Clinical trials: Sentinel Nodes
Head and Neck Squamous Cell Carcinoma (HNSCC)
Evaluation of Sentinel Lymph Nodes in Head and Neck Squamous Cell Carcinoma
The purpose of this study is to determine the false negative rate (FNR) associated with Lymphoseek-identified sentinel lymph nodes (SLNs) relative to the pathological status of non-sentinel lymph nodes in elective neck dissection…
- Trial name
- NCT00911326
- Testing
- Lymphoseek
- Where
- 13 sites in United States
- Volunteers
- 101 people
- Sponsor
- Navidea Biopharmaceuticals
Intraductal Carcinoma and Lobular Carcinoma in Situ
Management of Ductal Carcinoma in Situ or Pure Micro-invasive Extended Breast
When invasive components are discovered at mastectomy for vacuum-assisted biopsy (VAB)-diagnosed ductal carcinoma in situ (DCIS), the only option available is axillary lymph node dissection (ALND).
- Trial name
- CINNAMOME (NCT01841749)
- Testing
- sentinel node biopsy and mastectomy
- Where
- France
- Volunteers
- 228 people
- Sponsor
- Institut Bergonié
Melanoma, Breast Cancer
Contrast-enhanced Ultrasound for Sentinel Node Detection
This is a prospective single-center interventional non-inferiority study where subjects are participating for one day for patients 18 years or older with melanoma, breast cancer or head \& neck cancer (including melanoma of head…
- Conditions
- Melanoma, Breast Cancer, Head & Neck Cancer
- Trial name
- NCT07310758
- Testing
- Sonazoid
- Where
- Netherlands
- Volunteers
- 91 people
- Sponsor
- The Netherlands Cancer Institute
Uterine Cervical Neoplasms, Uterine Neoplasms
Sentinel Node Mapping in Women With Cervical and Endometrial Cancer
This study aims to evaluate the effect of SLN mapping on the incidence and severity of lymphedema in women with early stage cervical and endometrial cancer.
- Trial name
- SENTIREC I (NCT02825355)
- Where
- 3 sites in Denmark
- Volunteers
- 512 people
- Sponsor
- University of Southern Denmark
Head and Neck Melanoma
Targeted Silica Nanoparticles for Real-Time Image-Guided Intraoperative Mapping of Nodal Metastases
Current imaging devices usually detect cancer prior to surgery. However, these devices cannot be used during the surgical procedure to visualize lymph nodes with cancer (called "sentinel lymph nodes").
- Trial name
- NCT02106598
- Testing
- fluorescent cRGDY-PEG-Cy5.5-C dots
- Where
- 2 sites in United States
- Volunteers
- 67 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
PAS 1ml Magtrace® for Sentinel Lymph Node Biopsy in Breast Cancer Patients
The purpose of this study is to provide prospective evidence in the US population of the frequency of skin discoloration and Sentinel Lymph Node detection rate in patients who have recevied Magtrace for Sentinel Lymph Node Biopsy…
- Trial name
- MAGProm (NCT06610539)
- Where
- 2 sites in United States
- Volunteers
- 184 people
- Sponsor
- Endomagnetics Ltd.
Invasive Breast Cancer, Ipsilateral Recurrence
Sentinel Lymph Node Procedure in Ipsilateral Invasive Breast Cancer Relapse
Sentinel lymph node biopsy (SLNB) has become the standard procedure for staging of patients with clinically node-negative breast cancer.
- Conditions
- Invasive Breast Cancer, Ipsilateral Recurrence, Sentinel Lymph Node Biopsy
- Trial name
- FIGARO (NCT03630653)
- Testing
- Sentinel LN in breast cancer recurrence
- Where
- 9 sites in France
- Volunteers
- 50 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer
Sentinel Node Biopsy Vs Observation After Axillary PET
Several researches have proved that avoiding axillary surgery does not worsen the outcome of breast cancer patients with relatively low risk.
- Trial name
- SOAPET (NCT04072653)
- Testing
- SLNB is spared
- Where
- China
- Volunteers
- 1,528 people
- Sponsor
- Fudan University
Head and Neck Squamous Cell Carcinoma
SPIO-enhanced MRI in Oral Cancer for Sentinel Lymph Node Identification
To explore the feasibility of sentinel lymph node identification by SPIO injection followed by MRI in head-and-neck cancer patients.
- Trial name
- MAG-NODE (NCT04803331)
- Testing
- SPIO-enhanced MRI
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Breast Cancer
Sentinel Lymph Node Mapping With Near Infrared Fluorescent Markers
Surgery is the primary curative option for patients with cancer, with the overall objective of complete resection of all cancerous tissue while avoiding damage to healthy tissue.
- Trial name
- NCT03619967
- Testing
- Multispectral imager
- Where
- North Macedonia
- Volunteers
- 31 people
- Sponsor
- University of Illinois at Urbana-Champaign
Vulvar Cancer, Lymph Node Metastasis
MRI and Magnetometer-guided Sentinel Lymph Node Detection in Vulvar Cancer
The aim of the feasibility study is to evaluate whether SPIO-MRI and a magnetometer could be a potential substitute to the routine dual technique in pre-and intraoperative SLN localization.
- Trial name
- POSVUC (NCT06273501)
- Testing
- Magtrace
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Sahlgrenska University Hospital
Merkel Cell Carcinoma, Stage I, Merkel Cell Carcinoma, Stage II
Neoadjuvant Merkel Cell Carcinoma Therapy (Tx) With the PD-1 Inhibitor Cemiplimab
The study is a randomized, double blind, placebo-controlled, non-comparative phase II trial that investigates the efficacy of neoadjuvant anti-PD-1 antibody Cemiplimab treatment in patients with clinical stage I or II Merkel cell…
- Conditions
- Merkel Cell Carcinoma, Stage I, Merkel Cell Carcinoma, Stage II, Neoadjuvant Immunotherapy
- Trial name
- NeoMatryx (NCT07387198)
- Testing
- Cemiplimab 350 mg i.v. on day 1 of every 21 days cycle for 2 cycles
- Where
- 14 sites in Germany
- Volunteers
- 135 people
- Sponsor
- Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Breast Neoplasms, Breast Diseases
Clinical Evaluation of OSNA Breast Cancer System to Test Sentinel Lymph Nodes From Patients With Breast Cancer
The study will determine the sensitivity, specificity, negative predictive value and positive predictive value of the OSNA Breast Cancer System by comparing its performance to permanent section Hematoxylin and Eosin (H\&E) and…
- Trial name
- NCT01136369
- Testing
- OSNA Breast Cancer System
- Where
- 11 sites in United States
- Volunteers
- 496 people
- Sponsor
- Sysmex America, Inc.
Cutaneous Melanoma
Intradermal Injection of Anti-CTLA-4 in Patients With Stage I/II Melanoma
This study evaluates the clinical safety and tolerability, and the immunological effects of local intradermal injection of tremelimumab in patients with clinical stage I/II melanoma patients undergoing a sentinel node biopsy…
- Trial name
- NCT04274816
- Testing
- Tremelimumab
- Volunteers
- 13 people
- Sponsor
- A.J.M. van den Eertwegh
Breast Neoplasms
Study Assessing The Interest of Indocyanine Green Fluorescence Imaging With Radioisotope Method For Sentinel Lymph Node Biopsy in Patients With Breast Cancer
The sentinel node has a fundamental role in the management of early breast cancer. Currently, the double detection of blue and radioisotope is recommended.
- Trial name
- FLUOTECH (NCT02279108)
- Testing
- indocyanine green, isotope
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cancer of the Breast
Sentinel Node Biopsy and Axillary Sampling in Operable Breast Cancer
The advent of mammography and increased awareness of breast cancer has resulted in detection of smaller tumors, the majority of which would not have had metastasized to the axillary lymph nodes.
- Trial name
- NCT00128362
- Testing
- Radio-guided sentinel node biopsy, Axillary sampling
- Where
- India
- Volunteers
- 478 people
- Sponsor
- Tata Memorial Hospital
Breast Cancer
Bupivacaine vs Placebo for Unilateral Mastectomy Surgical Site Post-operative Pain Control
The purpose of this study is to compare using FDA-approved bupivacaine (a numbing medicine), along with the usual medications for post-operative pain control to using the usual medications for postoperative pain control alone.
- Trial name
- NCT03351348
- Testing
- Bupivacaine, patient-reported pain scores, saline
- Where
- 7 sites in United States
- Volunteers
- 165 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Melanoma
Comparing SLNE With or Without Preoperative Hybrid SPECT/CT in Melanoma
Melanoma has become a growing interdisciplinary problem in public health worldwide. It characteristically disseminates in an orderly progression through lymphatic channels to the regional lymph node and then to more distant…
- Trial name
- NCT03683550
- Testing
- SLNE with preoperative hybrid SPECT/CT, Standard SLNE
- Where
- 13 sites in Germany
- Volunteers
- 836 people
- Sponsor
- University Hospital, Essen
Melanoma
Melanoma Molecular Profiling Analysis
There is a significant need to develop new and more effective ways to treat melanoma that will decrease patient morbidity and mortality.
- Trial name
- NCT00889980
- Testing
- Biospecimen banking
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- University of Pittsburgh
Early Gastric Cancer
Pilot Study of Non-exposure Simple Suturing EFTR With Sentinel Lymph Node Navigation for EGC (Senorita3-pilot)
Laparoscopic sentinel lymph node dissection and stomach preserving surgery in early gastric cancer is less invasive method which can increase quality of life.
- Trial name
- NCT03216174
- Testing
- NESS-EFTR
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- National Cancer Center, Korea