Clinical trials: Sepsis, completed
Bacterial Infections, Urinary Tract Infections
Host RNA Profiles to Detect Infections in Young Infants
This study seeks to identify and test host RNA expression profiles as markers for infections in young infants. Preliminary studies have shown high sensitivity and specificity for the discrimination of bacterial from non-bacterial…
- Conditions
- Bacterial Infections, Urinary Tract Infections, Sepsis, Fever
- Trial name
- CHILD_YIC (NCT04823026)
- Where
- 4 sites in Denmark
- Volunteers
- 152 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sepsis, Oxidative Stress
Sepsis and Thiol-Disulfide Balance in Emergency Department
The aim of this study was to determine the effectiveness of thiol-disulfide homeostasis in predicting diagnosis and mortality in sepsis patients, and to compare it with other inflammatory markers.
- Trial name
- NCT07134868
- Testing
- Thiol- Disulfide Blood Sample Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Maternal Death, Maternal Infections Affecting Fetus or Newborn
Azithromycin-Prevention in Labor Use Study (A-PLUS)
Maternal and neonatal infections are among the most frequent causes of maternal and neonatal deaths, and current antibiotic strategies have not been effective in preventing many of these deaths.
- Conditions
- Maternal Death, Maternal Infections Affecting Fetus or Newborn, Neonatal SEPSIS, Maternal Sepsis During Labor
- Trial name
- NCT03871491
- Testing
- Azithromycin
- Where
- 8 sites in Bangladesh, Democratic Republic of the Congo and 5 more
- Volunteers
- 58,747 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Sepsis
Clinical Score Usefulness and EHR Integration
The SOFA score is a severity of illness and prognostic score used in the ICU. It has also recently been adopted as part of the definition of sepsis.
- Trial name
- ScoreInt (NCT02755025)
- Testing
- Automated SOFA scoring calculator
- Volunteers
- 215 people
- Sponsor
- Mayo Clinic
Acute Respiratory Distress Syndrome, Corona Virus Infection
Knowledge, Attitude and Practice of Dental Students About COVID-19
Coronavirus disease 2019 (abbreviated "COVID- 19") is a pandemic respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China.
- Conditions
- Acute Respiratory Distress Syndrome, Corona Virus Infection, Acute Lung Injury, Fever
- Trial name
- NCT04449081
- Testing
- Knowledge, Attitude, Practice, Awareness, Preference
- Where
- Malaysia
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
Septic Shock
Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis
Multicenter, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension.
- Trial name
- CLOVERS (NCT03434028)
- Testing
- Early Vasopressors, Early Fluids
- Where
- 50 sites in United States
- Volunteers
- 1,563 people
- Sponsor
- Massachusetts General Hospital
Vitamin A Deficiency in Children
Prevalence Of Vitamin A Deficiency In Critically Ill Children With Sepsis And Its Association With Clinical Outcomes
Aim of the work is to assess the prevalence of vitamin A deficiency in critically ill children with sepsis and the association between vitamin A deficiency and clinical outcomes
- Trial name
- NCT06391437
- Testing
- Extraction of blood sample
- Where
- Egypt
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Benha University
Infant, Premature, Hypoperfusion in Newborn
Monitoring of Systemic or Organ Perfusion for Preterm Infants
To investigate biomarker reflects systemic or specific organ perfusion well, we are going to the observational comparison study using several hemodynamic monitoring methods in the premature infants.
- Conditions
- Infant, Premature, Hypoperfusion in Newborn, Necrotizing Enterocolitis of Newborn, Sepsis Newborn
- Trial name
- NCT03136172
- Testing
- NIRS (near Infra-red spectroscopy)
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Inha University Hospital
Sepsis, Critically Ill
Serum TNF-a in Comparison to Sequential Organ Failure Assessment (SOFA) Score Monitoring in Critically Ill Patients
A total of ninety patients (52men and 38women) were included in the study. Forty five patients developed septic complication during ICU stay (sepsis group).
- Trial name
- NCT01708772
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Sepsis
Randomized, Parallel Group, Placebo Control, Unicentric, Interventional Study to Assess the Effect of Expanded Human Allogeneic Adipose-derived Mesenchymal Adult Stem Cells on the Human Response to Lipopolysaccharyde in Human Volunteers
Phase I, randomized, parallel group, placebo control, unicentric, interventional study. Thirty two healthy male volunteers aged between 18-35 years will be randomized into the eASCs or placebo group if they meet all the inclusion…
- Trial name
- CELLULA (NCT02328612)
- Testing
- Intravenous infusion of cells
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Tigenix S.A.U.
Sepsis
Serial Body Composition Change for Risk Prediction and Nutritional Guide in Treating Patients With Sepsis
To explore whether serial changes of data in body composition of patients with sepsis can help clinician to monitor prognosis.
- Trial name
- NCT04989569
- Testing
- Nutritional intervention
- Where
- Taiwan
- Volunteers
- 132 people
- Sponsor
- Chang Gung Memorial Hospital
Necrotizing Pancreatitis
ABTHERA ADVANCE™ Use Without Wittman Patch
The objective of this study is to evaluate the use of the ABTHERA ADVANCE for patients requiring open abdomen due to necrotizing pancreatitis.
- Trial name
- NCT04986943
- Testing
- Using ABTHERA Advance without a Wittmann Patch
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
Severe Sepsis, Septic Shock
Effects on Microcirculation of IgGAM in Severe Septic/Septic Shock Patients.
IgM-enriched immunoglobulins (IgGAM; Pentaglobin ® ) are new therapy for sepsis and septic shock since they support immune system especially in case of " immunoparalysis" .
- Trial name
- NCT02655133
- Testing
- Pentaglobin®, Physiologic solution
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Università Politecnica delle Marche
Shock
Evaluation of the Pharmacokinetics of Caspofungin in ICU Patients
Although the pharmacokinetics of Caspofungin has been studied in healthy subjects and patients, only a few studies have been performed in critically-ill patients.
- Trial name
- CaspoKin (NCT02596984)
- Testing
- Caspofungin
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sepsis, Septic Shock
Evaluation of Predictive Proteic Profile on Mortality in the Acute Phase of Septic Shock in Cancer Patients
The mortality induced by infections in onco-hematological patients is abnormally high at the acute phase of septic shock. Consequently, it is important to detect the population with a high risk of short term mortality among…
- Conditions
- Sepsis, Septic Shock, Cancer
- Trial name
- PROTEOHSEPS (NCT00930085)
- Testing
- SELDI-TOF MS for plasmatic proteic profile
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut Paoli-Calmettes
Septic Shock
Effects of Levosimendan on Microcirculation in Septic Shock
The present study was conducted as a prospective, randomized, controlled study to: investigate the effects of a combination of levosimendan and inhaled nitric oxide on systemic hemodynamics and microcirculation in patients with…
- Trial name
- NCT00800306
- Testing
- Levosimendan, dobutamine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Sepsis, Adult Disease
Sepsis Post Market Clinical Utility Simple Endpoint Study - Indiana University Hospital
The purpose of this study is to demonstrate that addition of the Monocyte Width Distribution (MDW) parameter to current standard of care improves a clinician's ability to recognize sepsis in the Emergency Department, resulting in…
- Conditions
- Sepsis, Adult Disease, Severe Sepsis, Emergency Department
- Trial name
- NCT04819035
- Testing
- CBC-DIFF Monocyte Volume Width Distribution (MDW)
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Beckman Coulter, Inc.
Endotoxemia, Inflammation
The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia
Excessive inflammation, production of free radicals and vascular injury are considered the main contributors to the development of organ dysfunction in patients with severe infections and sepsis.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT00916448
- Testing
- Atazanavir, E. coli endotoxin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis
Effect of the 1-hour Sepsis Bundle on In-hospital Mortality in Patients With Sepsis in the Emergency Department
Reducing the mortality and morbidity of sepsis is a worldwide priority for almost 20 years. Since an observational study in the NY state, which reported in-hospital mortality increased, associated with each supplemental hour to…
- Trial name
- 1BED (NCT05273034)
- Testing
- 1-hour sepsis bundle
- Where
- France
- Volunteers
- 873 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bacteremia
Effectiveness of Routine Sterile Gloving in Blood Culture
The purpose of this study is to determine whether routine sterile gloving can lower contamination rates in blood culture.
- Trial name
- NCT00973063
- Testing
- Routine sterile gloving
- Where
- South Korea
- Volunteers
- 1,854 people
- Sponsor
- Seoul National University Hospital
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