Clinical trials: Sentinel Nodes
Sentinel Lymph Node, Breast Cancer
Is Breast Massage Necessary to Find Sentinel Lymph Node?
Sentinel lymph node biopsy is important for staging in patients with breast cancer and changes the way of surgery. One of the most commonly used methods to find the sentinel lymph node during surgery is to apply blue dye around…
- Trial name
- NCT05663112
- Testing
- Sentinel lymph node biopsy, Breast massage, Blue dye injection
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Manisa Celal Bayar University
Endometrial Cancer
MCC-24-GYN-11: Comparison of Nodal Sampling in Endometrial Cancer
This study aims to estimate the recurrence-free survival rates in women with endometrial cancer treated with selective versus sentinel node surgical staging.
- Trial name
- NCT06677112
- Testing
- Selective surgical staging, REFLEX
- Where
- United States
- Volunteers
- 625 people
- Sponsor
- Rachel Miller
Breast Cancer
Role of Axillary Lymph Node Dissection for Residual MACROMETASTASES After NEOADJUVANT Chemotherapy in Patients With HER2+ and Triple Negative Breast Cancer: The OPBC-11/MACRONAC Study
In this multicenter retrospective cohort study the aim is to determine the safety of omission of axillary lymph node dissection in patients with TNBC and HER2+ tumors with residual macrometastases (in the SLN/TAD/TAS or MARI…
- Trial name
- MACRONAC (NCT07546695)
- Testing
- Data Collection from medical records of from an already existing database "ONCOLOGICAL BREAST SURGERY DATABASE OF THE UNIVERSITY HOSPITAL OF BASEL" which was initiated in 2016.
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- University Hospital, Basel, Switzerland
Ovarian Cancer, Adnexal Mass
ICG-Enabled Mapping of Ovarian Sentinel Lymph Nodes: A Feasibility Study
The purpose of this study is to find out how well ovarian sentinel lymph nodes (SLNs) can be identified with indocyanine green (ICG) dye during risk-reducing ovarian surgery.
- Trial name
- NCT04051502
- Testing
- Method 1: Indocyanine green dye, Method 2: Indocyanine green dye, Method 3: Indocyanine green dye
- Where
- 7 sites in United States
- Volunteers
- 48 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Axillary Sentinel Lymph Node Detection in Breast Cancers > 2 cm
The purpose of this study is to evaluate the quality criteria of the SLN detection technique in breast cancer patients with a tumor size (clinical measurement) greater than 2 centimeters (rate of false negatives, rate of…
- Trial name
- GAS2PLUS (NCT00636467)
- Testing
- No name
- Where
- 22 sites in France
- Volunteers
- 249 people
- Sponsor
- Centre Leon Berard
Early-Stage Breast Carcinoma
Surgical Trial to Evaluate the Impact of a Lymphoscintigraphy Prior to Sentinel Node Biopsy in Early Breast Cancer
Sentinel node biopsy is a well established tool for axillary staging in early breast cancer. So far the impact of a preoperative lymph node scintigraphy is unclear.
- Trial name
- NCT02481128
- Testing
- without preoperative access to lymphoscintigraphy findings
- Where
- 23 sites in Germany, Switzerland
- Volunteers
- 1,198 people
- Sponsor
- Kliniken Essen-Mitte
Colorectal Neoplasms, Colon Neoplasm
Fluorescent Sentinel Lymph Node Identification in Colon Carcinoma Using Intravenous Bevacizumab-800CW
This prospective study aims to assess the safety and feasibility of lymph node identification using bevacizumab-800CW in patients with cT1-3N0-2 tumours, using intravenous administration.
- Conditions
- Colorectal Neoplasms, Colon Neoplasm, Sentinel Lymph Node, Fluorescence
- Trial name
- IBIZA-2 (NCT05497726)
- Testing
- Sentinel lymph node detection using intravenous bevacizumab-800CW
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Meander Medical Center
Cervical Cancer
Robot-assisted Approach to Cervical Cancer
The purpose of the RACC trial is to compare the oncologic outcome defined as recurrence-free survival (RFS) between robot-assisted and open radical hysterectomy for the treatment of early stage cervical cancer.
- Trial name
- RACC (NCT03719547)
- Testing
- Abdominal radical hysterectomy, Robot-assisted radical hysterectomy, Sentinel lymph node biopsy
- Where
- Sweden
- Volunteers
- 800 people
- Sponsor
- Karolinska Institutet
Endometrial Neoplasms
Sentinel Lymph Node Mapping In Endometrial Cancer
Lymph node assessment provides the crucial information about the prognosis of endometrial cancer. Sentinel lymph node stands in the first station on the lymph node metastasis pathways.
- Trial name
- SLNMIEC (NCT03778255)
- Testing
- Sentinel Lymph Node Biopsy
- Where
- China
- Volunteers
- 635 people
- Sponsor
- Peking University People's Hospital
Endometrial Cancer, Sentinel Lymph Node
Tracers for Endometrial Cancer Sentinel Node Labeling
Sentinel lymph node (SLN) biopsy is currently used in the management of vulvar and breast cancers as well as in malignant melanoma, and is being intensively studied in patients with cervical and endometrial cancers.
- Trial name
- TESLA-1 (NCT04665544)
- Testing
- SLN side-specific detection rate using radioactive tracer with/without blue dye and ICG tracer.
- Where
- 6 sites in Czechia, Poland and 1 more
- Volunteers
- 83 people
- Sponsor
- University Medical Centre Maribor
Colon Cancer, Sentinel Lymph Node
Minimally INvasive Colon Cancer Surgery Through IMmunomics and Optical Mapping of the Sentinel Lymph Node.
The project investigates the feasibility of laparoscopic fluorescent imaging for the intraoperative detection of the sentinel lymph node (SLN) in colon cancer patients.
- Trial name
- MINIMAL (NCT03779009)
- Testing
- ICG-nanocoll (indocyanine green coupled to the human albumin colloidal particle nanocoll)
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
Breast Cancer, Sentinel Lymph Node
Artificial Intelligence Analysis of Fluorescence Image to Intraoperatively Detect Metastatic Sentinel Lymph Node.
The purpose of this study is to analysis the fluorescence image of the breast sentinel lymph node (SLN) using Indocyanine green (ICG).
- Trial name
- NCT05623280
- Testing
- Indocyanine green
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xiang'an Hospital of Xiamen University
Breast Cancer
Feasibility of Ultrasound Microbubble Contrast-Enhanced (CEUS) Sentinel Lymph Node Imaging With Guided Biopsy in Breast Cancer Patients
The goal of this clinical research is to learn if an ultrasound contrast agent called OPTISON (perflutren protein type A) is effective in finding sentinel lymph nodes before surgery.
- Trial name
- NCT02321527
- Testing
- Perflutren Protein-Type A Microspheres Injectable Suspension, Contrast-Enhanced Ultrasound (CEUS), Biopsy + Radioactive Seed Placement
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Sentinel Lymph Node
Indocyanine Green Fluorescence-guided Sentinel Node Biopsy in Breast Cancer Within a North African Population: a Retrospective Study
Background Radio Isotopes and Blue dye alone or in combination are the most commonly used tracer agents in sentinel Node Biopsy for early breast cancer.
- Trial name
- NCT04879680
- Testing
- sentinel node detection
- Volunteers
- 47 people
- Sponsor
- Faculty of Medicine, Sousse
Cervical Cancers
Sentinel Lymph Node (SLN) Mapping with Charcoal Carbon Dye in Early Stage Cervical Cancer
The aim of the present study is to compare the efficacy of charcoal carbon dye (CCD) in sentinel lymph node mapping compared to indocyanine green (ICG) mapping regarding detection rates, sensitivity, specificity, negative and…
- Trial name
- SLN (NCT06697054)
- Testing
- Sentinel node biopsy with either ICG or carbon dye injection to cervix
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Breast Carcinoma, Breast Cancer
Omission of Axillary Lymph Node Dissection in Case of Tumor Spread to Lymph Nodes in the Armpit in Breast Cancer
SENOMAC-ULTRA enrols patients who are planned for upfront surgery for a breast cancer that has spread to lymph nodes in the armpit, and that have been detected already prior to surgery by imaging, e.g. ultrasonography.
- Conditions
- Breast Carcinoma, Breast Cancer, Breast Surgery
- Trial name
- SENOMAC-ULTRA (NCT06869629)
- Testing
- Targeted axillary dissection, Axillary lymph node dissection
- Where
- 4 sites in Finland, South Korea and 1 more
- Volunteers
- 1,380 people
- Sponsor
- Karolinska Institutet
Melanoma (Skin)
MR Lymphography and Magnetic Sentinel Lymph Node Biopsy in Melanoma Patients
The sentinel lymph nodes (SLNs) are the first lymph nodes (LNs) to drain the tumor site and therefore the first LNs to bare metastases. Hence the importance to investigate these LNs for the best treatment strategy.
- Trial name
- MelaDiff (NCT05569707)
- Testing
- Magnetic sentinel lymph node biopsy by use of Magtrace®, in combination with SentiMag® and DiffMag
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- University of Twente
Thyroid Cancer
Lateral Neck Lymph Node Mapping in Thyroid Cancer
This study includes papillary thyroid cancer patients who have unpalpable lateral neck lymph nodes but suspicious on ultrasound and/or CT. Carbon nanoparticles is used as the tracer for lateral neck lymph node mapping.
- Trial name
- NCT04312087
- Testing
- Lateral neck sentinel lymph node biopsy, Modified lateral neck lymph node dissection, Super selective lateral neck lymph node dissection
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Fudan University
Endometrial Cancer
Predictors of Node Positivity in Endometrial Cancer
To investigate the role of histological and moleculr profile of endometrial cancer patietns in predicting the risk of nodal metastases in endometrila cancer patients.
- Trial name
- NCT05793333
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Breast Cancer Lymphedema
Axillary Reverse Mapping (ARM) in Breast Cancer Surgery to Prevent Lymphedema. (ARMtrial)
Breast cancer related lymphedema (BCRL) is a debilitating and distressing condition affecting approximately one out of five breast cancer survivors.
- Trial name
- NCT03333226
- Testing
- Axillary Reverse Mapping (ARM)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University Hospital of Ferrara