Clinical trials: Sepsis, Severe
Systemic Inflammatory Response Syndrome
Efficacy of Macrolide Immunomodulation in Severe Sepsis.
The purpose of this study is to determine whether macrolide treatment of patients with severe sepsis has an advantageous immunomodulatory and clinical effect compared to severe septic patients without macrolide therapy.
- Trial name
- NCT00708799
- Testing
- Azithromycin on admission - not enrolled in the RCT
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Sepsis, Adult Disease
Sepsis Post Market Observational Study and Potential Reduction of Time to Antibiotics - Washington University
The purpose of this study is to demonstrate that addition of the Monocyte Width Distribution (MDW) parameter to current standard of care improves a clinician's ability to recognize sepsis in the Emergency Department, resulting in…
- Conditions
- Sepsis, Adult Disease, Severe Sepsis, Emergency Department
- Trial name
- NCT04353388
- Testing
- CBC-DIFF Monocyte Volume Width Distribution (MDW)
- Where
- United States
- Volunteers
- 1,139 people
- Sponsor
- Beckman Coulter, Inc.
Sepsis Syndrome, Sepsis
Sepsis: From Syndrome to Personalized Care
This is a prospective, observational study designed to examine the performance of biomarkers, molecular biological methods and other analysis in blood from patient with suspected sepsis in the Emergency department, as well as…
- Conditions
- Sepsis Syndrome, Sepsis, Sepsis, Severe, Septic Shock
- Trial name
- NCT04203979
- Where
- Norway
- Volunteers
- 1,950 people
- Sponsor
- Oslo University Hospital
Critical Illness, Severe Sepsis
A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children
1. To research the current situation of severe infection in children in China, and to investigate the incidence, prognosis and disease burden of severe infection in children in different regions of China. 2.
- Trial name
- NCT04955210
- Testing
- Not applicable（Cohort study）
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Children's Hospital of Fudan University
Acute Kidney Injury, Chronic Kidney Disease
Severe Sepsis in Children - IMPRESS-C
Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Hypertension
- Trial name
- IMPRESS-C (NCT02598674)
- Testing
- Iodohippurate, 24 hour ambulatory Blood Pressure, Peripheral Arterial Tonometry
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Sepsis, Severe Sepsis
BaSES Trial: Basel Starch Evaluation in Sepsis
Background: In patients with severe sepsis and septic shock early aggressive volume replacement reduced mortality. Standard infusion therapy consists of crystalloid infusions.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- BaSES (NCT00273728)
- Testing
- hydroxy-ethyl starch (MW 130; 0.4) vs. normal saline
- Where
- 2 sites in Switzerland
- Volunteers
- 231 people
- Sponsor
- University Hospital, Basel, Switzerland
Severe Sepsis, Septic Shock
The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients
Major microvascular blood flow alterations have been documented in patients with severe sepsis. It was also demonstrated that the microcirculation improved in survivors of septic shock but failed to do so in patients dying from…
- Conditions
- Severe Sepsis, Septic Shock, Microcirculation
- Trial name
- NCT01319630
- Testing
- Sidestream Dark Field (SDF), Near Infrared Spectroscopy (NIRS)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mercy Research
Sepsis, Severe Infection
Evaluation of Monocyte Volume Distribution Width (MDW) for Early Detection of Sepsis
The measurement of monocyte volume width distribution (MDW) is intended for use with adult patients presenting to the emergency department (ED), where a CBC with Differential has been ordered, as an aid in the early detection of…
- Trial name
- MDW (NCT03145428)
- Testing
- CBC-Diff Monocyte volume width distribution (MDW)
- Where
- 3 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beckman Coulter, Inc.
Sepsis, Pneumonia
Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System
High mortality associated with sepsis and Multiple Organ Dysfunction Syndrome (MODS) calls for alternative, individualized therapies in selected patients that might benefit form specific interventions.
- Conditions
- Sepsis, Pneumonia, Gram-Negative Bacteria Infection, Multiple Organ Failure
- Trial name
- INCLASS (NCT03345992)
- Testing
- Clarithromycin, Water for injection
- Where
- 12 sites in Belgium, Greece
- Volunteers
- 110 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Meningococcal Infections, Septic Shock
Septic cArdiac Deficiency and MenIngococcal seveRe Sepsis
Use of brain natriuretic peptide to evaluate the cardiac function in the course of meningococcal septic shock or severe sepsis.
- Conditions
- Meningococcal Infections, Septic Shock, Severe Sepsis
- Trial name
- SAMIRA (NCT02041663)
- Testing
- BNP
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Sepsis, Septic Shock
Methylene Blue in Severe Sepsis and Septic Shock
This study is to see whether the intravenous administration of methylene blue improves the outcome in severe sepsis and septic shock.
- Trial name
- NCT01797978
- Testing
- Intravenous methylene blue administration
- Where
- 3 sites in South Korea
- Volunteers
- 354 people
- Sponsor
- Seoul National University Hospital
Bloodstream Infection, Ventilator Associated Bacterial Pneumonia
Optimising TREATment for Severe Gram-Negative Bacterial Infections
TREAT-GNB is an innovative trial to expedite the evaluation of various antibiotic choices and treatment strategies for severe multidrug-resistant Gram-negative bacterial infections, specifically bloodstream and lower respiratory…
- Conditions
- Bloodstream Infection, Ventilator Associated Bacterial Pneumonia, Hospital Acquired Bacterial Pneumonia, Carbapenem Resistant Bacterial Infection
- Trial name
- TREAT-GNB (NCT07004049)
- Testing
- Colistin/Polymyxin B + Sulbactam, Colistin/Polymyxin B + Tigecycline/Eravacycline, Colistin/Polymyxin B + Meropenem
- Where
- 41 sites in Australia, China and 10 more
- Volunteers
- 600 people
- Sponsor
- National University of Singapore
Septic Shock, Cytokine Storm
Cytokine Adsorption in Severe, Refractory Septic Shock
Septic shock and the underlying dysregulated inflammatory host-response remain a major contributor to mortality in critically ill patients. Cytokine adsorption represents an attractive approach to the treatment of septic shock.
- Trial name
- NCT04910893
- Testing
- Cytokine Adsorption, Standard of Care
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Severe Sepsis
A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock.
A study to evaluate the safety, tolerability and pharmacokinetics of Nivolumab in participants with severe sepsis or septic shock.
- Trial name
- NCT02960854
- Testing
- Nivolumab
- Where
- 16 sites in United States
- Volunteers
- 38 people
- Sponsor
- Bristol-Myers Squibb
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Electronic Application of a Severe Sepsis Screening Tool and Management Bundle
Thousands of children die from Sepsis following routine infections. Many of these deaths can be prevented with earlier recognition and focused management.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
- Trial name
- eASSIST-M (NCT01724463)
- Testing
- Severe Sepsis Management Bundle
- Where
- United States
- Volunteers
- 30,000 people
- Sponsor
- University of Tennessee
Sepsis, Acute Kidney Injury
Comparison of Balanced Crystalloids and Normal Saline in Septic Patients
In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal…
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock, Sepsis, Severe
- Trial name
- NCT03685214
- Testing
- 0.9% saline, lactated Ringer's solution
- Where
- China
- Volunteers
- 500 people
- Sponsor
- ZhiYong Peng
Sepsis
Effects of Voluven on Hemodynamics and Tolerability of Enteral Nutrition in Patients With Severe Sepsis
The rapidity and the quality of fluid resuscitation in patients with severe sepsis are important factors for the prevention of secondary multi-organ failure.
- Trial name
- CRYSTMAS (NCT00464204)
- Testing
- 6 % Hydroxyethylstarch 130/0.4 = "Voluven®", 0.9 % NaCl
- Where
- 24 sites in France, Germany
- Volunteers
- 196 people
- Sponsor
- Fresenius Kabi
Burns
An Investigation of the Effect of Types of Catheters on Bloodstream Infection in Patients With Major Burns: Prediction With Procalcitonin and Prognosis
Bloodstream infections and catheter-related infections frequently occur in burn patients. It is important to correctly assess and manage these infections.
- Trial name
- NCT05581316
- Testing
- Patients' procalcitonin, thrombocyte, and leukocyte levels were assessed every other day for 4 weeks, beginning on the first day they were admitted to the burn center.
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Hasan Kalyoncu University
Sepsis, Sepsis-induced Coagulopathy
Nafamostat Mesilate in the Treatment of Severe Infection-associated Coagulopathy
The objective of this study was to evaluate the therapeutic effect of nafamostat mesilate on patients with severe infection-related coagulation。
- Conditions
- Sepsis, Sepsis-induced Coagulopathy, Nafamostat Mesilate
- Trial name
- NMSICRCT (NCT06078839)
- Testing
- Nafamostat mesilate, 5% glucose
- Volunteers
- 778 people
- Sponsor
- Xu Li
Sepsis Syndrome, Sepsis
Mitochondrial DNA as a Biomarker of Sepsis Severity
Mitochondria are organelles (a specialized subunit of a cell) responsible for providing cells with energy. For reasons not yet understood, mitochondria will release their DNA into blood in response to cellular injury or cell…
- Conditions
- Sepsis Syndrome, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- MBOSS (NCT03077672)
- Where
- 2 sites in United States
- Volunteers
- 1,304 people
- Sponsor
- Weill Medical College of Cornell University