Clinical trials: Sentinel Nodes
Vulvar Cancer, Lymph Node Metastasis
MRI and Magnetometer-guided Sentinel Lymph Node Detection in Vulvar Cancer
The aim of the feasibility study is to evaluate whether SPIO-MRI and a magnetometer could be a potential substitute to the routine dual technique in pre-and intraoperative SLN localization.
- Trial name
- POSVUC (NCT06273501)
- Testing
- Magtrace
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Sahlgrenska University Hospital
Breast Neoplasm Female
Sentinel Node Biopsy Alone or With Axillary Dissection After Primary Chemotherapy
Many doctors believe that breast cancer patients scheduled for pre-operative chemotherapy whose cancer has spread to the axilla (determined by palpation plus ultrasound) should not receive sentinel node biopsy after chemotherapy…
- Trial name
- NCT04436809
- Testing
- Sentinel Node Biopsy, Axillary Dissection
- Volunteers
- 353 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Vulvar Neoplasm
New Strategy for the Treatment of Vulvar Cancer
Vulvar cancer is a rare disease that is treated with surgery, radiation and chemotherapy. When tumors are large (greater than 4 cm) or compromise the urethra (urine canal) and the anus, or when it is in the groin lymph nodes…
- Trial name
- NCT02067052
- Testing
- Surgery, radiotherapy and chemotherapy, Surgery
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Breast Neoplasms
Sienna+® Injection Time Study 4 Arms
Patients with breast cancer normally undergo a labelling with radioactive tracer typically 1 day before surgery, which enables the surgeon to localize the sentinel lymph node during surgery.
- Trial name
- Sentimag02 (NCT02612870)
- Testing
- Sienna+ retro, Sienna+ peri, Sienna+ retro 4-6
- Where
- 2 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- Kantonsspital Baden
Breast Cancer
SentiMag® Intraoperative Comparison in Breast Cancer
The purpose of this pivotal study is to provide prospective evidence that the SentiMag®/SiennaXP® is safe and non-inferior to the current standard of care for lymph node localization in patients with breast cancer as part of a…
- Trial name
- SentiMagIC (NCT02336737)
- Testing
- SiennaXP, Technetium Tc99m Sulfur Colloid, Isosulfan blue dye
- Where
- 6 sites in United States
- Volunteers
- 160 people
- Sponsor
- Endomagnetics Inc
Early Gastric Cancer, Gastric Adenocarcinoma
Image-Guided Platform-Assisted Sentinel Lymph Node Retrieval in Early Gastric Cancer
This prospective, single-center, randomized controlled trial aims to evaluate the clinical effectiveness of an Image-Guided Platform assisted by a deep learning model for sentinel lymph node (SLN) retrieval in patients with early…
- Trial name
- NCT07835087
- Testing
- Image-Guided Retrieval Specimen Platform, Traditional Palpation-Based Sentinel Lymph Node Retrieval
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Beijing Friendship Hospital
Melanoma, Surgery
Perioperative Examination of Inflammatory Markers in Relation to Sentinel Lymph Node Biopsy in Patients With Melanoma; a Pilot Study
We want to test if an association between sentinel lymph node biopsy (SLBN) and a systemic inflammatory response can be made.
- Trial name
- NCT05817149
- Testing
- Blood samples
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aalborg University Hospital
Colon Cancer, Sentinel Lymph Node
Minimally INvasive Colon Cancer Surgery Through IMmunomics and Optical Mapping of the Sentinel Lymph Node.
The project investigates the feasibility of laparoscopic fluorescent imaging for the intraoperative detection of the sentinel lymph node (SLN) in colon cancer patients.
- Trial name
- MINIMAL (NCT03779009)
- Testing
- ICG-nanocoll (indocyanine green coupled to the human albumin colloidal particle nanocoll)
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
Thyroid Cancer, Thyroid Carcinoma, Papillary
Near-infrared Fluorescence With Indocyanine Green for Identification of Sentinels and Parathyroids During Thyroidectomy
Indocyanine green (ICG) is a water-soluble organic dye that is cleared totally through the hepatobiliary system. It has a half-life of 3-4 mins, which allows repeated applications.
- Conditions
- Thyroid Cancer, Thyroid Carcinoma, Papillary, Thyroid Metastases, Thyroid Neoplasms
- Trial name
- NCT04424485
- Testing
- Total thyroidectomy (TT), Central lymph node dissection (CLND), Sentinel lymph node (SLN) bopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Umraniye Education and Research Hospital
Breast Cancer
Magnetic Tracer in the Sentinel Node Procedure in Breast Cancer: the Non-radioactive Alternative for Radio-isotopes
Rationale: In breast cancer, a sentinel node procedure is performed to investigate whether malignant cells have spread to the axillary lymph nodes.
- Trial name
- MagTrace (NCT05122585)
- Testing
- MagSeed and MagTrace in breast cancer patiënts
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Zuyderland Medisch Centrum
Uterine Cervical Neoplasms
Sentinel Lymph Node Mapping In Cervical Cancer
Lymph node assessment provides the crucial information about the prognosis of cervical cancer. Sentinel lymph node stands in the first station on the lymph node metastasis pathways.
- Trial name
- SLNMICC (NCT03778268)
- Testing
- sentinel lymph node biopsy
- Where
- 2 sites in China
- Volunteers
- 1,143 people
- Sponsor
- Peking University People's Hospital
Breast Cancer
Lymph Node Identification Using Magtrace and Magseed Before Chemotherapy
Magnetic tracer injected before preoperative chemotherapy in breast cancer patients for sentinel lymph node detection. Also, magnetic tracer in combination with magnetic clip for index node identification.
- Trial name
- SentiNeo2 (NCT06104371)
- Testing
- Magtrace
- Where
- Sweden
- Volunteers
- 459 people
- Sponsor
- Vastra Gotaland Region
Endometrial Cancer, Vulvar Cancers
The Effect of Dose and Storage Conditions of Indocyanine Green on Efficacy and Cost in Sentinel Lymph Node Mapping in Gynecological Cancer
This research will determine the impact of optimizing dosage and storage conditions for indocyanine green on health outcomes and will contribute to improving treatment processes in gynecological cancers.
- Conditions
- Endometrial Cancer, Vulvar Cancers, Cervical Cancer, Indocyanine Green (ICG)
- Trial name
- DOSTCONICG (NCT07380698)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Cukurova University
Breast Cancer
Safety and Efficacy of Sentinel Node Biopsy Omission for Breast Cancer Patients Who Plan to Have Adjuvant Chemotherapy
Eligible patients will be female, ages 18 and older and have a diagnosis of Clinical T1 or T2 invasive breast cancer with no suspicious palpable adenopathy.
- Trial name
- NCT02610621
- Testing
- Lumpectomy without sentinel node biopsy
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Diagnostic Value of Sentinel Node Biopsy Guided by Magnetic Probe
Magnetic Localization of Sentinel Nodes in Squamous Cell Oral Carcinoma.
Sentinel node biopsy has been shown to be a viable alternative to elective neck dissection in the early stages of squamous cell oral carcinoma.
- Trial name
- SentiMag (NCT06261983)
- Testing
- Sentinel node biopsy guided by magnetic probe
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Hospital Donostia
Breast Cancer Female, Node-positive Breast Cancer
Axillary Staging in Node Positive Breast Cancer Patients Receiving PST. SNB vs PET/MRI
The management of axillary nodes in breast cancer patients is a highly debated and evolving field. To date, an increasing number of patients with positive lymph nodes receives primary systemic therapy (PST) prior to surgery…
- Conditions
- Breast Cancer Female, Node-positive Breast Cancer, Sentinel Lymph Node
- Trial name
- NCT04826211
- Testing
- PET/MRI
- Where
- Italy
- Volunteers
- 109 people
- Sponsor
- IRCCS San Raffaele
Breast Cancer, Postoperative Recovery
ERAS Protocols in Breast Conserving Surgery
Enhanced Recovery After Surgery (ERAS) protocols have been of increasing interest in the surgical community for decades. The emphasis has been development of protocols to maximize pain control post-operatively without the use of…
- Trial name
- ERAS (NCT06938581)
- Testing
- ERAS Protocol, Standard Perioperative Care
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Nebraska
Melanoma, Sentinel Lymph Node
The Use of Magtrace®/Sentimag® in Sentinel Node Biopsy for Malignant Melanoma. The Magmen Study.
To evaluate the use of superparamagnetic iron oxide (Magtrace®) as a tracer in sentinel node biopsy in malignant melanoma of the extremities, and to evaluate the possible role of Magtrace®-MRI for staging.
- Trial name
- MAGMEN (NCT03898687)
- Testing
- SLN Biopsy with Magtrace®/Sentimag®
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Sahlgrenska University Hospital
Node-positive Breast Cancer
MUltimodal Targeted Axillary Surgery
The present trial will prospectively evaluate the accuracy of both a systematic predefined axillary ultrasound imaging together with tumor load quantification of suspicious and sentinel axillary lymph nodes to predict overall…
- Trial name
- MUTAS (NCT04039893)
- Testing
- Systematic axillary ultrasound imaging, Sentinel node, Excision of suspicious lymph nodes
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Parc de Salut Mar
Breast Cancer
Specimen X-Rays of Removed Axillary Lymph Nodes to Guide Pathological Sampling
X-ray mapping of sentinel lymph nodes and/or axillary tissue will assist pathologists in their ability to identify the number and location of lymph nodes as well as more accurately section lymph nodes contained in surgical…
- Trial name
- GPS (NCT01156454)
- Testing
- X-ray
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arkansas