Clinical trials: Sensitization
Oral Manifestations
Oral Irritation Study of Two Experimental Mouthrinses
This study is 25 days long. People participating in this study will be asked to brush their teeth two times a day. People will be assigned to a mouthwash and will rinse four times a day at the site for five days.
- Trial name
- NCT01156376
- Testing
- Potassium Oxalate without Fluoride, Potassium Oxalate with Fluoride, Active Comparator PO-116-A
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Back Pain Lower Back Chronic
Effectiveness of a Psychoeducative Intervention on Patients With Cronic Low Back Pain
One of the treatment modalities currently available in this hospital to treat this type of patients with low back pain who present with chronic pain are the group sessions that are carried out to provide information to the…
- Trial name
- PNE (NCT03964389)
- Testing
- Pain Neuroscience Education" (PNE)
- Where
- Spain
- Volunteers
- 179 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Rotator Cuff Lesion, Subacromial Impingement Syndrome
Investigation of the Effect of Central Sensitization Symptom Severity on Steroid Injection Results in Shoulder Pain
The aim of this study was to investigate the effect of the presence and severity of pre-treatment central sensitization on the results of subacromial/ intra-articular shoulder injection in patients with rotator cuff…
- Conditions
- Rotator Cuff Lesion, Subacromial Impingement Syndrome, Shoulder Pain, Chronic Pain
- Trial name
- NCT06404125
- Testing
- Range of Motion of Shoulde Joint, Hand Grip Test, Numeric Rating Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Central Sensitisation
Differences in Pain Processing Between Men and Women
Many chronic pain conditions show clear differences between between men and women, such as reported pain intensities or treatment effects, with chronic pain conditions being generally more frequent in women.
- Trial name
- NCT05031286
- Testing
- Cutaneous thermal stimuli
- Where
- Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Pregnancy Related
Human Anti-D (rh) Immunoglobulin (Rhesoglobin) Efficacy, Safety and Some Pharmacokinetics Parameters in Pregnant Women
Rhesus conflict between mother and fetus is due to the different antigenic composition of erythrocytes. During the first pregnancy, sensitization of the mother to fetal erythrocytes rhesus D (RhD) antigens is formed.
- Trial name
- NCT05245734
- Testing
- Human Anti-D (rh) immunoglobulin
- Where
- 16 sites in Ukraine
- Volunteers
- 281 people
- Sponsor
- Biopharma Plasma LLC
Migraine, Worker Health
Central Sensitization, Work-Related Stress, and Musculoskeletal Symptoms in Desk-Based Workers With and Without Migraine
Migraine is a common neurological disease causing significant disability worldwide, with an estimated global prevalence of 14.4%.
- Conditions
- Migraine, Worker Health, Sensitization, Musculoskeletal Pain
- Trial name
- NCT07554664
- Where
- Turkey (Türkiye)
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Bozok University
Allergy;Food
Relevance of Sensitization to Legumes in Children Allergic to Peanut
The objectives of this study are to determine in children allergic to peanut (i) the prevalence of sensitization to other legumes, (ii) the prevalence of allergy to each legume in patients who are sensitized to it (iii ) the…
- Trial name
- NCT04329078
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
Food Allergy
Prevalence of Food Allergies to Proteins From Different Legumes
The objective of the study is to assess the prevalence of a sensitization to proteins from legumes by skin prick test using commercial extracts (peanut, soy, and pea) and raw material (lupin) in atopic and healthy subjects.
- Trial name
- NCT01728168
- Where
- Germany
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of Jena
Scales, Repression-Sensitization, Anesthesia Awareness
Adaptation of Perioperative Satisfaction Scale in Regional Anesthesia and Investigation of Its Psychometric Properties
The aim of the study is to determine the psychometric properties of Perioperative Satisfaction Scale in Regional Anesthesia. In the Turkish version of the scale, a blind reverse translation method will use.
- Trial name
- NCT04009018
- Testing
- Perioperative Satisfaction Scale in Regional Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Ömer Faruk Boran
Fibrous Dysplasia of Bone, McCune Albright Syndrome
PAINDYS_Characterizing Pain in Fibrous Dysplasia of Bone/McCune-Albright Syndrome: an Exploratory Pilot Study
Fibrous dysplasia of bone (FD) / McCune-Albright syndrome (MAS) is a rare congenital bone disorder affecting one or multiple bones, caused by a mosaic somatic mutation of the GNAS gene.
- Trial name
- PAINDYS (NCT07476768)
- Testing
- Visit 1 at the center
- Where
- France
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Fibromyalgia Syndrome, Central Sensitisation
Investigation of the Relationship Between Central Sensitization and Balance in Fibromyalgia
The aim of the study is to investigate the relationship between central sensitization parameters and changes in static and dynamic balance in patients with fibromyalgia.
- Conditions
- Fibromyalgia Syndrome, Central Sensitisation, Postural Balance
- Trial name
- NCT06851091
- Testing
- Biodex Balance System, Pressure Pain Threshold (PPT) Measurement with Algometer, Conditioned Pain Modulation (CPM)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Dysmenorrhea, Menstrual Pain
Non-Steroidal Anti-Inflammatory Drug (NSAID) Response and Central Sensitization of Pain in Women With Dysmenorrhea
Menstrual pain is the most common gynecological complaint and the leading cause of school and work absences in reproductive-age girls and women.
- Conditions
- Dysmenorrhea, Menstrual Pain, Non-steroidal Anti-inflammatory Drug
- Trial name
- NCT05900336
- Testing
- Sodium Naproxen
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Osteoarthritis
Effects of Duloxetine on Pain Relief After Total Knee Arthroplasty in Central Sensitization Patient
This study aims to compare the effectiveness of duloxetine after total knee arthroplasty in Central sensitization patient. Central sensitization plays an important role in the chronic pain experienced by osteoarthritis…
- Trial name
- NCT02600247
- Testing
- Duloxetine, celecoxib, Pregabalin, acetaminophen/tramadol, oxycodone
- Volunteers
- 100 people
- Sponsor
- The Catholic University of Korea
Chronic Beryllium Disease (CBD), Beryllium Sensitization (BeS)
The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD)
Current studies suggest that alveolar macrophages (AM) act as silencers of most immune responses in the lung. However, in pathological conditions, such as asthma, hypersensitivity pneumonitis, and sarcoidosis, AMs become involved…
- Trial name
- NCT02596347
- Testing
- Blood draw, bronchoscopy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Jewish Health
Chronotype, Fibromyalgia Syndrome
Evaluation of Chronotype and Central Sensitization in Patients With Fibromyalgia Syndrome
The aim of study is to examine the chronotype preferences of patients with fibromyalgia syndrome and the relationship between central sensitization and chronotype, and to examine its relationship with pain intensity, disability…
- Trial name
- NCT06197087
- Testing
- cross-sectional observational survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Oğuzhan Kandemir
Contact Dermatitis, Sensitization Dermatitis
Prevention of Dermatitis in Epoxy Exposed Workers
The risk of sensitization and contact dermatitis among workers exposed to epoxy resin systems (ERS) is high despite extensive preventive efforts, probably because skin exposure is often left unrecognized.
- Trial name
- NCT03705182
- Testing
- Fluorescence visualization (feedback)
- Where
- Denmark
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Fibromyalgia
Daily Symptom Fluctuations and Functional Impact in Fibromyalgia
Fibromyalgia is a chronic condition that commonly causes widespread pain, fatigue, and difficulty in daily activities. These symptoms may change from day to day, even when their average severity is similar.
- Trial name
- NCT07826520
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Mardin Artuklu University
Posttraumatic Stress Symptom, Central Sensitization
Central Sensitization Syndromes and Post-Traumatic Stress in Women: Psychological Profile and Intervention
Central Sensitivity Syndromes (CSSs) are a group of conditions that are highly prevalent, particularly among women, and often occur alongside post-traumatic stress disorder (PTSD).
- Conditions
- Posttraumatic Stress Symptom, Central Sensitization, Chronic Pain Syndrome
- Trial name
- SINSENTRA (NCT07313280)
- Testing
- CSS-PTSD psychological interventions
- Where
- 3 sites in Spain
- Volunteers
- 12 people
- Sponsor
- University of Malaga
Knee Osteoarthritis
Neurofeedback for Pain Sensitization in Knee Osteoarthritis
The goal of this clinical trial is to learn whether a training method called neurofeedback is safe and practical to use in people with knee osteoarthritis (knee OA).
- Trial name
- NCT07832682
- Testing
- FWR Down-Conditioning Neurofeedback
- Volunteers
- 50 people
- Sponsor
- Northeastern University
Postoperative Pain
Effect of Perioperative Hypothermia on Postoperative Pain
This study aims to observe the impact of perioperative body temperature on postoperative pain and pain sensitization for the patients with laparoscopic surgery.
- Trial name
- NCT05681091
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University