Clinical trials: Sepsis, completed
Bacillus Cereus Infection
Contamination of Bacillus Species Sepsis.
Bacillus species are ubiquitous gram-positive spore-forming organisms. They rarely cause disease in the immunocompetent and are more frequently isolated as a culture contaminant.
- Trial name
- BACILLUS (NCT03377530)
- Testing
- Ways to prevent these infections.
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Hôpital NOVO
Hypoxic-Ischemic Encephalopathy, Sepsis
Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants
Historically, CKRT and hemodialysis were performed in small infants and newborns with devices developed for adults with high rates of complications and mortality.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Sepsis, Kidney Diseases, Metabolic Disease
- Trial name
- NCT05495607
- Testing
- CARPEDIEN
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sepsis, Cytokine Storm
Effect of Cytosorb on Blood Levels of Inflammatory Biomarkers of Sepsis.
Background: There is still an evident need for useful biomarkers and effective therapeutic approaches regarding the challenging management of sepsis.
- Trial name
- NCT04226430
- Testing
- Cytokine aphaeresis
- Volunteers
- 34 people
- Sponsor
- University of Gaziantep
Septic Shock
Hemodynamic Effects of Vasopressin in Early Septic Shock Stage
Vasopressin is a vasopressor used in patients with septic shock. However, its systemic hemodynamic effects and its microcirculation effects are not completely known and understood.
- Trial name
- NCT02053675
- Testing
- Vasopressin infusion
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
Hypothermia
Plastic Hat Trial to Prevent Hypothermia in Preterm Newborns in the Delivery Room
The purpose of this research project is to ascertain the effectiveness of plastic head covering in prevention of hypothermia. Hypothermia is defined by body temperature <36.5º Celsius by the World Health Organization.
- Trial name
- NCT00904228
- Testing
- placement of plastic cap during delivery room stabilization, placement of routine cap during delivery room stabilization
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Secondary Peritonitis After Intestinal Perforation
Procalcitonin Ratio's Impact on the Decision Upon On-demand Relaparotomy in Septic Peritonitis
Procalcitonin (PCT) serum levels are monitored in patients with secondary peritonitis after initial operative focus elimination to investigate the PCT ratio's impact on decision-making for or against early relaparotomy in the…
- Trial name
- NCT01768936
- Where
- Germany
- Volunteers
- 234 people
- Sponsor
- CHIR-Net
Sepsis
Efficacy & Safety of Resatorvid in Adults With Severe Sepsis
The purpose of this study is to determine the optimal dose of Resatorvid for reducing 28-day all-cause mortality in subjects with severe sepsis.
- Trial name
- NCT00143611
- Testing
- Resatorvid
- Where
- 144 sites in United States, Australia and 15 more
- Volunteers
- 277 people
- Sponsor
- Takeda
Sepsis
TELEmedicine as an Intervention for Sepsis in Emergency Departments
Sepsis is a life-threatening condition that has doubled in incidence over the past decade, and timely aggressive medical intervention has been shown to save lives.
- Trial name
- TELEvISED (NCT04441944)
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 1,191 people
- Sponsor
- University of Iowa
Sepsis, Septic Shock
Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey
The goal of this observational study is to validate the effectiveness of the new SOFA-2 score in predicting mortality and to determine the current frequency of sepsis in adult patients admitted to Intensive Care Units (ICUs) in…
- Conditions
- Sepsis, Septic Shock, Critical Illness, Organ Dysfunction
- Trial name
- TURK-SOFA2 (NCT07300306)
- Where
- Turkey (Türkiye)
- Volunteers
- 3,379 people
- Sponsor
- Marmara University
Sepsis
The Effect of Semi-quantitative Procalcitonin Assay to The Adequacy of Empirical Antibiotics and Mortality in Septic Patients
Sepsis is a serious clinical condition with a considerable morbidity and mortality. Procalcitonin (PCT) is a good biomarker for early diagnosis and infection monitoring.
- Trial name
- NCT01862185
- Testing
- semi-quantitative procalcitonin
- Where
- Indonesia
- Volunteers
- 205 people
- Sponsor
- Universitas Indonesia
Sepsis
Reconstruction of Monocytic Immunocompetence by Granulocyte-macrophage-colony Stimulating Factor (GM-CSF) in Patients With Severe Sepsis and Septic Shock
There is basic science evidence that GM-CSF reconstructs cellular immunity in septic patients. In this prospective, randomised double-blind, placebo-controlled trial, we investigate whether this can be achieved in patients with…
- Trial name
- NCT00252915
- Testing
- GM-CSF (verum)
- Volunteers
- 38 people
- Sponsor
- Charite University, Berlin, Germany
Sepsis
Role of Enteral Lactoferrin as an Adjuvant for Prevention of Sepsis Among Preterm Neonates
Lactoferrin (LF) is a multifunctional glycoprotein and is naturally present in various body secretions, including human milk, tears, saliva, airway mucus, and the secondary granules of neutrophils 1-2.
- Trial name
- NCT07480434
- Testing
- Bovine Lactoferrin Supplement
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Zartash Sial Paeds Med
Catheter Related Bloodstream Infection
Trial Evaluating the Efficacy of a Chlorhexidine-Impregnated Sponge (BIOPATCH®) to Reduce Catheter-Related Bloodstream Infections in Hemodialysis Patients
There are currently no published data on the efficacy of the chlorhexidine-impregnated foam dressing to reduce catheter-related bloodstream infections (BSI) in hemodialysis patients.
- Trial name
- NCT00550693
- Testing
- Chlorhexidine-impregnated foam dressing
- Where
- 2 sites in United States
- Volunteers
- 121 people
- Sponsor
- Washington University School of Medicine
Bacteraemia Post Debridement
PVP Iodine Effect on Post Debridement Bacteraemia
The study investigates the effect of supra- and subgingival rinsing of 10% PVP prior to ultrasonic debridement in patients with periodontitis (as compared to rinsing with water) in terms of post treatment bacteraemia.
- Trial name
- PJB 1 (NCT01647347)
- Testing
- Supra- and subgingival rinsing with 10% PVP-iodine, Water
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Neonatal SEPSIS
Neonatal Sepsis at Neonatal Intensive Care Units in Ghana
Background: Neonatal sepsis is a major contributor to global under five mortality. In developing countries a major proportion of neonatal sepsis is thought to emanate from the healthcare setting, due to challenges in infection…
- Trial name
- NCT03755635
- Testing
- The WHO multimodal hand hygiene strategy
- Where
- Ghana
- Volunteers
- 5,433 people, healthy volunteers welcome
- Sponsor
- Stephanie Bjerrum
Septic Shock
SQUEEZE Trial: A Trial to Determine Whether Septic Shock Reversal is Quicker in Pediatric Patients Randomized to an Early Goal Directed Fluid Sparing Strategy vs. Usual Care
The purpose of the SQUEEZE Trial is to determine which fluid resuscitation strategy results in the best outcomes for children treated for suspected or confirmed septic shock.
- Trial name
- SQUEEZE (NCT03080038)
- Testing
- Fluid Sparing Resuscitation Strategy
- Where
- 8 sites in Canada
- Volunteers
- 406 people
- Sponsor
- McMaster University
Trauma Injury, Acute Coronary Syndrome
Smart Glasses in Emergency Medicine From the Hangzhou Asian Games
The findings of our study will reveal that using smart glasses in the emergency department(ED) could facilitate patient admission. AR Smart Glasses offer the potential to enhance the effectiveness and speed of treatment within ED.
- Conditions
- Trauma Injury, Acute Coronary Syndrome, Stroke, Acute, Septic Shock
- Trial name
- SGINHZAG (NCT06623825)
- Testing
- teleconsultation by Augmented Reality smart glasses, teleconsultation by two-way radio connection.
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sir Run Run Shaw Hospital
Sepsis
Effect of Lipopolysaccharide on Skeletal Muscle Functions
The investigators aim to examine how the skeletal muscles of the human volunteers respond to experimental septic conditions to aid understanding of muscle wasting and its biology..
- Trial name
- LPS (NCT01423968)
- Testing
- Lipopolysaccharide infusion, saline
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sepsis, Septic Shock
Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intensive Care Unit: A Quality Improvement Project at AFHJ
Study Title: Implementation of a Sepsis Management Protocol at Armed Forces Hospital Jazan (AFHJ). Purpose: The purpose of this quality improvement project is to determine if implementing a standardized, evidence-based "sepsis…
- Conditions
- Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome (SIRS), Critical Illness
- Trial name
- NCT07460024
- Testing
- Adapted Surviving Sepsis Campaign (SSC) Protocol, Standard Clinical Care
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Bacterial Infections
Safety and Efficacy Study of Angiotech Central Venous Catheter to Prevent Bacterial Catheter Colonization
The main purpose of this study is to determine if the Angiotech central venous catheter (CVC) is equal in effectiveness to a CVC coated with chlorhexidine and silver sulfadiazine in preventing bacterial catheter colonization.
- Trial name
- NCT00288418
- Testing
- Central Venous Catheter
- Where
- 21 sites in United States
- Volunteers
- 960 people
- Sponsor
- Angiotech Pharmaceuticals
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