Clinical trials: Seniors
Frailty, Sarcopenic Obesity
Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors
The continuing increase in prevalence of obesity in older adults including many older Veterans has become a major health concern.
- Conditions
- Frailty, Sarcopenic Obesity, Aging
- Trial name
- DEMFOS (NCT04221750)
- Testing
- Lifestyle therapy, Metformin Hydrochloride, Healthy Lifestyle
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Aged
Village Interactive Training and Learning Study
The purpose of this research study is to help scientists and health care providers learn more about preventing dementia and brain disease in older adults.
- Trial name
- VITAL (NCT01709799)
- Testing
- Exercise, Exergames, Cognitive Training
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Florida
Inflammation
The ENRGISE (ENabling Reduction of Low-Grade Inflammation in SEniors) Pilot Study
ENRGISE Pilot Study will test the ability of anti-inflammatory interventions for preventing major mobility disability by improving or preserving walking ability.
- Trial name
- ENRGISE (NCT02676466)
- Testing
- Omega-3 fish oil, Losartan
- Where
- 5 sites in United States
- Volunteers
- 289 people
- Sponsor
- University of Florida
Macular Degeneration, Wet Macular Degeneration
Aflibercept After Ranibizumab in Exudative Age-related Macular Degeneration
The purpose of the current study is to evaluate the ability of Eylea to induce a regression of PED height on patients previously extensively treated by Lucentis.
- Conditions
- Macular Degeneration, Wet Macular Degeneration, Retinal Degeneration, Retinal Diseases
- Trial name
- ARI2 (NCT02157077)
- Testing
- Aflibercept
- Where
- 9 sites in France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Cognitive Decline
Evaluation of Cognitive State in Seniors Using Neurosteer EEG System
This is an observational study. Patients who fulfill all inclusion criteria and none of the exclusion criteria will be enrolled in the study, be neurologically evaluated and will go through EEG recordings while listening to an…
- Trial name
- NCT05528445
- Testing
- Neurosteer EEG recorder
- Where
- Israel
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Neurosteer Ltd.
Myocardial Infarction
Study of Access Site for Enhancing PCI in STEMI for Seniors (SAFE STEMI for Seniors)
Patients with partially blocked blood vessel(s) in their heart may need a medical procedure called "Percutaneous Coronary Intervention (PCI)" to open the narrowed blood vessel(s).
- Trial name
- NCT02939976
- Testing
- Single Vessel Disease, Multi-vessel Disease, Culprit Vessel Only, Multi-vessel Disease, Complete Revascularization
- Where
- United States
- Volunteers
- 427 people
- Sponsor
- David Kong, M.D.
Alzheimers, Falls, Aging in Place
Advance Planning for Home Services for Seniors
The goal of this study is to develop and test an advance planning tool to help seniors understand projected health needs and plan ways to remain in their own homes when these crises occur.
- Trial name
- APHS (NCT02256072)
- Testing
- Plan Your Lifespan Website, Go4Life Website
- Where
- 2 sites in United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Obesity, Weight Loss
Effect of High Protein Weight Loss for Seniors
Intentional weight loss in obese, older adults remains controversial. Although caloric restriction, resulting in significant weight and fat mass loss, ameliorates many clinical consequences of obesity, recommendation of…
- Trial name
- NCT02730988
- Testing
- Weight Stable Group
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Cancer Survivorship, Safety and Efficacy
The HEALS Project - Health Education and Active Living for Surviving Seniors
Persons over age 65 years constitute a large and growing population of cancer survivors. Available data indicate that both short- and long-term female breast cancer survivors report more limitations related to strength and…
- Conditions
- Cancer Survivorship, Safety and Efficacy, Quality of Life
- Trial name
- HEALS (NCT01305044)
- Testing
- Tai Chi Chih, Health Education Classes
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Utah
Loneliness, Social Isolation
The Emotional, Physical and Cognitive Benefits of Purposeful Green Space Activities on Seniors
This project explores if various nature based activities can lead to acute improvements in emotional, physical and cognitive health outcomes and encouraging senior center (JABA) service users to return to a safe environment.
- Conditions
- Loneliness, Social Isolation, Mood, Well Aging
- Trial name
- NCT04913363
- Testing
- Green space
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Underage Drinking, Alcohol Use, Underage
REAL Parenting Alcohol and Substance Use App
High school students' alcohol, nicotine, and marijuana use are major public health problems. Among the many consequences of these risky behaviors are impaired driving and impaired passenger fatalities as well as increased health…
- Trial name
- RP (NCT03932097)
- Testing
- REAL Parenting, Active Control Materials
- Where
- United States
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Real Prevention, LLC
Subjective Cognitive Decline
DEMA-Pro Intervention for Seniors With Subjective Cognitive Decline and Living at Home
More than 4.4 million patients receive home health services following discharge from the hospital or rehabilitation facility. A substantial number (70%) are older adults with subjective cognitive decline (SCD), an early clinical…
- Trial name
- NCT04796415
- Testing
- the DEMA-Pro intervention
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Indiana University
Immunity to Influenza Vaccine
Cell Mediated Immunity in Older Adults
This study is to study the immune response to the flu vaccine in people 65 years old and older. Only adults 65 years old and older and who are getting their flu vaccine are being asked to join in this study.
- Trial name
- CMI (NCT01189123)
- Testing
- High dose influenza vaccine Sanofi-Pasteur, fluzone by sanofi pasteur
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Quality of Life, Self Efficacy
Oral Health Education Interventions Among Seniors
The study aims to assess the efficacy of an oral health education group based activity versus an individual based oral health education activity in terms of changes in oral health related quality of life (OHRQoL), self-efficacy…
- Conditions
- Quality of Life, Self Efficacy, Knowledge
- Trial name
- NCT03301714
- Testing
- Oral Health Education
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Temple University
Hip Fractures, Femoral Fractures
Mobilizing Evidence Into Action to Improve Outcomes of Vulnerable Seniors
This is a parallel Randomized Controlled Trial comparing two different delivery modes of post hip fracture management-a specialized Fracture Follow-up Clinic versus Usual Care alone.
- Trial name
- NCT01254942
- Testing
- B4 Clinic, Usual Care
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- University of British Columbia
Cognitive Function
Seniors Health and Activity Research Program-Pilot
The purpose of this pilot study is to develop and conduct well-designed trial to assess whether a multi-factorial intervention involving physical activity and cognitive training reduces the risk of significant cognitive decline…
- Trial name
- SHARP-P (NCT00688155)
- Testing
- Physical Activity Training, Cognitive Training, Healthy Aging Education
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes
Home-based Diabetes-Modified Behavioral Activation Treatment for Low Income Seniors With T2DM
The objective of this protocol is to evaluate the efficacy and cost-effectiveness of 8 sessions of in-home, telephone-delivered, culturally-modified, manualized diabetes-modified, behavioral activation treatment (Home DM-BAT)…
- Trial name
- HOME DM-BAT (NCT04203147)
- Testing
- Supportive Therapy (Control), Home DM-BAT
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- State University of New York at Buffalo
Stress, Psychologic
Mindfulness to Improve Elders' Immune and Health Status
The purpose of the study is to better understand effects of the Mindfulness-Based Stress-Reduction (MBSR) program on the physical and emotional health and well-being of adults ages 65 and older.
- Trial name
- NCT01027780
- Testing
- Mindfulness-Based Stress Reduction
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Hypertension, Aging
ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension
The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older…
- Conditions
- Hypertension, Aging, Sedentary Lifestyle
- Trial name
- ACES (NCT03295734)
- Testing
- Aerobic exercise, Perindopril, Losartan
- Where
- 2 sites in United States
- Volunteers
- 223 people
- Sponsor
- University of Alabama at Birmingham
Physical Activity
Peer Empowerment Program for Physical Activity in Low Income and Minority Seniors
Older adults are the least active population group in the US. Yet, research has shown that an increase in physical activity (PA) can have immediate and profound effects on cardiovascular health.
- Trial name
- PEP4PA (NCT02405325)
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego