Clinical trials: Sepsis, completed
Shock, Septic, Community Acquired Pneumonia
Clinical Practice Guidelines and Impact of Audit and Feedback in the Emergency Department
This study will develop and test an intervention given to emergency medicine providers to improve adherence to clinical practice guidelines (CPGs) for pneumonia and sepsis.
- Trial name
- NCT02427048
- Testing
- Feedback with Peer Comparison
- Volunteers
- 24 people
- Sponsor
- Denver Health and Hospital Authority
Septic Shock
Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot
Life-threatening infections account for 10% of all intensive care unit admissions and constitute the second more frequent cause of death in the ICU after heart diseases.
- Trial name
- NCT01648036
- Testing
- Unfractionated heparin, Dalteparin
- Where
- 9 sites in Canada
- Volunteers
- 76 people
- Sponsor
- University of Manitoba
Sepsis and Septic Shock
The Prognostic Impact of Right Ventricular Systolic Dysfunction on the Survival of Patients With Sepsis and Septic Shock
This study sought to evaluate the association of right ventricular systolic dysfunction and 28-day in-hospital mortality in patients with sepsis and septic shock.
- Trial name
- NCT06193109
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Burapha University
Severe Sepsis and Septic Shock
Statistical Analysis Plan for an Individual Patient Data Meta-analysis of Three, International Trials Comparing Protocolised With Usual Resuscitation in Patients Presenting to the Emergency Department With Severe Sepsis and Septic Shock
This is the statistical analysis plan for an individual patient data meta-analysis (IPDMA) of three EGDT clinical trials.
- Trial name
- NCT02030158
- Volunteers
- 4,210 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Staphylococcus Aureus Infection
Probability of Target Attainment With Standard Intermittent Bolus Administration of Cefazolin in Patients With Complicated Infections Caused by Staphylococcus Aureus
Given the paucity of pharmacological data on cefazolin treatment of Methicillin-susceptible S. aureus (MSSA) complicated S. aureus infection (CSAI), the primary purpose of this study is to investigate the probability of…
- Trial name
- TARGET II (NCT04503252)
- Testing
- Blood samples for the measurement of the concentration of cefazolin, S. aureus culture isolate, structured telephone interview
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Infection, Bacterial, Infection, Fungal
How to Reduce Unnecessary Blood Cultures: Construction and Validation of a Predictive Score for Blood Culture Positivity in Intensive Care
Prospective observational cohort consisting of all adult patients admitted to participating critical care units (ICU and CCU) during the study period, with blood cultures collected as part of their care, and who did not express…
- Conditions
- Infection, Bacterial, Infection, Fungal, Bacteremia
- Trial name
- PROBIty (NCT05686577)
- Testing
- no intervention
- Where
- 10 sites in France
- Volunteers
- 2,411 people
- Sponsor
- University Hospital, Tours
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome
GM-CSF for Reversal of Immunoparalysis in Pediatric Sepsis-induced MODS
The GRACE-2 study is a prospective, multi-center, double-blind, randomized controlled trial of the drug GM-CSF vs placebo in children with sepsis-induced multiple organ dysfunction syndrome (MODS) who have immunoparalysis with…
- Trial name
- GRACE-2 (NCT05266001)
- Testing
- GM-CSF
- Where
- 25 sites in United States
- Volunteers
- 141 people
- Sponsor
- Nationwide Children's Hospital
Sepsis, Septic Shock
Fluids in Septic Shock (FISSH)
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world.
- Trial name
- FISSH (NCT03677102)
- Testing
- higher chloride crystalloid, lower chloride crystalloid
- Where
- 30 sites in Canada, Saudi Arabia
- Volunteers
- 1,113 people
- Sponsor
- McMaster University
Bacteremia
Incidence of Bacteremia Following Argon Plasma Coagulation in Patients With Endobronchial Lesions
Incidence of Bacteremia Following Argon Plasma Coagulation in Patients with Endobronchial Lesions
- Trial name
- NCT01179022
- Where
- Israel
- Volunteers
- 46 people
- Sponsor
- Meir Medical Center
Sepsis
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis
The purpose of this study is to determine whether inhaled nitric oxide is an effective treatment for microcirculatory dysfunction and acute organ system failure in the early stage of sepsis therapy.
- Trial name
- NCT00608322
- Testing
- Inhaled nitric oxide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Candidiasis
Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis
The purpose of this study is to further evaluate the safety and effectiveness of intravenous anidulafungin (Eraxis™) in patients with a diagnosis of candidemia or invasive candidiasis, which is a fungus infection of the blood or…
- Trial name
- NCT00496197
- Testing
- Eraxis (anidulafungin), Diflucan (fluconazole), Vfend (voriconazole)
- Where
- 43 sites in United States, South Korea
- Volunteers
- 282 people
- Sponsor
- Pfizer
Septic Shock
Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock
Sepsis is defined as a life-threatening event due to a dysregulated immune response to an host. Blood purification techniques may be considered as a therapeutic weapon to front sepsis and septic shock.
- Trial name
- NCT03456180
- Testing
- Haemoadsorption with Cytosorb cartridge
- Volunteers
- 10 people
- Sponsor
- Università Politecnica delle Marche
Meningococcal Infections, Neisseria Meningitis Sepsis
The Long-term Impact of Invasive Meningococcal Disease in Australian Adolescents and Young Adults
Survivors of invasive meningococcal disease (IMD) experience a range of mild to severe sequelae that impact upon their quality of life.
- Conditions
- Meningococcal Infections, Neisseria Meningitis Sepsis, Neisseria Infection
- Trial name
- AMEND (NCT03798574)
- Where
- 4 sites in Australia
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Sepsis
The Effects of HIV Protease Inhibitors in Severe Sepsis
Sepsis is the leading cause of death in critically ill patients in the United States. It develops in approximately 750,000 Americans annually, and more than 210,000 of them die.
- Trial name
- NCT00346580
- Testing
- Nelfinavir
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Sepsis, Septic Shock
Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock
Sepsis is a critical burden for a healthcare. From 2000 to 2020, the number of publications and clinical studies on the topic of Sepsis and septic shock on the National Library of Medicine resource The National Center for…
- Trial name
- NCT06404424
- Testing
- Efferon LPS, Efferon CT
- Where
- Russia
- Volunteers
- 82 people
- Sponsor
- Efferon JSC
Sepsis, Hip Fractures
The Association Between Preoperative Sepsis and the Mortality After Hip Fracture Surgery
The worldwide occurrence of hip fracture is high with an annual incidence of approximately 100 per 100.000 people. Mortality for patients undergoing hip fracture surgery is high with a 30-day mortality rate varying between 4.5…
- Trial name
- NCT03201679
- Testing
- Repair of hip fracture
- Volunteers
- 1,967 people
- Sponsor
- Bispebjerg Hospital
Septic Shock
Lactic Acid in the Rectum and Life-Threatening Infection
Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of lactic acid.
- Trial name
- NCT00197938
- Testing
- Measurement of rectal lactic acid.
- Where
- 5 sites in Denmark, Finland
- Volunteers
- 130 people
- Sponsor
- Herlev Hospital
Septic Shock
The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation
The study aims to compare the effects of restrictive fluid management on cardiac dysfunction and vascular integrity in septic shock patients.
- Trial name
- NCT04282252
- Testing
- I.V. SOLUTIONS
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Karolinska Institutet
Candidemia
Safety and Efficacy of Interferon-Gamma 1b in Patients With Candidemia
A multi-center open label adaptive randomized interventional phase 2 study to evaluate safety and efficacy of rIFN-y treatment in patiens with candidemia.
- Trial name
- HDM-FUN Cand (NCT04979052)
- Testing
- Interferon Gamma-1B
- Where
- 6 sites in United States, Germany and 4 more
- Volunteers
- 65 people
- Sponsor
- Radboud University Medical Center
Sepsis, Retinal Microcirculation Disorder
Ocular Microvascular Changes in Patients With Sepsis
This study evaluates differences in the ocular microcirculation between septic patients and healthy subjects and the course of ocular microvasculature in survivors and non-survivors over a 24 hours period of time in septic…
- Conditions
- Sepsis, Retinal Microcirculation Disorder, Conjunctiva; Disorder
- Trial name
- NCT04214743
- Testing
- Incident dark field videomicroscope from Braedius, Fundus camera from Optomed
- Where
- Lithuania
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
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