Clinical trials: Sentinel Nodes
Lung Cancer
SLN Detection With Tc-MSA-ICG in Lung Cancer Patients
It is necessary to develop a technique of sentinel lymph node detection using radioactive fluorescent dual contrast agent consisting targetable albumin for specific marker to accurately determine whether or not the sentinel lymph…
- Trial name
- NCT05039905
- Testing
- 99mTc-MSA-ICG
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Korea University Guro Hospital
Melanoma, Head and Neck Cancer
Evaluation of Intraoperative Usage of Sentinella in Detecting Sentinel Lymph Nodes
The aim of this study is to investigate whether the Sentinella camera improves intraoperative detection and removal of sentinel lymph nodes (SLNs) when used in conjunction with standard detection methods.
- Conditions
- Melanoma, Head and Neck Cancer, Breast Cancer
- Trial name
- NCT02416336
- Testing
- Sentinella Intraoperative imaging protocol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oncovision Inc
Endometrial Cancer
Pelvic Sentinel Node Detection Using Indocyanine Green Learning Curve
According to ESGO-ESTRO-ESMO guidelines, pelvic Sentinel lymph node detection is suitable for lymph node staging in endometrial carcinoma of the uteri.
- Trial name
- ENDO-GREEN (NCT04958278)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Breast Neoplasm, Neoadjuvant Therapy
RISAS Procedure in Node Positive Breast Cancer Following NAC
Chemotherapy in clinically node positive breast cancer patients is increasingly administrated in a neoadjuvant setting. The standard treatment regimen in these cases is then: neoadjuvant chemotherapy (NAC) followed by breast…
- Conditions
- Breast Neoplasm, Neoadjuvant Therapy, Axillary Lymph Nodes, Pathological Complete Response
- Trial name
- RISAS (NCT02800317)
- Testing
- RISAS
- Where
- 14 sites in Netherlands
- Volunteers
- 248 people
- Sponsor
- Erasmus Medical Center
Thyroid Cancer, Lymph Node Metastasis
The Usefulness of Staining Lymph Nodes During Operations for Cancer Thyroid in Detecting the Nodes That Have Cancer
Detection of lymph nodes starting to be involved by cancer spreading from the thyroid gland during operation is useful. It saves the patient from having a second operation to remove these nodes later on when they become obvious.
- Trial name
- NCT00794053
- Testing
- detecting lymph node metastasis by staining
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- University of Alexandria
Cervical Cancer
Analysis of Parametrial Lymph Nodes as Sentinel Nodes in Patients With Cervical Cancer
The goal of this clinical research study is to find out if the parametrial nodes are "sentinel" nodes (the lymph nodes believed to be the greatest risk for the spread of cancer) and if intraoperative lymphatic mapping can…
- Trial name
- NCT00631241
- Testing
- Single Photon Emission Computed Tomography, Intraoperative Lymphatic Mapping
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Technetium Tc 99m Sulfur Colloid and Blue Dye In Detecting Sentinel Lymph Nodes in Patients With Breast Cancer
RATIONALE: It is not yet known whether injecting technetium Tc 99m sulfur colloid and blue dye near the tumor is more effective than injecting them near the nipple in identifying sentinel lymph nodes in patients with stage I or…
- Trial name
- NCT00052676
- Testing
- patent blue V dye, radionuclide imaging, sentinel lymph node biopsy
- Where
- 7 sites in France
- Sponsor
- Centre Paul Strauss
Germ Cell Tumor of Testis
Sentinel Node Identification Using Gamma and Near-Infrared Imaging in TesticulAr MaLignancies
Testicular seminoma is a malignant tumor with a very high probability of cure. Current treatment approaches provide excellent long-term cancer outcomes.
- Trial name
- SIGNAL (NCT07777887)
- Testing
- Standard treatment: orchiectomy followed by drug therapy and, if necessary, retroperitoneal lymphadenectomy, sentinel lymph node mapping using technetium-99m (Tc-99m) and indocyanine green (ICG) with subsequent orchiectomy
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Breast Cancer
Hybrid Gamma Camera in Breast Surgery
A novel hand held hybrid optical-gamma camera (hereinafter referred to as the "camera") has been developed and can be used to image radiotracer distribution at the patient bedside.
- Trial name
- HICAM (NCT02621099)
- Testing
- Hybrid optical-gamma imaging
- Where
- United Kingdom
- Sponsor
- University of Nottingham
Melanoma
Multicenter Selective Lymphadenectomy Trial (MSLT)
Subjects must be diagnosed with melanoma. All subjects receive Wide Excision (WEX) of their melanoma. If the melanoma meets study requirements, the subject is randomized to receive either (1) no further surgical procedures as…
- Trial name
- NCT00275496
- Testing
- Sentinel Lymph Node Dissection, Complete Lymph Node Dissection, Wide Excision
- Volunteers
- 2,001 people
- Sponsor
- Saint John's Cancer Institute
Malignant Melanoma
Sentinel Node With Ultrasound Contrast in Melanoma
The purpose is to evaluate,in 20 patients, if the sentinel node(s) in melanoma can be detected by lymph contrast ultrasound. In comparing the patients will also get lymph-scintigraphy and sentinel node detection wiht blue dye.
- Trial name
- NCT00370136
- Testing
- ultrasound contrast
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Melanoma
Pilot Study of IFN α2b for Melanoma Patients
The presence of malignant cells in lymph nodes is a critical parameter in the staging of melanoma cancer patients. Assessment of lymph nodes is currently done by histopathology alone.
- Trial name
- NCT00871533
- Testing
- IFNα2b, PEG- IFNα2b
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Vulvar Cancer
Indocyanine Green for Detection of Sentinel Lymph Nodes In Comparison to ICG Plus Technetium in the Evaluation of Vulvar Squamous Cell Carcinoma
The aim of this study is to confirm prospectively if the use of near infrared-indocyanine green (NIR-ICG) alone offers similar accuracy and sensitivity to the gold standard dual technique for sentinel lymph node detection in…
- Trial name
- IGNITE-V (NCT06039111)
- Testing
- ICG alone
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Breast Cancer
Sentinel Lymph Node Biopsy With or Without Para-Sentinel Lymph Node Dissection in Breast Cancer
Sentinel lymph node biopsy（SLNB） is an established way of predicting axillary nodal metastasis in early breast cancer. We aim to determinethe，in a prospective randomized, controlled trial, effect of sentinel lymph node biopsy…
- Trial name
- NCT02651142
- Testing
- Patients receive SLNB
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shandong University
Head Cancer, Neck Cancer
Study Comparing Lymphoseek® vs. Albumin Nanocolloid in Head and Neck, Melanoma and Breast Cancer
Comparison of the concordance of albumin nanocolloid and Lymphoseek® in the detection of lymph nodes of primary and secondary stage drainage by performing two lymphogammagrams
- Conditions
- Head Cancer, Neck Cancer, Melanoma, Breast Cancer
- Trial name
- SENTINELSEEK (NCT04261179)
- Testing
- Lymphoseek, Nanocoll
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Anna Cruceta
Breast Cancer, Sentinel Lymph Node
Dynamics and Tracer Distribution of Tilmanocept in Early Stage Breast Cancer
A sentinel node procedure is recommended for patients with early stages of breast cancer to exclude metastases to local lymph nodes.
- Trial name
- NCT04487912
- Testing
- Tilmanocept, Nanocolloid
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Sentinel Lymph Node, Melanoma (Skin)
SPY-X: A Study to Assess the Feasibility of Using SPY Alone for Sentinel Node Localization for Melanoma or Breast Cancer
The objective of this study is to determine if fluorescence lymphangiography can be used alone to localize sentinel nodes in patients with melanoma or breast cancer.
- Conditions
- Sentinel Lymph Node, Melanoma (Skin), Breast Cancer
- Trial name
- SPYX (NCT03294330)
- Testing
- IC-Green KIT
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Milton S. Hershey Medical Center
Breast Cancer
Role of Indocyanine Green (ICG) for Detection of Sentinel Nodes in Breast Cancer
This is a single-center prospective study evaluating the diagnostic performance and safety of Infracyanine in women with early breast cancer whose the research of sentinel node(s) combines isotopes and Infracyanine.
- Trial name
- NCT02875626
- Testing
- Infracyanine
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie
Breast Cancer
Prognostic Study of Sentinel Lymph Node and Bone Marrow Metastases in Women With Stage I or Stage IIA Breast Cancer
RATIONALE: Biopsy of sentinel lymph nodes and bone marrow may improve the ability to detect and determine the extent of cancer. PURPOSE: Phase III prognostic study of sentinel lymph node metastases and bone marrow metastases in…
- Trial name
- NCT00003854
- Testing
- immunohistochemistry staining method, lymphangiography, sentinel lymph node biopsy
- Where
- 116 sites in United States, Australia and 1 more
- Volunteers
- 4,590 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Ovarian Cancer, Adnexal Mass
ICG-Enabled Mapping of Ovarian Sentinel Lymph Nodes: A Feasibility Study
The purpose of this study is to find out how well ovarian sentinel lymph nodes (SLNs) can be identified with indocyanine green (ICG) dye during risk-reducing ovarian surgery.
- Trial name
- NCT04051502
- Testing
- Method 1: Indocyanine green dye, Method 2: Indocyanine green dye, Method 3: Indocyanine green dye
- Where
- 7 sites in United States
- Volunteers
- 48 people
- Sponsor
- Memorial Sloan Kettering Cancer Center