Clinical trials: Sepsis, completed
Acute Kidney Injury, Renal Artery Blood Flow
Characteristics of Renal Blood Flow in AKI Patients in ICU and Its Clinical Significance
To study the changes in the renal artery and renal vein with renal cortical and medullary microcirculatory blood flow in patients with sepsis; to study the relationship between renal arteriolar and renal vein with renal cortical…
- Conditions
- Acute Kidney Injury, Renal Artery Blood Flow, Renal Venous Return, Renal Microcirculation
- Trial name
- NCT06090773
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking Union Medical College Hospital
Alcoholic Hepatitis, Sepsis
Vitamin C Infusion for TReatment in Sepsis and Alcoholic Hepatitis
The purpose of this research study is to test the safety, tolerability, and effectiveness of Vitamin C (ascorbic acid) intravenous infusion when used to treat alcoholic hepatitis (inflammation of the liver from heavy alcohol use)…
- Trial name
- CITRIS-AH (NCT03829683)
- Testing
- Vitamin C, Dextrose 5% in water
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Sepsis
A Prognostic Model Based on POCUS at ICU Admission in Critically Ill Patients With Sepsis
Sepsis is responsible for one in three patient deaths. Understanding the severity of the disease, directing medications, prognosticating, and communicating with family members depend on the ability to predict outcomes in a…
- Trial name
- NCT06082154
- Testing
- ultrasound
- Where
- Nepal
- Volunteers
- 175 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Sepsis, Intensive Care (ICU)
Investigation of the Relationship Between MD, MLR and NLR With APRs in Sepsis in the ICU
The aim of this study is to investigate, in patients admitted to the intensive care unit either for reasons other than sepsis who subsequently develop sepsis or with a primary diagnosis of sepsis, whether monocyte distribution…
- Conditions
- Sepsis, Intensive Care (ICU), Acute Phase Biomarkers
- Trial name
- NCT07537179
- Testing
- Monocyte Distribution
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oguz Gundogdu
West Nile Fever
Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults
The purpose of this study is to determine whether a single subcutaneous injection of ChimeriVax-WN02 vaccine is well tolerated, safe and induces protective antibodies against West Nile Disease.
- Trial name
- NCT00442169
- Testing
- ChimeriVax-WN02 Low Dose, ChimeriVax-WN02 Medium Dose, ChimeriVax-WN02 High Dose
- Where
- 5 sites in United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Severe Sepsis
A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock.
A study to evaluate the safety, tolerability and pharmacokinetics of Nivolumab in participants with severe sepsis or septic shock.
- Trial name
- NCT02960854
- Testing
- Nivolumab
- Where
- 16 sites in United States
- Volunteers
- 38 people
- Sponsor
- Bristol-Myers Squibb
Severe Trauma
Immune-cell Membrane Trafficking
Organ failure following trauma is a leading cause of morbidity and mortality. It appears that the development of organ failure is a direct result of an altered immune response.
- Trial name
- NCT00638521
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- University of Washington
ARDS, Septic Shock
ARDS Prediction Score in Critically Ill Patients in China
ARDS is a severe disease, it's important to predict the incidence of ARDS.
- Trial name
- NCT02174081
- Where
- China
- Volunteers
- 698 people
- Sponsor
- Jianfeng Xie
Septic Shock
Activated Protein C and Corticosteroids for Human Septic Shock
This study aims at comparing the efficacy and safety of recombinant human activated protein C to that of low dose of corticosteroids and at investigating the interaction between these drugs in the management of septic shock
- Trial name
- APROCCHS (NCT00625209)
- Testing
- recombinant human activated protein C and hydrocortisone and fludrocortisone
- Where
- 4 sites in France
- Volunteers
- 1,241 people
- Sponsor
- University of Versailles
Sepsis
The Efficacy and Safety of Ta1 for Sepsis
The purpose of this study is to determine whether thymalfasin is safe and effective in patients who have sepsis
- Trial name
- TESTS (NCT02867267)
- Testing
- Thymosin alpha 1
- Where
- 22 sites in China
- Volunteers
- 1,106 people
- Sponsor
- Sun Yat-sen University
Sepsis
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis
The purpose of this study is to determine whether inhaled nitric oxide is an effective treatment for microcirculatory dysfunction and acute organ system failure in the early stage of sepsis therapy.
- Trial name
- NCT00608322
- Testing
- Inhaled nitric oxide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Endotoxemia
Pathophysiology and Clinical Relevance of Endotoxin Tolerance in Humans
A number of diseases lead to a so called systemic inflammatory response syndrome (SIRS). This excessive response is self-destructive and leads to major complications of the initial disease: dysfunction of the microcirculation…
- Trial name
- NCT00246714
- Testing
- repeated injections of endotoxin during 5 days
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Septic Peritonitis
Effects of Dexmedetomidine vs Propofol in Patients With Intra-abdominal Sepsis
Sepsis is defined as systemic response to infection ,and it is a main problem in ICU and despite advance in supportive care, the mortality rate in patients with severe sepsis continues to exceed 30% [Bone RC 1993].The effects of…
- Trial name
- NCT04718714
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Optimal Intensity of Renal Replacement Therapy on Sepsis Patients
Effect of the Intensity of Continuous Renal Replacement Therapy
In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from 50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.
- Trial name
- NCT01251081
- Testing
- extra high volume hemofiltration, high volume hemofiltration
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Zhejiang University
Critical Illness, Sepsis
Does GM-CSF Restore Neutrophil Phagocytosis in Critical Illness?
Despite the introduction of multiple preventative measures rates of hospital acquired infection in the intensive care unit remain high. New approaches to tackling this problem are required.
- Conditions
- Critical Illness, Sepsis, Immuno-suppression
- Trial name
- GMCSF (NCT01653665)
- Testing
- Leukine, Normal Saline
- Where
- 4 sites in United Kingdom
- Volunteers
- 64 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Sepsis
The Distribution of Plasma Drug Concentrations of Beta-lactam Antibiotics in Intensive Care Unit Patients
In this project, intensive care unit (ICU) patients treated with beta-lactam antibiotics are included with the aim to investigate the potential underdosing in this patient group.
- Trial name
- TDM-ICU (NCT02446392)
- Testing
- No intervention.
- Where
- 4 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Linkoeping University
Exercise Program, Standard Care Control
Home-based Digital Exercise Training Program to Improve Physical Function of Older Sepsis Survivors - HEAL Sepsis Trial
Older sepsis survivors have poor physical function and need post-sepsis physical rehabilitation. Often times, sepsis survivors live far from research facilities and do not have access to rehabilitation services.
- Trial name
- NCT05568511
- Testing
- App-based exercise program, Standard of Care
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Florida
Sepsis, Relative Adrenal Insufficiency
Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis
The purpose of this pilot study is to (1) examine the changes in gene expression in patients who suffer from severe sepsis and whose shock (inadequate oxygen delivery to vital organs) state does not respond to fluid and…
- Trial name
- NCT00185783
- Testing
- Hydrocortisone Administration (Standard of Care Therapy)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Cirrhosis With Septic Shock
Comparison And Outcomes Of Fluid Resucitation With 0.9% Normal Saline And 5% Albumin In Cirrhosis Patients With Sepsis Induced Hypotension
300 consecutive patients with cirrhosis of any aetiology admitted with features of sepsis and sepsis induced hypotension to the intensive care unit, the emergency department and the step down units of Institute of Liver and…
- Trial name
- NCT02462902
- Testing
- 5% albumin Infusion, 0.9% sodium chloride solution
- Where
- India
- Volunteers
- 308 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Septic Shock
Effects of Terlipressin on Renal Perfusion in Patients With Septic Shock
This open-label, randomized controlled trial aimed to investigate the effect of a fixed dose of terlipressin added to usual care vs. usual care alone on renal perfusion in patients with septic shock.
- Trial name
- NCT04948372
- Testing
- Terlipressin treatment, Usual care
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Southeast University, China
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