Clinical trials: Sepsis, completed
Endotoxemia, Sepsis
Determining the Fingerprint of Endotoxin Tolerance
An explorative, prospective study in 100 healthy volunteers who will be challenged with endotoxin twice to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance
- Conditions
- Endotoxemia, Sepsis, Systemic Inflammation, Immunosuppresion
- Trial name
- 100LPS (NCT06801873)
- Testing
- Endotoxin (E. coli O:113, Reference Endotoxin)
- Where
- Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Kidney Calculi, Urinary Tract Infections
Do Dynamic Urinary Leukocyte and Nitrite Changes Improve Risk Prediction for Infectious Complications Following PCNL?
Background Percutaneous nephrolithotomy (PCNL) is widely recognized as the primary surgical approach for managing sizable and anatomically complex kidney stones., yet postoperative infection-related complications remain common…
- Conditions
- Kidney Calculi, Urinary Tract Infections, Sepsis
- Trial name
- NCT07238673
- Where
- China
- Volunteers
- 346 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Candida
Candida PCR Diagnosis Strategy in Patients From Intensive Care Units
The aim of this study is to evaluate the implementation of a new technique for invasive candidiasis diagnosis by PCR. The main objective will be to evaluate the effect of this strategy on the time required to obtain results in…
- Trial name
- CANDI-PCR (NCT04874441)
- Testing
- Diagnosis strategy based on C. glabrata / krusei PCR
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Toulouse
Invasive Candidiasis
β-D-Glucan (BDG) Surveillance With Preemptive Anidulafungin vs. Standard Care for Invasive Candidiasis in Surgical Intensive Care Unit (SICU) Patients
This is a single center, prospective, open label assessment of β-D-glucan surveillance with preemptive anidulafungin therapy versus standard care for the prevention of invasive candidiasis in at-risk surgical intensive care unit…
- Trial name
- NCT00672841
- Testing
- Preemptive Therapy with Anidulafungin, Empiric antifungal therapy based on physician discretion.
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Duke University
Bacteremia
Spanish Bacteriemia Cohort 2016: Epidemiology, Clinical Management and Prognosis Factors
Bacteremia The Hypothesis of the study are the followings: To demonstrate relevant epidemiologic and clinical changes with potentially impact in the management and prognosis of the patients with bacteremia.
- Trial name
- PRO-BAC (NCT03148769)
- Where
- 29 sites in Spain
- Volunteers
- 5,320 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Sepsis
Indicators of Inflammation and Coagulation in Sepsis
We will collect blood samples from patients with the diagnosis of sepsis and other ICU patients. We will describe the course of different mediator levels and organ injury markers and follow their progression throughout the course…
- Trial name
- NCT01128283
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Oklahoma
Ventilator Associated Pneumonia
GRam Stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) Trial
Background: Optimising the use of antibiotic agents is a pressing challenge to overcoming the rapid emergence and spread of multidrug-resistant pathogens in intensive care units (ICUs).
- Trial name
- NCT03506113
- Testing
- Gram stain-guided antibiotic choice, Guidelines-based antibiotics choice
- Where
- 12 sites in Japan
- Volunteers
- 206 people
- Sponsor
- Osaka General Medical Center
Gram-negative Bacteremia, Bacteremia
Clinical Outcomes and Cost of Gram Negative Bacteremia
This study examines the clinical outcomes and healthcare costs associated with gram negative bacteremia at Duke University Medical Center from 2002-2015.
- Trial name
- NCT02599220
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Duke University
Sepsis
Lactate Metabolism After an Endotoxin Challenge in Healthy Humans
Sepsis is characterized by hyperlactatemia, the severity of which is proportionate with sepsis severity. The pathophysiological mechanisms (increased lactate production vs decreased lactate utilization; tissues involved in…
- Trial name
- NCT01647997
- Testing
- bacterial endotoxin challenge
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Central Venous Catheter Thrombosis, Central Venous Catheter Related Bloodstream Infection
CLiCK in the Critical Care Unit
Insertion of a central venous access device (CVAD) allows clinicians to easily access the circulation of a patient to administer life-saving interventions.
- Conditions
- Central Venous Catheter Thrombosis, Central Venous Catheter Related Bloodstream Infection, Catheter Complications, Catheter Blockage
- Trial name
- CLiCK (NCT04548713)
- Testing
- 4% EDTA, Saline
- Where
- 6 sites in Canada
- Volunteers
- 1,449 people
- Sponsor
- Fraser Health
Catecholamine-resistant Hypotension (CRH), Distributive Shock
A Phase 3 Study of LJPC-501 in Patients With Catecholamine-Resistant Hypotension
This is a Phase 3, double-blind, randomized study of LJPC-501 (angiotensin II) in adult patients diagnosed with catecholamine-resistant hypotension (CRH) conducted in multiple centers globally.
- Conditions
- Catecholamine-resistant Hypotension (CRH), Distributive Shock, High Output Shock, Sepsis
- Trial name
- ATHOS-3 (NCT02338843)
- Testing
- LJPC-501
- Where
- 115 sites in United States, Australia and 8 more
- Volunteers
- 344 people
- Sponsor
- La Jolla Pharmaceutical Company
Sepsis, Glucocorticoid
Clinical Characteristics and Risk Factors for In-Hospital Mortality in Surgical Patients With Abdominal Sepsis
A retrospective study of sepsis patients with abdominal infections who underwent abdominal surgery was conducted in an attempt to reveal the epidemiological characteristics of sepsis after abdominal surgery, risk factors, and to…
- Trial name
- NCT06756750
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Chinese PLA General Hospital
Critical Illness, Pharmacokinetics
Optimization of PK/PD Target Attainment for Meropenem in Critically Ill Patients With Sepsis
WP1.1. PK/PD target attainment: Plasma exposure, Excretion via urine \& ELF exposure; WP1.2. Predictive dosing algorithm; WP1.3. ECMO subset
- Trial name
- NCT03560557
- Volunteers
- 116 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Failure, Critical Illness
Safety and Tolerance on Lipids of Parenteral and Enteral Nutrition in Critically Ill Patients With Liver Failure
The purpose of the study is to determine the tolerance on lipid metabolism and the safety of short-term parenteral nutrition as compared to enteral nutrition in critically ill patients with liver failure.
- Trial name
- SELLIFA (NCT00522730)
- Testing
- Parenteral nutrition, Enteral nutrition
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sepsis - to Reduce Mortality in the Intensive Care Unit, Hemodiafiltration
Comparative Effectiveness of Oxiris Hemofilters Versus Conventional Hemofilters in Septic Patients
We divided patients in 2 groups. First group was the patients who received Oxiris filters during CRRT. Second group was the patiens who have received CRRT filters other than Oxiris.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Hemodiafiltration, Cytokine
- Trial name
- NCT06735365
- Testing
- CRRT
- Where
- Turkey (Türkiye)
- Volunteers
- 426 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Delirium
Neuronal Damage In Delirium Study
The purpose of this study is to evaluate associations between neuronal damage biomarkers (S100 calcium-binding protein beta [S-100β], neuron-specific enolase [NSE], ubiquitin carboxy-terminal hydrolase L1 [UCHL1], and…
- Trial name
- NDID (NCT03724201)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Sepsis
Resuscitation Failure, Oxidative Stress, and Necroptosis as Mortality Predictor in Septic Patient
Resuscitation failure, oxidative stress and necroptosis were able to predict mortality in septic patient
- Trial name
- NCT04169412
- Testing
- Blood Collection
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Universitas Sriwijaya
Intra-Abdominal Infections, Intestinal Obstruction
Capillary Leak Index as a Prognostic Indicator for Post-Operative Abdominal Sepsis in Critically Ill Patients
In this study the investigators going to evaluate the "CLI" as an early prognostic indicator for post-operative abdominal sepsis in critically ill patients.
- Conditions
- Intra-Abdominal Infections, Intestinal Obstruction, Appendicitis Acute, Perforated Viscus
- Trial name
- CLI (NCT06901544)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Sepsis, Critical Illness
Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients
Patients admitted to the ICU with diagnosis of sepsis and requiring mechanical ventilation for at least 24-hours and receiving enteral or parenteral nutrition will be prospectively randomized to one of two arms.
- Conditions
- Sepsis, Critical Illness, Respiratory Failure, Nutrition Disorders
- Trial name
- NCT03440593
- Testing
- Caloric delivery will target results of IC measurement.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
AKI, Sepsis
Effect of CRRT Duration on Solute Removal
The only FDA approved treatment for acute kidney injury(AKI) for patients is Dialysis-also known as renal replacement therapy(RRT). Continuous RRT(CRRT) is the preferred method in the ICU.
- Trial name
- NCT04458571
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Colorado, Denver
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