Clinical trials: Sentinel Nodes
Sentinel Lymph Node Biopsy, Breast Cancer
A Study to Find the Best Dose of ASP5354 to Show Lymph Nodes in People With Breast Cancer or Melanoma During Surgery
This study was for women with breast cancer and for adults with melanoma. Breast cancer was a type of cancer when cells in the breast turn into cancer cells, which might grow out of control.
- Conditions
- Sentinel Lymph Node Biopsy, Breast Cancer, Melanoma
- Trial name
- NCT05457842
- Testing
- pudexacianinium chloride
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Astellas Pharma Inc
Breast Cancer, Estrogen-receptor-positive Breast Cancer
Electronic Medical Record-Based Nudge to Reduce SLNB
The goal of this prospective, historically-controlled, quality improvement project is to determine whether and to what extent an electronic health record (EHR)-based nudge affects rates of sentinel lymph node biopsy (SLNB) in…
- Trial name
- NCT06006910
- Testing
- Column-based nudge in the EHR, No column-based nudge in the EHR
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pittsburgh Medical Center
Breast Cancer
Internal Mammary Sentinel Lymph Node Biopsy in Early Breast Cancer Patients With Clinically Axillary Node -Negative
In addition to the axillary lymph node, the internal mammary lymph node (IMLN) chain is also the first-echelon nodal drainage site for metastasis and provides important prognostic information in breast cancer patients.
- Trial name
- IMSLNB-EBCP (NCT01642511)
- Testing
- 99mTc-labeled Sulfur Colloid, Axillary Sentinel Lymph Node Biopsy, Methylthioninium
- Where
- China
- Volunteers
- 407 people
- Sponsor
- Shandong Cancer Hospital and Institute
Laparoscopic Hysterectomy and Sentinel Lymph Node Biopsy
Complications of Laparoscopic Hysterectomy and Sentinel Lymph Node Biopsy for Endometrial Carcinoma
Endometrial adenocarcinoma is believed to be a more treatable malignancy. Poor prognosis is associated with age, grade and depth of myometrial invasion, lymph node status, tumor size, invasion of lymphovascular space and…
- Trial name
- NCT04894552
- Testing
- Laparoscopic Hysterectomy and Sentinel Lymph Node Biopsy for Endometrial Carcinoma
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams Maternity Hospital
Cancer
Fluorescein for Lymphatic Mapping and Sentinel Lymph Node (SLN) Biopsy in Patients With Stage I and II Malignant Melanoma
The purpose of this research study is to use two different drugs to find where melanoma might spread and to remove these tissues.
- Trial name
- NCT00847522
- Testing
- Fluorescein
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Utah
Invasive Breast Cancer
Evaluation of an Integrated Imaging System For In Vivo Detection of Fluorescently Labeled Lesions
This is a pilot study to test and characterize the ability of the Smart Goggles system to detect fluorescently labeled sentinel lymph nodes (SLNs).
- Trial name
- NCT02802553
- Testing
- Smart Goggle, Cardio-Green, SPY Elite Imaging system
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Safety and Efficacy of Omission of Sentinel Node Biopsy in Patients With Estrogen-Positive Breast Cancer Over Age 65
This study will examine the outcomes of lumpectomy, surgery to remove a tumor, without sentinel node biopsy (SNB) for women at least 65 years of age with clinically node-negative breast cancer.
- Trial name
- NCT02564848
- Testing
- Lumpectomy without sentinel node biopsy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cedars-Sinai Medical Center
Breast Cancer
Sentinel Lymph Node Biopsy With Superparamagnetic Iron Oxide for Breast Cancer Patients After Neoadjuvant Treatment.
The purpose of this study is to determine the detection rate and the false negative rate of sentinel lymph node (SLN) by superparamagnetic iron oxide (SPIO) alone or in addition to radioisotope and compared to the standard method…
- Trial name
- SENTINAC-01 (NCT02249208)
- Testing
- Tc+blue dye, Tc+SPIO, SPIO alone
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Sentinel Lymph Node
Sentinel Lymph Nodes Biopsy in Cervical Cancer
This study aims to compare sentinel lymph nodes biopsy versus comprehensive lymphadenectomy in patients with early stage cervical cancer who underwent radical hysterectomy.
- Trial name
- NCT06169787
- Testing
- sentinel lymph node biopsy, comprehensive pelvic lymphadenectomy
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Far Eastern Memorial Hospital
Endometrial Cancer Stage I, Sentinel Lymph Node
Sentinel Node Biopsy in Endometrial Cancer
Endometrial cancer (EC) is the most common gynaecological cancer. Current treatment of EC typically includes removal of the uterus and to determine the extent of the disease (removal of fallopian tubes, ovaries \& if required a…
- Conditions
- Endometrial Cancer Stage I, Sentinel Lymph Node, Surgery
- Trial name
- ENDO-3 (NCT04073706)
- Testing
- TH BSO with SNB Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted, TH BSO without retroperitoneal node dissection Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted
- Where
- 23 sites in United States, Argentina and 5 more
- Volunteers
- 760 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Cervical Cancer, Endometrial Cancer
Positron Lymphography Via Intracervical 18F-FDG Injection for Pre-surgical Lymphatic Mapping in Stage IB1 Cervical Cancer and High-grade Endometrial Cancer
The purpose of this study is to see if a radioactive substance called 18F-Fluorodeoxyglucose (18F- FDG), injected into the cervix during a PET/CT scan done before surgery can show us more clearly which lymph nodes in the pelvis…
- Trial name
- NCT02285192
- Testing
- 18F-Fluorodeoxyglucose (18F-FDG), PET/CT imaging, PET/MRI imaging
- Where
- 7 sites in United States
- Volunteers
- 42 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pediatric Patients With Solid Tumors
A Study Comparing Green Fluorescent Dye and Radioactive Dye for Sentinel Lymph Node Biopsy in Pediatric Cancers
This study is being done in patients that have tumors to find out how well sentinel lymph nodes (SLNs) can be found with a special dye called indocyanine green (ICG).
- Trial name
- NCT02910726
- Testing
- Sentinel Lymph Node Biopsy, indocyanine green (ICG)
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colon Cancer, Rectal Cancer
Lymphoseek® as Lymphoid Tissue Targeting Agents in Colon Cancer(CNC)
45 patients undergoing a colon (large bowel/intestine)removal operation for the diagnosis of colon cancer will be included in this study. During colon operation the affected portion of the colon is removed.
- Trial name
- NCT01902953
- Testing
- Lymphoseek and VBD Sln dissection
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Maimonides Medical Center
Ductal Carcinoma in Situ
Selective Omission of Sentinel Lymph Node Biopsy in Mastectomy for Ductal Carcinoma in Situ: Identifying Eligible Candidates
This study aimed to assess the prevalence of upgrade to invasive breast cancer and axillary lymph node metastasis in patients who were diagnosed with DCIS on biopsy and subsequently underwent mastectomy with axillary surgery to…
- Trial name
- NCT05961280
- Testing
- Mastectomy with sentinel lymph node biopsy
- Volunteers
- 385 people
- Sponsor
- Gangnam Severance Hospital
Uterine Neoplasms, Sentinel Lymph Node Biopsy
Sentinel Node Biopsy in Endometrial Cancer
The purpose of this study is to determine if there is a difference between the lymphatic drainage of the cervix and corpus of the uterus after injecting a radiocolloid in the cervix and blue dye in the corpus of the uterus and to…
- Trial name
- NCT01564264
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Hamilton Health Sciences Corporation
Gynecological Surgeries
A Real-World Study to Evaluate the Clinical Performance and Safety of da Vinci SP Surgical System for Single-Port Gynecological Surgeries(SPiM-RWS-GYN)
Study name：A Real-World Study to Evaluate the Clinical Performance and Safety of da Vinci SP Surgical System for Single-Port Gynecological Surgeries Study purpose：This clinical trial is a real-world study to evaluate the clinical…
- Trial name
- NCT06082011
- Testing
- da Vinci SP Surgical System
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Ruijin Hospital
Melanoma
Immunotherapy of Melanoma Patients
The purpose of this study is to test whether vaccination with antigenic peptides induces an immune response in the vaccine site sentinel lymph node of patients with microscopically detectable lymph node melanoma metastases.
- Trial name
- NCT00112216
- Testing
- Melan-A analog peptide, FluMa peptide, Mage-A10 peptide
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Breast Cancer, Axillary Lymph Node Metastasis
A Prospective Multicenter Study of the TuFEst-LN Model for Axillary Lymph Node Status Assessment in Breast Cancer
Through the research of this project, we expect to validate the clinical utility of the TuFEst-LN model in assessing axillary lymph node status in breast cancer patients.
- Trial name
- PRO-TuFEst-LN (NCT07304934)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Head and Neck Cancer
Diagnostic Trial in Patients Who Are Undergoing Surgery for Early Stage Mouth Cancer
RATIONALE: Diagnostic procedures to detect cancer cells in sentinel lymph nodes may help plan effective cancer treatment. PURPOSE: Diagnostic trial to study the effectiveness of lymph node mapping and sentinel lymph node…
- Trial name
- NCT00042926
- Testing
- immunohistochemistry staining method, conventional surgery, lymphangiography
- Volunteers
- 161 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer
Bupivacaine vs Placebo for Unilateral Mastectomy Surgical Site Post-operative Pain Control
The purpose of this study is to compare using FDA-approved bupivacaine (a numbing medicine), along with the usual medications for post-operative pain control to using the usual medications for postoperative pain control alone.
- Trial name
- NCT03351348
- Testing
- Bupivacaine, patient-reported pain scores, saline
- Where
- 7 sites in United States
- Volunteers
- 165 people
- Sponsor
- Memorial Sloan Kettering Cancer Center