Clinical trials: Sensitization
- Condition Sensitization
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Erythema, Sensitisation
50 Human Subject Repeat Insult Patch Test
Consumer products or raw materials designed for consistent reapplication to areas of the skin may, under proper conditions, prove to be contact sensitizers or irritants in certain individuals.
- Trial name
- HRIPT (NCT04498676)
- Testing
- CB-0002B
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CAGE Bio Inc.
Skin Irritation
Patch Test Skin Irritation/Sensitization of Cetaphil Restoraderm Skin Restoring Body Wash
Determine if Cetaphil Restoraderm Skin Restoring Body Wash proves to be a contact sensitizer or irritant in certain individuals.
- Trial name
- NCT01892410
- Testing
- Cetaphil Restoraderm Skin Restoring Body Wash
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Osteoporosis, Postmenopausal
A Multiple-Dose Study to Evaluate Skin Irritation and Sensitization of Teriparatide Administered Transdermally in Healthy Postmenopausal Women
This study is a Phase 1, multi-center, 2-part, subject- and investigator-blind, randomized, placebo-controlled, multiple dose study of transdermal teriparatide (80-µg dose) in healthy postmenopausal women.
- Trial name
- NCT01250145
- Testing
- LY333334
- Where
- 5 sites in United States, Germany and 1 more
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Skin Reaction to Mechanical, Thermal and Radiation Stimuli, Skin Sensitisation
Study Comparing iNPWT Dressing and Devices Affect on Bioburden Levels and Skin Condition After Seven Days
Incisional dressings aim to prevent contamination of an incisional wound and protect against skin irritation. Surgeons use incisional negative pressure wound therapy (iNPWT) to manage incisional wounds.
- Trial name
- HHiNPWT7DC (NCT05559697)
- Testing
- Sponsor incisional negative pressure wound therapy device and dressing, Standard of Care incisional negative pressure wound therapy system
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- DeRoyal Industries, Inc.
Female Dry Genital Mucosa
Dermal and Gynecological Acceptability (Irritability and Sensitization in the Genital Mucosa) of an Investigational Product and Evaluation of Moisture Efficacy by TEWL and Perceived Efficacy.
To evaluate the safety of an investigational product through the verification of signs of irritability and sensitization of the genital mucosa, as well as the instrumental moisturizing efficacy by TEWL and barrier integrity…
- Trial name
- DERM GYN ACCEP (NCT03007615)
- Testing
- Intimate Lubricant Gel
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Kley Hertz S/A
Healthy
Phase I Study to Assess Irritation, Sensitization and Adhesion of a Novel Ibuprofen 200 mg TEPI Medicated Plaster
This trial will be conducted with the aim to investigate the dermal response (skin irritation, sensitization) and the adhesion of Ibuprofen 200 mg TEPI Medicated Plaster as compared to a Placebo TEPI Plaster in two phases…
- Trial name
- NCT03639571
- Testing
- Ibuprofen 200 mg TEPI Medicated Plaster
- Where
- Bulgaria
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medherant Ltd
Sensitivity, Contact
Sensitization Study of ATx201 in Healthy Volunteers
This is a Phase I, single-site study to evaluate the sensitization potential of topically applied ATx201 GEL, 2% and 4%, along with a placebo control, in healthy human subjects.
- Trial name
- NCT03375957
- Testing
- ATx201
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- UNION therapeutics
Skin Care
A Photoxicity and Photoallergy Study of a Developmental Face Cream, Serum and Lotion
The purpose of this study is to demonstrate the absence of sensitisation and irritation potential of a product when applied to the skin and exposed to ultraviolet (UV) radiation.
- Trial name
- NCT04006795
- Testing
- Serum, Lotion, Cream
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Major Depressive Disorder (MDD)
A Study to Assess the Skin Irritation and Sensitization of Selegiline TDS in Healthy Subjects
The two products used in this study are transdermal patches that contain selegiline. The test drug is the Selegiline Transdermal Delivery System (TDS). The comparator drug is the EMSAM® TDS.
- Trial name
- NCT07452692
- Testing
- Selegiline Transdermal Delivery System
- Where
- 3 sites in Bulgaria
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Oral Manifestations
Oral Irritation Study of Two Experimental Mouthrinses
This study is 25 days long. People participating in this study will be asked to brush their teeth two times a day. People will be assigned to a mouthwash and will rinse four times a day at the site for five days.
- Trial name
- NCT01156376
- Testing
- Potassium Oxalate without Fluoride, Potassium Oxalate with Fluoride, Active Comparator PO-116-A
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Healthy
Human Repeated Insult Patch Test (HRIPT) of Azelaic Acid Pre Foam Formulation
The purpose of this study is to determine the dermal sensitization potential of azelaic acid pre-foam formulation.
- Trial name
- NCT01430533
- Testing
- azelaic acid pre foam formulation, Vehicle pre foam formulation, Water
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Sunburn
Dermal Irritation, Sensitization and Cumulative Irritation Potential of 6% Bemotrizinol
The purpose of this clinical trial is to evaluate the dermal safety of Bemotrizinol (6%).
- Trial name
- NCT05260359
- Testing
- 6% Bemotrizinol (BEMT) in a basic sunscreen oil formulation, 6% Bemotrizinol (BEMT) dispersion in petrolatum, Sunscreen oil vehicle with 10% ethanol as penetration enhancer without BEMT
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Determine Sensitivity of Skin to Cetaphil Daily Advance Ultra Hydrating Lotion
Patch Test Skin Irritation/Sensitization of Cetaphil Daily Advance Ultra Hydration Lotion
Determine if Cetaphil Daily Advance Ultra Hydrating Lotion proves to be a contact sensitizer or irritant in certain individuals.
- Trial name
- NCT01885130
- Testing
- Cetaphil Daily Advance Ultra Hydrating Lotion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Skin Sensitisation
Skin Sensitization Test (Modified Draize-95 Test)
Skin Sensitization Test (Modified Draize-95 Test) to Support a Low Dermatitis Potential Claim for a Blue Non Sterile Powder Free Nitrile Examination Gloves.
- Trial name
- NCT03886987
- Testing
- Blue Non Sterile Powder Free Nitrile Examination Gloves
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Central Medicare Sdn. Bhd.
Menopause, Healthy Female Participants
A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects
The two products used in this study are transdermal patches that contain selegiline. The test drug is the Estradiol/Levonorgestrel Transdermal Delivery System (TDS). The comparator drug is the Climara Pro® TDS.
- Trial name
- NCT07794150
- Testing
- Estradiol/Levonorgestrel Transdermal System
- Where
- 2 sites in United States, India
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Pain
A Safety Study to Investigate the Skin Sensitization Potential of MFC51123
This research study is being carried out to determine the possibility that a new medication causes allergic reactions. This new medication contains two active ingredients (diclofenac and menthol) together in a gel and is being…
- Trial name
- NCT02192203
- Testing
- Diclofenac + Menthol Gel, Diclofenac Only Gel, Menthol Only Gel
- Where
- United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Skin Care
To Assess the Cutaneous Irritation and Sensitization Potential of a Cosmetic Facial Product Using a Human Repeat Insult Patch Test (HRIPT) in Healthy Participants
The objective of this clinical study is to assess the irritation and sensitisation potential of a cosmetic test product after repeated semi-occlusive patch applications to healthy human participants by following a conventional…
- Trial name
- NCT03175562
- Testing
- Facial micellar cleanser, Saline Solution: Sodium Chloride (NaCl; 0.9%)
- Where
- Brazil
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bioequivalence - Irritation and Sensitization Potential of Transdermal Patch
Irritation and Sensitization Potential of Repeat Applications of Rotigotine Patch
STUDY TITLE: A Multiple Site Study to Evaluate the Irritation and Sensitization Potential of Repeat Applications of Rotigotine Transdermal System, 1 mg/24 hr Versus Neupro (Rotigotine Transdermal System), 1 mg/24 hr in Healthy…
- Trial name
- NCT02727205
- Testing
- Rotigotine Transdermal System
- Where
- 2 sites in United States, Canada
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Inflamax Research Incorporated
Cumulative Irritation and Sensitization
Study Will Assess Skin Irritation and Sensitization for HP-1050 Patch
A randomized, evaluator-blinded study to assess skin irritation and skin sensitization of HP-1050 transdermal system (HP-1050) in comparison to XULANE patch in healthy female volunteers.
- Trial name
- NCT04624867
- Testing
- HP-1050 Patch
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Noven Pharmaceuticals, Inc.
Irritation/Irritant, Sensitisation
Human Skin Safety Testing of 6 Mitopure Topical Products Using a Human Repeat Insult Patch Test (HRIPT) in Healthy Volunteers
The objective of this study is to investigate the irritation and sensitization potential of 6 different topically applied test articles containing Mitopure in a shared panel of healthy volunteers by means of repeated cutaneous…
- Trial name
- GLOW-Safety-3 (NCT07100912)
- Testing
- Mitopure Topical Formula 5, Mitopure Topical Formula 6, Mitopure Topical Formula 7
- Where
- United Kingdom
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Amazentis SA