Clinical trials: Sepsis, completed
Severe, Septic
Effects of Alkaline Phosphatase on Renal Function in Septic Patients
Septic shock is the most common cause of death in patients requiring intensive care. The kidney is one of the first organs to fail, stressing the importance to search for clinical interventions that may protect the kidneys during…
- Conditions
- Severe, Septic, Shock
- Trial name
- NCT00457613
- Testing
- bolus injection, followed by a continuous infusion ( 24 h) (Alkaline phosphatase)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Sepsis
Digital Capillary Refill for Monitoring of Sepsis
Observational study for monitoring of capillary refill time in sepsis
- Trial name
- NCT04529655
- Testing
- Capillary Refill Assessment
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Oregon Health and Science University
Localized Infection, Sepsis
The Procalcitonin and Survival Study
This is a randomised, single blinded, multicentre trial to evaluate whether daily procalcitonin (PCT) measurements and immediate diagnostic and therapeutic responses to abnormal values and day-to-day changes can reduce the…
- Conditions
- Localized Infection, Sepsis, Multiple Organ Failure
- Trial name
- PASS (NCT00271752)
- Testing
- Earlier therapeutic changes regarding infection
- Where
- 9 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Danish Procalcitonin Study Group
Sepsis
Impact and Safety of AI in Decision Making in the ICU: a Simulation Experiment
The impact of deploying artificial intelligence (AI) in healthcare settings in unclear, in particular with regards to how it will influence human decision makers.
- Trial name
- ICU (NCT05495438)
- Testing
- Hypothetical AI
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Septic Shock
Midodrine Effect on the Mortality Rates in Septic Shock Patients
Assessing the safety and efficacy of the adjunctive use of midodrine as a vasopressor in septic shock patients by measuring the difference in the mortality rates between control and intervention groups.
- Trial name
- NCT05778838
- Testing
- Midodrine Oral Tablet
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Noha Mansour
Sepsis, Critical Illness
Methionine Metabolism in Enterally Fed Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while muscle and structural protein synthesis…
- Trial name
- NCT01889264
- Testing
- Observational
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Sepsis
Impact of Heart Rate Characteristics Monitoring in Neonates
Hypothesis: Fewer neonates managed using information from heart rate characteristics (HRC) will require intubation and mechanical ventilation as a result of sepsis and sepsis-like illness.
- Trial name
- HeRO (NCT00307333)
- Testing
- HeRO heart rate characteristics monitor
- Where
- 8 sites in United States
- Volunteers
- 3,003 people
- Sponsor
- University of Virginia
Sepsis, Septic Shock
Impact of Early Sepsis Care Guided by the National Early Warning Score 2 in the Emergency Department
The goal of this pilot clinical trial is to determine the feasibility of conducting a fully powered type 1 hybrid effectiveness-implementation trial on early sepsis care that is guided by early warning score in adult emergency…
- Trial name
- NEWS-1-TRIPS (NCT05731349)
- Testing
- 2018 Surviving Sepsis Campaign Hour-1 Bundle
- Where
- 4 sites in Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Toxic Shock Syndrome, Vaccination; Sepsis
rTSST-1 Variant Vaccine Phase 1 First-in-man Trail
Toxic Shock Syndrome (TSS) a severe condition with high morbidity and mortality results from the hosts overwhelming inflammatory response and cytokine storm. Staphylococcal superantigen toxins are the main causative agents.
- Trial name
- rTSST-1 (NCT02340338)
- Testing
- rTSST-1 Variant Candidate Vaccine
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Biomedizinische Forschungs gmbH
Septic Shock
Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients
The investigators hypothesize that dobutamine is able to revert negative redistribution of flow by inducing a selective vasodilatory effect on hypoperfused territories, particularly at the sublingual and gastric mucosa, and at…
- Trial name
- NCT01271153
- Testing
- Dobutamine
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Late-Onset Neonatal Sepsis
Evaluation of bioMarkErs to Reduce Antibiotics Use in hospitalizeD nEonates
Late-onset neonatal sepsis (LOS), occurring in newborn of at least 7 days of life, is frequently observed in Neonatal Intensive Care Units (NICUs) and potentially severe (mortality, neurologic and respiratory impairments).
- Trial name
- EMERAUDE (NCT03299751)
- Testing
- Diagnostic performances of biomarkers combination
- Where
- 2 sites in France
- Volunteers
- 233 people
- Sponsor
- Hospices Civils de Lyon
Sepsis, Immune Deficiency
Assessing the Effects of CytoSorb Hemoperfusion on the Development on Immunoparalysis
In this randomized, open-label study, the investigators will assess whether CytoSorb hemoperfusion will prevent or attenuate the development of immunoparalysis in healthy volunteers undergoing repeated experimental endotoxemia.
- Conditions
- Sepsis, Immune Deficiency, Hemoperfusion, Blood Purification
- Trial name
- EndoSorb (NCT04643639)
- Testing
- CytoSorb hemoperfusion
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Systemic Infection
Pharmacokinetics (PK) of Antistaphylococcal Antibiotics in Infants (NICHD-2012-02-Staph Trio)
Multiple center, open-label, PK study
- Trial name
- Staph (NCT01728363)
- Testing
- Antibiotic
- Where
- 10 sites in United States
- Volunteers
- 63 people
- Sponsor
- Phillip Brian Smith
Septic Shock, Resuscitation
The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capillary Refill Time In Adult Patients With Septic Shock
The aim of this study is to compare the effect of resuscitation guided by Left ventricular outflow tract-velocity time integral (LVOT-VTI) variation versus the effect of resuscitation guided by inferior vena cava (IVC) variation…
- Trial name
- NCT06122909
- Testing
- Group VTI, Group IVC
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Kasr El Aini Hospital
Severe Sepsis or Septic Shock
Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)
Sepsis occurs when a serious infection - most commonly infection of the lungs, urinary system, or blood - leads to acute organ failure. It is a common, expensive, and frequently lethal condition.
- Trial name
- PITSTOP (NCT03068741)
- Testing
- Comparison 1: Prehospital Ceftriaxone, Comparison 2: Liberal fluids, Comparison 2: Conservative fluids
- Where
- 4 sites in Canada
- Volunteers
- 2,061 people
- Sponsor
- Dr. Damon Scales
Sepsis
Follow-up Data of Patients Treated With XIGRIS® in France
The transparency commission wishes that the laboratory Lilly France sets up a follow-up study describing the conditions of use of Xigris® in France.
- Trial name
- NCT00803231
- Where
- France
- Volunteers
- 1,004 people
- Sponsor
- Eli Lilly and Company
Septic Shock
Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock
The purpose of this study is to assess the concordance of therapeutic changes proposed after an early hemodynamic evaluation (hemodynamic profile) in septic shock patients using jointly the transpulmonary thermodilution technique…
- Trial name
- HEMOSEPSIS (NCT01188993)
- Testing
- early septic shock
- Where
- 2 sites in France
- Volunteers
- 153 people
- Sponsor
- University Hospital, Limoges
SARS-CoV-2 Acute Respiratory Disease, SARS-CoV-2 Sepsis
The Corona Study of Middle Norway
CUT COVID is a cohort study establised to collect information on patients hospitalized because or with infection by SARS-CoV-2. The cohort data includes clinical data and biological samples from multiple timepoints during…
- Conditions
- SARS-CoV-2 Acute Respiratory Disease, SARS-CoV-2 Sepsis, SARS CoV 2 Infection
- Trial name
- CUT COVID-19 (NCT05638178)
- Testing
- No intervention
- Where
- 5 sites in Norway
- Volunteers
- 223 people
- Sponsor
- St. Olavs Hospital
Bacteremia
Clinical Performance and Reproducibility of the Accelerate PhenoTest™ Blood Culture (BC) Kit With New Antibiotic Wave I Updates
This is a performance and reproducibility study to validate new or updated antimicrobials on the Accelerate PhenoTest™ BC kit. The data from this study will be used to support the submission to the FDA for clearance in the US and…
- Trial name
- NCT04295915
- Testing
- Specimens that meet inclusion criteria
- Where
- 3 sites in United States
- Volunteers
- 731 people, healthy volunteers welcome
- Sponsor
- Accelerate Diagnostics, Inc.
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