Clinical trials: Sepsis, completed
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Sepsis
Effect of Intravenous Vitamin C on SOFA Score Among Septic Patients
This study aimed to explore the effect of intravenous (IV) vitamin C on sequential organ failure assessment (SOFA) score among septic patients in intensive care unit (ICU).
- Trial name
- NCT04137276
- Testing
- vitamin C, vitamin B1, vitamin B1
- Where
- Indonesia
- Volunteers
- 33 people
- Sponsor
- Universitas Indonesia
Severe Sepsis, Septic Shock
Procalcitonin Monitoring Sepsis Study
The purpose of this study is to investigate the relationship between a procalcitonin decrease over 72 hours and outcome in patients who have severe sepsis or septic shock.
- Trial name
- MOSES (NCT01523717)
- Where
- 13 sites in United States
- Volunteers
- 858 people
- Sponsor
- Brahms AG
Septic Shock, Anemia
TRANSfusion in Patients With Onco-hematological Malignancies ResusciTated From Septic Shock
Septic shock is a frequent complication associated with high mortality in patients with malignancies. The best transfusion strategy (restrictive or liberal) for the resuscitation of septic shock remains a controversial issue, in…
- Conditions
- Septic Shock, Anemia, Cancer
- Trial name
- TRANSPORT (NCT03837171)
- Testing
- Liberal Red blood cell transfusion, Restrictive Red blood cell transfusion
- Where
- 20 sites in France
- Volunteers
- 192 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Staphylococcal Sepsis
Safety and Pharmacokinetics Study in Adults for the Prevention of S. Epidermidis Infection in Low Birth Weight Infants
The purpose of this Phase 1 study is to evaluate the safety and pharmacokinetics of BSYX-A110 in a small number of healthy adult volunteers.
- Trial name
- NCT00636285
- Testing
- BSYX-A110
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Biosynexus Incorporated
Sepsis
Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis
In an effort to better understand the interaction between the different mediators, the investigators propose to examine the time course of mediators, the indexes of organ injury and the coagulation cascade.
- Trial name
- Histone (NCT01012115)
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Oklahoma
Sepsis
Efficacy & Safety of Resatorvid in Adults With Severe Sepsis
The purpose of this study is to determine the optimal dose of Resatorvid for reducing 28-day all-cause mortality in subjects with severe sepsis.
- Trial name
- NCT00143611
- Testing
- Resatorvid
- Where
- 144 sites in United States, Australia and 15 more
- Volunteers
- 277 people
- Sponsor
- Takeda
Endotoxemia
The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia
During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death.
- Trial name
- NCT01091571
- Testing
- Dipyridamole, LPS
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis
Pharmacoeconomic Analysis of First Line Meropenem Versus Standard Antibiotic Treatment in Seriously Infected Secondary Nosocomial Sepsis Syndrome Patients.
This study will directly compare meropenem with standard first line antibiotic therapies in subjects entering an ICU with secondary nosocomial sepsis, or who contract sepsis while resident in an ICU.
- Trial name
- NCT00318552
- Testing
- Meropenem
- Where
- 12 sites in Hungary
- Volunteers
- 160 people
- Sponsor
- Pfizer
Diagnostic
Role of Inflammatory Markers in Sepsis
A diagnostic and prognostic study, in which the expression of CD64 in activated neutrophils and CD64 and IL17A regulatory T cells in patients with sepsis will be evaluated as a probable marker for sepsis as a primary objective
- Trial name
- NCT06111963
- Testing
- Serology tests
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Septic Shock
Muscle Ultrasound Study in Shock Patients
Intensive Care Unit (ICU) patients are known to lose muscle mass and function for many reasons, ranging from prolonged immobilization, to the effects of ICU treatments such as mechanical ventilation (MV), to the critical illness…
- Trial name
- MUSiShock (NCT04550143)
- Testing
- Diaphragm ultrasound (DUS), Peripheral Muscle Ultrasound (PMUS), Airway occlusion pressure (P0.1)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Premature Birth, Late-onset Invasive Infection
Speed of Increasing Milk Feeds Trial
Survival of preterm infants has increased greatly over the years, so a major aim now is to improve the long term outlook for these babies and to avoid serious complications.
- Conditions
- Premature Birth, Late-onset Invasive Infection, Necrotizing Enterocolitis
- Trial name
- SIFT (NCT01727609)
- Testing
- Milk feed (breast milk or formula milk)
- Where
- 57 sites in Ireland, United Kingdom
- Volunteers
- 2,804 people
- Sponsor
- University of Oxford
Candidemia
Negative Beta Glucan in ICU Patients
This is a prospective study aimed at testing a strategy of early initiation of an antifungal agent to patients admitted to intensive care units (ICUs) at risk for invasive candidiasis.
- Trial name
- NCT01734525
- Testing
- Anidulafungin
- Where
- Brazil
- Volunteers
- 85 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Bacteremia, Sepsis
Rapid Blood Culture Identification Panel in Pediatric Patients in Guatemala
The purpose of this study is to assess the clinical impact of a rapid multiplex PCR blood culture identification panel on time to optimal antimicrobial therapy when compared to conventional microbiological culture methods in…
- Trial name
- NCT05314816
- Testing
- Blood culture identification panel
- Where
- Guatemala
- Volunteers
- 479 people
- Sponsor
- University of Colorado, Denver
Severe Sepsis
The Efficacy of Si-Ni-Tang (a Chinese Herbal Formula) for Severe Sepsis
The purpose of this study is to evaluate the efficacy of Si-Ni-Tang (a Chinese Herbal Formula documented in Shang Han Lun) in treating severe sepsis.
- Trial name
- NCT02777606
- Testing
- Si-Ni-Tang
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Septicaemia
Monitoring of the Mitochondrial Function of Circulating Myeloid Cells in Patients Hospitalized in the Intensive Care Unit of Dijon University Hospital
Severe infections (sepsis) are a common cause of admission to the intensive care unit. They represent a significant health risk for patients in the short and medium term.
- Trial name
- Myelochondria (NCT04439617)
- Testing
- blood examination
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Sepsis, Septic Shock
Pharmacokinetics of XueBiJing in Patients With Sepsis
Pharmacokinetics and disposition of XueBiJing compounds in patients with sepsis
- Conditions
- Sepsis, Septic Shock, Community Acquired Pneumonia
- Trial name
- NCT03475732
- Testing
- XueBiJing injection
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Southeast University, China
Toxic Shock Syndrome, Vaccination; Sepsis
rTSST-1 Variant Vaccine Phase 1 First-in-man Trail
Toxic Shock Syndrome (TSS) a severe condition with high morbidity and mortality results from the hosts overwhelming inflammatory response and cytokine storm. Staphylococcal superantigen toxins are the main causative agents.
- Trial name
- rTSST-1 (NCT02340338)
- Testing
- rTSST-1 Variant Candidate Vaccine
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Biomedizinische Forschungs gmbH
Malaria,Falciparum, Malaria
Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria
This is an open-label, adaptive study that will utilise the P. falciparum induced blood stage malaria (IBSM) model to characterise the pharmacokinetic/pharmacodynamic (PK/PD) profile of pyronaridine.
- Conditions
- Malaria,Falciparum, Malaria, Malaria Recrudescence, Parasitemia
- Trial name
- NCT05287893
- Testing
- Pyronaridine, P. falciparum IBSM infection
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
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