Clinical trials: Sentinel Nodes
Breast Cancer, Breast Neoplasms
Axillary Management After Neoadjuvant Chemotherapy
The standard treatment for locally advanced and node-positive breast cancer is surgery following neoadjuvant chemotherapy (NAC).
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Cancer Female
- Trial name
- NCT06096545
- Testing
- Axillary sentinal lymph node biopsy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Medipol University
Breast Cancer, Sentinel Lymph Node
Sentinel Lymph Node Localisation With an Ultra-low Dose of Magtrace in Breast Cancer Patients
The overall aim is to demonstrate that the use of superparamagnetic iron oxide nanoparticles (SPIO) as a tracer in an ultra-low dose (0.1 ml) is non-inferior for sentinel lymph node (SLN) detection in patients with breast cancer…
- Trial name
- MagSnow2 (NCT06169072)
- Testing
- Superparamagnetic Iron Oxide, Technetium99
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Vastra Gotaland Region
Early-stage Upper Gastrointestinal Cancer, Stomach Cancer, Adenocarcinoma
Clinical Study on Using Laparoscopic Sentinel Lymph Node Navigation Combined With Dual Endoscopy Surgery for Early Gastric Cancer
Gastric cancer is a common malignant tumour worldwide, and in China, the incidence and mortality rates of gastric cancer remain high.
- Conditions
- Early-stage Upper Gastrointestinal Cancer, Stomach Cancer, Adenocarcinoma, Laparoscopy-assisted Surgery, Endoscope
- Trial name
- NCT07708012
- Testing
- Combined double-scope surgery
- Where
- 2 sites in China
- Volunteers
- 9 people
- Sponsor
- wangdongsheng
Sentinel Lymph Node Biopsy, Locoregional Neoplasm Recurrence
SLNB After Neoadjuvant Treatment in Node Positive Patients
From May 2016 till May 2018 all breast cancer patients with operable disease submitted to surgery after neoadjuvant treatment would be divided in four groups considering initially clinical axillary stage, axillary procedure that…
- Conditions
- Sentinel Lymph Node Biopsy, Locoregional Neoplasm Recurrence, Progression, Disease
- Trial name
- NCT03833960
- Volunteers
- 65 people
- Sponsor
- Clinical Hospital Center Rijeka
Recurrent Melanoma
Lymph Node Mapping Using Indocyanine Green Solution in Diagnosing Patients With Malignant Melanoma
This clinical trial compares and contrasts lymph node mapping using indocyanine green (IC-GREEN), isosulfan blue (ISB), and TSC and Lymphoscintigraphy with 99-technetium (99Tc) sulfur colloid (TSC).
- Trial name
- NCT01898403
- Testing
- Indocyanine green solution, Isosulfan blue (ISB), Lymphoscintigraphy with 99-technetium (99Tc) sulfur colloid (TSC)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Sentinel Lymph Node, Ovarian Carcinoma
Sentinel Lymph Node Biopsy in Early-Stage Ovarian Cancer
The primary goal of this prospective study is to define the efficacy of the sentinel lymph node biopsy (SLNB) procedure by comparing it to the results obtained from systematic lymphadenectomy, each performed in participants with…
- Trial name
- NCT05927818
- Testing
- Sentinel lymph node biopsy (using sterile charcoal stain) in early ovarian cancer
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Breast Cancer
Sentinel Lymph Node Biopsy and Primary Tumor Gene Expression Profiling in Finding Axillary Lymph Node Metastases in Women Who Have Received Neoadjuvant Therapy for Stage II, Stage III, or Stage IV Breast Cancer
RATIONALE: Sentinel lymph node biopsy and gene expression profiling of the primary breast tumor may help determine if tumor cells have spread to the axillary lymph nodes and help doctors plan more effective surgery for breast…
- Trial name
- NCT00080860
- Testing
- microarray analysis, immunohistochemistry staining method, conventional surgery
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Stomach Neoplasm
ICG-NIR Guided Lymph Node Dissection in Gastric Cancer
As the survival rate of patients with gastric cancer has increased, there has been a growing interest in interventions that improve postoperative quality of life.
- Trial name
- NCT04056260
- Testing
- ICG-NIR guided surgery
- Volunteers
- 219 people
- Sponsor
- Ho Seok Seo
Cutaneous Melanoma, Melanoma
Sonazoid-Enhanced Ultrasound in Detecting Sentinel Lymph Node in Patients With Cutaneous Melanoma
This pilot phase I trial studies how well sonazoid-enhanced ultrasound works in detecting sentinel lymph node in patients with cutaneous melanoma.
- Trial name
- NCT02968680
- Testing
- Sentinel Lymph Node Biopsy, Ultrasonography, Sonazoid
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Southern California
Breast Cancer by AJCC V8 Anatomic Stage, Breast Cancer
De-escalation of Axillary Dissection for Node-positive Breast Cancer
Recent studies have demonstrated the safety of de-escalation of nodal surgery for clinically node-positive breast cancer patients after a favorable response to neoadjuvant systemic therapy (NST).
- Trial name
- NCT07856160
- Testing
- TAD+ALND
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Cervical Cancer Stage IB1
Carbon Nanoparticles and Indocyanine Green for Sentinel Lymph Node Biopsy in Early Stage Cervical Cancer
The metastasis rate of pelvic lymph node in early cervical cancer is low. Systemic lymph node resection is traumatic and has many complications.
- Trial name
- NCT05167149
- Testing
- Carbon nanoparticles, Indocyanine green
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Axillary Web Syndrome, Breast Cancer
Axillary Web Syndrome After Breast Cancer Surgery: Incidence, Risk Factors, and Functional Outcomes
Axillary web syndrome (AWS), sometimes called "cording," is a condition that can develop after breast cancer surgery in which the lymph nodes under the arm are removed or sampled.
- Conditions
- Axillary Web Syndrome, Breast Cancer, Breast Cancer Lymphedema, Postoperative Complications
- Trial name
- NCT07780240
- Testing
- Axillary surgery (sentinel lymph node biopsy or axillary lymph node dissection)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Antalya City Hospital
Breast Cancer Female, Early-Stage Breast Cancer
Methylene Blue Intradermal Injection for Sentinel Lymph Node Biopsy for Breast Cancer Patients
This study is designed to compare the effectiveness of intradermal injection and subcutaneous injection with methylene blue for early-stage breast cancer patients who need sentinel lymph node biopsy.
- Conditions
- Breast Cancer Female, Early-Stage Breast Cancer, Sentinel Lymph Node
- Trial name
- NCT02982148
- Testing
- methylene blue intradermal injection, methylene blue subcutaneous injection
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Uterine Cervical Neoplasms
A Trial of Comparing the Pathology Status of Lymphoseek®-Identified Sentinel Lymph Nodes Relative to the Pathological Pathology Status of Nonsentinel Lymph Nodes in Nodal Staging of Subjects With Known Cancer of the Cervix Who Are Undergoing Lymph Node Dissection
Prospective, open-label, within-patient, multi-center study of Lymphoseek in the detection of lymph nodes in subjects with known cancer of the cervix.
- Trial name
- NCT02509585
- Testing
- Tc99m tilmanocept
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Cardinal Health 414, LLC
Colonic Neoplasms, Sentinel Lymph Node
Fluorescent Sentinel Lymph Node Identification in Colon Carcinoma Using Submucosal Bevacizumab-800CW.
This prospective study aims to assess the safety and feasibility of lymph node identification using bevacizumab-800CW in patients with cT1-3N0-2 tumours, using peritumoral submucosal injections
- Conditions
- Colonic Neoplasms, Sentinel Lymph Node, Fluorescence, Colorectal Neoplasms
- Trial name
- IBIZA-1 (NCT05498051)
- Testing
- Sentinel lymph node identification
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Meander Medical Center
Melanoma (Skin)
MR Lymphography and Magnetic Sentinel Lymph Node Biopsy in Melanoma Patients
The sentinel lymph nodes (SLNs) are the first lymph nodes (LNs) to drain the tumor site and therefore the first LNs to bare metastases. Hence the importance to investigate these LNs for the best treatment strategy.
- Trial name
- MelaDiff (NCT05569707)
- Testing
- Magnetic sentinel lymph node biopsy by use of Magtrace®, in combination with SentiMag® and DiffMag
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- University of Twente
Gynaecological Malignant Tumours With Indication of Pelvic Lymphadenectomy
Lower-Limb Drainage Mapping in Pelvic Lymphadenectomy for Gynaecological Cancer
The purpose of this study is to evaluate the feasibility of an isotopic technique to identify, and to map the lower-limb drainage nodes during pelvic lymphadenectomy for gynaecological cancers.
- Trial name
- SENTIJAMBE (NCT01946672)
- Testing
- Lower-limb drainage isotopic intraoperative detection
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer
OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer
RATIONALE: Studying protein expression in sentinel lymph node tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT00900302
- Testing
- protein expression analysis, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- OHSU Knight Cancer Institute
Breast Cancer, Radiotherapy
Level I-II Axillary Irradiation in Breast Cancer With Sentinel-Node Macro-metastases
The RELAX trial is an open-label, multicenter, non-inferiority, randomized, phase 3 clinical trial. Multiple randomized trials have demonstrated the safety of omitting complete axillary-lymph-node dissection in patients with…
- Trial name
- RELAX (NCT07469267)
- Testing
- Entire regional nodal irradiation, Level I-II axillary irradiation
- Where
- 15 sites in China
- Volunteers
- 1,608 people
- Sponsor
- Fudan University
Breast Cancer
Evaluation Of Lymph Nodes After Neoadjuvant Chemotherapy
This research protocol is studying the accuracy of the sentinel lymph node biopsy procedure in breast cancer patients who have cancer cells in the lymph nodes in the armpit (axilla) who have received chemotherapy or endocrine…
- Trial name
- NCT02752009
- Testing
- Axillary Lymph Node Sampling Clip
- Sponsor
- Dana-Farber Cancer Institute