Clinical trials: Sepsis, Septic Shock
Septic Shock
Hemodynamics Effects of Fludrocortisone on the Pressor Response to Noradrenaline Septic Shock Patients
The benefit of low-dose steroids in septic shock is still debated today, especially with mineralocorticoids. Fludrocortisone is a synthetic mineralocorticoid, an analogue of aldosterone, which has shown, in combination with…
- Trial name
- FLUDROSEPSIS (NCT05001854)
- Testing
- Fludrocortisone
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Rennes University Hospital
Sepsis, Septic Shock
Investigation of the Role of Brain Natriuretic Peptide and Lactate in Early Goal-directed Therapy for Patients With Severe Sepsis and Septic Shock
B-type natriuretic peptide (BNP) is a cardiac neurohormone which rapidly released by the ventricle in response to myocardial stretch.
- Trial name
- NCT01539551
- Testing
- check BNP and lactate
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Adult Patients With Septic Shock Admitted in Intensive Care Unit
Remote Ischemic Postconditioning in Septic Shock
Septic shock is a leading cause of death worldwide despite intensive research efforts. Only a few interventions have been proven to be effective in improving patient-centered outcomes.
- Trial name
- RIPOST-sepsis (NCT07273942)
- Testing
- Remote ischemic conditioning, No intervention
- Where
- 23 sites in France
- Volunteers
- 720 people
- Sponsor
- Hospices Civils de Lyon
Septic Shock
Non Invasive Evaluation of Fluid Responsiveness in Septic Patient
The study aims to evaluate the accuracy of fluid responsiveness assessment with non-invasive cardiometry compared to ultrasound guided inferior vena cava (IVC) collapsibility for management of critically ill septic patients with…
- Trial name
- NCT05310942
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Septic Shock
Effect of Shenfu Injection on the Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective single-center clinical trial aims to evaluate the circulatory and microcirculatory effects of Shenfu Injection in patients with septic shock.
- Trial name
- NCT07603024
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Septic Shock
Ivabradine for Heart Rate Control In Septic Shock
Septic shock is a major health problem, with several million cases annually worldwide and a mortality approaching 45%. Tachycardia is associated with excess mortality during septic shock.
- Trial name
- IRISS (NCT04031573)
- Testing
- Ivabradine
- Where
- France
- Volunteers
- 429 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Trans Cranial Doppler Ultrasonography in Heamodynamic Optimisation in Septic Shock
Hemodynamic Optimisation Guided With Transcranial Doppler in Septic Shock
Randomized, controlled, prospective trial, including ICU patients with Sepsis or septic Shock, at the early phase. patients will be randomized in 2 groups regarding the hemodynamic management and catecholamin doses: Group 1…
- Trial name
- NCT04398069
- Testing
- hemodynamic optimisation aiming to achieve normal cerebral perfusion
- Where
- Tunisia
- Volunteers
- 24 people
- Sponsor
- Mongi Slim Hospital
Septic Shock, Multiorgan Failure
Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study
This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).
- Conditions
- Septic Shock, Multiorgan Failure, Sepsis
- Trial name
- NCT07539883
- Where
- South Korea
- Volunteers
- 360 people
- Sponsor
- Seoul National University Bundang Hospital
Severe Sepsis
ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis
The purpose of this study is to compare eritoran tetrasodium and placebo in patients with severe sepsis and to demonstrate a reduction of mortality from all causes.
- Trial name
- NCT00334828
- Testing
- eritoran tetrasodium
- Where
- 251 sites in United States, Argentina and 22 more
- Volunteers
- 2,000 people
- Sponsor
- Eisai Inc.
Septic Shock
Membrane Shedding During Septic Shock
Microparticles (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with emerging role in pathophysiology of immune and…
- Trial name
- NCT01604551
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Severe Sepsis With Septic Shock, Severe Sepsis Without Septic Shock
Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Sepsis
Sepsis is a clinical syndrome which infection trigger systemic inflammatory response. Uncontrolled inflammatory process leads to multiple organ dysfunction and cause early mortality in severe sepsis.
- Trial name
- NCT02135770
- Testing
- Unfractionated heparin
- Where
- Indonesia
- Volunteers
- 115 people
- Sponsor
- Universitas Indonesia
Septic Shock
Study the Impact of Statins in Septic Shock
Sepsis is a common, expensive, frequently fatal and highly complex inflammatory syndrome wherein multiple cellular and humoral pathways are involved.
- Trial name
- NCT02681653
- Testing
- Atorvastatin
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Severe Sepsis and Septic Shock
Extracorporeal Immune Support System (EISS) for the Treatment of Septic Patients
The purpose of this study is to investigate the effect of an extracorporeal application of a bed-side bioreactor containing human donor granulocytes on the course and outcome of septic shock in humans.
- Trial name
- EISS-1 (NCT00818597)
- Testing
- EISS
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Rostock
Septic Shock
Initiation of Hydrocortisone for the Treatment of Septic Shock
The purpose of this study : 1）to determine whether hydrocortisone is effective in the treatment of septic shock and 2) to identify the role of timing of low dose hydrocortisone administration in septic shock patients.
- Trial name
- NCT02580240
- Testing
- Hydrocortisone, saline
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Northern Jiangsu People's Hospital
Vasorin, Septic Shock
Diagnostic and Prognostic Evaluation of Vasorin During Septic Shock
Septic shock is the most severe form of infection. Currently, an early specific biomarker for septic shock is needed. Remember that shock situations are numerous, not only septic (eg hemorrhagic, cardiogenic...), and also…
- Conditions
- Vasorin, Septic Shock, Shock, Biomarker
- Trial name
- VASO-DIAG (NCT07203833)
- Testing
- blood sample
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Septic Shock, Chronic Heart Failure
eMESH Struct. 2022-23
A flexible energy metabolism matched with the contractile needs of the muscle is essential to a normal heart. Loss of metabolic flexibility and cardiac systolic efficiency coexist in Sepsis-induced Myocardial Dysfunction (SIMD)…
- Trial name
- eMESH (NCT05202938)
- Testing
- ultrasound cardiography, FDG PET scan, Palmitate PET scan
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Sepsis, Septic Shock
Early Norepinephrine Administration and Rapid Dose Adjustment
The goal of this clinical trial is to determine whether early initiation of norepinephrine with rapid dose adjustment improves clinical outcomes in adult patients with septic shock.
- Trial name
- CENSER2 (NCT07343206)
- Testing
- Early norepinephrine administration and rapid dose adjustment, Control
- Where
- 6 sites in Thailand
- Volunteers
- 600 people
- Sponsor
- Siriraj Hospital
Septic Shock, Multiple Organ Failure
Severe Sepsis/Septic Shock on Admission to the General Surgical ICU
Severe sepsis/septic shock are serious complications of infection with high morbidity and mortality. Recent information showed that early and aggressive resuscitation may help improving survival and outcome especially the…
- Conditions
- Septic Shock, Multiple Organ Failure, Fatal Outcome
- Trial name
- NCT01363635
- Where
- Thailand
- Volunteers
- 800 people
- Sponsor
- Mahidol University
Septic Shock, Severe Sepsis
Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock
Catecholamines infusion is a major component of septic shock management. International guidelines recommend that norepinephrine should be preferred to epinephrine, though phase III trials are lacking.
- Conditions
- Septic Shock, Severe Sepsis, Infections
- Trial name
- CATS (NCT00148278)
- Testing
- norepinephrine and dobutamine
- Where
- 15 sites in France
- Volunteers
- 330 people
- Sponsor
- University of Versailles
Septic Shock, Sepsis
Impact of Systematic Point-of-Care Ultrasound Implementation on Clinical Outcomes and Survival in Septic Shock: A Retrospective Single-Center Cohort Study
This study aims to evaluate the clinical impact of the systematic implementation of point-of-care ultrasound (POCUS) in the management of patients with septic shock in the intensive care unit (ICU).
- Trial name
- SHOCK (NCT07565649)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra