectively assigned to one or more interventions to evaluate the effects of those interventions on health-related behavioral outcomes.
- Trial name
- NCT06164106
- Testing
- Virtual Crisis Response Planning, In-Person Crisis Response Planning, Crisis Risk Counseling
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Ohio State University
Borderline Personality Disorder, Suicide
Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder
This study will compare the effectiveness of two treatments, dialectical behavior therapy versus fluoxetine with clinical management, for reducing the risk of self-injury and suicidal behavior in people with borderline…
- Trial name
- NCT00834834
- Testing
- Fluoxetine, DBT, Citalopram
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- New York State Psychiatric Institute
Inflammatory Bowel Diseases, Depressive Episode
Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health
This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the impacts on quality-of-life outcomes and use of healthcare services in people aged 5 - 25 years…
- Conditions
- Inflammatory Bowel Diseases, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorder
- Trial name
- NCT05206734
- Testing
- No specific intervention
- Where
- United Kingdom
- Volunteers
- 19,469 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Suicide, Attempted, Suicide and Self-harm
Real-time Intervention for Suicide Risk Reduction: Primary Open Pilot
The goal of this study is to provide an initial pilot test of an Ecological Momentary Intervention (EMI) designed the reduce the distress associated with negative emotion among individuals at risk for suicide that pairs content…
- Trial name
- NCT03950765
- Testing
- Ecological momentary intervention
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rutgers, The State University of New Jersey
Suicide
Circle of Life. Improving Capacity of Swampy Cree Community Members to Recognize People at Risk for Suicide
Primary Hypothesis: Participants in the Applied Suicide Intervention Skills Training (ASIST) gatekeeper training will be significantly more likely to have increased knowledge and preparedness to help people with suicidal ideation…
- Trial name
- NCT01287416
- Testing
- Applied Suicide Intervention Skills Training, Resilience Retreat
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Lesch-Nyhan Disease
Safety and Tolerability of the D1 Dopamine Receptor Antagonist Ecopipam in Patients With Lesch-Nyhan Disease
The purpose of this study is to determine the effects of ecopipam in patients with Lesch-Nyhan Disease (LND). Ecopipam specifically blocks the actions of one chemical in the brain that helps nerves talk to one another; ecopipam…
- Trial name
- NCT01065558
- Testing
- Ecopipam
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Psyadon Pharma
Depression, Suicidal Ideation
Text2Connect, Component 2 of iCHART (Integrated Care to Help At-Risk Teens)
This study proposes to develop and examine a personalized, text-based intervention designed to improve engagement with mental health (MH) treatment.
- Trial name
- T2C (NCT03982043)
- Testing
- Text2Connect
- Where
- 4 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of Pittsburgh
Depression, Suicidal Ideation
Text 2 Connect- Texting Intervention for Mental Health Treatment Utilization
Text2Connect (T2C) proposes to test a text-based intervention designed to improve engagement with mental health treatment.
- Trial name
- T2C (NCT04560075)
- Testing
- Text2Connect, Psychoeducational Videos (PE) Only
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of Pittsburgh
Suicide
Ottawa Suicide Prevention in Men Pilot Study
To refine a novel intervention using a combination of a smart phone application with best practice psychotherapy for men who have presented to hospital with intentional self-harm.
- Trial name
- OSSUPilot (NCT02718248)
- Testing
- CHESS Mobile Health smart phone application, Problem solving therapy
- Where
- 2 sites in Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Depression, Anxiety, Suicidal Ideation
A Trauma-Informed Approach for Positive Youth Development for Montana Students
Given the prevalence of suicide and mental health issues in rural Montana, this project is intended to help mitigate stressors that may contribute to poor behavioral and mental health in high school-aged children.
- Conditions
- Depression, Anxiety, Suicidal Ideation, Stress, Trauma
- Trial name
- NCT04664855
- Testing
- Trauma-Informed Yoga
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Montana State University
Suicide, Depression
Cranial Electric Stimulation to Modify Suicide Risk Factors in Psychiatric Inpatients.
This pilot study aims to investigate whether a treatment called cranial electric stimulation or CES can decrease risk factors for suicide. The specific CES device we will use is called Alpha-Stim®.
- Conditions
- Suicide, Depression, Anxiety, Insomnia
- Trial name
- NCT02846740
- Testing
- Alpha-Stim®., Montgomery-Åsberg Depression Rating Scale, Hamilton Anxiety Rating Scale, The Pittsburgh Sleep Quality Index and agitated behavior Scale
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Suicidal Ideation, Suicide, Attempted
Improving Treatment Outcomes for Suicidal Veterans With PTSD
The efficacy of cognitive processing therapy (CPT) for reducing the symptoms of posttraumatic stress disorder (PTSD) across populations including military personnel and veterans is well supported.
- Conditions
- Suicidal Ideation, Suicide, Attempted, Ptsd
- Trial name
- NCT04690582
- Testing
- Cognitive Processing Therapy (CPT), Crisis Response Plan (CRP), Safety Planning Intervention (SPI)
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Ohio State University
Posttraumatic Stress Disorder, Depression
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
The overarching goal of this UH2-UH3 proposal is to work with the NIH Health Care Systems Research Collaboratory to develop and implement a large scale, cluster randomized pragmatic clinical trial demonstration project that…
- Conditions
- Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation
- Trial name
- TSOS6 (NCT02655354)
- Testing
- Motivational Interviewing, Cognitive Behavioral Therapy Elements, Care Management
- Where
- 24 sites in United States
- Volunteers
- 635 people
- Sponsor
- University of Washington
Suicide, Engagement, Patient
The BH-Works Suicide Prevention Program for Sexual and Gender Minority Youth
Youth suicide is a serious public health concern. Compared to their heterosexual and cisgender peers, sexual and gender minority (SGM) adolescents report higher rates of suicidal ideation and suicide attempts.
- Trial name
- NCT05922670
- Testing
- The Behavioral Health-Works Suicide Prevention Program for Sexual and Gender Minority Youth
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Virginia Polytechnic Institute and State University
Insomnia, Depression
Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)
There is a strong association between sleep disturbance and suicidal thoughts and behaviors. Sleep disturbance is also highly comorbid with other common conditions associated with suicide such as depression and posttraumatic…
- Conditions
- Insomnia, Depression, Posttraumatic Stress Disorder, Suicidal Ideation
- Trial name
- NCT02248675
- Testing
- CBT-I, TAU
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development