Clinical trials: Sepsis, completed
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether…
- Trial name
- PRoMPT BOLUS (NCT04102371)
- Testing
- Lactated Ringer, Normal Saline, Plasma-lyte
- Where
- 22 sites in United States
- Volunteers
- 9,041 people
- Sponsor
- Children's Hospital of Philadelphia
Sepsis
Diagnostic and Prognostic Biomarkers of Sepsis
This study aims to evaluate sepsis biomarkers as soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and soluble urokinase plasminogen activator receptor (sUPAR) in diagnosis of sepsis in comparison to the…
- Trial name
- NCT04767893
- Where
- Egypt
- Volunteers
- 67 people
- Sponsor
- Sohag University
Central Line Bloodstream Infections
The Effectiveness of Silver Alginate (Algidex) Patch in the Prevention of Central Line Infections in Very Low Birth Weight Infants
The purpose of this study is to determine whether silver alginate (Algidex) patch is effective in the prevention of central line infections in very low birth weight infants.
- Trial name
- NCT00964093
- Testing
- Silver Alginate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Sepsis Syndrome
The Benefit of Adding Fish Oil to the Nutrition of Critically Ill Patients
We study whether an increased proportion of omega-3-fatty acids (contained in fish oil) in the nutrition of critically ill patients reduces systemic inflammation.
- Trial name
- NCT00142220
- Testing
- Defined percentage of omega-3-fatty acids
- Where
- Germany
- Volunteers
- 160 people
- Sponsor
- University Medicine Greifswald
Systemic Infections
Safety and Tolerability of Ceftazidime-Avibactam for Pediatric Patients With Suspected or Confirmed Infections
To assess the pharmacokinetics, safety and tolerability of a single dose of CAZ-AVI in children from 3 months of age to <18 years.
- Trial name
- NCT01893346
- Testing
- CAZ-AVI
- Where
- 10 sites in United States
- Volunteers
- 35 people
- Sponsor
- Pfizer
Intubated ICU Patients, Sepsis and Septic Shock
Association of Arterio-Venous Oxygen and Carbon Dioxide Gradients With Tissue Hypoperfusion and Mortality in Sepsis
In patients with sepsis who are treated in the intensive care unit under invasive mechanical ventilation, the combined evaluation of ScvO₂ and PcvCO₂ may provide a comprehensive insight into tissue oxygenation and metabolic…
- Trial name
- NCT07711405
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Hospital Acquired Pneumonia, Ventilator-Associated Pneumonia
Hospital-acquired Pneumonia in Intensive Care Unit
hospital-acquired pneumonia are a common disease in intensive care unit. The prevention, the diagnosis and the treatment of hospital acquired pneumonia are a frequent challenge.
- Conditions
- Hospital Acquired Pneumonia, Ventilator-Associated Pneumonia, Sepsis, Pneumonia
- Trial name
- PNEUMOCARE (NCT03348579)
- Testing
- Guidelines publication and application, Targeted experience feedback
- Where
- France
- Volunteers
- 1,850 people
- Sponsor
- Nantes University Hospital
Septic Shock
Hemodynamic Effects of Dexmedetomidine in Septic Shock
The current treatment regimen of patients with septic shock requires a sufficient hemodynamic support aiming to preserve tissue oxygen requirements and perfusion.
- Trial name
- NCT02638545
- Testing
- Dexmedetomidine
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- University of Roma La Sapienza
Sepsis
Clinical Protocol Validation to Identify Prognostic Markers for Critical Care Pediatric Patients
The purpose of this study is to monitor the respiratory, metabolic and nutritional status of critically ill pediatric patients undergoing mechanical ventilation and to correlate the clinical and physiopathological findings with…
- Trial name
- PCL07 (NCT00792883)
- Where
- Brazil
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Septic Shock
Muscle Lactate and Lactate to Pyruvate Ratio Clearance in Septic Shock Patients
We conducted this study aiming to assess the performance of muscle Lactate and lactate to pyruvate (L/P) ratio clearance in predicting mortality in septic shock patients by using microdialysis.
- Trial name
- ClMLsepsis (NCT03700346)
- Testing
- microdialysis
- Where
- 2 sites in Tunisia
- Volunteers
- 73 people
- Sponsor
- Military Hospital of Tunis
Staphylococcus Aureus, Bacteremia
Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia
To study whether fluoroquinolone (trovafloxacin or levofloxacin), added to standard treatment, could reduce the high mortality and complication rates in Staphylococcus aureus bacteremia.
- Conditions
- Staphylococcus Aureus, Bacteremia, Endocarditis, Sepsis
- Trial name
- FINLEVO (NCT00548002)
- Testing
- trovafloxacin and levofloxacin
- Where
- Finland
- Volunteers
- 430 people
- Sponsor
- University of Helsinki
Signs and Symptoms, Respiratory
Improved Patient Safety Through Continuous Bi-channel RR and SpO2 Monitoring With Masimo Patient SafetyNet
The investigator intend to perform an observational study, by adding Respiratory Rate monitoring to an already existing Patient SafetyNet system with SpO2 (Oxygen Saturation) and PR (Pulse Rate) monitoring.
- Trial name
- SafetyNet (NCT03043911)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Baylor Research Institute
Sepsis
Quantification of Dilutional Anemia in the Initial Phase of Sepsis Management: Preliminary Retrospective Study
This is a single-center retrospective study conducted at Mercy hospital, aiming to investigate the correlation between changes in hemoglobin (Hb) levels and the volume of vascular refill administered during the first 48 hours.
- Trial name
- QUADS (NCT06242561)
- Testing
- Data collection from sepsis management
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Bacteremia
Cefepime vs. Carbapenems for Treating AmpC β-lactamase-producing Enterobacteriaceae Bloodstream Infections
Recent international recommendations suggest the use of carbapenem rather than cefepime in this situation, but with a low level of evidence, given the few existing studies.
- Trial name
- CARBAPENEM (NCT05535751)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Health Care Associated Infection, Ventilator Associated Pneumonia
Daily Chlorexidine Bath for Health Care Associated Infection Prevention
Cluster randomized controlled trial comparing two bathing strategies in critically ill patients. The intervention group will receive daily bathing with chlorhexidine. The control group will receive usual care.
- Conditions
- Health Care Associated Infection, Ventilator Associated Pneumonia, Central Line-associated Bloodstream Infection (CLABSI), Catheter-Associated Urinary Tract Infection
- Trial name
- CLEAN-IT (NCT05485051)
- Testing
- 2% chlorhexidine digluconate solution with surface-active agents, Usual Baths
- Where
- 16 sites in Brazil
- Volunteers
- 15,730 people
- Sponsor
- Hospital do Coracao
Critical Illness Myopathy, Myopathy Critical Illness
Understanding the Mechanisms of Critical Illness Myopathy by Use of a Novel Electrophysiological Method - MVRCs
Critical illness myopathy (CIM) is a disabling condition that develops in critically ill patients. The syndrome is not only a cause of prolonged intensive care hospitalisation but also a main reason for delayed recovery.
- Trial name
- NCT04711070
- Where
- 2 sites in Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sándor Beniczky
Central Line-associated Bloodstream Infection (CLABSI)
Hydrochloric Acid Lock Therapy for Central Line-associated Bloodstream Infections
Aim: This study will test whether treatment of central line-associated bloodstream infections (CLABSI) with hydrochloric acid lock therapy (HALT) can significantly reduce the risk of treatment failure (comprising failure to clear…
- Trial name
- NCT05376566
- Testing
- Hydrochloric Acid (2 M), Normal saline
- Where
- 4 sites in Denmark
- Volunteers
- 212 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sepsis, Severe Sepsis
Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya
Sepsis is a clinical syndrome representing deranged hemodynamics (such as tachycardia) secondary to severe infection. In high-income countries (HICs), early resuscitation of septic patients with protocol-driven therapy, including…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02346331
- Testing
- WHO algorithm of fluid boluses guided by physical examination, Frequent patient monitoring, Early administration of empiric antibiotics
- Where
- Kenya
- Volunteers
- 198 people
- Sponsor
- Duke University
Alcohol Consumption
Effects of Ethanol on Gut Wall Integrity
Objective: To determine the immediate effects of oral alcohol consumption in healthy volunteers on gut wall integrity as measured by I-FABP and LBP. Study design: Randomized, single blinded cross over study.
- Trial name
- E-GUT (NCT02126072)
- Testing
- Alcohol, Water
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Pneumonia, Acute Pyelonephritis
NGS-Based Assay of Blood Samples of Sepsis Patients for Rapid Bacterial Identification
Rapid detection of microorganisms is a promising approach towards early administration of appropriate antibiotics for sepsis. This study aims to investigate the potential of a new NGS platform for the rapid diagnosis of…
- Conditions
- Pneumonia, Acute Pyelonephritis, Bacteremia, Biliary Tract Infection
- Trial name
- BIOARTE (NCT06141395)
- Testing
- NGS-based assay for bacterial identification
- Where
- 4 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
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