Clinical trials: Sensitivity
Asthma
Comparing Bronchodilation of Symbicort With and Without Valved Holding Chamber (Aerochamber Plus)
This study will compare the amount of bronchial tube relaxation from the Formoterol medicine contained in the Symbicort pressure Metered Dose Inhaler(pMDI)(a combination of Budesonide, a steroid, and Formoterol, a drug which…
- Trial name
- WSMR2 (NCT00915538)
- Testing
- pMDI budesonide/formotrol 160/4.5 is in group 1, Symbicort 160/4.5 plus Aerochamber Plus included in group 2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Western Sky Medical Research
Dentine Hypersensitivity
The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity
A study to compare the efficacy of a test dentifrice against a control dentifrice in reducing dentinal hypersensitivity over an eight week treatment period.
- Trial name
- NCT01592864
- Testing
- Stannous Fluoride, Sodium Monofluorophosphate
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Allergic Rhinitis
Intranasal Steroids and Oxymetazoline in Allergic Rhinitis
We hypothesize that once daily use of oxymetazoline will not cause significant rhinitis medicamentosa and that the combination of fluticasone furoate plus oxymetazoline leads to faster relief of nasal congestion secondary to…
- Trial name
- NCT00584987
- Testing
- Fluticasone furoate, Oxymetazoline
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Insulin Sensitivity
Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim2)
The purpose of this study is to determine whether microbiome modulation and an experimental reduction in plasma LPS concentration improve inflammation and insulin action in insulin resistant (obese and T2DM) subjects.
- Trial name
- MicroB2 (NCT02127125)
- Testing
- Maltodextrin, Synbiotic, Sevelamer
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Eating Behavior, Eating Habit
Young Adult Eating Habits
Most individuals with obesity become so before age 35 and adolescent's unhealthy dietary patterns, specifically high intake of ultra-processed foods and poor overall diet quality, may contribute to energy overconsumption and…
- Trial name
- YAEH (NCT05550818)
- Testing
- High Ultra Processed Food Diet, No Ultra Processed Food Diet
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Seasonal Allergic Rhinitis
Pilot Study to Evaluate Ear Acupressure Effects in Treating Seasonal Allergic Rhinitis
We hypothesize that ear acupressure will be effective in treating seasonal allergic rhinitis by changing the immune parameters and the psychological impact factors are associated with ear acupressure treatment outcome.
- Trial name
- NCT01921348
- Testing
- acupressure pellets
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Allergic Conjunctivitis
A Six-Week Safety Study of an Investigational Ophthalmic Solution
The purpose of this study was to evaluate the ocular safety of an investigational ophthalmic solution in subjects 2 years of age and older with asymptomatic eyes when administered once daily in both eyes for up to 6 weeks.
- Trial name
- NCT01698814
- Testing
- AL-4943A Ophthalmic Solution, AL-4943A Ophthalmic Solution Vehicle
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Pre Diabetes
Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity
The purpose of this study is to determine the effects of oral abscisic acid (ABA) on glucose metabolism in subjects with defined prediabetes.
- Trial name
- ABA (NCT04722354)
- Testing
- Hyperinsulemic euglycemic clamp, Muscle Biopsy, Oral abscisic acid (ABA)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Asthma
Airway Smooth Muscle and Asthma Severity
Our hypothesis is that the severity of asthma is determined by the way in which airway smooth muscle cells grow and release inflammatory mediators.
- Trial name
- NCT00779870
- Testing
- bronchoscopy
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Atopic Dermatitis Eczema, Atopic Dermatitis
Trends in the Epidemiology and Treatment of Atopic Dermatitis in the United Kingdom (UK)
Atopic dermatitis (AD), commonly called eczema, is one of the most frequently occurring skin conditions. It is estimated to affect around one fifth of children in developed countries and is also becoming increasingly common in…
- Conditions
- Atopic Dermatitis Eczema, Atopic Dermatitis, Eczema
- Trial name
- NCT03823794
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 148,166 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Type 2 Diabetes
Pharmacogenomics of Thiazolidinediones
The purpose of this study is to determine predictors of response to pioglitazone, an anti-diabetic medication. The investigators know from randomized clinical trials that some 30% of patients do not respond to this type of…
- Trial name
- PPAR (NCT01135394)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Asthma
Asthma in Central Texas Project
Asthma is the most common chronic childhood illness and disproportionately affects children who are ethnic minorities and poor. Few studies of childhood asthma have been conducted with children who live in rural areas or have…
- Trial name
- NCT01676896
- Testing
- Asthma in-school class, Asthma Day Camp, Health Promotion in-school class
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Dentine Hypersensitivity
The Efficacy of a Dentifrice in Providing Relief From Immediate and Short Term Relief From Dentinal Hypersensitivity
A randomised, examiner blind, two treatment arm, stratified, parallel design, single-site study in subjects with at least two sensitive teeth to compare the efficacy of a test dentifrice against that of a control dentifrice in…
- Trial name
- NCT03072719
- Testing
- Stannous Fluoride, Sodium Monofluorophosphate
- Where
- Ireland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
Clinical Study to Evaluate the Anti-sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers
The aim of this study is to confirm the clinical Dentin Hypersensitivity (DH) efficacy of a 0.454 percent (%) Stannous Fluoride (SnF2) toothpaste.
- Trial name
- NCT06359028
- Testing
- Stannous fluoride toothpaste, Crest cavity protection toothpaste
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- HALEON
Dermatitis, Atopic
A Study for AR100DP1 in Mild to Moderate Atopic Dermatitis (AD)
This is a Phase I/IIa Open-Label, Dose-Escalation Study to Determine the Safety, Tolerability, and Efficacy of AR100DP1 in Health Subjects, and Subjects with Mild to Moderate Atopic Dermatitis.
- Trial name
- NCT04220411
- Testing
- AR100DP1
- Where
- Taiwan
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Arjil Pharmaceuticals LLC
COPD, Asthma
LungVITamin D and OmegA-3 Trial (lungVITAL)
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,871 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids…
- Conditions
- COPD, Asthma, Pulmonary Function, Pneumonia
- Trial name
- lungVITAL (NCT01728571)
- Testing
- Vitamin D3, fish oil
- Where
- United States
- Volunteers
- 25,871 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Neuroendocrine Neoplasms
A Prospective, Open-label Study of [68Ga]Ga-DOTA-TATE in Patients With Neuroendocrine Neoplasms (NENs) and Healthy Volunteers in Japan
The purpose of this study was to evaluate the diagnostic performance of [68Ga]Ga-DOTA-TATE Positron Emission Tomography (PET)/Computerized Tomography (CT) imaging compared with conventional imaging (CIM) as standard of truth in…
- Trial name
- NCT06240741
- Testing
- [68Ga]Ga-DOTA-TATE, 68Ge/68Ga Generator
- Where
- 8 sites in Japan
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Asthma
Comparing Maintenance of Device Mastery With Turbohaler© vs. Spiromax© in Healthcare Professionals naïve to Both Devices
This study is conducted to assess the ease of device mastery of a placebo SYMBICORT TURBOHALER vs a placebo Budesonide/Formoterol SPIROMAX device among healthcare professionals in-training (HCP).
- Trial name
- HCP-ELIOT (NCT02570425)
- Testing
- Training on BF Spiromax followed by SYMBICORT Turbohaler, Training on SYMBICORT Turbohaler followed by BF Spiromax
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Research in Real-Life Ltd
Mild Cognitive Impairment, Healthy Aging
SHARE(D) Stage II: Alzheimer's Risk Disclosure Protocol Piloting
The goal of this study is to test efficacy and safety of person-centered, culturally-informed protocols for disclosure of different combinations of Alzheimer's dementia risk factors.
- Trial name
- SHARE(D) (NCT04309500)
- Testing
- Personalized DAT Risk Disclosure Protocol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Atopic Dermatitis
Efficacy and Safety of IDP-124 Lotion for the Treatment of Moderate to Severe Atopic Dermatitis in Pediatric and Adult Subjects (301)
Efficacy and Safety of IDP-124 Lotion for the Treatment of Moderate to Severe Atopic Dermatitis in Pediatric and Adult Subjects
- Trial name
- NCT03002571
- Testing
- IDP-124 Lotion, IDP-124 Vehicle Lotion
- Where
- United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.