Clinical trials: Sentinel Nodes
Breast Cancer
Preoperative Localization of Sentinel Lymph Node in Breast Cancer Patients By Novel Computed Tomography-Lymphography Guided Technique
A question is raised about the possibility of accurate localization of the SLN (sentinel lymph node) detected by CTLG (Computed Tomography Lymphography) which offers a detection rate of 100% in many studies In Oncology center…
- Trial name
- NCT03442543
- Testing
- preoperative localization of SLN detected by CTLG by either methods
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Cervical Cancer, Sentinel Lymph Node
TMTP1 Targeting Micro-metastasis LN in Laparoscopic SLN Detection in Cervical Cancer
Investigators aimed to determine the validity of the investigator's novel tumor targeted fluorescent peptide TMTP1-ICG to increased accuracy of laparoscopic SLN mapping
- Trial name
- NCT03549195
- Testing
- ICG, ICG-CP, ICG-TMTP1
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Breast Cancer
Use of Sentinel Lymph Node Biopsy in Patients With Early-Stage, Palpable Node-Positive HR+/HER2- Breast Cancer Having Upfront Surgery and Adjuvant Radiation
The purpose of this study is to find out how often the researchers can avoid an ALND in patients with early-stage, node-positive HR+/HER2- breast cancer who are having upfront surgery.
- Trial name
- NCT04854005
- Testing
- Breast surgery
- Where
- 10 sites in United States
- Volunteers
- 78 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colon Cancer, Lymph Node
Ex-vivo Sentinel Lymph Node in Stage I-II Colon Cancer: Kappa Analysis With Immunochemistry and Molecular Biology
Unmask Trial aims to evaluate the Kappa concordance between immunochemistry and molecular biology to detecting cancer cells in sentinel lymph node in patients undergoing colectomy for non metastatic colon cancer.
- Conditions
- Colon Cancer, Lymph Node, Sentinel Node
- Trial name
- UNMASK (NCT02861430)
- Testing
- Immunochemistry and molecular biology on sentinel lymph node specimen
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Breast Cancer
The Use of Bioimpedance to Determine Pre-Clinical Lymphedema in the Post-Operative Breast Cancer Patient
Primary Objective: To determine whether early intervention (with garment sleeve and gauntlet) in patients with pre-clinical lymphedema can halt the progression of lymphedema.
- Trial name
- L-Dex (NCT01521000)
- Testing
- Garment Sleeve
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Main Line Health
Lymphedema of Limb, Sentinel Lymph Node
Early Detection of Lower Extremity Lymphedema After Lymphadenectomy in Gynecological Cancer
This study aims to detect and treat early lower limb lymphedema secondary to lymphadenectomy with the aim of increasing the quality of life of patients with this chronic condition.
- Trial name
- NCT03917771
- Testing
- Early lymphedema detection, Usual follow-up
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Donostia
HER2-positive Breast Cancer, Stage I Breast Cancer
Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy
This is a prospective, single arm, open-label, unicenter, exploratory study in women with primary operable HER2-positive, HER2-enriched/ERBB2-high breast cancer according to PAM50 intrinsic subtype and a ERBB2 pre-defined cutoff…
- Trial name
- ELPIS (NCT04578106)
- Testing
- Trastuzumab and pertuzumab Subcutaneous Fixed-Dose Combination
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Fundacio Clinic Barcelona
Testicular Germ Cell Tumor
Sentinel Lymph Node Biopsy in Stage AI-IIA Germ Cell Tumors
The goal of this clinical trial is to evaluate the efficacy of sentinel lymph node biopsy in stage AI-IIA germ cell tumors (seminoma/nonseminoma).
- Trial name
- PITERLAND (NCT06133699)
- Testing
- Orchofuniculectomy with simultaneous laparoscopic biopsy of the sentinel lymph node using indocyanine green dye with/without methylene blue dye., Radiopharmaceutical administration (Technetium/methylene blue)
- Where
- Russia
- Volunteers
- 44 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Breast Cancer (Early Breast Cancer), Sentinel Lymph Node Biopsy
NAUTILUS-04: No Axillary Surgical Treatment in Low-Risk Clinically Node-Negative Breast Cancer Without Whole-Breast Radiotherapy
The safety of omitting sentinel lymph node biopsy (SLNB) has been established only in patients undergoing breast-conserving surgery with whole-breast radiotherapy, as demonstrated in the prior randomized trials.
- Trial name
- NAUTILUS-04 (NCT07841704)
- Testing
- Omission of axillary surgery, Sentinel lymph node biopsy
- Where
- South Korea
- Volunteers
- 1,520 people
- Sponsor
- Wonshik Han
Breast Cancer Female, Early-Stage Breast Cancer
Methylene Blue Intradermal Injection for Sentinel Lymph Node Biopsy for Breast Cancer Patients
This study is designed to compare the effectiveness of intradermal injection and subcutaneous injection with methylene blue for early-stage breast cancer patients who need sentinel lymph node biopsy.
- Conditions
- Breast Cancer Female, Early-Stage Breast Cancer, Sentinel Lymph Node
- Trial name
- NCT02982148
- Testing
- methylene blue intradermal injection, methylene blue subcutaneous injection
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Endometrial Cancer
Comparison of Nodal Staging in Endometrial Cancer
This study aims to estimate the recurrence-free survival rates in women with endometrial cancer treated with selective versus sentinel node surgical staging.
- Trial name
- NCT04970368
- Testing
- Sentinel node procedure, Selective staging
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Frederick R. Ueland, M.D.
Melanoma (Skin)
Interferon Alfa-2b in Treating Patients With Melanoma and Early Lymph Node Metastasis
RATIONALE: Interferon alfa-2b may interfere with the growth of cancer cells. PURPOSE: Randomized phase III trial to study the effectiveness of interferon alfa-2b in treating patients who have melanoma with early lymph node…
- Trial name
- NCT00004196
- Testing
- recombinant interferon alfa, lymphangiography, Observation
- Where
- 4 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Alabama at Birmingham
Melanoma
Evaluation of the Effects of Local Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in Adjuvant Administration on Dendritic Cells in Skin of Melanoma Patients and in Sentinel Lymph Nodes: MEL38
Goal: To characterize the cellular events that occur in vivo after vaccination with an emulsion of GMCSF-in-adjuvant. Design: Open-label, single dose study in two stages.
- Trial name
- MEL38 (NCT00912574)
- Testing
- GM-CSF-in-adjuvant, Montanide ISA-51, GM-CSF and Montanide ISA-51
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Virginia
Endometrial Cancer, Sentinel Lymph Node
Intraoperative Examination of Sentinel Node in Endometrial Cancer (TRSGO-SLN-003)
More than half of the cases with macrometastatic sentinel lymph node (SLN) have non-SLN metastasis and leaving these nodes in-situ may impair the survival.
- Trial name
- TRSGOSLN003 (NCT04560491)
- Testing
- Intraoperative examination of sentinel node
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people
- Sponsor
- Ankara University
Rectal Cancer
Feasibility Study to Develop Sentinel Lymph Node Mapping in Rectal Cancer Patients
The purpose of this study is to see if investigators can develop a technique to identify sentinel lymph nodes in the rectum for rectal cancer patients with the use of a radiotracer (Tc-sulfur colloid), a dye (Spot), and imaging…
- Trial name
- NCT02112240
- Testing
- Intraoperative Mobile Gamma Camera imaging, Endoscopic injection of 99mTc-sulfur colloid, Endoscopic injections of Spot
- Where
- United States
- Sponsor
- University of Virginia
Breast Cancer Lymphedemas
Bioelectrical Impedance Utilization and Dietary Intake Relation in the Breast Cancer Related Lymphedema
The purpose of this study was to investigate the clinical role of bioelectrical impedance analysis (BIA) and the relationship between the occurrence of breast cancer related lymphedema (BCRL) and dietary factors in breast cancer…
- Trial name
- NCT03391206
- Testing
- Inbody 720
- Where
- South Korea
- Volunteers
- 228 people
- Sponsor
- Severance Hospital
Breast Cancer
Clinical Application of Dual Sentinel Lymph Node Staining Method in Breast Cancer
This study aimed to evaluate the feasibility of dual sentinel node staining method using mixture of indocyanine green(ICG) and radioisotope (RI) in breast cancer patients who receive neoadjuvant chemotherapy.
- Trial name
- NCT02168452
- Testing
- sentinel lymph node biopsy(SLNB)
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- National Cancer Center, Korea
Axillary Web Syndrome, Breast Cancer
Axillary Web Syndrome After Breast Cancer Surgery: Incidence, Risk Factors, and Functional Outcomes
Axillary web syndrome (AWS), sometimes called "cording," is a condition that can develop after breast cancer surgery in which the lymph nodes under the arm are removed or sampled.
- Conditions
- Axillary Web Syndrome, Breast Cancer, Breast Cancer Lymphedema, Postoperative Complications
- Trial name
- NCT07780240
- Testing
- Axillary surgery (sentinel lymph node biopsy or axillary lymph node dissection)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Antalya City Hospital
Endometrial Neoplasms
Sentinel Node and Endometrial Cancer
The purpose of this study is to investigate the relevance of sentinel node in endometrial cancer. Sentinel node is thought to reflect the status of lymph node.
- Trial name
- Senti-Endo (NCT00987051)
- Testing
- Detection of sentinel node
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thyroid Neoplasm
Lateral Neck Sentinel Lymph Node Biopsy(LSLNB)in PTC
Objective: To investigate the incidence of lateral neck node occult metastasis and to show the usefulness of sentinel lymph node biopsy (SLNB) in the detection of lateral neck node metastasis in thyroid carcinoma, the…
- Trial name
- LSLNB (NCT01137097)
- Testing
- Lateral sentinel lymph node biopsy
- Where
- South Korea
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center